Incidental Mutation 'R4938:Glp2r'
ID |
382856 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Glp2r
|
Ensembl Gene |
ENSMUSG00000049928 |
Gene Name |
glucagon-like peptide 2 receptor |
Synonyms |
GLP-2, 9530092J08Rik |
MMRRC Submission |
042537-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R4938 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
11 |
Chromosomal Location |
67554877-67661979 bp(-) (GRCm39) |
Type of Mutation |
nonsense |
DNA Base Change (assembly) |
G to T
at 67648419 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Stop codon
at position 94
(Y94*)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000061560
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021289]
[ENSMUST00000051765]
|
AlphaFold |
Q5IXF8 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000021289
|
SMART Domains |
Protein: ENSMUSP00000021289 Gene: ENSMUSG00000049928
Domain | Start | End | E-Value | Type |
Pfam:7tm_2
|
17 |
225 |
4.8e-54 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000051765
AA Change: Y94*
|
SMART Domains |
Protein: ENSMUSP00000061560 Gene: ENSMUSG00000049928 AA Change: Y94*
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
Pfam:HRM
|
53 |
122 |
3.4e-16 |
PFAM |
Pfam:7tm_2
|
137 |
394 |
1.5e-79 |
PFAM |
|
Meta Mutation Damage Score |
0.9717 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
Validation Efficiency |
99% (74/75) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014] PHENOTYPE: Mice homozygous for a null mutation display defects in Paneth cell physiology, increased small bowel bacterial loads, and increased susceptibility to small bowel injury. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 67 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Arl14ep |
G |
T |
2: 106,799,663 (GRCm39) |
H59Q |
probably damaging |
Het |
Atp6v0a4 |
T |
A |
6: 38,055,749 (GRCm39) |
I321F |
possibly damaging |
Het |
Cdr2l |
A |
G |
11: 115,284,651 (GRCm39) |
D329G |
possibly damaging |
Het |
Cep55 |
A |
G |
19: 38,058,364 (GRCm39) |
E319G |
probably damaging |
Het |
Cfhr2 |
C |
T |
1: 139,741,265 (GRCm39) |
V237I |
probably benign |
Het |
Clasrp |
A |
G |
7: 19,318,703 (GRCm39) |
|
probably null |
Het |
Col12a1 |
C |
A |
9: 79,607,632 (GRCm39) |
E399* |
probably null |
Het |
Cyp19a1 |
T |
A |
9: 54,080,647 (GRCm39) |
I237F |
probably benign |
Het |
Dnajc6 |
T |
G |
4: 101,494,010 (GRCm39) |
N847K |
probably damaging |
Het |
E330013P04Rik |
C |
G |
19: 60,150,453 (GRCm39) |
|
noncoding transcript |
Het |
Entpd2 |
A |
G |
2: 25,289,429 (GRCm39) |
T304A |
probably benign |
Het |
Etl4 |
A |
G |
2: 20,803,460 (GRCm39) |
T779A |
probably benign |
Het |
Fam107b |
A |
T |
2: 3,773,907 (GRCm39) |
I35L |
probably benign |
Het |
Fgg |
A |
T |
3: 82,920,175 (GRCm39) |
Y318F |
probably benign |
Het |
Fitm1 |
A |
C |
14: 55,814,076 (GRCm39) |
T191P |
probably damaging |
Het |
Fras1 |
A |
G |
5: 96,924,583 (GRCm39) |
M3675V |
probably damaging |
Het |
Fry |
C |
T |
5: 150,401,454 (GRCm39) |
R731W |
probably damaging |
Het |
Galnt17 |
A |
T |
5: 131,335,237 (GRCm39) |
S68T |
probably benign |
Het |
Grm1 |
C |
T |
10: 10,812,257 (GRCm39) |
A256T |
probably damaging |
Het |
Hoxd13 |
A |
G |
2: 74,499,027 (GRCm39) |
Y125C |
probably benign |
Het |
Hspa14 |
A |
T |
2: 3,492,646 (GRCm39) |
I373K |
probably benign |
Het |
Ifnlr1 |
A |
G |
4: 135,432,593 (GRCm39) |
E343G |
probably benign |
Het |
Ighv5-9 |
A |
G |
12: 113,625,582 (GRCm39) |
S54P |
probably benign |
Het |
Insyn2b |
G |
A |
11: 34,352,231 (GRCm39) |
G91E |
probably damaging |
Het |
Irf2bpl |
A |
G |
12: 86,928,892 (GRCm39) |
S594P |
possibly damaging |
Het |
Kcnq2 |
A |
G |
2: 180,728,766 (GRCm39) |
S548P |
probably damaging |
Het |
Lrp2 |
G |
A |
2: 69,302,712 (GRCm39) |
R3006W |
probably damaging |
Het |
Lrrc4c |
A |
T |
2: 97,459,646 (GRCm39) |
I91F |
probably damaging |
Het |
Mdh1b |
T |
C |
1: 63,750,663 (GRCm39) |
D435G |
probably benign |
Het |
Mettl3 |
A |
T |
14: 52,537,184 (GRCm39) |
S182T |
probably damaging |
Het |
Mllt6 |
A |
G |
11: 97,569,233 (GRCm39) |
T862A |
probably benign |
Het |
Mmp27 |
G |
T |
9: 7,578,983 (GRCm39) |
R412I |
probably damaging |
Het |
Mstn |
A |
G |
1: 53,105,582 (GRCm39) |
N308S |
possibly damaging |
Het |
Ncapg |
A |
G |
5: 45,828,551 (GRCm39) |
T101A |
probably benign |
Het |
Ngf |
C |
T |
3: 102,427,790 (GRCm39) |
R180W |
probably damaging |
Het |
Notch1 |
G |
A |
2: 26,364,136 (GRCm39) |
Q862* |
probably null |
Het |
Nsrp1 |
T |
C |
11: 76,936,570 (GRCm39) |
D542G |
probably damaging |
Het |
Nup214 |
C |
A |
2: 31,873,171 (GRCm39) |
T255K |
probably benign |
Het |
Or5b21 |
T |
A |
19: 12,839,916 (GRCm39) |
M259K |
probably damaging |
Het |
Or8b43 |
T |
A |
9: 38,360,679 (GRCm39) |
D170E |
probably benign |
Het |
Papln |
C |
T |
12: 83,829,677 (GRCm39) |
P911S |
probably benign |
Het |
Pdxdc1 |
A |
G |
16: 13,693,933 (GRCm39) |
V163A |
probably benign |
Het |
Plekhj1 |
A |
T |
10: 80,633,609 (GRCm39) |
I76N |
probably damaging |
Het |
Pnp2 |
A |
G |
14: 51,201,025 (GRCm39) |
|
probably null |
Het |
Polr3gl |
T |
C |
3: 96,487,208 (GRCm39) |
E89G |
probably benign |
Het |
Polrmt |
A |
G |
10: 79,582,385 (GRCm39) |
M1T |
probably null |
Het |
Prss37 |
A |
G |
6: 40,491,917 (GRCm39) |
I221T |
possibly damaging |
Het |
Ptx4 |
C |
T |
17: 25,342,139 (GRCm39) |
Q205* |
probably null |
Het |
Qsox1 |
T |
C |
1: 155,655,414 (GRCm39) |
E583G |
probably benign |
Het |
Riok3 |
T |
A |
18: 12,288,300 (GRCm39) |
N492K |
probably benign |
Het |
Sec13 |
A |
G |
6: 113,712,153 (GRCm39) |
W61R |
probably damaging |
Het |
Slc20a2 |
T |
C |
8: 23,051,221 (GRCm39) |
V418A |
possibly damaging |
Het |
Smad9 |
G |
A |
3: 54,696,651 (GRCm39) |
V239I |
probably benign |
Het |
Stmn2 |
A |
G |
3: 8,610,792 (GRCm39) |
E92G |
probably damaging |
Het |
Taf1c |
A |
G |
8: 120,325,537 (GRCm39) |
V775A |
probably benign |
Het |
Thsd7a |
T |
A |
6: 12,330,991 (GRCm39) |
I1384L |
probably benign |
Het |
Tnxb |
A |
G |
17: 34,932,606 (GRCm39) |
Y2275C |
probably damaging |
Het |
Trmo |
G |
T |
4: 46,382,388 (GRCm39) |
T243N |
probably benign |
Het |
Tyrp1 |
C |
T |
4: 80,758,883 (GRCm39) |
A252V |
probably damaging |
Het |
Vasp |
T |
C |
7: 18,991,642 (GRCm39) |
*376W |
probably null |
Het |
Vmn1r231 |
T |
C |
17: 21,110,613 (GRCm39) |
I101V |
possibly damaging |
Het |
Zfp532 |
T |
C |
18: 65,756,837 (GRCm39) |
S257P |
probably benign |
Het |
Zfp563 |
G |
A |
17: 33,324,683 (GRCm39) |
C426Y |
probably damaging |
Het |
Zfp647 |
TGCACG |
TGCACGCACG |
15: 76,795,244 (GRCm39) |
|
probably null |
Het |
Zfp703 |
C |
A |
8: 27,469,801 (GRCm39) |
H488Q |
probably damaging |
Het |
Zfp964 |
A |
G |
8: 70,116,758 (GRCm39) |
N452D |
possibly damaging |
Het |
Zfyve28 |
A |
C |
5: 34,390,698 (GRCm39) |
Y188D |
probably damaging |
Het |
|
Other mutations in Glp2r |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01018:Glp2r
|
APN |
11 |
67,600,470 (GRCm39) |
missense |
probably benign |
|
IGL02244:Glp2r
|
APN |
11 |
67,612,817 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02484:Glp2r
|
APN |
11 |
67,630,992 (GRCm39) |
missense |
possibly damaging |
0.90 |
R0013:Glp2r
|
UTSW |
11 |
67,600,538 (GRCm39) |
missense |
possibly damaging |
0.88 |
R0013:Glp2r
|
UTSW |
11 |
67,600,538 (GRCm39) |
missense |
possibly damaging |
0.88 |
R0195:Glp2r
|
UTSW |
11 |
67,600,534 (GRCm39) |
missense |
probably damaging |
0.99 |
R1612:Glp2r
|
UTSW |
11 |
67,633,033 (GRCm39) |
missense |
possibly damaging |
0.46 |
R1699:Glp2r
|
UTSW |
11 |
67,648,367 (GRCm39) |
missense |
probably benign |
0.09 |
R1944:Glp2r
|
UTSW |
11 |
67,637,618 (GRCm39) |
missense |
probably benign |
0.01 |
R3971:Glp2r
|
UTSW |
11 |
67,637,641 (GRCm39) |
missense |
possibly damaging |
0.65 |
R4417:Glp2r
|
UTSW |
11 |
67,555,342 (GRCm39) |
intron |
probably benign |
|
R4681:Glp2r
|
UTSW |
11 |
67,621,453 (GRCm39) |
splice site |
probably null |
|
R4914:Glp2r
|
UTSW |
11 |
67,648,419 (GRCm39) |
nonsense |
probably null |
|
R4918:Glp2r
|
UTSW |
11 |
67,648,419 (GRCm39) |
nonsense |
probably null |
|
R4940:Glp2r
|
UTSW |
11 |
67,648,419 (GRCm39) |
nonsense |
probably null |
|
R4941:Glp2r
|
UTSW |
11 |
67,637,529 (GRCm39) |
splice site |
probably null |
|
R4963:Glp2r
|
UTSW |
11 |
67,648,419 (GRCm39) |
nonsense |
probably null |
|
R4966:Glp2r
|
UTSW |
11 |
67,648,419 (GRCm39) |
nonsense |
probably null |
|
R5023:Glp2r
|
UTSW |
11 |
67,631,858 (GRCm39) |
missense |
possibly damaging |
0.82 |
R5121:Glp2r
|
UTSW |
11 |
67,612,926 (GRCm39) |
splice site |
probably null |
|
R5313:Glp2r
|
UTSW |
11 |
67,648,357 (GRCm39) |
missense |
probably damaging |
0.96 |
R5705:Glp2r
|
UTSW |
11 |
67,600,565 (GRCm39) |
missense |
probably benign |
0.30 |
R5790:Glp2r
|
UTSW |
11 |
67,655,625 (GRCm39) |
missense |
probably damaging |
1.00 |
R6074:Glp2r
|
UTSW |
11 |
67,637,640 (GRCm39) |
missense |
unknown |
|
R6595:Glp2r
|
UTSW |
11 |
67,655,603 (GRCm39) |
missense |
probably benign |
0.10 |
R6910:Glp2r
|
UTSW |
11 |
67,621,497 (GRCm39) |
missense |
probably benign |
0.28 |
R7511:Glp2r
|
UTSW |
11 |
67,648,417 (GRCm39) |
missense |
probably damaging |
0.98 |
R7627:Glp2r
|
UTSW |
11 |
67,637,589 (GRCm39) |
missense |
unknown |
|
R7681:Glp2r
|
UTSW |
11 |
67,600,505 (GRCm39) |
missense |
probably benign |
0.45 |
R7779:Glp2r
|
UTSW |
11 |
67,600,609 (GRCm39) |
nonsense |
probably null |
|
R8743:Glp2r
|
UTSW |
11 |
67,612,901 (GRCm39) |
missense |
probably damaging |
0.98 |
R8841:Glp2r
|
UTSW |
11 |
67,653,555 (GRCm39) |
missense |
probably damaging |
1.00 |
R9093:Glp2r
|
UTSW |
11 |
67,621,459 (GRCm39) |
nonsense |
probably null |
|
R9380:Glp2r
|
UTSW |
11 |
67,637,572 (GRCm39) |
missense |
possibly damaging |
0.67 |
R9576:Glp2r
|
UTSW |
11 |
67,655,622 (GRCm39) |
missense |
probably benign |
0.01 |
R9733:Glp2r
|
UTSW |
11 |
67,648,367 (GRCm39) |
missense |
probably benign |
0.09 |
Z1186:Glp2r
|
UTSW |
11 |
67,635,773 (GRCm39) |
missense |
probably benign |
|
Z1186:Glp2r
|
UTSW |
11 |
67,661,662 (GRCm39) |
missense |
probably benign |
0.01 |
Z1186:Glp2r
|
UTSW |
11 |
67,600,394 (GRCm39) |
missense |
probably damaging |
0.98 |
Z1186:Glp2r
|
UTSW |
11 |
67,600,470 (GRCm39) |
missense |
probably benign |
|
Z1186:Glp2r
|
UTSW |
11 |
67,600,472 (GRCm39) |
missense |
probably benign |
|
Z1186:Glp2r
|
UTSW |
11 |
67,630,949 (GRCm39) |
missense |
probably benign |
0.03 |
Z1186:Glp2r
|
UTSW |
11 |
67,630,993 (GRCm39) |
missense |
probably benign |
|
Z1186:Glp2r
|
UTSW |
11 |
67,631,878 (GRCm39) |
missense |
probably benign |
|
Z1186:Glp2r
|
UTSW |
11 |
67,631,885 (GRCm39) |
missense |
probably benign |
0.00 |
Z1186:Glp2r
|
UTSW |
11 |
67,633,129 (GRCm39) |
missense |
probably benign |
|
Z1187:Glp2r
|
UTSW |
11 |
67,635,773 (GRCm39) |
missense |
probably benign |
|
Z1187:Glp2r
|
UTSW |
11 |
67,633,129 (GRCm39) |
missense |
probably benign |
|
Z1187:Glp2r
|
UTSW |
11 |
67,631,885 (GRCm39) |
missense |
probably benign |
0.00 |
Z1187:Glp2r
|
UTSW |
11 |
67,631,878 (GRCm39) |
missense |
probably benign |
|
Z1187:Glp2r
|
UTSW |
11 |
67,630,993 (GRCm39) |
missense |
probably benign |
|
Z1187:Glp2r
|
UTSW |
11 |
67,600,472 (GRCm39) |
missense |
probably benign |
|
Z1187:Glp2r
|
UTSW |
11 |
67,600,470 (GRCm39) |
missense |
probably benign |
|
Z1187:Glp2r
|
UTSW |
11 |
67,600,394 (GRCm39) |
missense |
probably damaging |
0.98 |
Z1187:Glp2r
|
UTSW |
11 |
67,661,662 (GRCm39) |
missense |
probably benign |
0.01 |
Z1188:Glp2r
|
UTSW |
11 |
67,635,773 (GRCm39) |
missense |
probably benign |
|
Z1188:Glp2r
|
UTSW |
11 |
67,633,129 (GRCm39) |
missense |
probably benign |
|
Z1188:Glp2r
|
UTSW |
11 |
67,631,885 (GRCm39) |
missense |
probably benign |
0.00 |
Z1188:Glp2r
|
UTSW |
11 |
67,631,878 (GRCm39) |
missense |
probably benign |
|
Z1188:Glp2r
|
UTSW |
11 |
67,630,993 (GRCm39) |
missense |
probably benign |
|
Z1188:Glp2r
|
UTSW |
11 |
67,600,472 (GRCm39) |
missense |
probably benign |
|
Z1188:Glp2r
|
UTSW |
11 |
67,600,470 (GRCm39) |
missense |
probably benign |
|
Z1188:Glp2r
|
UTSW |
11 |
67,600,394 (GRCm39) |
missense |
probably damaging |
0.98 |
Z1188:Glp2r
|
UTSW |
11 |
67,661,662 (GRCm39) |
missense |
probably benign |
0.01 |
Z1189:Glp2r
|
UTSW |
11 |
67,661,662 (GRCm39) |
missense |
probably benign |
0.01 |
Z1189:Glp2r
|
UTSW |
11 |
67,600,394 (GRCm39) |
missense |
probably damaging |
0.98 |
Z1189:Glp2r
|
UTSW |
11 |
67,631,885 (GRCm39) |
missense |
probably benign |
0.00 |
Z1189:Glp2r
|
UTSW |
11 |
67,635,773 (GRCm39) |
missense |
probably benign |
|
Z1190:Glp2r
|
UTSW |
11 |
67,633,129 (GRCm39) |
missense |
probably benign |
|
Z1190:Glp2r
|
UTSW |
11 |
67,631,885 (GRCm39) |
missense |
probably benign |
0.00 |
Z1190:Glp2r
|
UTSW |
11 |
67,631,878 (GRCm39) |
missense |
probably benign |
|
Z1190:Glp2r
|
UTSW |
11 |
67,630,993 (GRCm39) |
missense |
probably benign |
|
Z1190:Glp2r
|
UTSW |
11 |
67,630,949 (GRCm39) |
missense |
probably benign |
0.03 |
Z1190:Glp2r
|
UTSW |
11 |
67,600,472 (GRCm39) |
missense |
probably benign |
|
Z1190:Glp2r
|
UTSW |
11 |
67,600,470 (GRCm39) |
missense |
probably benign |
|
Z1190:Glp2r
|
UTSW |
11 |
67,600,394 (GRCm39) |
missense |
probably damaging |
0.98 |
Z1190:Glp2r
|
UTSW |
11 |
67,661,662 (GRCm39) |
missense |
probably benign |
0.01 |
Z1190:Glp2r
|
UTSW |
11 |
67,635,773 (GRCm39) |
missense |
probably benign |
|
Z1191:Glp2r
|
UTSW |
11 |
67,635,773 (GRCm39) |
missense |
probably benign |
|
Z1191:Glp2r
|
UTSW |
11 |
67,633,129 (GRCm39) |
missense |
probably benign |
|
Z1191:Glp2r
|
UTSW |
11 |
67,631,885 (GRCm39) |
missense |
probably benign |
0.00 |
Z1191:Glp2r
|
UTSW |
11 |
67,631,878 (GRCm39) |
missense |
probably benign |
|
Z1191:Glp2r
|
UTSW |
11 |
67,630,993 (GRCm39) |
missense |
probably benign |
|
Z1191:Glp2r
|
UTSW |
11 |
67,600,472 (GRCm39) |
missense |
probably benign |
|
Z1191:Glp2r
|
UTSW |
11 |
67,600,470 (GRCm39) |
missense |
probably benign |
|
Z1191:Glp2r
|
UTSW |
11 |
67,600,394 (GRCm39) |
missense |
probably damaging |
0.98 |
Z1191:Glp2r
|
UTSW |
11 |
67,661,662 (GRCm39) |
missense |
probably benign |
0.01 |
Z1192:Glp2r
|
UTSW |
11 |
67,661,662 (GRCm39) |
missense |
probably benign |
0.01 |
Z1192:Glp2r
|
UTSW |
11 |
67,635,773 (GRCm39) |
missense |
probably benign |
|
Z1192:Glp2r
|
UTSW |
11 |
67,633,129 (GRCm39) |
missense |
probably benign |
|
Z1192:Glp2r
|
UTSW |
11 |
67,631,885 (GRCm39) |
missense |
probably benign |
0.00 |
Z1192:Glp2r
|
UTSW |
11 |
67,631,878 (GRCm39) |
missense |
probably benign |
|
Z1192:Glp2r
|
UTSW |
11 |
67,600,472 (GRCm39) |
missense |
probably benign |
|
Z1192:Glp2r
|
UTSW |
11 |
67,600,470 (GRCm39) |
missense |
probably benign |
|
Z1192:Glp2r
|
UTSW |
11 |
67,600,394 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Predicted Primers |
PCR Primer
(F):5'- AAGTGCTGGTGGAAGGTCTC -3'
(R):5'- AACATCTAGAGGTTTCGTGGTTTC -3'
Sequencing Primer
(F):5'- AAGGTCTCGTGTCCCCCTAAAG -3'
(R):5'- TCCCAAATAAACAGTAGGGATGC -3'
|
Posted On |
2016-04-27 |