Incidental Mutation 'R4952:Arhgef2'
| ID |
382041 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgef2
|
| Ensembl Gene |
ENSMUSG00000028059 |
| Gene Name |
rho/rac guanine nucleotide exchange factor (GEF) 2 |
| Synonyms |
P40, Lfc, Lbcl1, GEFH1, LFP40, GEF-H1 |
| MMRRC Submission |
042549-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.595)
|
| Stock # |
R4952 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
88605966-88648052 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 88642462 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 591
(L591P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134840
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000029694]
[ENSMUST00000107510]
[ENSMUST00000170653]
[ENSMUST00000175779]
[ENSMUST00000175903]
[ENSMUST00000175911]
[ENSMUST00000176500]
[ENSMUST00000176804]
[ENSMUST00000177303]
[ENSMUST00000177498]
|
| AlphaFold |
Q60875 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000029694
AA Change: L608P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000029694
Gene: ENSMUSG00000028059
AA Change: L608P
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
40 |
86 |
4.22e-9 |
SMART |
|
low complexity region
|
90 |
95 |
N/A |
INTRINSIC |
|
low complexity region
|
133 |
146 |
N/A |
INTRINSIC |
|
RhoGEF
|
240 |
432 |
1.86e-58 |
SMART |
|
PH
|
474 |
574 |
9.56e-11 |
SMART |
|
coiled coil region
|
588 |
619 |
N/A |
INTRINSIC |
|
low complexity region
|
812 |
827 |
N/A |
INTRINSIC |
|
coiled coil region
|
829 |
866 |
N/A |
INTRINSIC |
|
low complexity region
|
872 |
888 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000107510
AA Change: L581P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000103134
Gene: ENSMUSG00000028059
AA Change: L581P
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
13 |
59 |
4.22e-9 |
SMART |
|
low complexity region
|
63 |
68 |
N/A |
INTRINSIC |
|
low complexity region
|
106 |
119 |
N/A |
INTRINSIC |
|
RhoGEF
|
213 |
405 |
1.86e-58 |
SMART |
|
PH
|
447 |
547 |
9.56e-11 |
SMART |
|
coiled coil region
|
561 |
592 |
N/A |
INTRINSIC |
|
low complexity region
|
785 |
800 |
N/A |
INTRINSIC |
|
coiled coil region
|
802 |
839 |
N/A |
INTRINSIC |
|
low complexity region
|
845 |
861 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170653
AA Change: L579P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000127843
Gene: ENSMUSG00000028059
AA Change: L579P
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
13 |
59 |
4.22e-9 |
SMART |
|
low complexity region
|
63 |
68 |
N/A |
INTRINSIC |
|
low complexity region
|
104 |
117 |
N/A |
INTRINSIC |
|
RhoGEF
|
211 |
403 |
1.86e-58 |
SMART |
|
PH
|
445 |
545 |
9.56e-11 |
SMART |
|
coiled coil region
|
559 |
590 |
N/A |
INTRINSIC |
|
low complexity region
|
783 |
798 |
N/A |
INTRINSIC |
|
coiled coil region
|
800 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
843 |
859 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000175779
AA Change: L593P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000135177
Gene: ENSMUSG00000028059
AA Change: L593P
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
25 |
71 |
4.22e-9 |
SMART |
|
low complexity region
|
75 |
80 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
131 |
N/A |
INTRINSIC |
|
RhoGEF
|
225 |
417 |
1.86e-58 |
SMART |
|
PH
|
459 |
559 |
9.56e-11 |
SMART |
|
coiled coil region
|
573 |
604 |
N/A |
INTRINSIC |
|
low complexity region
|
797 |
812 |
N/A |
INTRINSIC |
|
coiled coil region
|
814 |
851 |
N/A |
INTRINSIC |
|
low complexity region
|
857 |
873 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000175903
AA Change: L591P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000135168
Gene: ENSMUSG00000028059
AA Change: L591P
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
25 |
71 |
4.22e-9 |
SMART |
|
low complexity region
|
75 |
80 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
131 |
N/A |
INTRINSIC |
|
RhoGEF
|
223 |
415 |
1.86e-58 |
SMART |
|
PH
|
457 |
557 |
9.56e-11 |
SMART |
|
coiled coil region
|
571 |
602 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
810 |
N/A |
INTRINSIC |
|
coiled coil region
|
812 |
849 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
871 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175911
|
| SMART Domains |
Protein: ENSMUSP00000135428
Gene: ENSMUSG00000028059
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
32 |
78 |
4.22e-9 |
SMART |
|
low complexity region
|
82 |
87 |
N/A |
INTRINSIC |
|
low complexity region
|
125 |
138 |
N/A |
INTRINSIC |
|
RhoGEF
|
232 |
424 |
1.86e-58 |
SMART |
|
PH
|
466 |
566 |
9.56e-11 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176272
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176500
AA Change: L593P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000134834
Gene: ENSMUSG00000028059
AA Change: L593P
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
25 |
71 |
4.22e-9 |
SMART |
|
low complexity region
|
75 |
80 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
131 |
N/A |
INTRINSIC |
|
RhoGEF
|
225 |
417 |
1.86e-58 |
SMART |
|
PH
|
459 |
559 |
9.56e-11 |
SMART |
|
coiled coil region
|
573 |
604 |
N/A |
INTRINSIC |
|
low complexity region
|
797 |
812 |
N/A |
INTRINSIC |
|
coiled coil region
|
814 |
851 |
N/A |
INTRINSIC |
|
low complexity region
|
857 |
873 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176804
AA Change: L606P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000135397
Gene: ENSMUSG00000028059
AA Change: L606P
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
40 |
86 |
4.22e-9 |
SMART |
|
low complexity region
|
90 |
95 |
N/A |
INTRINSIC |
|
low complexity region
|
133 |
146 |
N/A |
INTRINSIC |
|
RhoGEF
|
238 |
430 |
1.86e-58 |
SMART |
|
PH
|
472 |
572 |
9.56e-11 |
SMART |
|
coiled coil region
|
586 |
617 |
N/A |
INTRINSIC |
|
low complexity region
|
810 |
825 |
N/A |
INTRINSIC |
|
coiled coil region
|
827 |
864 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
886 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000177091
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000177099
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177303
AA Change: L579P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000135131
Gene: ENSMUSG00000028059
AA Change: L579P
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
13 |
59 |
4.22e-9 |
SMART |
|
low complexity region
|
63 |
68 |
N/A |
INTRINSIC |
|
low complexity region
|
106 |
119 |
N/A |
INTRINSIC |
|
RhoGEF
|
211 |
403 |
1.86e-58 |
SMART |
|
PH
|
445 |
545 |
9.56e-11 |
SMART |
|
coiled coil region
|
559 |
590 |
N/A |
INTRINSIC |
|
low complexity region
|
783 |
798 |
N/A |
INTRINSIC |
|
coiled coil region
|
800 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
843 |
859 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177498
AA Change: L591P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000134840
Gene: ENSMUSG00000028059
AA Change: L591P
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
25 |
71 |
4.22e-9 |
SMART |
|
low complexity region
|
75 |
80 |
N/A |
INTRINSIC |
|
low complexity region
|
116 |
129 |
N/A |
INTRINSIC |
|
RhoGEF
|
223 |
415 |
1.86e-58 |
SMART |
|
PH
|
457 |
557 |
9.56e-11 |
SMART |
|
coiled coil region
|
571 |
602 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
810 |
N/A |
INTRINSIC |
|
coiled coil region
|
812 |
849 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
871 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000177418
|
| Meta Mutation Damage Score |
0.9209 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.3%
- 10x: 96.5%
- 20x: 93.0%
|
| Validation Efficiency |
99% (93/94) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit impaired response to viral infection. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930522L14Rik |
A |
G |
5: 109,739,197 (GRCm38) |
|
probably null |
Het |
| 4933421I07Rik |
T |
C |
7: 42,447,659 (GRCm38) |
Y76C |
possibly damaging |
Het |
| Adcy4 |
C |
T |
14: 55,779,029 (GRCm38) |
D322N |
probably damaging |
Het |
| Ak9 |
A |
G |
10: 41,420,589 (GRCm38) |
M1444V |
probably benign |
Het |
| Amfr |
A |
G |
8: 93,973,159 (GRCm38) |
|
probably benign |
Het |
| Ankef1 |
A |
G |
2: 136,550,529 (GRCm38) |
E546G |
probably damaging |
Het |
| Ankrd24 |
A |
G |
10: 81,647,148 (GRCm38) |
M977V |
probably benign |
Het |
| Ap3m1 |
A |
T |
14: 21,040,066 (GRCm38) |
S5T |
probably benign |
Het |
| Aqr |
C |
A |
2: 114,109,937 (GRCm38) |
D1243Y |
probably damaging |
Het |
| Arid4a |
C |
A |
12: 71,023,525 (GRCm38) |
T70K |
possibly damaging |
Het |
| Asphd1 |
C |
T |
7: 126,948,685 (GRCm38) |
A149T |
probably benign |
Het |
| Avpr1a |
T |
A |
10: 122,449,754 (GRCm38) |
M317K |
probably damaging |
Het |
| Birc2 |
T |
C |
9: 7,836,740 (GRCm38) |
I109V |
probably damaging |
Het |
| Catsperd |
A |
G |
17: 56,632,303 (GRCm38) |
Y44C |
probably damaging |
Het |
| Ccdc114 |
A |
C |
7: 45,942,191 (GRCm38) |
E293A |
probably damaging |
Het |
| Crygb |
T |
G |
1: 65,082,109 (GRCm38) |
S20R |
probably benign |
Het |
| Cyp3a25 |
T |
C |
5: 145,991,524 (GRCm38) |
N237S |
probably benign |
Het |
| Dkk3 |
C |
T |
7: 112,118,351 (GRCm38) |
A304T |
probably benign |
Het |
| Dst |
T |
C |
1: 34,271,422 (GRCm38) |
L4101S |
probably damaging |
Het |
| Dysf |
A |
G |
6: 84,149,986 (GRCm38) |
N1407S |
possibly damaging |
Het |
| Epb41 |
A |
G |
4: 132,000,270 (GRCm38) |
V265A |
probably damaging |
Het |
| Faim2 |
C |
T |
15: 99,521,228 (GRCm38) |
E75K |
possibly damaging |
Het |
| Fbn1 |
T |
A |
2: 125,317,534 (GRCm38) |
D2208V |
probably damaging |
Het |
| Fbxo28 |
A |
G |
1: 182,326,385 (GRCm38) |
S129P |
probably damaging |
Het |
| Fbxw14 |
T |
A |
9: 109,276,201 (GRCm38) |
I299L |
probably benign |
Het |
| Fras1 |
C |
T |
5: 96,647,498 (GRCm38) |
A1050V |
probably benign |
Het |
| Fyb |
C |
A |
15: 6,638,811 (GRCm38) |
T495K |
probably damaging |
Het |
| Ghdc |
A |
T |
11: 100,769,151 (GRCm38) |
W257R |
probably damaging |
Het |
| Gm10719 |
T |
C |
9: 3,018,962 (GRCm38) |
L69S |
probably benign |
Het |
| Gm11492 |
A |
G |
11: 87,567,772 (GRCm38) |
N324S |
probably benign |
Het |
| Gm12250 |
G |
T |
11: 58,188,384 (GRCm38) |
|
noncoding transcript |
Het |
| Gm4846 |
A |
T |
1: 166,483,934 (GRCm38) |
F452Y |
probably damaging |
Het |
| Gm8773 |
T |
A |
5: 5,575,387 (GRCm38) |
F28I |
probably benign |
Het |
| Gm884 |
T |
C |
11: 103,614,207 (GRCm38) |
T2312A |
possibly damaging |
Het |
| Gpbp1 |
T |
C |
13: 111,440,750 (GRCm38) |
D202G |
probably damaging |
Het |
| Gpd2 |
C |
A |
2: 57,307,013 (GRCm38) |
Y193* |
probably null |
Het |
| Grhl2 |
G |
T |
15: 37,287,249 (GRCm38) |
R229L |
probably benign |
Het |
| Gtf2a1 |
A |
G |
12: 91,575,749 (GRCm38) |
F59L |
possibly damaging |
Het |
| Heatr1 |
G |
T |
13: 12,410,599 (GRCm38) |
W640L |
probably benign |
Het |
| Kalrn |
A |
T |
16: 34,357,415 (GRCm38) |
|
probably null |
Het |
| Keap1 |
T |
C |
9: 21,237,286 (GRCm38) |
T142A |
probably damaging |
Het |
| Kpna2 |
G |
A |
11: 106,991,235 (GRCm38) |
T255M |
probably damaging |
Het |
| Kpna3 |
A |
G |
14: 61,370,389 (GRCm38) |
C456R |
probably damaging |
Het |
| Lama1 |
G |
A |
17: 67,767,566 (GRCm38) |
|
probably null |
Het |
| Mag |
C |
A |
7: 30,909,156 (GRCm38) |
E178* |
probably null |
Het |
| Map3k13 |
A |
G |
16: 21,911,019 (GRCm38) |
I467V |
probably benign |
Het |
| Mga |
A |
G |
2: 119,903,301 (GRCm38) |
E210G |
probably damaging |
Het |
| Msi2 |
C |
T |
11: 88,366,784 (GRCm38) |
|
probably null |
Het |
| Naa16 |
A |
T |
14: 79,345,085 (GRCm38) |
D521E |
probably damaging |
Het |
| Nav2 |
C |
T |
7: 49,304,540 (GRCm38) |
|
probably benign |
Het |
| Nek10 |
T |
A |
14: 14,860,986 (GRCm38) |
L513M |
possibly damaging |
Het |
| Nek5 |
T |
A |
8: 22,079,088 (GRCm38) |
I573L |
probably benign |
Het |
| Nek5 |
T |
C |
8: 22,096,799 (GRCm38) |
K332R |
probably benign |
Het |
| Ntn1 |
CCTTCTTCT |
CCTTCT |
11: 68,213,026 (GRCm38) |
|
probably benign |
Het |
| Olfr111 |
A |
T |
17: 37,530,750 (GRCm38) |
T258S |
possibly damaging |
Het |
| Olfr263 |
G |
A |
13: 21,133,344 (GRCm38) |
V190I |
probably benign |
Het |
| Olfr773 |
T |
A |
10: 129,186,597 (GRCm38) |
T275S |
probably benign |
Het |
| Olfr875 |
T |
A |
9: 37,773,064 (GRCm38) |
M135K |
probably damaging |
Het |
| Orai1 |
T |
G |
5: 123,029,250 (GRCm38) |
V162G |
probably damaging |
Het |
| P2rx6 |
T |
C |
16: 17,567,444 (GRCm38) |
S134P |
probably damaging |
Het |
| Pappa2 |
G |
A |
1: 158,857,136 (GRCm38) |
T811I |
probably null |
Het |
| Pcdhga10 |
T |
C |
18: 37,747,160 (GRCm38) |
|
probably benign |
Het |
| Pex16 |
C |
T |
2: 92,379,060 (GRCm38) |
R241* |
probably null |
Het |
| Plxnb1 |
T |
C |
9: 109,114,836 (GRCm38) |
F1969L |
probably damaging |
Het |
| Postn |
A |
G |
3: 54,390,315 (GRCm38) |
|
probably benign |
Het |
| Prdm15 |
A |
T |
16: 97,806,077 (GRCm38) |
I752N |
probably damaging |
Het |
| Rasgef1c |
A |
T |
11: 49,979,512 (GRCm38) |
K468M |
probably damaging |
Het |
| Rbfox1 |
A |
G |
16: 7,277,088 (GRCm38) |
S111G |
probably benign |
Het |
| Rbm28 |
T |
C |
6: 29,138,598 (GRCm38) |
D405G |
probably damaging |
Het |
| Rell1 |
A |
G |
5: 63,939,667 (GRCm38) |
|
probably benign |
Het |
| Rfx3 |
A |
G |
19: 27,830,672 (GRCm38) |
S224P |
probably damaging |
Het |
| Scarb2 |
A |
T |
5: 92,454,777 (GRCm38) |
I260K |
probably damaging |
Het |
| Slc15a4 |
A |
G |
5: 127,603,837 (GRCm38) |
F72L |
probably damaging |
Het |
| Spg7 |
C |
A |
8: 123,090,171 (GRCm38) |
R534S |
probably damaging |
Het |
| Stoml2 |
T |
C |
4: 43,029,589 (GRCm38) |
T164A |
probably benign |
Het |
| Syt11 |
C |
T |
3: 88,762,283 (GRCm38) |
G101S |
possibly damaging |
Het |
| Traj12 |
A |
G |
14: 54,206,556 (GRCm38) |
|
probably benign |
Het |
| Traj7 |
A |
T |
14: 54,211,524 (GRCm38) |
|
probably benign |
Het |
| Tysnd1 |
C |
T |
10: 61,702,076 (GRCm38) |
T175I |
possibly damaging |
Het |
| Usp48 |
T |
G |
4: 137,606,693 (GRCm38) |
Y139* |
probably null |
Het |
| Vmn2r72 |
A |
G |
7: 85,751,109 (GRCm38) |
L244P |
probably benign |
Het |
| Wasf1 |
C |
A |
10: 40,936,190 (GRCm38) |
P325Q |
unknown |
Het |
| Zc3h18 |
T |
A |
8: 122,410,900 (GRCm38) |
|
probably benign |
Het |
| Zfp712 |
A |
G |
13: 67,040,841 (GRCm38) |
S541P |
possibly damaging |
Het |
|
| Other mutations in Arhgef2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01913:Arhgef2
|
APN |
3 |
88,631,919 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02165:Arhgef2
|
APN |
3 |
88,646,220 (GRCm38) |
missense |
probably damaging |
1.00 |
|
monument
|
UTSW |
3 |
88,633,648 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0090:Arhgef2
|
UTSW |
3 |
88,639,348 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0330:Arhgef2
|
UTSW |
3 |
88,642,501 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0414:Arhgef2
|
UTSW |
3 |
88,632,268 (GRCm38) |
splice site |
probably benign |
|
|
R0631:Arhgef2
|
UTSW |
3 |
88,634,436 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1635:Arhgef2
|
UTSW |
3 |
88,639,321 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R1688:Arhgef2
|
UTSW |
3 |
88,640,300 (GRCm38) |
missense |
probably benign |
0.32 |
|
R1751:Arhgef2
|
UTSW |
3 |
88,643,953 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1767:Arhgef2
|
UTSW |
3 |
88,643,953 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1836:Arhgef2
|
UTSW |
3 |
88,639,459 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1853:Arhgef2
|
UTSW |
3 |
88,632,915 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R1934:Arhgef2
|
UTSW |
3 |
88,629,791 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R2155:Arhgef2
|
UTSW |
3 |
88,636,044 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2206:Arhgef2
|
UTSW |
3 |
88,629,914 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2360:Arhgef2
|
UTSW |
3 |
88,634,416 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3916:Arhgef2
|
UTSW |
3 |
88,633,033 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4090:Arhgef2
|
UTSW |
3 |
88,643,878 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4732:Arhgef2
|
UTSW |
3 |
88,631,940 (GRCm38) |
nonsense |
probably null |
|
|
R4733:Arhgef2
|
UTSW |
3 |
88,631,940 (GRCm38) |
nonsense |
probably null |
|
|
R4837:Arhgef2
|
UTSW |
3 |
88,632,943 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5152:Arhgef2
|
UTSW |
3 |
88,629,568 (GRCm38) |
splice site |
probably null |
|
|
R5194:Arhgef2
|
UTSW |
3 |
88,635,649 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5250:Arhgef2
|
UTSW |
3 |
88,633,648 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5334:Arhgef2
|
UTSW |
3 |
88,646,329 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R5514:Arhgef2
|
UTSW |
3 |
88,642,997 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5560:Arhgef2
|
UTSW |
3 |
88,634,437 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R5595:Arhgef2
|
UTSW |
3 |
88,642,976 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5879:Arhgef2
|
UTSW |
3 |
88,643,617 (GRCm38) |
splice site |
probably null |
|
|
R5910:Arhgef2
|
UTSW |
3 |
88,635,020 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5914:Arhgef2
|
UTSW |
3 |
88,635,869 (GRCm38) |
missense |
probably benign |
|
|
R5918:Arhgef2
|
UTSW |
3 |
88,636,080 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6181:Arhgef2
|
UTSW |
3 |
88,635,620 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6489:Arhgef2
|
UTSW |
3 |
88,643,014 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7167:Arhgef2
|
UTSW |
3 |
88,643,872 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
R7289:Arhgef2
|
UTSW |
3 |
88,635,885 (GRCm38) |
missense |
probably benign |
|
|
R7318:Arhgef2
|
UTSW |
3 |
88,632,303 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7353:Arhgef2
|
UTSW |
3 |
88,635,686 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7402:Arhgef2
|
UTSW |
3 |
88,633,566 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7441:Arhgef2
|
UTSW |
3 |
88,643,955 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R7899:Arhgef2
|
UTSW |
3 |
88,621,262 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7934:Arhgef2
|
UTSW |
3 |
88,629,914 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8002:Arhgef2
|
UTSW |
3 |
88,646,810 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8254:Arhgef2
|
UTSW |
3 |
88,642,603 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8297:Arhgef2
|
UTSW |
3 |
88,639,432 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8314:Arhgef2
|
UTSW |
3 |
88,621,293 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8350:Arhgef2
|
UTSW |
3 |
88,646,220 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8450:Arhgef2
|
UTSW |
3 |
88,646,220 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8755:Arhgef2
|
UTSW |
3 |
88,629,543 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9632:Arhgef2
|
UTSW |
3 |
88,621,269 (GRCm38) |
missense |
probably benign |
0.43 |
|
R9710:Arhgef2
|
UTSW |
3 |
88,621,269 (GRCm38) |
missense |
probably benign |
0.43 |
|
V1662:Arhgef2
|
UTSW |
3 |
88,633,329 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGCTGACCCTGAGCTATC -3'
(R):5'- AACCCAACTCCTTTATGGGTTGTG -3'
Sequencing Primer
(F):5'- TGAGCTATCCCTCTGCTGAC -3'
(R):5'- TGAGTGAACAGCCTAGACTCTTCAG -3'
|
| Posted On |
2016-04-27 |
Incidental Mutation