Incidental Mutation 'R4938:Glp2r'
ID 382856
Institutional Source Beutler Lab
Gene Symbol Glp2r
Ensembl Gene ENSMUSG00000049928
Gene Name glucagon-like peptide 2 receptor
Synonyms GLP-2, 9530092J08Rik
MMRRC Submission 042537-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4938 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 67554877-67661979 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 67648419 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 94 (Y94*)
Ref Sequence ENSEMBL: ENSMUSP00000061560 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021289] [ENSMUST00000051765]
AlphaFold Q5IXF8
Predicted Effect probably benign
Transcript: ENSMUST00000021289
SMART Domains Protein: ENSMUSP00000021289
Gene: ENSMUSG00000049928

DomainStartEndE-ValueType
Pfam:7tm_2 17 225 4.8e-54 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000051765
AA Change: Y94*
SMART Domains Protein: ENSMUSP00000061560
Gene: ENSMUSG00000049928
AA Change: Y94*

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:HRM 53 122 3.4e-16 PFAM
Pfam:7tm_2 137 394 1.5e-79 PFAM
Meta Mutation Damage Score 0.9717 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.6%
Validation Efficiency 99% (74/75)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]
PHENOTYPE: Mice homozygous for a null mutation display defects in Paneth cell physiology, increased small bowel bacterial loads, and increased susceptibility to small bowel injury. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arl14ep G T 2: 106,799,663 (GRCm39) H59Q probably damaging Het
Atp6v0a4 T A 6: 38,055,749 (GRCm39) I321F possibly damaging Het
Cdr2l A G 11: 115,284,651 (GRCm39) D329G possibly damaging Het
Cep55 A G 19: 38,058,364 (GRCm39) E319G probably damaging Het
Cfhr2 C T 1: 139,741,265 (GRCm39) V237I probably benign Het
Clasrp A G 7: 19,318,703 (GRCm39) probably null Het
Col12a1 C A 9: 79,607,632 (GRCm39) E399* probably null Het
Cyp19a1 T A 9: 54,080,647 (GRCm39) I237F probably benign Het
Dnajc6 T G 4: 101,494,010 (GRCm39) N847K probably damaging Het
E330013P04Rik C G 19: 60,150,453 (GRCm39) noncoding transcript Het
Entpd2 A G 2: 25,289,429 (GRCm39) T304A probably benign Het
Etl4 A G 2: 20,803,460 (GRCm39) T779A probably benign Het
Fam107b A T 2: 3,773,907 (GRCm39) I35L probably benign Het
Fgg A T 3: 82,920,175 (GRCm39) Y318F probably benign Het
Fitm1 A C 14: 55,814,076 (GRCm39) T191P probably damaging Het
Fras1 A G 5: 96,924,583 (GRCm39) M3675V probably damaging Het
Fry C T 5: 150,401,454 (GRCm39) R731W probably damaging Het
Galnt17 A T 5: 131,335,237 (GRCm39) S68T probably benign Het
Grm1 C T 10: 10,812,257 (GRCm39) A256T probably damaging Het
Hoxd13 A G 2: 74,499,027 (GRCm39) Y125C probably benign Het
Hspa14 A T 2: 3,492,646 (GRCm39) I373K probably benign Het
Ifnlr1 A G 4: 135,432,593 (GRCm39) E343G probably benign Het
Ighv5-9 A G 12: 113,625,582 (GRCm39) S54P probably benign Het
Insyn2b G A 11: 34,352,231 (GRCm39) G91E probably damaging Het
Irf2bpl A G 12: 86,928,892 (GRCm39) S594P possibly damaging Het
Kcnq2 A G 2: 180,728,766 (GRCm39) S548P probably damaging Het
Lrp2 G A 2: 69,302,712 (GRCm39) R3006W probably damaging Het
Lrrc4c A T 2: 97,459,646 (GRCm39) I91F probably damaging Het
Mdh1b T C 1: 63,750,663 (GRCm39) D435G probably benign Het
Mettl3 A T 14: 52,537,184 (GRCm39) S182T probably damaging Het
Mllt6 A G 11: 97,569,233 (GRCm39) T862A probably benign Het
Mmp27 G T 9: 7,578,983 (GRCm39) R412I probably damaging Het
Mstn A G 1: 53,105,582 (GRCm39) N308S possibly damaging Het
Ncapg A G 5: 45,828,551 (GRCm39) T101A probably benign Het
Ngf C T 3: 102,427,790 (GRCm39) R180W probably damaging Het
Notch1 G A 2: 26,364,136 (GRCm39) Q862* probably null Het
Nsrp1 T C 11: 76,936,570 (GRCm39) D542G probably damaging Het
Nup214 C A 2: 31,873,171 (GRCm39) T255K probably benign Het
Or5b21 T A 19: 12,839,916 (GRCm39) M259K probably damaging Het
Or8b43 T A 9: 38,360,679 (GRCm39) D170E probably benign Het
Papln C T 12: 83,829,677 (GRCm39) P911S probably benign Het
Pdxdc1 A G 16: 13,693,933 (GRCm39) V163A probably benign Het
Plekhj1 A T 10: 80,633,609 (GRCm39) I76N probably damaging Het
Pnp2 A G 14: 51,201,025 (GRCm39) probably null Het
Polr3gl T C 3: 96,487,208 (GRCm39) E89G probably benign Het
Polrmt A G 10: 79,582,385 (GRCm39) M1T probably null Het
Prss37 A G 6: 40,491,917 (GRCm39) I221T possibly damaging Het
Ptx4 C T 17: 25,342,139 (GRCm39) Q205* probably null Het
Qsox1 T C 1: 155,655,414 (GRCm39) E583G probably benign Het
Riok3 T A 18: 12,288,300 (GRCm39) N492K probably benign Het
Sec13 A G 6: 113,712,153 (GRCm39) W61R probably damaging Het
Slc20a2 T C 8: 23,051,221 (GRCm39) V418A possibly damaging Het
Smad9 G A 3: 54,696,651 (GRCm39) V239I probably benign Het
Stmn2 A G 3: 8,610,792 (GRCm39) E92G probably damaging Het
Taf1c A G 8: 120,325,537 (GRCm39) V775A probably benign Het
Thsd7a T A 6: 12,330,991 (GRCm39) I1384L probably benign Het
Tnxb A G 17: 34,932,606 (GRCm39) Y2275C probably damaging Het
Trmo G T 4: 46,382,388 (GRCm39) T243N probably benign Het
Tyrp1 C T 4: 80,758,883 (GRCm39) A252V probably damaging Het
Vasp T C 7: 18,991,642 (GRCm39) *376W probably null Het
Vmn1r231 T C 17: 21,110,613 (GRCm39) I101V possibly damaging Het
Zfp532 T C 18: 65,756,837 (GRCm39) S257P probably benign Het
Zfp563 G A 17: 33,324,683 (GRCm39) C426Y probably damaging Het
Zfp647 TGCACG TGCACGCACG 15: 76,795,244 (GRCm39) probably null Het
Zfp703 C A 8: 27,469,801 (GRCm39) H488Q probably damaging Het
Zfp964 A G 8: 70,116,758 (GRCm39) N452D possibly damaging Het
Zfyve28 A C 5: 34,390,698 (GRCm39) Y188D probably damaging Het
Other mutations in Glp2r
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01018:Glp2r APN 11 67,600,470 (GRCm39) missense probably benign
IGL02244:Glp2r APN 11 67,612,817 (GRCm39) missense probably damaging 1.00
IGL02484:Glp2r APN 11 67,630,992 (GRCm39) missense possibly damaging 0.90
R0013:Glp2r UTSW 11 67,600,538 (GRCm39) missense possibly damaging 0.88
R0013:Glp2r UTSW 11 67,600,538 (GRCm39) missense possibly damaging 0.88
R0195:Glp2r UTSW 11 67,600,534 (GRCm39) missense probably damaging 0.99
R1612:Glp2r UTSW 11 67,633,033 (GRCm39) missense possibly damaging 0.46
R1699:Glp2r UTSW 11 67,648,367 (GRCm39) missense probably benign 0.09
R1944:Glp2r UTSW 11 67,637,618 (GRCm39) missense probably benign 0.01
R3971:Glp2r UTSW 11 67,637,641 (GRCm39) missense possibly damaging 0.65
R4417:Glp2r UTSW 11 67,555,342 (GRCm39) intron probably benign
R4681:Glp2r UTSW 11 67,621,453 (GRCm39) splice site probably null
R4914:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4918:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4940:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4941:Glp2r UTSW 11 67,637,529 (GRCm39) splice site probably null
R4963:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4966:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R5023:Glp2r UTSW 11 67,631,858 (GRCm39) missense possibly damaging 0.82
R5121:Glp2r UTSW 11 67,612,926 (GRCm39) splice site probably null
R5313:Glp2r UTSW 11 67,648,357 (GRCm39) missense probably damaging 0.96
R5705:Glp2r UTSW 11 67,600,565 (GRCm39) missense probably benign 0.30
R5790:Glp2r UTSW 11 67,655,625 (GRCm39) missense probably damaging 1.00
R6074:Glp2r UTSW 11 67,637,640 (GRCm39) missense unknown
R6595:Glp2r UTSW 11 67,655,603 (GRCm39) missense probably benign 0.10
R6910:Glp2r UTSW 11 67,621,497 (GRCm39) missense probably benign 0.28
R7511:Glp2r UTSW 11 67,648,417 (GRCm39) missense probably damaging 0.98
R7627:Glp2r UTSW 11 67,637,589 (GRCm39) missense unknown
R7681:Glp2r UTSW 11 67,600,505 (GRCm39) missense probably benign 0.45
R7779:Glp2r UTSW 11 67,600,609 (GRCm39) nonsense probably null
R8743:Glp2r UTSW 11 67,612,901 (GRCm39) missense probably damaging 0.98
R8841:Glp2r UTSW 11 67,653,555 (GRCm39) missense probably damaging 1.00
R9093:Glp2r UTSW 11 67,621,459 (GRCm39) nonsense probably null
R9380:Glp2r UTSW 11 67,637,572 (GRCm39) missense possibly damaging 0.67
R9576:Glp2r UTSW 11 67,655,622 (GRCm39) missense probably benign 0.01
R9733:Glp2r UTSW 11 67,648,367 (GRCm39) missense probably benign 0.09
Z1186:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1186:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1186:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,630,949 (GRCm39) missense probably benign 0.03
Z1186:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1186:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1187:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1187:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1188:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1188:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1188:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1189:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1189:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1189:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1189:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1190:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,630,949 (GRCm39) missense probably benign 0.03
Z1190:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1190:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1190:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1191:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1191:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1192:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1192:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1192:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AAGTGCTGGTGGAAGGTCTC -3'
(R):5'- AACATCTAGAGGTTTCGTGGTTTC -3'

Sequencing Primer
(F):5'- AAGGTCTCGTGTCCCCCTAAAG -3'
(R):5'- TCCCAAATAAACAGTAGGGATGC -3'
Posted On 2016-04-27