Incidental Mutation 'R4952:Nek10'
ID 382092
Institutional Source Beutler Lab
Gene Symbol Nek10
Ensembl Gene ENSMUSG00000042567
Gene Name NIMA (never in mitosis gene a)- related kinase 10
Synonyms LOC238944
MMRRC Submission 042549-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4952 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 14803415-15012059 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 14860986 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Leucine to Methionine at position 513 (L513M)
Ref Sequence ENSEMBL: ENSMUSP00000153142 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112630] [ENSMUST00000112631] [ENSMUST00000224491]
AlphaFold Q3UGM2
Predicted Effect noncoding transcript
Transcript: ENSMUST00000063220
Predicted Effect possibly damaging
Transcript: ENSMUST00000112630
AA Change: L513M

PolyPhen 2 Score 0.465 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000108249
Gene: ENSMUSG00000042567
AA Change: L513M

DomainStartEndE-ValueType
ARM 197 238 8.23e1 SMART
ARM 278 320 5.18e0 SMART
low complexity region 387 400 N/A INTRINSIC
ARM 401 448 7.09e1 SMART
S_TKc 519 791 2.36e-75 SMART
low complexity region 799 811 N/A INTRINSIC
low complexity region 839 863 N/A INTRINSIC
low complexity region 908 926 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112631
AA Change: L513M

PolyPhen 2 Score 0.079 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000108250
Gene: ENSMUSG00000042567
AA Change: L513M

DomainStartEndE-ValueType
ARM 197 238 8.23e1 SMART
ARM 278 320 5.18e0 SMART
low complexity region 387 400 N/A INTRINSIC
ARM 401 448 7.09e1 SMART
S_TKc 519 791 2.36e-75 SMART
low complexity region 799 811 N/A INTRINSIC
low complexity region 839 863 N/A INTRINSIC
low complexity region 908 926 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134866
Predicted Effect possibly damaging
Transcript: ENSMUST00000224491
AA Change: L513M

PolyPhen 2 Score 0.465 (Sensitivity: 0.89; Specificity: 0.90)
Meta Mutation Damage Score 0.0762 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.3%
  • 10x: 96.5%
  • 20x: 93.0%
Validation Efficiency 99% (93/94)
Allele List at MGI
Other mutations in this stock
Total: 84 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522L14Rik A G 5: 109,739,197 (GRCm38) probably null Het
4933421I07Rik T C 7: 42,447,659 (GRCm38) Y76C possibly damaging Het
Adcy4 C T 14: 55,779,029 (GRCm38) D322N probably damaging Het
Ak9 A G 10: 41,420,589 (GRCm38) M1444V probably benign Het
Amfr A G 8: 93,973,159 (GRCm38) probably benign Het
Ankef1 A G 2: 136,550,529 (GRCm38) E546G probably damaging Het
Ankrd24 A G 10: 81,647,148 (GRCm38) M977V probably benign Het
Ap3m1 A T 14: 21,040,066 (GRCm38) S5T probably benign Het
Aqr C A 2: 114,109,937 (GRCm38) D1243Y probably damaging Het
Arhgef2 T C 3: 88,642,462 (GRCm38) L591P probably damaging Het
Arid4a C A 12: 71,023,525 (GRCm38) T70K possibly damaging Het
Asphd1 C T 7: 126,948,685 (GRCm38) A149T probably benign Het
Avpr1a T A 10: 122,449,754 (GRCm38) M317K probably damaging Het
Birc2 T C 9: 7,836,740 (GRCm38) I109V probably damaging Het
Catsperd A G 17: 56,632,303 (GRCm38) Y44C probably damaging Het
Ccdc114 A C 7: 45,942,191 (GRCm38) E293A probably damaging Het
Crygb T G 1: 65,082,109 (GRCm38) S20R probably benign Het
Cyp3a25 T C 5: 145,991,524 (GRCm38) N237S probably benign Het
Dkk3 C T 7: 112,118,351 (GRCm38) A304T probably benign Het
Dst T C 1: 34,271,422 (GRCm38) L4101S probably damaging Het
Dysf A G 6: 84,149,986 (GRCm38) N1407S possibly damaging Het
Epb41 A G 4: 132,000,270 (GRCm38) V265A probably damaging Het
Faim2 C T 15: 99,521,228 (GRCm38) E75K possibly damaging Het
Fbn1 T A 2: 125,317,534 (GRCm38) D2208V probably damaging Het
Fbxo28 A G 1: 182,326,385 (GRCm38) S129P probably damaging Het
Fbxw14 T A 9: 109,276,201 (GRCm38) I299L probably benign Het
Fras1 C T 5: 96,647,498 (GRCm38) A1050V probably benign Het
Fyb C A 15: 6,638,811 (GRCm38) T495K probably damaging Het
Ghdc A T 11: 100,769,151 (GRCm38) W257R probably damaging Het
Gm10719 T C 9: 3,018,962 (GRCm38) L69S probably benign Het
Gm11492 A G 11: 87,567,772 (GRCm38) N324S probably benign Het
Gm12250 G T 11: 58,188,384 (GRCm38) noncoding transcript Het
Gm4846 A T 1: 166,483,934 (GRCm38) F452Y probably damaging Het
Gm8773 T A 5: 5,575,387 (GRCm38) F28I probably benign Het
Gm884 T C 11: 103,614,207 (GRCm38) T2312A possibly damaging Het
Gpbp1 T C 13: 111,440,750 (GRCm38) D202G probably damaging Het
Gpd2 C A 2: 57,307,013 (GRCm38) Y193* probably null Het
Grhl2 G T 15: 37,287,249 (GRCm38) R229L probably benign Het
Gtf2a1 A G 12: 91,575,749 (GRCm38) F59L possibly damaging Het
Heatr1 G T 13: 12,410,599 (GRCm38) W640L probably benign Het
Kalrn A T 16: 34,357,415 (GRCm38) probably null Het
Keap1 T C 9: 21,237,286 (GRCm38) T142A probably damaging Het
Kpna2 G A 11: 106,991,235 (GRCm38) T255M probably damaging Het
Kpna3 A G 14: 61,370,389 (GRCm38) C456R probably damaging Het
Lama1 G A 17: 67,767,566 (GRCm38) probably null Het
Mag C A 7: 30,909,156 (GRCm38) E178* probably null Het
Map3k13 A G 16: 21,911,019 (GRCm38) I467V probably benign Het
Mga A G 2: 119,903,301 (GRCm38) E210G probably damaging Het
Msi2 C T 11: 88,366,784 (GRCm38) probably null Het
Naa16 A T 14: 79,345,085 (GRCm38) D521E probably damaging Het
Nav2 C T 7: 49,304,540 (GRCm38) probably benign Het
Nek5 T A 8: 22,079,088 (GRCm38) I573L probably benign Het
Nek5 T C 8: 22,096,799 (GRCm38) K332R probably benign Het
Ntn1 CCTTCTTCT CCTTCT 11: 68,213,026 (GRCm38) probably benign Het
Olfr111 A T 17: 37,530,750 (GRCm38) T258S possibly damaging Het
Olfr263 G A 13: 21,133,344 (GRCm38) V190I probably benign Het
Olfr773 T A 10: 129,186,597 (GRCm38) T275S probably benign Het
Olfr875 T A 9: 37,773,064 (GRCm38) M135K probably damaging Het
Orai1 T G 5: 123,029,250 (GRCm38) V162G probably damaging Het
P2rx6 T C 16: 17,567,444 (GRCm38) S134P probably damaging Het
Pappa2 G A 1: 158,857,136 (GRCm38) T811I probably null Het
Pcdhga10 T C 18: 37,747,160 (GRCm38) probably benign Het
Pex16 C T 2: 92,379,060 (GRCm38) R241* probably null Het
Plxnb1 T C 9: 109,114,836 (GRCm38) F1969L probably damaging Het
Postn A G 3: 54,390,315 (GRCm38) probably benign Het
Prdm15 A T 16: 97,806,077 (GRCm38) I752N probably damaging Het
Rasgef1c A T 11: 49,979,512 (GRCm38) K468M probably damaging Het
Rbfox1 A G 16: 7,277,088 (GRCm38) S111G probably benign Het
Rbm28 T C 6: 29,138,598 (GRCm38) D405G probably damaging Het
Rell1 A G 5: 63,939,667 (GRCm38) probably benign Het
Rfx3 A G 19: 27,830,672 (GRCm38) S224P probably damaging Het
Scarb2 A T 5: 92,454,777 (GRCm38) I260K probably damaging Het
Slc15a4 A G 5: 127,603,837 (GRCm38) F72L probably damaging Het
Spg7 C A 8: 123,090,171 (GRCm38) R534S probably damaging Het
Stoml2 T C 4: 43,029,589 (GRCm38) T164A probably benign Het
Syt11 C T 3: 88,762,283 (GRCm38) G101S possibly damaging Het
Traj12 A G 14: 54,206,556 (GRCm38) probably benign Het
Traj7 A T 14: 54,211,524 (GRCm38) probably benign Het
Tysnd1 C T 10: 61,702,076 (GRCm38) T175I possibly damaging Het
Usp48 T G 4: 137,606,693 (GRCm38) Y139* probably null Het
Vmn2r72 A G 7: 85,751,109 (GRCm38) L244P probably benign Het
Wasf1 C A 10: 40,936,190 (GRCm38) P325Q unknown Het
Zc3h18 T A 8: 122,410,900 (GRCm38) probably benign Het
Zfp712 A G 13: 67,040,841 (GRCm38) S541P possibly damaging Het
Other mutations in Nek10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01361:Nek10 APN 14 14,850,957 (GRCm38) missense probably damaging 0.99
IGL02067:Nek10 APN 14 14,861,639 (GRCm38) missense probably benign 0.12
IGL02361:Nek10 APN 14 14,843,856 (GRCm38) missense probably damaging 1.00
IGL02687:Nek10 APN 14 14,840,570 (GRCm38) missense probably damaging 1.00
IGL02929:Nek10 APN 14 14,821,119 (GRCm38) missense possibly damaging 0.82
IGL03229:Nek10 APN 14 14,986,686 (GRCm38) missense probably benign 0.10
P0041:Nek10 UTSW 14 14,861,603 (GRCm38) missense probably benign 0.01
R0007:Nek10 UTSW 14 14,840,574 (GRCm38) missense probably benign 0.10
R0007:Nek10 UTSW 14 14,840,574 (GRCm38) missense probably benign 0.10
R0142:Nek10 UTSW 14 14,861,560 (GRCm38) missense possibly damaging 0.96
R0433:Nek10 UTSW 14 14,860,927 (GRCm38) missense probably benign 0.32
R0633:Nek10 UTSW 14 14,857,782 (GRCm38) critical splice acceptor site probably null
R1087:Nek10 UTSW 14 14,827,059 (GRCm38) missense possibly damaging 0.59
R1184:Nek10 UTSW 14 14,931,325 (GRCm38) splice site probably benign
R1250:Nek10 UTSW 14 14,853,887 (GRCm38) missense probably damaging 1.00
R1371:Nek10 UTSW 14 14,850,983 (GRCm38) missense probably damaging 0.98
R1506:Nek10 UTSW 14 14,999,078 (GRCm38) splice site probably benign
R1829:Nek10 UTSW 14 14,863,454 (GRCm38) critical splice acceptor site probably null
R1831:Nek10 UTSW 14 14,842,789 (GRCm38) missense probably benign
R1833:Nek10 UTSW 14 14,842,789 (GRCm38) missense probably benign
R1990:Nek10 UTSW 14 14,860,764 (GRCm38) missense probably benign
R1997:Nek10 UTSW 14 14,827,003 (GRCm38) missense probably benign 0.09
R2011:Nek10 UTSW 14 14,885,122 (GRCm38) missense probably damaging 1.00
R2158:Nek10 UTSW 14 14,885,047 (GRCm38) splice site probably null
R2288:Nek10 UTSW 14 14,853,956 (GRCm38) nonsense probably null
R2568:Nek10 UTSW 14 14,999,112 (GRCm38) missense possibly damaging 0.89
R2907:Nek10 UTSW 14 14,980,613 (GRCm38) missense possibly damaging 0.81
R2965:Nek10 UTSW 14 14,836,202 (GRCm38) missense probably damaging 1.00
R3922:Nek10 UTSW 14 14,861,585 (GRCm38) missense possibly damaging 0.88
R4032:Nek10 UTSW 14 14,853,877 (GRCm38) splice site probably null
R4700:Nek10 UTSW 14 14,842,841 (GRCm38) missense possibly damaging 0.69
R4742:Nek10 UTSW 14 14,861,624 (GRCm38) missense probably null 0.03
R4785:Nek10 UTSW 14 14,855,714 (GRCm38) missense probably benign
R4890:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4891:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4920:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4924:Nek10 UTSW 14 14,846,594 (GRCm38) splice site probably null
R4928:Nek10 UTSW 14 14,930,577 (GRCm38) missense probably damaging 1.00
R4948:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4953:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R5092:Nek10 UTSW 14 14,820,851 (GRCm38) missense possibly damaging 0.81
R5097:Nek10 UTSW 14 14,857,851 (GRCm38) missense probably benign 0.00
R5593:Nek10 UTSW 14 14,980,544 (GRCm38) nonsense probably null
R5696:Nek10 UTSW 14 14,860,736 (GRCm38) splice site probably null
R5813:Nek10 UTSW 14 14,986,704 (GRCm38) missense probably benign 0.01
R5829:Nek10 UTSW 14 14,865,404 (GRCm38) missense probably damaging 1.00
R5872:Nek10 UTSW 14 14,850,896 (GRCm38) missense probably benign 0.06
R5939:Nek10 UTSW 14 14,931,290 (GRCm38) missense possibly damaging 0.58
R6025:Nek10 UTSW 14 14,865,633 (GRCm38) missense probably benign 0.41
R6235:Nek10 UTSW 14 14,821,113 (GRCm38) nonsense probably null
R6539:Nek10 UTSW 14 14,860,789 (GRCm38) missense possibly damaging 0.94
R6542:Nek10 UTSW 14 14,999,108 (GRCm38) missense probably benign 0.44
R6561:Nek10 UTSW 14 14,828,448 (GRCm38) missense possibly damaging 0.48
R6659:Nek10 UTSW 14 14,861,684 (GRCm38) missense probably benign 0.29
R7039:Nek10 UTSW 14 14,986,700 (GRCm38) missense probably damaging 0.99
R7039:Nek10 UTSW 14 14,826,946 (GRCm38) missense possibly damaging 0.63
R7102:Nek10 UTSW 14 14,828,517 (GRCm38) missense probably damaging 1.00
R7185:Nek10 UTSW 14 14,846,621 (GRCm38) missense probably benign 0.03
R7198:Nek10 UTSW 14 14,850,947 (GRCm38) missense probably damaging 0.99
R7202:Nek10 UTSW 14 14,836,171 (GRCm38) missense probably benign 0.01
R7251:Nek10 UTSW 14 14,853,965 (GRCm38) missense probably benign
R7345:Nek10 UTSW 14 14,955,503 (GRCm38) missense probably benign
R7590:Nek10 UTSW 14 15,006,693 (GRCm38) makesense probably null
R7593:Nek10 UTSW 14 14,826,955 (GRCm38) missense probably benign 0.04
R7616:Nek10 UTSW 14 14,937,759 (GRCm38) missense probably benign 0.27
R7635:Nek10 UTSW 14 14,850,932 (GRCm38) missense probably benign 0.01
R7817:Nek10 UTSW 14 15,001,017 (GRCm38) missense probably benign 0.00
R7826:Nek10 UTSW 14 14,860,846 (GRCm38) splice site probably null
R7986:Nek10 UTSW 14 15,001,020 (GRCm38) missense probably benign 0.17
R8765:Nek10 UTSW 14 14,999,104 (GRCm38) missense probably damaging 0.97
R8856:Nek10 UTSW 14 14,937,610 (GRCm38) missense probably damaging 0.96
R8973:Nek10 UTSW 14 14,931,321 (GRCm38) critical splice donor site probably null
R9002:Nek10 UTSW 14 14,980,590 (GRCm38) missense probably damaging 1.00
R9088:Nek10 UTSW 14 14,931,314 (GRCm38) missense probably damaging 1.00
R9195:Nek10 UTSW 14 14,821,139 (GRCm38) missense probably benign 0.03
R9464:Nek10 UTSW 14 14,937,766 (GRCm38) missense probably benign
R9511:Nek10 UTSW 14 14,828,511 (GRCm38) missense probably benign 0.05
R9529:Nek10 UTSW 14 14,850,833 (GRCm38) missense probably benign
R9590:Nek10 UTSW 14 14,853,888 (GRCm38) missense probably damaging 1.00
Z1177:Nek10 UTSW 14 15,001,157 (GRCm38) nonsense probably null
Z1177:Nek10 UTSW 14 14,853,948 (GRCm38) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCTTATAAGGACTTGGTATCACAGTTG -3'
(R):5'- TGAGAGCCAAGGCAACACTC -3'

Sequencing Primer
(F):5'- GGACTTGGTATCACAGTTGAATTTAC -3'
(R):5'- CATAATTACCACCCAGTGTTGG -3'
Posted On 2016-04-27