Mutagenetix > Incidental Mutation

Incidental Mutation 'R4951:Olfr938'

381985

Institutional Source

Beutler Lab

Gene Symbol

Olfr938

Ensembl Gene

ENSMUSG00000048501

Gene Name

olfactory receptor 938

Synonyms

GA_x6K02T2PVTD-32774646-32773699, MOR171-25

MMRRC Submission

042548-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

R4951 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

39077698-39078887 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 39078259 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 162 (F162S)

Ref Sequence

ENSEMBL: ENSMUSP00000055053 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000056499]

AlphaFold

Q9EQ93

Predicted Effect

probably benign
Transcript: ENSMUST00000056499
AA Change: F162S

PolyPhen 2 Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000055053
Gene: ENSMUSG00000048501
AA Change: F162S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	8e-49	PFAM
Pfam:7tm_1	41	290	5.5e-18	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000175411

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215888

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.5%
20x: 93.1%

Validation Efficiency

98% (94/96)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 84 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9230110F15Rik	A	G	9: 35,839,436	V30A	probably damaging	Het
Adcy1	G	A	11: 7,138,336	E452K	possibly damaging	Het
Adcy10	T	C	1: 165,563,963	L1263P	probably damaging	Het
Adgrg1	G	A	8: 95,005,246	V179M	probably damaging	Het
Agap1	T	A	1: 89,609,503	V77E	probably damaging	Het
Ahnak	A	T	19: 9,017,835	K5494N	probably damaging	Het
Arhgap19	A	G	19: 41,774,106	M437T	probably benign	Het
C2cd4c	C	A	10: 79,613,005	A103S	possibly damaging	Het
Clip1	A	T	5: 123,630,345	D776E	probably benign	Het
Cntn3	C	T	6: 102,169,025	V952M	possibly damaging	Het
Col6a6	A	G	9: 105,767,198		probably null	Het
Crtac1	C	T	19: 42,414,131	A13T	probably benign	Het
Ddx50	C	T	10: 62,634,120	A363T	probably damaging	Het
Dock9	A	G	14: 121,653,135	V241A	probably benign	Het
Dysf	T	C	6: 84,114,120		probably null	Het
Enpp3	A	T	10: 24,798,277	M375K	probably damaging	Het
Fam13c	G	A	10: 70,551,791		probably null	Het
Ftcd	C	T	10: 76,584,683	A417V	probably benign	Het
Gak	A	G	5: 108,582,718	S941P	probably benign	Het
Ganc	A	G	2: 120,456,047	T786A	probably benign	Het
Gfi1	A	C	5: 107,720,143	S420A	probably damaging	Het
Ghsr	A	T	3: 27,372,361	T189S	possibly damaging	Het
Glb1l	C	T	1: 75,208,375	G122D	probably damaging	Het
Gm10065	C	T	13: 21,479,251	S64N	unknown	Het
Gm5087	C	A	14: 13,158,749		noncoding transcript	Het
Gm7102	C	T	19: 61,175,926	G24R	unknown	Het
Gm973	G	A	1: 59,541,474		probably null	Het
Gm9930	A	T	10: 9,534,705		noncoding transcript	Het
H6pd	A	T	4: 149,981,587	Y781N	probably damaging	Het
Ide	G	A	19: 37,285,232	L695F	unknown	Het
Il17re	T	A	6: 113,468,907	V393E	probably damaging	Het
Lipo1	A	G	19: 33,782,221	V205A	probably benign	Het
Lipo5	C	T	19: 33,468,851	E49K	probably damaging	Het
Lonp1	A	T	17: 56,620,335	M306K	possibly damaging	Het
Lrig1	A	G	6: 94,663,978	L82P	probably damaging	Het
Lrp2	A	T	2: 69,535,988	C256S	probably damaging	Het
Map1b	A	T	13: 99,432,427	I1262K	unknown	Het
Mctp1	C	T	13: 76,827,775	P756S	probably damaging	Het
Mdn1	T	A	4: 32,707,459	W1583R	probably damaging	Het
Mis12	T	A	11: 71,025,647	Y169N	probably benign	Het
Msh5	G	A	17: 35,038,420	Q333*	probably null	Het
Necap2	A	T	4: 141,072,523		probably null	Het
Nfatc2	T	C	2: 168,571,072	D211G	probably damaging	Het
Nlrx1	A	G	9: 44,253,429	V906A	possibly damaging	Het
Olfr1239	T	A	2: 89,417,772	I214F	probably benign	Het
Olfr1456-ps1	A	T	19: 13,079,256		noncoding transcript	Het
Olfr320	G	A	11: 58,684,763	V297I	probably damaging	Het
Olfr723	A	T	14: 49,929,058	L162*	probably null	Het
Pkhd1l1	T	A	15: 44,533,891	N2057K	possibly damaging	Het
Ppip5k2	T	C	1: 97,711,749	K1078R	possibly damaging	Het
Prdm11	A	G	2: 92,980,609	I215T	probably damaging	Het
Ptpn13	C	T	5: 103,588,046	P2137L	probably benign	Het
Rif1	T	A	2: 52,084,986		probably null	Het
Rnf17	T	C	14: 56,522,391	V1551A	probably benign	Het
Ror2	C	T	13: 53,117,147	V391I	probably benign	Het
Rps6ka2	A	T	17: 7,292,789	D542V	probably damaging	Het
Sema4g	A	G	19: 44,996,571		probably null	Het
Serpinb6d	T	G	13: 33,666,383	S64R	probably benign	Het
Serpine1	C	T	5: 137,069,351	R156K	probably benign	Het
Setdb2	A	G	14: 59,402,303	I713T	possibly damaging	Het
Slamf7	A	G	1: 171,639,125	F171L	probably benign	Het
Slc15a5	A	G	6: 138,073,066	L117S	probably damaging	Het
Slc8a3	T	A	12: 81,314,699	T449S	probably benign	Het
Slc8a3	T	A	12: 81,315,986	T20S	probably damaging	Het
Smc2	G	A	4: 52,462,926	V639M	possibly damaging	Het
Sra1	A	T	18: 36,676,441	C223*	probably null	Het
Srgap1	A	T	10: 121,785,552	M1012K	probably benign	Het
Stk-ps2	A	T	1: 46,029,442		noncoding transcript	Het
Taar6	A	T	10: 23,985,208	S147T	probably benign	Het
Taf15	G	A	11: 83,484,811	G34D	possibly damaging	Het
Tarbp1	T	C	8: 126,447,445	E874G	possibly damaging	Het
Tob2	T	C	15: 81,851,723	Y15C	probably damaging	Het
Trim12a	A	G	7: 104,304,358	V182A	possibly damaging	Het
Trim67	A	G	8: 124,794,667	E256G	probably benign	Het
Trrap	T	A	5: 144,805,720	S1382T	possibly damaging	Het
Ttc39d	T	A	17: 80,216,033	S40R	probably benign	Het
Ttn	A	T	2: 76,949,062	V1158E	probably benign	Het
Vmn1r19	C	T	6: 57,404,942	T160I	probably benign	Het
Vmn2r100	T	C	17: 19,532,038	I781T	probably benign	Het
Vmn2r85	T	C	10: 130,425,244	E408G	probably damaging	Het
Vwde	T	C	6: 13,187,139	D783G	probably damaging	Het
Wdr27	A	T	17: 14,876,133	D796E	probably damaging	Het
Zfp365	C	T	10: 67,889,991		probably null	Het
Zfp9	T	G	6: 118,464,447	H418P	probably damaging	Het

Other mutations in Olfr938

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01020:Olfr938	APN	9	39078451	missense	probably damaging	0.96
IGL01298:Olfr938	APN	9	39078724	missense	possibly damaging	0.63
IGL02930:Olfr938	APN	9	39078012	missense	probably damaging	1.00
IGL03346:Olfr938	APN	9	39077962	missense	probably damaging	0.99
IGL03346:Olfr938	APN	9	39077961	missense	probably benign	0.35
IGL03399:Olfr938	APN	9	39078237	nonsense	probably null
R0536:Olfr938	UTSW	9	39078329	missense	probably benign	0.03
R1170:Olfr938	UTSW	9	39078229	missense	possibly damaging	0.50
R1951:Olfr938	UTSW	9	39078284	missense	probably benign	0.07
R1952:Olfr938	UTSW	9	39078284	missense	probably benign	0.07
R2066:Olfr938	UTSW	9	39078214	missense	probably damaging	1.00
R2906:Olfr938	UTSW	9	39078373	missense	probably benign	0.39
R4707:Olfr938	UTSW	9	39078262	missense	probably benign	0.00
R4767:Olfr938	UTSW	9	39078692	missense	possibly damaging	0.71
R5888:Olfr938	UTSW	9	39077967	nonsense	probably null
R5905:Olfr938	UTSW	9	39078083	missense	probably damaging	1.00
R6028:Olfr938	UTSW	9	39078083	missense	probably damaging	1.00
R6329:Olfr938	UTSW	9	39077903	missense	probably benign	0.02
R7240:Olfr938	UTSW	9	39078610	missense	probably damaging	0.99
R7345:Olfr938	UTSW	9	39078334	missense	probably damaging	1.00
R8058:Olfr938	UTSW	9	39078566	missense	probably damaging	1.00
R9023:Olfr938	UTSW	9	39078011	missense	probably benign	0.09
R9547:Olfr938	UTSW	9	39078631	missense	probably damaging	0.99
X0062:Olfr938	UTSW	9	39078466	missense	probably benign	0.15

Predicted Primers

PCR Primer
(F):5'- GCCTCCAGTGGATTGAATGTG -3'
(R):5'- CACAATGCATAGCTCAGTTCTAC -3'

Sequencing Primer
(F):5'- CTCCAGTGGATTGAATGTGGAGAAC -3'
(R):5'- AATGCATAGCTCAGTTCTACTTCTTC -3'

Posted On

2016-04-27