Incidental Mutation 'R4974:Parp4'
| ID |
382523 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Parp4
|
| Ensembl Gene |
ENSMUSG00000054509 |
| Gene Name |
poly (ADP-ribose) polymerase family, member 4 |
| Synonyms |
VPARP, Adprtl1, C030027K23Rik, VAULT3, p193, PH5P, E230037B21Rik |
| MMRRC Submission |
042569-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.151)
|
| Stock # |
R4974 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
14 |
| Chromosomal Location |
56813076-56897251 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 56827355 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 163
(V163E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124258
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000161553]
|
| AlphaFold |
E9PYK3 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000161553
AA Change: V163E
PolyPhen 2
Score 0.917 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000124258
Gene: ENSMUSG00000054509
AA Change: V163E
| Domain | Start | End | E-Value | Type |
|---|
|
BRCT
|
3 |
84 |
4.32e-9 |
SMART |
|
low complexity region
|
97 |
104 |
N/A |
INTRINSIC |
|
SCOP:d1a26_1
|
252 |
352 |
2e-19 |
SMART |
|
Pfam:PARP
|
371 |
559 |
1.8e-50 |
PFAM |
|
VIT
|
600 |
728 |
1.5e-57 |
SMART |
|
VWA
|
867 |
1030 |
6.08e-13 |
SMART |
|
Blast:14_3_3
|
1149 |
1205 |
5e-10 |
BLAST |
|
low complexity region
|
1255 |
1264 |
N/A |
INTRINSIC |
|
low complexity region
|
1348 |
1362 |
N/A |
INTRINSIC |
|
low complexity region
|
1371 |
1394 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1395 |
1416 |
4.48e-6 |
PROSPERO |
|
Pfam:Drf_FH1
|
1443 |
1542 |
3.3e-15 |
PFAM |
|
low complexity region
|
1553 |
1587 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1588 |
1608 |
2.45e-5 |
PROSPERO |
|
low complexity region
|
1695 |
1708 |
N/A |
INTRINSIC |
|
low complexity region
|
1739 |
1750 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.4186 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.8%
- 20x: 94.2%
|
| Validation Efficiency |
97% (94/97) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants are helathy and fertile. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A730061H03Rik |
C |
T |
14: 55,797,574 (GRCm39) |
|
probably benign |
Het |
| Acsf2 |
A |
C |
11: 94,460,155 (GRCm39) |
M399R |
possibly damaging |
Het |
| Adra2c |
C |
A |
5: 35,438,268 (GRCm39) |
R347S |
probably benign |
Het |
| Akap9 |
A |
G |
5: 4,011,466 (GRCm39) |
K723R |
possibly damaging |
Het |
| Anxa9 |
A |
C |
3: 95,215,324 (GRCm39) |
|
probably benign |
Het |
| Aqr |
T |
C |
2: 113,943,832 (GRCm39) |
H1102R |
probably damaging |
Het |
| Armh3 |
A |
T |
19: 45,808,726 (GRCm39) |
F655Y |
probably damaging |
Het |
| Arrdc2 |
A |
G |
8: 71,290,162 (GRCm39) |
V173A |
probably benign |
Het |
| Aspm |
T |
C |
1: 139,405,748 (GRCm39) |
V1545A |
probably benign |
Het |
| Bbs5 |
C |
T |
2: 69,477,578 (GRCm39) |
|
probably benign |
Het |
| Bnip2 |
A |
G |
9: 69,910,716 (GRCm39) |
T255A |
possibly damaging |
Het |
| Cacna1b |
T |
C |
2: 24,538,535 (GRCm39) |
T1531A |
probably damaging |
Het |
| Cast |
T |
C |
13: 74,955,942 (GRCm39) |
K9R |
probably benign |
Het |
| Cfap46 |
A |
T |
7: 139,187,104 (GRCm39) |
|
probably null |
Het |
| Cfap57 |
G |
T |
4: 118,450,251 (GRCm39) |
L624M |
probably damaging |
Het |
| Cyp2c39 |
A |
T |
19: 39,552,323 (GRCm39) |
M339L |
probably benign |
Het |
| Dcst1 |
T |
A |
3: 89,265,110 (GRCm39) |
T247S |
probably benign |
Het |
| Dnajc18 |
T |
A |
18: 35,816,372 (GRCm39) |
I189F |
possibly damaging |
Het |
| Eef2kmt |
T |
C |
16: 5,066,876 (GRCm39) |
T126A |
probably benign |
Het |
| Epha2 |
A |
G |
4: 141,049,016 (GRCm39) |
E624G |
probably damaging |
Het |
| Erbb3 |
G |
A |
10: 128,408,317 (GRCm39) |
H866Y |
probably benign |
Het |
| F13a1 |
C |
T |
13: 37,100,837 (GRCm39) |
|
probably null |
Het |
| Fgd3 |
T |
A |
13: 49,432,078 (GRCm39) |
N392I |
probably damaging |
Het |
| Fgf7 |
A |
T |
2: 125,930,160 (GRCm39) |
M98L |
probably benign |
Het |
| G2e3 |
T |
A |
12: 51,415,922 (GRCm39) |
S553T |
probably benign |
Het |
| Glipr1 |
C |
A |
10: 111,829,411 (GRCm39) |
E117* |
probably null |
Het |
| Gm11060 |
A |
T |
2: 104,924,128 (GRCm39) |
|
probably benign |
Het |
| Gm4787 |
A |
G |
12: 81,424,403 (GRCm39) |
I585T |
probably damaging |
Het |
| Gm6055 |
A |
T |
14: 48,316,915 (GRCm39) |
|
noncoding transcript |
Het |
| Gpbar1 |
TACCAC |
TAC |
1: 74,318,704 (GRCm39) |
|
probably benign |
Het |
| Gpt2 |
T |
A |
8: 86,246,068 (GRCm39) |
|
probably benign |
Het |
| Gtf2ird1 |
A |
T |
5: 134,386,685 (GRCm39) |
Y345* |
probably null |
Het |
| Hmcn1 |
T |
A |
1: 150,695,200 (GRCm39) |
T235S |
probably benign |
Het |
| Igkv5-48 |
A |
G |
6: 69,703,738 (GRCm39) |
Y56H |
possibly damaging |
Het |
| Il17re |
C |
T |
6: 113,446,530 (GRCm39) |
T427I |
probably benign |
Het |
| Itpr3 |
A |
T |
17: 27,302,582 (GRCm39) |
D80V |
probably damaging |
Het |
| Kif21a |
G |
T |
15: 90,833,213 (GRCm39) |
H1317N |
probably benign |
Het |
| Kif28 |
T |
C |
1: 179,526,209 (GRCm39) |
K144E |
probably damaging |
Het |
| Kif4-ps |
A |
C |
12: 101,113,330 (GRCm39) |
|
noncoding transcript |
Het |
| Klk1b11 |
C |
T |
7: 43,427,160 (GRCm39) |
T148I |
probably damaging |
Het |
| Klkb1 |
T |
A |
8: 45,739,995 (GRCm39) |
H99L |
probably damaging |
Het |
| Kpna6 |
A |
C |
4: 129,550,198 (GRCm39) |
|
probably null |
Het |
| Lama3 |
G |
T |
18: 12,685,883 (GRCm39) |
K1132N |
probably damaging |
Het |
| Lcp1 |
T |
A |
14: 75,445,911 (GRCm39) |
L264* |
probably null |
Het |
| Map2 |
T |
C |
1: 66,452,664 (GRCm39) |
V360A |
probably benign |
Het |
| Med13 |
A |
T |
11: 86,189,673 (GRCm39) |
S1079T |
probably damaging |
Het |
| Mettl13 |
A |
G |
1: 162,364,789 (GRCm39) |
M162T |
probably damaging |
Het |
| Mppe1 |
T |
G |
18: 67,361,133 (GRCm39) |
E208A |
probably benign |
Het |
| Msantd2 |
A |
C |
9: 37,400,675 (GRCm39) |
K19T |
possibly damaging |
Het |
| Mylk3 |
A |
G |
8: 86,091,412 (GRCm39) |
V131A |
probably damaging |
Het |
| Myocd |
A |
T |
11: 65,074,299 (GRCm39) |
S609T |
possibly damaging |
Het |
| Ncbp3 |
G |
A |
11: 72,944,355 (GRCm39) |
|
probably null |
Het |
| Neb |
T |
A |
2: 52,136,871 (GRCm39) |
L3203F |
probably damaging |
Het |
| Notch2 |
C |
A |
3: 98,046,949 (GRCm39) |
T1756K |
probably benign |
Het |
| Nphp4 |
A |
T |
4: 152,622,250 (GRCm39) |
R544W |
probably damaging |
Het |
| Or3a1c |
A |
T |
11: 74,046,745 (GRCm39) |
Y255F |
probably benign |
Het |
| Or4p18 |
T |
G |
2: 88,232,756 (GRCm39) |
H174P |
probably damaging |
Het |
| Or5c1 |
A |
T |
2: 37,222,578 (GRCm39) |
D273V |
probably damaging |
Het |
| Pcdhgb1 |
C |
A |
18: 37,815,425 (GRCm39) |
Q639K |
probably benign |
Het |
| Pcnx2 |
A |
G |
8: 126,577,869 (GRCm39) |
V936A |
probably benign |
Het |
| Pcsk7 |
T |
A |
9: 45,830,160 (GRCm39) |
M418K |
probably damaging |
Het |
| Pglyrp4 |
T |
C |
3: 90,640,314 (GRCm39) |
I188T |
probably benign |
Het |
| Pgs1 |
A |
G |
11: 117,896,345 (GRCm39) |
R339G |
probably benign |
Het |
| Pik3r3 |
A |
G |
4: 116,143,388 (GRCm39) |
I294V |
probably benign |
Het |
| Pik3r6 |
A |
G |
11: 68,430,771 (GRCm39) |
D520G |
probably damaging |
Het |
| Pkdrej |
A |
G |
15: 85,704,610 (GRCm39) |
V442A |
probably benign |
Het |
| Ppfibp1 |
T |
A |
6: 146,931,917 (GRCm39) |
|
probably benign |
Het |
| Ppp3ca |
C |
A |
3: 136,640,810 (GRCm39) |
Q454K |
possibly damaging |
Het |
| Ppp5c |
A |
T |
7: 16,743,861 (GRCm39) |
M191K |
probably damaging |
Het |
| Prl4a1 |
A |
T |
13: 28,207,308 (GRCm39) |
Y194F |
possibly damaging |
Het |
| Ptpn21 |
G |
T |
12: 98,646,362 (GRCm39) |
T1032K |
probably damaging |
Het |
| Ptprh |
A |
T |
7: 4,554,006 (GRCm39) |
|
probably null |
Het |
| Ptprm |
T |
A |
17: 66,985,062 (GRCm39) |
R1447S |
probably benign |
Het |
| Pxk |
T |
A |
14: 8,140,734 (GRCm38) |
D236E |
probably damaging |
Het |
| Qars1 |
T |
C |
9: 108,386,130 (GRCm39) |
F107S |
probably damaging |
Het |
| Rbbp6 |
A |
G |
7: 122,599,031 (GRCm39) |
|
probably benign |
Het |
| Rptor |
A |
T |
11: 119,712,466 (GRCm39) |
|
probably benign |
Het |
| Rtn4 |
T |
A |
11: 29,690,994 (GRCm39) |
M1095K |
probably damaging |
Het |
| Serpinb3b |
T |
A |
1: 107,082,445 (GRCm39) |
H273L |
probably benign |
Het |
| Sgce |
G |
A |
6: 4,689,630 (GRCm39) |
T401M |
probably benign |
Het |
| Slc12a6 |
C |
T |
2: 112,188,870 (GRCm39) |
R1083W |
probably damaging |
Het |
| Slc45a4 |
A |
T |
15: 73,456,299 (GRCm39) |
M635K |
probably damaging |
Het |
| Slc6a1 |
T |
A |
6: 114,284,662 (GRCm39) |
V240D |
probably damaging |
Het |
| Snx9 |
G |
A |
17: 5,952,794 (GRCm39) |
|
probably null |
Het |
| Spred3 |
A |
G |
7: 28,867,249 (GRCm39) |
V49A |
probably damaging |
Het |
| Tars1 |
A |
G |
15: 11,390,477 (GRCm39) |
F334S |
probably damaging |
Het |
| Tdpoz1 |
A |
G |
3: 93,578,454 (GRCm39) |
V110A |
probably benign |
Het |
| Tfrc |
T |
G |
16: 32,437,097 (GRCm39) |
V252G |
probably damaging |
Het |
| Tm6sf2 |
T |
C |
8: 70,528,128 (GRCm39) |
|
probably benign |
Het |
| Txlnb |
T |
C |
10: 17,714,717 (GRCm39) |
V383A |
probably damaging |
Het |
| Utp20 |
C |
A |
10: 88,652,811 (GRCm39) |
V368L |
probably benign |
Het |
| Vmn2r12 |
A |
T |
5: 109,239,372 (GRCm39) |
V397E |
probably damaging |
Het |
| Zdhhc12 |
G |
A |
2: 29,981,538 (GRCm39) |
R175W |
probably damaging |
Het |
| Zfyve9 |
A |
G |
4: 108,538,097 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Parp4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00479:Parp4
|
APN |
14 |
56,853,917 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL00571:Parp4
|
APN |
14 |
56,884,810 (GRCm39) |
missense |
unknown |
|
|
IGL00737:Parp4
|
APN |
14 |
56,821,620 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00793:Parp4
|
APN |
14 |
56,840,334 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL01108:Parp4
|
APN |
14 |
56,844,897 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01131:Parp4
|
APN |
14 |
56,823,217 (GRCm39) |
splice site |
probably benign |
|
|
IGL01485:Parp4
|
APN |
14 |
56,859,661 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL01704:Parp4
|
APN |
14 |
56,839,783 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01993:Parp4
|
APN |
14 |
56,848,245 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02125:Parp4
|
APN |
14 |
56,827,959 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL02851:Parp4
|
APN |
14 |
56,886,326 (GRCm39) |
missense |
unknown |
|
|
IGL02863:Parp4
|
APN |
14 |
56,886,243 (GRCm39) |
missense |
unknown |
|
|
IGL03065:Parp4
|
APN |
14 |
56,875,326 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03117:Parp4
|
APN |
14 |
56,840,313 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL03271:Parp4
|
APN |
14 |
56,823,082 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03309:Parp4
|
APN |
14 |
56,825,265 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03408:Parp4
|
APN |
14 |
56,839,865 (GRCm39) |
missense |
probably damaging |
0.99 |
|
poisonous
|
UTSW |
14 |
56,873,205 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0515_Parp4_195
|
UTSW |
14 |
56,851,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
toxic
|
UTSW |
14 |
56,866,615 (GRCm39) |
missense |
probably benign |
0.28 |
|
venomous
|
UTSW |
14 |
56,827,355 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
virulent
|
UTSW |
14 |
56,825,235 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0278:Parp4
|
UTSW |
14 |
56,844,980 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0320:Parp4
|
UTSW |
14 |
56,825,953 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0445:Parp4
|
UTSW |
14 |
56,840,205 (GRCm39) |
splice site |
probably null |
|
|
R0452:Parp4
|
UTSW |
14 |
56,886,300 (GRCm39) |
missense |
unknown |
|
|
R0511:Parp4
|
UTSW |
14 |
56,873,172 (GRCm39) |
splice site |
probably benign |
|
|
R0515:Parp4
|
UTSW |
14 |
56,851,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0608:Parp4
|
UTSW |
14 |
56,839,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0800:Parp4
|
UTSW |
14 |
56,827,408 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0959:Parp4
|
UTSW |
14 |
56,885,576 (GRCm39) |
missense |
unknown |
|
|
R1207:Parp4
|
UTSW |
14 |
56,885,339 (GRCm39) |
missense |
unknown |
|
|
R1207:Parp4
|
UTSW |
14 |
56,885,339 (GRCm39) |
missense |
unknown |
|
|
R1342:Parp4
|
UTSW |
14 |
56,827,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1520:Parp4
|
UTSW |
14 |
56,835,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1565:Parp4
|
UTSW |
14 |
56,827,329 (GRCm39) |
splice site |
probably benign |
|
|
R1574:Parp4
|
UTSW |
14 |
56,839,752 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1574:Parp4
|
UTSW |
14 |
56,839,752 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1649:Parp4
|
UTSW |
14 |
56,827,885 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1666:Parp4
|
UTSW |
14 |
56,861,620 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1781:Parp4
|
UTSW |
14 |
56,864,838 (GRCm39) |
splice site |
probably null |
|
|
R1799:Parp4
|
UTSW |
14 |
56,885,589 (GRCm39) |
missense |
unknown |
|
|
R1823:Parp4
|
UTSW |
14 |
56,827,329 (GRCm39) |
splice site |
probably benign |
|
|
R1859:Parp4
|
UTSW |
14 |
56,886,372 (GRCm39) |
missense |
unknown |
|
|
R1919:Parp4
|
UTSW |
14 |
56,861,474 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2000:Parp4
|
UTSW |
14 |
56,851,181 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2032:Parp4
|
UTSW |
14 |
56,866,553 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R2034:Parp4
|
UTSW |
14 |
56,871,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2177:Parp4
|
UTSW |
14 |
56,896,746 (GRCm39) |
missense |
unknown |
|
|
R2291:Parp4
|
UTSW |
14 |
56,851,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2865:Parp4
|
UTSW |
14 |
56,851,181 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3012:Parp4
|
UTSW |
14 |
56,832,873 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3841:Parp4
|
UTSW |
14 |
56,825,235 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3913:Parp4
|
UTSW |
14 |
56,857,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4064:Parp4
|
UTSW |
14 |
56,861,597 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4201:Parp4
|
UTSW |
14 |
56,829,848 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4288:Parp4
|
UTSW |
14 |
56,844,951 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4360:Parp4
|
UTSW |
14 |
56,866,661 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4506:Parp4
|
UTSW |
14 |
56,889,761 (GRCm39) |
missense |
unknown |
|
|
R4577:Parp4
|
UTSW |
14 |
56,827,867 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4633:Parp4
|
UTSW |
14 |
56,885,048 (GRCm39) |
missense |
unknown |
|
|
R4762:Parp4
|
UTSW |
14 |
56,848,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4836:Parp4
|
UTSW |
14 |
56,823,195 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5049:Parp4
|
UTSW |
14 |
56,873,188 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5479:Parp4
|
UTSW |
14 |
56,861,552 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5683:Parp4
|
UTSW |
14 |
56,884,886 (GRCm39) |
nonsense |
probably null |
|
|
R5884:Parp4
|
UTSW |
14 |
56,852,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5965:Parp4
|
UTSW |
14 |
56,861,489 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6001:Parp4
|
UTSW |
14 |
56,878,740 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6027:Parp4
|
UTSW |
14 |
56,866,615 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6230:Parp4
|
UTSW |
14 |
56,844,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6242:Parp4
|
UTSW |
14 |
56,832,856 (GRCm39) |
nonsense |
probably null |
|
|
R6355:Parp4
|
UTSW |
14 |
56,839,757 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R6414:Parp4
|
UTSW |
14 |
56,864,838 (GRCm39) |
splice site |
probably null |
|
|
R6418:Parp4
|
UTSW |
14 |
56,858,108 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6477:Parp4
|
UTSW |
14 |
56,884,694 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6542:Parp4
|
UTSW |
14 |
56,885,339 (GRCm39) |
missense |
unknown |
|
|
R6759:Parp4
|
UTSW |
14 |
56,857,947 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6995:Parp4
|
UTSW |
14 |
56,851,196 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7002:Parp4
|
UTSW |
14 |
56,839,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7026:Parp4
|
UTSW |
14 |
56,858,049 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7062:Parp4
|
UTSW |
14 |
56,852,216 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7101:Parp4
|
UTSW |
14 |
56,827,430 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7124:Parp4
|
UTSW |
14 |
56,840,256 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7162:Parp4
|
UTSW |
14 |
56,886,333 (GRCm39) |
missense |
unknown |
|
|
R7293:Parp4
|
UTSW |
14 |
56,885,303 (GRCm39) |
small deletion |
probably benign |
|
|
R7297:Parp4
|
UTSW |
14 |
56,885,138 (GRCm39) |
missense |
not run |
|
|
R7337:Parp4
|
UTSW |
14 |
56,839,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7539:Parp4
|
UTSW |
14 |
56,873,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7575:Parp4
|
UTSW |
14 |
56,875,375 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7808:Parp4
|
UTSW |
14 |
56,873,205 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7854:Parp4
|
UTSW |
14 |
56,896,805 (GRCm39) |
missense |
unknown |
|
|
R7960:Parp4
|
UTSW |
14 |
56,832,708 (GRCm39) |
splice site |
probably null |
|
|
R8152:Parp4
|
UTSW |
14 |
56,884,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8344:Parp4
|
UTSW |
14 |
56,886,186 (GRCm39) |
missense |
unknown |
|
|
R8416:Parp4
|
UTSW |
14 |
56,825,271 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8726:Parp4
|
UTSW |
14 |
56,866,556 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8752:Parp4
|
UTSW |
14 |
56,886,073 (GRCm39) |
missense |
unknown |
|
|
R8804:Parp4
|
UTSW |
14 |
56,853,900 (GRCm39) |
nonsense |
probably null |
|
|
R9046:Parp4
|
UTSW |
14 |
56,864,927 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9176:Parp4
|
UTSW |
14 |
56,873,274 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R9303:Parp4
|
UTSW |
14 |
56,852,224 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9303:Parp4
|
UTSW |
14 |
56,832,790 (GRCm39) |
frame shift |
probably null |
|
|
R9305:Parp4
|
UTSW |
14 |
56,852,224 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9305:Parp4
|
UTSW |
14 |
56,832,790 (GRCm39) |
frame shift |
probably null |
|
|
R9360:Parp4
|
UTSW |
14 |
56,878,775 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9430:Parp4
|
UTSW |
14 |
56,866,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9491:Parp4
|
UTSW |
14 |
56,832,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9729:Parp4
|
UTSW |
14 |
56,885,888 (GRCm39) |
missense |
unknown |
|
|
RF020:Parp4
|
UTSW |
14 |
56,884,806 (GRCm39) |
missense |
unknown |
|
|
Z1177:Parp4
|
UTSW |
14 |
56,829,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGGGTATTTTCCTCTATGATAAGAAAA -3'
(R):5'- AATGTCTCCCACAGGCCC -3'
Sequencing Primer
(F):5'- TTGAACTCCTGACCTTCGGAAGAG -3'
(R):5'- CCTGGCGGCAGAGGAAAAG -3'
|
| Posted On |
2016-04-27 |
Incidental Mutation