|Institutional Source||Beutler Lab|
|Gene Name||musashi RNA-binding protein 2|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R4952 (G1)|
|Chromosomal Location||88339382-88718513 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (1 bp from exon)|
|DNA Base Change (assembly)||C to T at 88366784 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000103542 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000092794] [ENSMUST00000107909]|
|Meta Mutation Damage Score||0.9593|
|Coding Region Coverage||
|Validation Efficiency||99% (93/94)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit lethality, decreased body size, and decreased hematopoietic stem cells. Mice homozygous for a conditional knock-out allele exhibit impaired hematopoietic stem cell physiology upon induction. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Msi2||
(F):5'- GGGTTTTCAGTCCCCTAACTG -3'
(R):5'- AGGCATCTTAAGATTCCGTGCC -3'
(F):5'- TAACTGTGACAGACTCCTGCAGG -3'
(R):5'- TAAGATTCCGTGCCTTCCAGAAG -3'