Incidental Mutation 'R4951:Dock9'
ID 382011
Institutional Source Beutler Lab
Gene Symbol Dock9
Ensembl Gene ENSMUSG00000025558
Gene Name dedicator of cytokinesis 9
Synonyms D14Wsu89e, B230309H04Rik, Zizimin1
MMRRC Submission 042548-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4951 (G1)
Quality Score 112
Status Validated
Chromosome 14
Chromosomal Location 121779458-122035249 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 121890547 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 241 (V241A)
Ref Sequence ENSEMBL: ENSMUSP00000047881 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040700] [ENSMUST00000100299] [ENSMUST00000212181] [ENSMUST00000212376]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000040700
AA Change: V241A

PolyPhen 2 Score 0.347 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000047881
Gene: ENSMUSG00000025558
AA Change: V241A

DomainStartEndE-ValueType
Pfam:DUF3398 58 151 5.6e-36 PFAM
PH 172 280 1.38e-16 SMART
Blast:PH 297 372 4e-25 BLAST
Pfam:DOCK-C2 631 822 5.3e-51 PFAM
Pfam:DHR-2 1523 2068 2.1e-212 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000100299
AA Change: V243A

PolyPhen 2 Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000097872
Gene: ENSMUSG00000025558
AA Change: V243A

DomainStartEndE-ValueType
Pfam:DUF3398 58 153 1.5e-32 PFAM
PH 174 282 1.38e-16 SMART
Blast:PH 299 374 4e-25 BLAST
Pfam:DOCK-C2 632 825 1.3e-59 PFAM
low complexity region 1752 1763 N/A INTRINSIC
Pfam:Ded_cyto 1836 2013 2.4e-69 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212181
AA Change: V241A

PolyPhen 2 Score 0.169 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect
Predicted Effect probably benign
Transcript: ENSMUST00000212376
AA Change: V255A

PolyPhen 2 Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)
Meta Mutation Damage Score 0.1039 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.5%
  • 20x: 93.1%
Validation Efficiency 98% (94/96)
Allele List at MGI
Other mutations in this stock
Total: 84 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy1 G A 11: 7,088,336 (GRCm39) E452K possibly damaging Het
Adcy10 T C 1: 165,391,532 (GRCm39) L1263P probably damaging Het
Adgrg1 G A 8: 95,731,874 (GRCm39) V179M probably damaging Het
Agap1 T A 1: 89,537,225 (GRCm39) V77E probably damaging Het
Ahnak A T 19: 8,995,199 (GRCm39) K5494N probably damaging Het
Arhgap19 A G 19: 41,762,545 (GRCm39) M437T probably benign Het
C2cd4c C A 10: 79,448,839 (GRCm39) A103S possibly damaging Het
Clip1 A T 5: 123,768,408 (GRCm39) D776E probably benign Het
Cntn3 C T 6: 102,145,986 (GRCm39) V952M possibly damaging Het
Col6a6 A G 9: 105,644,397 (GRCm39) probably null Het
Crtac1 C T 19: 42,402,570 (GRCm39) A13T probably benign Het
Ddx50 C T 10: 62,469,899 (GRCm39) A363T probably damaging Het
Dysf T C 6: 84,091,102 (GRCm39) probably null Het
Enpp3 A T 10: 24,674,175 (GRCm39) M375K probably damaging Het
Fam13c G A 10: 70,387,621 (GRCm39) probably null Het
Ftcd C T 10: 76,420,517 (GRCm39) A417V probably benign Het
Gak A G 5: 108,730,584 (GRCm39) S941P probably benign Het
Ganc A G 2: 120,286,528 (GRCm39) T786A probably benign Het
Gfi1 A C 5: 107,868,009 (GRCm39) S420A probably damaging Het
Ghsr A T 3: 27,426,510 (GRCm39) T189S possibly damaging Het
Glb1l C T 1: 75,185,019 (GRCm39) G122D probably damaging Het
Gm10065 C T 13: 21,663,421 (GRCm39) S64N unknown Het
Gm5087 C A 14: 13,158,749 (GRCm38) noncoding transcript Het
Gm973 G A 1: 59,580,633 (GRCm39) probably null Het
Gm9930 A T 10: 9,410,449 (GRCm39) noncoding transcript Het
H6pd A T 4: 150,066,044 (GRCm39) Y781N probably damaging Het
Ide G A 19: 37,262,631 (GRCm39) L695F unknown Het
Il17re T A 6: 113,445,868 (GRCm39) V393E probably damaging Het
Lipo3 A G 19: 33,759,621 (GRCm39) V205A probably benign Het
Lipo5 C T 19: 33,446,251 (GRCm39) E49K probably damaging Het
Lonp1 A T 17: 56,927,335 (GRCm39) M306K possibly damaging Het
Lrig1 A G 6: 94,640,959 (GRCm39) L82P probably damaging Het
Lrp2 A T 2: 69,366,332 (GRCm39) C256S probably damaging Het
Map1b A T 13: 99,568,935 (GRCm39) I1262K unknown Het
Mctp1 C T 13: 76,975,894 (GRCm39) P756S probably damaging Het
Mdn1 T A 4: 32,707,459 (GRCm39) W1583R probably damaging Het
Mis12 T A 11: 70,916,473 (GRCm39) Y169N probably benign Het
Mplkipl1 C T 19: 61,164,364 (GRCm39) G24R unknown Het
Msh5 G A 17: 35,257,396 (GRCm39) Q333* probably null Het
Necap2 A T 4: 140,799,834 (GRCm39) probably null Het
Nfatc2 T C 2: 168,412,992 (GRCm39) D211G probably damaging Het
Nlrx1 A G 9: 44,164,726 (GRCm39) V906A possibly damaging Het
Or2ak7 G A 11: 58,575,589 (GRCm39) V297I probably damaging Het
Or4a2 T A 2: 89,248,116 (GRCm39) I214F probably benign Het
Or4l1 A T 14: 50,166,515 (GRCm39) L162* probably null Het
Or5b125-ps1 A T 19: 13,056,620 (GRCm39) noncoding transcript Het
Or8g24 A G 9: 38,989,555 (GRCm39) F162S probably benign Het
Pate5 A G 9: 35,750,732 (GRCm39) V30A probably damaging Het
Pkhd1l1 T A 15: 44,397,287 (GRCm39) N2057K possibly damaging Het
Ppip5k2 T C 1: 97,639,474 (GRCm39) K1078R possibly damaging Het
Prdm11 A G 2: 92,810,954 (GRCm39) I215T probably damaging Het
Ptpn13 C T 5: 103,735,912 (GRCm39) P2137L probably benign Het
Rif1 T A 2: 51,974,998 (GRCm39) probably null Het
Rnf17 T C 14: 56,759,848 (GRCm39) V1551A probably benign Het
Ror2 C T 13: 53,271,183 (GRCm39) V391I probably benign Het
Rps6ka2 A T 17: 7,560,188 (GRCm39) D542V probably damaging Het
Sema4g A G 19: 44,985,010 (GRCm39) probably null Het
Serpinb6d T G 13: 33,850,366 (GRCm39) S64R probably benign Het
Serpine1 C T 5: 137,098,205 (GRCm39) R156K probably benign Het
Setdb2 A G 14: 59,639,752 (GRCm39) I713T possibly damaging Het
Slamf7 A G 1: 171,466,693 (GRCm39) F171L probably benign Het
Slc15a5 A G 6: 138,050,064 (GRCm39) L117S probably damaging Het
Slc8a3 T A 12: 81,362,760 (GRCm39) T20S probably damaging Het
Slc8a3 T A 12: 81,361,473 (GRCm39) T449S probably benign Het
Smc2 G A 4: 52,462,926 (GRCm39) V639M possibly damaging Het
Sra1 A T 18: 36,809,494 (GRCm39) C223* probably null Het
Srgap1 A T 10: 121,621,457 (GRCm39) M1012K probably benign Het
Stk-ps2 A T 1: 46,068,602 (GRCm39) noncoding transcript Het
Taar6 A T 10: 23,861,106 (GRCm39) S147T probably benign Het
Taf15 G A 11: 83,375,637 (GRCm39) G34D possibly damaging Het
Tarbp1 T C 8: 127,174,184 (GRCm39) E874G possibly damaging Het
Tob2 T C 15: 81,735,924 (GRCm39) Y15C probably damaging Het
Trim12a A G 7: 103,953,565 (GRCm39) V182A possibly damaging Het
Trim67 A G 8: 125,521,406 (GRCm39) E256G probably benign Het
Trrap T A 5: 144,742,530 (GRCm39) S1382T possibly damaging Het
Ttc39d T A 17: 80,523,462 (GRCm39) S40R probably benign Het
Ttn A T 2: 76,779,406 (GRCm39) V1158E probably benign Het
Vmn1r19 C T 6: 57,381,927 (GRCm39) T160I probably benign Het
Vmn2r100 T C 17: 19,752,300 (GRCm39) I781T probably benign Het
Vmn2r85 T C 10: 130,261,113 (GRCm39) E408G probably damaging Het
Vwde T C 6: 13,187,138 (GRCm39) D783G probably damaging Het
Wdr27 A T 17: 15,096,395 (GRCm39) D796E probably damaging Het
Zfp365 C T 10: 67,725,821 (GRCm39) probably null Het
Zfp9 T G 6: 118,441,408 (GRCm39) H418P probably damaging Het
Other mutations in Dock9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00236:Dock9 APN 14 121,905,880 (GRCm39) missense probably benign 0.12
IGL00817:Dock9 APN 14 121,935,703 (GRCm39) missense probably damaging 0.96
IGL00923:Dock9 APN 14 121,844,504 (GRCm39) unclassified probably benign
IGL01385:Dock9 APN 14 121,817,995 (GRCm39) missense possibly damaging 0.94
IGL01567:Dock9 APN 14 121,890,496 (GRCm39) missense probably damaging 1.00
IGL01767:Dock9 APN 14 121,860,282 (GRCm39) missense possibly damaging 0.91
IGL01811:Dock9 APN 14 121,796,440 (GRCm39) missense probably damaging 1.00
IGL02512:Dock9 APN 14 121,856,950 (GRCm39) splice site probably benign
IGL02525:Dock9 APN 14 121,877,538 (GRCm39) missense probably damaging 1.00
IGL02550:Dock9 APN 14 121,935,724 (GRCm39) start codon destroyed probably null 0.07
IGL02559:Dock9 APN 14 121,862,559 (GRCm39) splice site probably benign
IGL02666:Dock9 APN 14 121,818,111 (GRCm39) missense probably benign 0.42
IGL02674:Dock9 APN 14 121,833,023 (GRCm39) splice site probably null
IGL02795:Dock9 APN 14 121,877,390 (GRCm39) missense probably benign 0.04
IGL03074:Dock9 APN 14 121,844,682 (GRCm39) missense possibly damaging 0.95
IGL03095:Dock9 APN 14 121,876,940 (GRCm39) missense probably damaging 1.00
IGL03294:Dock9 APN 14 121,879,035 (GRCm39) splice site probably benign
R0036:Dock9 UTSW 14 121,860,265 (GRCm39) missense probably damaging 1.00
R0050:Dock9 UTSW 14 121,844,637 (GRCm39) missense probably benign 0.43
R0050:Dock9 UTSW 14 121,844,637 (GRCm39) missense probably benign 0.43
R0164:Dock9 UTSW 14 121,835,077 (GRCm39) missense probably damaging 1.00
R0164:Dock9 UTSW 14 121,835,077 (GRCm39) missense probably damaging 1.00
R0270:Dock9 UTSW 14 121,813,411 (GRCm39) missense probably benign 0.02
R0494:Dock9 UTSW 14 121,899,996 (GRCm39) missense possibly damaging 0.64
R0726:Dock9 UTSW 14 121,889,180 (GRCm39) nonsense probably null
R1029:Dock9 UTSW 14 121,837,096 (GRCm39) splice site probably null
R1214:Dock9 UTSW 14 121,823,728 (GRCm39) missense probably benign 0.02
R1231:Dock9 UTSW 14 121,813,362 (GRCm39) missense possibly damaging 0.61
R1535:Dock9 UTSW 14 121,783,476 (GRCm39) missense probably damaging 1.00
R1629:Dock9 UTSW 14 121,780,986 (GRCm39) missense possibly damaging 0.88
R1637:Dock9 UTSW 14 121,889,187 (GRCm39) missense possibly damaging 0.66
R1733:Dock9 UTSW 14 121,864,292 (GRCm39) missense probably benign 0.01
R1772:Dock9 UTSW 14 121,847,210 (GRCm39) missense probably benign 0.07
R1855:Dock9 UTSW 14 121,877,571 (GRCm39) missense probably damaging 1.00
R1888:Dock9 UTSW 14 121,862,617 (GRCm39) missense probably benign 0.18
R1888:Dock9 UTSW 14 121,862,617 (GRCm39) missense probably benign 0.18
R1901:Dock9 UTSW 14 121,862,565 (GRCm39) splice site probably null
R1920:Dock9 UTSW 14 121,820,792 (GRCm39) missense probably damaging 1.00
R1987:Dock9 UTSW 14 121,829,242 (GRCm39) missense probably benign 0.00
R3035:Dock9 UTSW 14 121,844,249 (GRCm39) missense possibly damaging 0.60
R3851:Dock9 UTSW 14 121,866,498 (GRCm39) splice site probably null
R4020:Dock9 UTSW 14 121,844,267 (GRCm39) missense probably benign 0.00
R4021:Dock9 UTSW 14 121,864,324 (GRCm39) missense possibly damaging 0.80
R4089:Dock9 UTSW 14 121,820,883 (GRCm39) missense probably damaging 1.00
R4258:Dock9 UTSW 14 121,818,854 (GRCm39) missense probably benign 0.00
R4423:Dock9 UTSW 14 121,799,465 (GRCm39) critical splice donor site probably null
R4561:Dock9 UTSW 14 121,796,419 (GRCm39) missense probably benign 0.01
R4604:Dock9 UTSW 14 121,905,871 (GRCm39) missense probably damaging 1.00
R4646:Dock9 UTSW 14 121,823,658 (GRCm39) missense probably damaging 1.00
R4647:Dock9 UTSW 14 121,823,658 (GRCm39) missense probably damaging 1.00
R4776:Dock9 UTSW 14 121,847,509 (GRCm39) missense possibly damaging 0.81
R4809:Dock9 UTSW 14 121,784,008 (GRCm39) missense probably benign 0.37
R4865:Dock9 UTSW 14 121,780,917 (GRCm39) makesense probably null
R5151:Dock9 UTSW 14 121,815,582 (GRCm39) missense probably damaging 1.00
R5359:Dock9 UTSW 14 121,890,472 (GRCm39) missense possibly damaging 0.69
R5366:Dock9 UTSW 14 121,815,615 (GRCm39) missense probably damaging 1.00
R5502:Dock9 UTSW 14 121,847,594 (GRCm39) splice site probably null
R5579:Dock9 UTSW 14 121,837,107 (GRCm39) missense probably damaging 1.00
R5753:Dock9 UTSW 14 121,872,037 (GRCm39) missense probably benign 0.05
R5836:Dock9 UTSW 14 121,918,763 (GRCm39) missense probably damaging 1.00
R5858:Dock9 UTSW 14 121,866,204 (GRCm39) missense probably benign 0.00
R5890:Dock9 UTSW 14 121,905,820 (GRCm39) critical splice donor site probably null
R6075:Dock9 UTSW 14 121,783,385 (GRCm39) missense probably benign
R6298:Dock9 UTSW 14 121,872,006 (GRCm39) missense probably damaging 1.00
R6306:Dock9 UTSW 14 121,799,492 (GRCm39) missense probably damaging 1.00
R6321:Dock9 UTSW 14 121,783,433 (GRCm39) missense probably damaging 1.00
R6330:Dock9 UTSW 14 121,842,655 (GRCm39) start codon destroyed probably null 0.00
R6719:Dock9 UTSW 14 121,847,439 (GRCm39) missense probably damaging 1.00
R6784:Dock9 UTSW 14 121,780,926 (GRCm39) missense probably damaging 1.00
R6826:Dock9 UTSW 14 121,860,330 (GRCm39) missense probably damaging 1.00
R6830:Dock9 UTSW 14 121,860,330 (GRCm39) missense probably damaging 1.00
R6838:Dock9 UTSW 14 121,784,008 (GRCm39) missense possibly damaging 0.71
R6868:Dock9 UTSW 14 121,823,676 (GRCm39) missense probably benign 0.37
R6919:Dock9 UTSW 14 121,880,564 (GRCm39) missense probably benign 0.42
R6989:Dock9 UTSW 14 121,864,791 (GRCm39) missense probably damaging 1.00
R7539:Dock9 UTSW 14 121,818,848 (GRCm39) missense probably damaging 1.00
R7645:Dock9 UTSW 14 121,835,075 (GRCm39) missense probably benign 0.44
R7875:Dock9 UTSW 14 121,863,396 (GRCm39) nonsense probably null
R7900:Dock9 UTSW 14 121,783,491 (GRCm39) missense possibly damaging 0.84
R8040:Dock9 UTSW 14 121,889,206 (GRCm39) missense probably benign 0.06
R8420:Dock9 UTSW 14 121,783,454 (GRCm39) missense probably damaging 1.00
R8511:Dock9 UTSW 14 121,918,847 (GRCm39) missense probably damaging 1.00
R8511:Dock9 UTSW 14 121,864,801 (GRCm39) missense probably benign 0.40
R8514:Dock9 UTSW 14 121,896,199 (GRCm39) missense probably benign 0.25
R8691:Dock9 UTSW 14 121,877,517 (GRCm39) missense possibly damaging 0.49
R8804:Dock9 UTSW 14 121,842,595 (GRCm39) missense probably damaging 0.98
R8894:Dock9 UTSW 14 121,860,373 (GRCm39) missense probably benign 0.10
R8900:Dock9 UTSW 14 121,817,940 (GRCm39) missense probably damaging 1.00
R9069:Dock9 UTSW 14 121,866,324 (GRCm39) missense probably damaging 0.98
R9218:Dock9 UTSW 14 121,905,871 (GRCm39) missense probably damaging 1.00
R9233:Dock9 UTSW 14 121,820,781 (GRCm39) missense probably benign 0.09
R9236:Dock9 UTSW 14 121,876,970 (GRCm39) missense probably damaging 1.00
R9285:Dock9 UTSW 14 121,833,012 (GRCm39) missense probably benign
R9451:Dock9 UTSW 14 121,787,601 (GRCm39) splice site probably benign
R9461:Dock9 UTSW 14 121,842,601 (GRCm39) missense probably benign 0.05
R9484:Dock9 UTSW 14 121,818,844 (GRCm39) missense probably damaging 1.00
R9517:Dock9 UTSW 14 121,829,236 (GRCm39) missense probably benign 0.07
R9542:Dock9 UTSW 14 121,864,775 (GRCm39) missense probably damaging 1.00
R9694:Dock9 UTSW 14 121,818,791 (GRCm39) missense probably damaging 1.00
R9701:Dock9 UTSW 14 121,876,983 (GRCm39) missense probably benign 0.01
R9703:Dock9 UTSW 14 121,781,989 (GRCm39) makesense probably null
R9726:Dock9 UTSW 14 121,835,149 (GRCm39) missense possibly damaging 0.61
R9741:Dock9 UTSW 14 121,877,516 (GRCm39) missense probably damaging 1.00
Z1088:Dock9 UTSW 14 121,792,687 (GRCm39) missense probably damaging 1.00
Z1176:Dock9 UTSW 14 121,889,194 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GCTGACAAACTGTGAAAGGCTC -3'
(R):5'- AGCAAATGCCCTTAGCCGTC -3'

Sequencing Primer
(F):5'- TGAAAGGCTCACATCTTCCTAC -3'
(R):5'- TGTGACCTTCTGGACAAGC -3'
Posted On 2016-04-27