Incidental Mutation 'R4959:Kif21b'
| ID |
382117 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kif21b
|
| Ensembl Gene |
ENSMUSG00000041642 |
| Gene Name |
kinesin family member 21B |
| Synonyms |
2610511N21Rik, N-5 kinesin |
| MMRRC Submission |
042556-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.157)
|
| Stock # |
R4959 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
136059127-136105736 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 136076108 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Tyrosine
at position 299
(C299Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114297
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075164]
[ENSMUST00000130864]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000075164
AA Change: C299Y
PolyPhen 2
Score 0.766 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000074661
Gene: ENSMUSG00000041642
AA Change: C299Y
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
6 |
379 |
6.39e-159 |
SMART |
|
Blast:KISc
|
469 |
543 |
1e-14 |
BLAST |
|
low complexity region
|
578 |
628 |
N/A |
INTRINSIC |
|
coiled coil region
|
632 |
825 |
N/A |
INTRINSIC |
|
low complexity region
|
847 |
866 |
N/A |
INTRINSIC |
|
coiled coil region
|
931 |
991 |
N/A |
INTRINSIC |
|
low complexity region
|
1109 |
1123 |
N/A |
INTRINSIC |
|
low complexity region
|
1239 |
1249 |
N/A |
INTRINSIC |
|
low complexity region
|
1266 |
1279 |
N/A |
INTRINSIC |
|
WD40
|
1299 |
1336 |
2.89e-5 |
SMART |
|
WD40
|
1339 |
1377 |
5.69e-4 |
SMART |
|
WD40
|
1404 |
1441 |
6.42e-1 |
SMART |
|
WD40
|
1444 |
1486 |
1.5e-3 |
SMART |
|
WD40
|
1494 |
1532 |
4.8e-2 |
SMART |
|
WD40
|
1535 |
1575 |
1.55e-5 |
SMART |
|
WD40
|
1578 |
1615 |
3.81e-5 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000122892
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000130864
AA Change: C299Y
PolyPhen 2
Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000114297
Gene: ENSMUSG00000041642
AA Change: C299Y
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
6 |
379 |
6.39e-159 |
SMART |
|
Blast:KISc
|
469 |
543 |
1e-14 |
BLAST |
|
low complexity region
|
578 |
628 |
N/A |
INTRINSIC |
|
coiled coil region
|
632 |
825 |
N/A |
INTRINSIC |
|
low complexity region
|
847 |
866 |
N/A |
INTRINSIC |
|
coiled coil region
|
931 |
991 |
N/A |
INTRINSIC |
|
low complexity region
|
1109 |
1123 |
N/A |
INTRINSIC |
|
low complexity region
|
1239 |
1249 |
N/A |
INTRINSIC |
|
low complexity region
|
1266 |
1279 |
N/A |
INTRINSIC |
|
WD40
|
1299 |
1336 |
2.89e-5 |
SMART |
|
WD40
|
1339 |
1377 |
5.69e-4 |
SMART |
|
WD40
|
1404 |
1441 |
6.42e-1 |
SMART |
|
WD40
|
1444 |
1486 |
1.5e-3 |
SMART |
|
WD40
|
1494 |
1532 |
4.8e-2 |
SMART |
|
WD40
|
1535 |
1575 |
1.55e-5 |
SMART |
|
WD40
|
1578 |
1615 |
5.1e-6 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.2%
- 10x: 95.6%
- 20x: 89.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the kinesin superfamily. Kinesins are ATP-dependent microtubule-based motor proteins that are involved in the intracellular transport of membranous organelles. Single nucleotide polymorphisms in this gene are associated with inflammatory bowel disease and multiple sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
PHENOTYPE: Homozygous KO reduces dendrite branching and spine density as a result of reduced microtubule growth, resulting in impaired spatial learning and cued conditioning behavior. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 99 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
A |
T |
12: 71,211,321 (GRCm39) |
E685V |
possibly damaging |
Het |
| 2700049A03Rik |
G |
T |
12: 71,211,320 (GRCm39) |
E685* |
probably null |
Het |
| 6820408C15Rik |
T |
A |
2: 152,282,808 (GRCm39) |
I221K |
possibly damaging |
Het |
| Aadacl3 |
A |
T |
4: 144,183,656 (GRCm39) |
C136S |
probably benign |
Het |
| Abhd16a |
T |
A |
17: 35,321,318 (GRCm39) |
S498T |
probably benign |
Het |
| Acrv1 |
G |
A |
9: 36,605,996 (GRCm39) |
|
probably null |
Het |
| Adamts18 |
G |
A |
8: 114,463,357 (GRCm39) |
R830* |
probably null |
Het |
| Art3 |
A |
G |
5: 92,551,478 (GRCm39) |
Y279C |
probably damaging |
Het |
| Atm |
A |
T |
9: 53,426,601 (GRCm39) |
D552E |
probably benign |
Het |
| Ccdc154 |
T |
C |
17: 25,389,888 (GRCm39) |
L508P |
probably damaging |
Het |
| Ccser2 |
A |
T |
14: 36,662,753 (GRCm39) |
S144T |
probably benign |
Het |
| Cgn |
C |
T |
3: 94,685,564 (GRCm39) |
A320T |
probably benign |
Het |
| Cklf |
A |
G |
8: 104,988,184 (GRCm39) |
K106E |
probably benign |
Het |
| Clec12a |
C |
A |
6: 129,330,628 (GRCm39) |
T70K |
probably benign |
Het |
| CN725425 |
G |
A |
15: 91,129,904 (GRCm39) |
A256T |
possibly damaging |
Het |
| Crb2 |
G |
T |
2: 37,680,482 (GRCm39) |
R470L |
probably damaging |
Het |
| Csn1s1 |
T |
G |
5: 87,821,120 (GRCm39) |
S33A |
probably benign |
Het |
| D630045J12Rik |
C |
T |
6: 38,125,302 (GRCm39) |
V1571M |
possibly damaging |
Het |
| Deup1 |
G |
A |
9: 15,523,310 (GRCm39) |
Q58* |
probably null |
Het |
| Dph2 |
T |
A |
4: 117,748,527 (GRCm39) |
D82V |
probably damaging |
Het |
| Dsp |
C |
T |
13: 38,375,686 (GRCm39) |
A1157V |
probably benign |
Het |
| Evi5l |
G |
T |
8: 4,255,406 (GRCm39) |
V477L |
probably benign |
Het |
| Fam187b |
T |
A |
7: 30,681,687 (GRCm39) |
H131Q |
probably damaging |
Het |
| Fam193b |
A |
G |
13: 55,691,097 (GRCm39) |
I259T |
probably damaging |
Het |
| Fam91a1 |
A |
G |
15: 58,303,059 (GRCm39) |
T323A |
probably benign |
Het |
| Fat4 |
T |
G |
3: 39,037,195 (GRCm39) |
S3616A |
probably benign |
Het |
| Fbxo38 |
A |
T |
18: 62,655,578 (GRCm39) |
N369K |
probably benign |
Het |
| Fitm1 |
T |
A |
14: 55,813,831 (GRCm39) |
|
probably null |
Het |
| Fkbp5 |
T |
C |
17: 28,647,343 (GRCm39) |
E164G |
probably damaging |
Het |
| Fpr-rs3 |
T |
C |
17: 20,844,211 (GRCm39) |
Y310C |
possibly damaging |
Het |
| Fryl |
A |
T |
5: 73,192,401 (GRCm39) |
M2678K |
probably benign |
Het |
| Fsip2 |
T |
C |
2: 82,815,169 (GRCm39) |
I3634T |
probably benign |
Het |
| Gm3233 |
T |
C |
10: 77,595,399 (GRCm39) |
|
probably benign |
Het |
| Gzmd |
T |
G |
14: 56,369,955 (GRCm39) |
T9P |
unknown |
Het |
| Htr2b |
A |
T |
1: 86,027,813 (GRCm39) |
I231N |
probably damaging |
Het |
| Il2ra |
A |
G |
2: 11,681,664 (GRCm39) |
T90A |
possibly damaging |
Het |
| Kbtbd2 |
A |
G |
6: 56,758,943 (GRCm39) |
F60S |
probably benign |
Het |
| Lsm5 |
A |
T |
6: 56,680,309 (GRCm39) |
D44E |
probably damaging |
Het |
| Mapk1 |
T |
A |
16: 16,836,170 (GRCm39) |
M106K |
probably damaging |
Het |
| Mpp2 |
A |
G |
11: 101,954,117 (GRCm39) |
V193A |
probably damaging |
Het |
| Muc4 |
T |
C |
16: 32,575,437 (GRCm39) |
S1398P |
possibly damaging |
Het |
| Ndufs2 |
A |
G |
1: 171,065,578 (GRCm39) |
Y282H |
probably damaging |
Het |
| Nes |
T |
A |
3: 87,882,983 (GRCm39) |
L414Q |
probably damaging |
Het |
| Neurl2 |
T |
A |
2: 164,675,122 (GRCm39) |
|
probably null |
Het |
| Ngef |
A |
G |
1: 87,431,070 (GRCm39) |
F159S |
possibly damaging |
Het |
| Nlrx1 |
T |
C |
9: 44,165,448 (GRCm39) |
H816R |
possibly damaging |
Het |
| Or10v5 |
A |
G |
19: 11,806,300 (GRCm39) |
L30P |
probably benign |
Het |
| Or1e22 |
A |
T |
11: 73,376,893 (GRCm39) |
Y252* |
probably null |
Het |
| Or2f1 |
T |
C |
6: 42,721,621 (GRCm39) |
S217P |
probably damaging |
Het |
| Or4c106 |
T |
C |
2: 88,682,516 (GRCm39) |
V74A |
possibly damaging |
Het |
| Or4f17-ps1 |
T |
A |
2: 111,357,969 (GRCm39) |
F103L |
probably damaging |
Het |
| Or4p7 |
T |
A |
2: 88,221,674 (GRCm39) |
L28I |
probably benign |
Het |
| Or7g35 |
A |
G |
9: 19,496,504 (GRCm39) |
T224A |
probably benign |
Het |
| Pcgf2 |
A |
T |
11: 97,582,515 (GRCm39) |
Y7N |
possibly damaging |
Het |
| Pdlim5 |
G |
A |
3: 142,017,740 (GRCm39) |
|
probably benign |
Het |
| Pdzd2 |
A |
G |
15: 12,375,734 (GRCm39) |
V1467A |
probably damaging |
Het |
| Pigp |
C |
A |
16: 94,160,006 (GRCm39) |
G134V |
probably benign |
Het |
| Pik3c2g |
T |
C |
6: 139,789,657 (GRCm39) |
Y385H |
possibly damaging |
Het |
| Pnliprp2 |
G |
A |
19: 58,754,750 (GRCm39) |
E265K |
probably benign |
Het |
| Prl3c1 |
G |
T |
13: 27,386,471 (GRCm39) |
|
probably null |
Het |
| Ptpn4 |
A |
T |
1: 119,692,826 (GRCm39) |
Y110* |
probably null |
Het |
| Ptprq |
C |
T |
10: 107,522,416 (GRCm39) |
V546I |
probably damaging |
Het |
| Rd3l |
C |
T |
12: 111,946,578 (GRCm39) |
|
probably null |
Het |
| Rpl37 |
G |
A |
15: 5,147,128 (GRCm39) |
R56Q |
possibly damaging |
Het |
| Rttn |
A |
T |
18: 89,060,292 (GRCm39) |
H998L |
probably damaging |
Het |
| Rufy1 |
A |
T |
11: 50,292,315 (GRCm39) |
F491L |
probably benign |
Het |
| Simc1 |
T |
G |
13: 54,673,131 (GRCm39) |
V493G |
possibly damaging |
Het |
| Slc22a14 |
CTTTCCTGAA |
C |
9: 119,003,101 (GRCm39) |
|
probably benign |
Het |
| Slc25a46 |
A |
T |
18: 31,735,807 (GRCm39) |
I144N |
possibly damaging |
Het |
| Smtn |
A |
T |
11: 3,477,825 (GRCm39) |
M1K |
probably null |
Het |
| Snd1 |
C |
A |
6: 28,884,250 (GRCm39) |
Y766* |
probably null |
Het |
| Spata31d1d |
C |
T |
13: 59,875,102 (GRCm39) |
G811D |
probably damaging |
Het |
| Spta1 |
A |
C |
1: 174,074,174 (GRCm39) |
D2371A |
probably damaging |
Het |
| Stard6 |
A |
C |
18: 70,631,631 (GRCm39) |
D74A |
possibly damaging |
Het |
| Stim2 |
G |
T |
5: 54,262,712 (GRCm39) |
R318L |
probably benign |
Het |
| Sufu |
C |
T |
19: 46,463,991 (GRCm39) |
T401I |
possibly damaging |
Het |
| Suz12 |
G |
A |
11: 79,920,057 (GRCm39) |
G539D |
probably damaging |
Het |
| Sytl2 |
C |
G |
7: 90,025,245 (GRCm39) |
S411C |
probably damaging |
Het |
| Taf6 |
G |
A |
5: 138,181,465 (GRCm39) |
Q156* |
probably null |
Het |
| Tead4 |
T |
C |
6: 128,247,950 (GRCm39) |
D29G |
probably damaging |
Het |
| Thada |
T |
C |
17: 84,751,611 (GRCm39) |
Y455C |
probably damaging |
Het |
| Tlr6 |
G |
C |
5: 65,111,002 (GRCm39) |
T635S |
possibly damaging |
Het |
| Tlr9 |
A |
G |
9: 106,101,876 (GRCm39) |
D389G |
probably benign |
Het |
| Tmem54 |
A |
T |
4: 129,002,073 (GRCm39) |
H40L |
probably damaging |
Het |
| Trappc9 |
G |
T |
15: 72,808,905 (GRCm39) |
N540K |
probably damaging |
Het |
| Trbv28 |
C |
T |
6: 41,248,788 (GRCm39) |
S106F |
probably damaging |
Het |
| Trrap |
A |
T |
5: 144,793,770 (GRCm39) |
H3384L |
probably damaging |
Het |
| Usp16 |
T |
A |
16: 87,277,802 (GRCm39) |
M684K |
probably damaging |
Het |
| Vat1 |
G |
A |
11: 101,351,426 (GRCm39) |
T305M |
probably damaging |
Het |
| Vmn2r85 |
A |
G |
10: 130,257,302 (GRCm39) |
S544P |
probably damaging |
Het |
| Vps8 |
T |
C |
16: 21,278,536 (GRCm39) |
S267P |
probably damaging |
Het |
| Ylpm1 |
T |
A |
12: 85,096,719 (GRCm39) |
V1242E |
probably damaging |
Het |
| Zfp267 |
C |
T |
3: 36,218,285 (GRCm39) |
R102C |
possibly damaging |
Het |
| Zfp322a |
T |
C |
13: 23,541,052 (GRCm39) |
Y230C |
probably damaging |
Het |
| Zfp352 |
T |
A |
4: 90,112,376 (GRCm39) |
V172E |
probably benign |
Het |
| Zfp936 |
A |
T |
7: 42,839,034 (GRCm39) |
H167L |
probably damaging |
Het |
| Zkscan14 |
A |
G |
5: 145,132,302 (GRCm39) |
Y410H |
probably benign |
Het |
| Zkscan17 |
A |
G |
11: 59,394,538 (GRCm39) |
M21T |
probably damaging |
Het |
| Zswim4 |
G |
T |
8: 84,938,852 (GRCm39) |
A1010D |
probably benign |
Het |
|
| Other mutations in Kif21b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00990:Kif21b
|
APN |
1 |
136,080,080 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL01020:Kif21b
|
APN |
1 |
136,081,832 (GRCm39) |
splice site |
probably benign |
|
|
IGL01288:Kif21b
|
APN |
1 |
136,099,922 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02105:Kif21b
|
APN |
1 |
136,099,041 (GRCm39) |
missense |
probably benign |
|
|
IGL02264:Kif21b
|
APN |
1 |
136,087,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02303:Kif21b
|
APN |
1 |
136,087,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02308:Kif21b
|
APN |
1 |
136,087,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02310:Kif21b
|
APN |
1 |
136,087,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02419:Kif21b
|
APN |
1 |
136,079,005 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02553:Kif21b
|
APN |
1 |
136,081,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02568:Kif21b
|
APN |
1 |
136,100,605 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02657:Kif21b
|
APN |
1 |
136,099,968 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL03068:Kif21b
|
APN |
1 |
136,086,093 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03230:Kif21b
|
APN |
1 |
136,090,550 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0629_Kif21b_729
|
UTSW |
1 |
136,099,895 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Schiessen
|
UTSW |
1 |
136,075,607 (GRCm39) |
critical splice donor site |
probably null |
|
|
wolfen
|
UTSW |
1 |
136,072,496 (GRCm39) |
nonsense |
probably null |
|
|
R0190:Kif21b
|
UTSW |
1 |
136,098,957 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0349:Kif21b
|
UTSW |
1 |
136,077,049 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0501:Kif21b
|
UTSW |
1 |
136,090,837 (GRCm39) |
missense |
probably benign |
0.44 |
|
R0620:Kif21b
|
UTSW |
1 |
136,087,166 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0629:Kif21b
|
UTSW |
1 |
136,099,895 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0741:Kif21b
|
UTSW |
1 |
136,087,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1087:Kif21b
|
UTSW |
1 |
136,090,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1217:Kif21b
|
UTSW |
1 |
136,080,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1464:Kif21b
|
UTSW |
1 |
136,083,891 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1464:Kif21b
|
UTSW |
1 |
136,083,891 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1511:Kif21b
|
UTSW |
1 |
136,097,062 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1512:Kif21b
|
UTSW |
1 |
136,080,543 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1513:Kif21b
|
UTSW |
1 |
136,083,849 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1591:Kif21b
|
UTSW |
1 |
136,077,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1616:Kif21b
|
UTSW |
1 |
136,099,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1628:Kif21b
|
UTSW |
1 |
136,098,958 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1658:Kif21b
|
UTSW |
1 |
136,099,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1728:Kif21b
|
UTSW |
1 |
136,087,859 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1741:Kif21b
|
UTSW |
1 |
136,083,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1784:Kif21b
|
UTSW |
1 |
136,087,859 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1807:Kif21b
|
UTSW |
1 |
136,075,531 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1896:Kif21b
|
UTSW |
1 |
136,075,583 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1970:Kif21b
|
UTSW |
1 |
136,098,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1984:Kif21b
|
UTSW |
1 |
136,075,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1985:Kif21b
|
UTSW |
1 |
136,075,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1986:Kif21b
|
UTSW |
1 |
136,075,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1988:Kif21b
|
UTSW |
1 |
136,080,002 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1990:Kif21b
|
UTSW |
1 |
136,089,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2014:Kif21b
|
UTSW |
1 |
136,076,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2045:Kif21b
|
UTSW |
1 |
136,088,051 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2141:Kif21b
|
UTSW |
1 |
136,080,002 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2248:Kif21b
|
UTSW |
1 |
136,100,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2886:Kif21b
|
UTSW |
1 |
136,075,612 (GRCm39) |
splice site |
probably benign |
|
|
R2896:Kif21b
|
UTSW |
1 |
136,081,955 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R3706:Kif21b
|
UTSW |
1 |
136,087,148 (GRCm39) |
missense |
probably benign |
0.06 |
|
R3780:Kif21b
|
UTSW |
1 |
136,083,964 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3827:Kif21b
|
UTSW |
1 |
136,090,732 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4227:Kif21b
|
UTSW |
1 |
136,081,831 (GRCm39) |
splice site |
probably null |
|
|
R4600:Kif21b
|
UTSW |
1 |
136,075,602 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4608:Kif21b
|
UTSW |
1 |
136,075,924 (GRCm39) |
intron |
probably benign |
|
|
R4749:Kif21b
|
UTSW |
1 |
136,072,487 (GRCm39) |
nonsense |
probably null |
|
|
R4841:Kif21b
|
UTSW |
1 |
136,072,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4842:Kif21b
|
UTSW |
1 |
136,072,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4933:Kif21b
|
UTSW |
1 |
136,079,063 (GRCm39) |
splice site |
probably null |
|
|
R5018:Kif21b
|
UTSW |
1 |
136,099,972 (GRCm39) |
missense |
probably benign |
0.30 |
|
R5116:Kif21b
|
UTSW |
1 |
136,080,521 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5119:Kif21b
|
UTSW |
1 |
136,090,838 (GRCm39) |
missense |
probably benign |
|
|
R5197:Kif21b
|
UTSW |
1 |
136,072,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5230:Kif21b
|
UTSW |
1 |
136,099,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5249:Kif21b
|
UTSW |
1 |
136,096,966 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5337:Kif21b
|
UTSW |
1 |
136,098,881 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5358:Kif21b
|
UTSW |
1 |
136,100,030 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5466:Kif21b
|
UTSW |
1 |
136,075,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5557:Kif21b
|
UTSW |
1 |
136,097,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5727:Kif21b
|
UTSW |
1 |
136,097,747 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5865:Kif21b
|
UTSW |
1 |
136,078,875 (GRCm39) |
nonsense |
probably null |
|
|
R5929:Kif21b
|
UTSW |
1 |
136,078,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6274:Kif21b
|
UTSW |
1 |
136,077,156 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R6349:Kif21b
|
UTSW |
1 |
136,086,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6648:Kif21b
|
UTSW |
1 |
136,080,135 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6831:Kif21b
|
UTSW |
1 |
136,072,496 (GRCm39) |
nonsense |
probably null |
|
|
R7156:Kif21b
|
UTSW |
1 |
136,075,562 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7165:Kif21b
|
UTSW |
1 |
136,077,186 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7327:Kif21b
|
UTSW |
1 |
136,087,387 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R7680:Kif21b
|
UTSW |
1 |
136,075,607 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7975:Kif21b
|
UTSW |
1 |
136,098,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8356:Kif21b
|
UTSW |
1 |
136,100,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8467:Kif21b
|
UTSW |
1 |
136,100,021 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9031:Kif21b
|
UTSW |
1 |
136,073,042 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9101:Kif21b
|
UTSW |
1 |
136,078,893 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9191:Kif21b
|
UTSW |
1 |
136,100,559 (GRCm39) |
nonsense |
probably null |
|
|
R9261:Kif21b
|
UTSW |
1 |
136,077,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9280:Kif21b
|
UTSW |
1 |
136,099,445 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9307:Kif21b
|
UTSW |
1 |
136,101,800 (GRCm39) |
missense |
probably benign |
|
|
R9562:Kif21b
|
UTSW |
1 |
136,077,090 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9563:Kif21b
|
UTSW |
1 |
136,077,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9565:Kif21b
|
UTSW |
1 |
136,077,090 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9758:Kif21b
|
UTSW |
1 |
136,080,961 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9760:Kif21b
|
UTSW |
1 |
136,076,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF024:Kif21b
|
UTSW |
1 |
136,086,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0053:Kif21b
|
UTSW |
1 |
136,077,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0066:Kif21b
|
UTSW |
1 |
136,100,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Kif21b
|
UTSW |
1 |
136,081,875 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Kif21b
|
UTSW |
1 |
136,076,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATCAGGAGGTACGGTCTGAG -3'
(R):5'- TCCTGGGTCGGTTCATAGACTG -3'
Sequencing Primer
(F):5'- TGAGTGAGCCGATGTCACCTTC -3'
(R):5'- CGGTTCATAGACTGGTCTGATAAAC -3'
|
| Posted On |
2016-04-27 |
Incidental Mutation