Incidental Mutation 'R4950:Vstm5'
ID 381923
Institutional Source Beutler Lab
Gene Symbol Vstm5
Ensembl Gene ENSMUSG00000031937
Gene Name V-set and transmembrane domain containing 5
Synonyms
MMRRC Submission 042547-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R4950 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 15239045-15259416 bp(+) (GRCm38)
Type of Mutation splice site (3 bp from exon)
DNA Base Change (assembly) A to G at 15257794 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000034413 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034411] [ENSMUST00000034413] [ENSMUST00000213788]
AlphaFold Q9D806
Predicted Effect probably benign
Transcript: ENSMUST00000034411
SMART Domains Protein: ENSMUSP00000034411
Gene: ENSMUSG00000031935

DomainStartEndE-ValueType
low complexity region 51 82 N/A INTRINSIC
Pfam:Med17 123 452 8.5e-13 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000034413
SMART Domains Protein: ENSMUSP00000034413
Gene: ENSMUSG00000031937

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
IG 39 138 2e-3 SMART
transmembrane domain 147 169 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000213788
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.5%
  • 20x: 92.9%
Validation Efficiency 100% (58/58)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bpifb9b A T 2: 154,311,659 (GRCm38) D215V probably damaging Het
Cacna1i A G 15: 80,368,671 (GRCm38) E625G probably damaging Het
Cage1 C T 13: 38,023,326 (GRCm38) S181N possibly damaging Het
Ccdc36 A C 9: 108,421,510 (GRCm38) S36R probably damaging Het
Ccdc73 A C 2: 104,992,366 (GRCm38) I887L probably benign Het
Cfap65 T A 1: 74,906,336 (GRCm38) K1408* probably null Het
Cngb1 C A 8: 95,248,507 (GRCm38) G654W probably damaging Het
Cxcl15 A T 5: 90,795,245 (GRCm38) E35D possibly damaging Het
Ddi1 A G 9: 6,266,073 (GRCm38) S99P probably benign Het
Disp3 A T 4: 148,258,126 (GRCm38) D622E possibly damaging Het
Dnajc22 G A 15: 99,101,734 (GRCm38) V267I probably benign Het
Dph5 G A 3: 115,928,643 (GRCm38) G257S probably benign Het
Elmo2 A T 2: 165,314,813 (GRCm38) probably null Het
Fam186a T C 15: 99,941,653 (GRCm38) R2237G unknown Het
Fez1 G A 9: 36,867,882 (GRCm38) R285Q probably damaging Het
Fsip2 A T 2: 82,946,932 (GRCm38) H101L probably damaging Het
Fsip2 G A 2: 82,977,414 (GRCm38) C1359Y probably benign Het
Fxyd7 G A 7: 31,047,390 (GRCm38) T15I probably benign Het
Gpr155 A T 2: 73,382,185 (GRCm38) D31E probably benign Het
Irx6 A T 8: 92,678,800 (GRCm38) Y432F probably damaging Het
Itih5 A C 2: 10,235,081 (GRCm38) I340L probably damaging Het
Lao1 T C 4: 118,965,375 (GRCm38) L164S probably damaging Het
Mcoln3 T C 3: 146,139,519 (GRCm38) I490T probably damaging Het
Mef2b T C 8: 70,167,196 (GRCm38) Y311H probably damaging Het
Mras A T 9: 99,394,484 (GRCm38) L111Q probably damaging Het
Mrc1 A G 2: 14,271,280 (GRCm38) D475G probably damaging Het
Nrcam T C 12: 44,598,490 (GRCm38) I1155T probably damaging Het
Ntrk1 A G 3: 87,789,611 (GRCm38) probably null Het
Olfr58 G A 9: 19,783,731 (GRCm38) M199I probably benign Het
Olfr885 T C 9: 38,062,001 (GRCm38) I227T probably damaging Het
Parp9 A T 16: 35,948,007 (GRCm38) I186F probably damaging Het
Pcdhac2 T A 18: 37,145,230 (GRCm38) V421E probably benign Het
Pck1 T A 2: 173,154,827 (GRCm38) I178K probably benign Het
Pde6b A G 5: 108,430,703 (GRCm38) K836E probably benign Het
Ptprd T A 4: 76,140,515 (GRCm38) probably null Het
Pwp2 A G 10: 78,183,006 (GRCm38) Y56H probably benign Het
Rarb G A 14: 16,432,085 (GRCm38) probably benign Het
Rpain C G 11: 70,970,921 (GRCm38) H50Q probably benign Het
Rps9 CTGTTTG CTG 7: 3,704,759 (GRCm38) probably null Het
Rubcn A T 16: 32,843,193 (GRCm38) S358T probably damaging Het
Ryr2 G A 13: 11,742,011 (GRCm38) R1586C probably damaging Het
Slfn9 T C 11: 82,981,904 (GRCm38) I669V probably benign Het
Slx1b T C 7: 126,691,767 (GRCm38) probably benign Het
Spsb3 T A 17: 24,887,511 (GRCm38) probably benign Het
Tbx15 A G 3: 99,326,384 (GRCm38) I288V possibly damaging Het
Tlr2 C A 3: 83,837,332 (GRCm38) E481D probably damaging Het
Trim17 A T 11: 58,970,428 (GRCm38) D253V probably damaging Het
Trim69 A G 2: 122,178,746 (GRCm38) D429G probably damaging Het
Vwa3b A G 1: 37,085,332 (GRCm38) Q337R probably benign Het
Zfp113 T C 5: 138,145,472 (GRCm38) N172S probably benign Het
Zfp607a T A 7: 27,878,751 (GRCm38) H415Q probably damaging Het
Zfp87 G A 13: 67,517,899 (GRCm38) T148I probably benign Het
Other mutations in Vstm5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01597:Vstm5 APN 9 15,257,379 (GRCm38) missense probably damaging 1.00
IGL01781:Vstm5 APN 9 15,257,672 (GRCm38) missense probably damaging 1.00
IGL02940:Vstm5 APN 9 15,257,666 (GRCm38) missense probably damaging 1.00
R1155:Vstm5 UTSW 9 15,257,553 (GRCm38) missense probably damaging 1.00
R1721:Vstm5 UTSW 9 15,257,367 (GRCm38) missense probably benign 0.13
R2368:Vstm5 UTSW 9 15,257,731 (GRCm38) missense probably benign 0.00
R3160:Vstm5 UTSW 9 15,257,298 (GRCm38) missense probably benign 0.02
R3161:Vstm5 UTSW 9 15,257,298 (GRCm38) missense probably benign 0.02
R3162:Vstm5 UTSW 9 15,257,298 (GRCm38) missense probably benign 0.02
R4612:Vstm5 UTSW 9 15,257,493 (GRCm38) missense probably benign 0.22
R4692:Vstm5 UTSW 9 15,257,422 (GRCm38) missense probably damaging 0.99
R5088:Vstm5 UTSW 9 15,257,305 (GRCm38) missense possibly damaging 0.87
R6351:Vstm5 UTSW 9 15,257,533 (GRCm38) missense probably damaging 1.00
R7063:Vstm5 UTSW 9 15,239,253 (GRCm38) start gained probably benign
R7720:Vstm5 UTSW 9 15,239,356 (GRCm38) missense probably benign 0.08
R9300:Vstm5 UTSW 9 15,257,289 (GRCm38) missense probably damaging 1.00
R9491:Vstm5 UTSW 9 15,257,290 (GRCm38) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ATTAAGAGAGACCTTGCCTCCCC -3'
(R):5'- AGTCAAAGGCAACCTCTTTTGG -3'

Sequencing Primer
(F):5'- CTCCTGTCCCACCGCAGAG -3'
(R):5'- TTCCGGGAATTATCAGCCAG -3'
Posted On 2016-04-27