Incidental Mutation 'R4941:Arap2'
| ID |
383076 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arap2
|
| Ensembl Gene |
ENSMUSG00000037999 |
| Gene Name |
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
| Synonyms |
Centd1 |
| MMRRC Submission |
042539-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4941 (G1)
|
| Quality Score |
107 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
62759788-62923502 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 62906821 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Threonine
at position 66
(M66T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124743
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000076623]
[ENSMUST00000159470]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000076623
AA Change: M66T
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000075924
Gene: ENSMUSG00000037999
AA Change: M66T
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
3 |
70 |
3.69e-7 |
SMART |
|
low complexity region
|
222 |
233 |
N/A |
INTRINSIC |
|
PH
|
481 |
574 |
6.45e-17 |
SMART |
|
PH
|
586 |
679 |
9.05e-12 |
SMART |
|
ArfGap
|
684 |
805 |
9.2e-33 |
SMART |
|
PH
|
891 |
1003 |
1.51e-8 |
SMART |
|
PH
|
1013 |
1112 |
9.21e-4 |
SMART |
|
RhoGAP
|
1124 |
1300 |
1.36e-50 |
SMART |
|
Pfam:RA
|
1325 |
1416 |
2.1e-7 |
PFAM |
|
PH
|
1429 |
1533 |
2.68e-14 |
SMART |
|
coiled coil region
|
1561 |
1590 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159470
AA Change: M66T
PolyPhen 2
Score 0.205 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000124743
Gene: ENSMUSG00000037999
AA Change: M66T
| Domain | Start | End | E-Value | Type |
|---|
|
SAM
|
3 |
70 |
3.69e-7 |
SMART |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 98.0%
- 10x: 95.4%
- 20x: 89.0%
|
| Validation Efficiency |
97% (112/116) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A4galt |
T |
A |
15: 83,112,529 (GRCm39) |
I85F |
probably damaging |
Het |
| Abcc6 |
T |
A |
7: 45,661,947 (GRCm39) |
I435F |
probably benign |
Het |
| Adam3 |
T |
C |
8: 25,167,332 (GRCm39) |
|
probably benign |
Het |
| Adrb3 |
T |
C |
8: 27,717,450 (GRCm39) |
Y333C |
probably damaging |
Het |
| Ago4 |
A |
T |
4: 126,419,847 (GRCm39) |
D43E |
probably benign |
Het |
| Agt |
T |
A |
8: 125,283,727 (GRCm39) |
Q464L |
probably benign |
Het |
| Amdhd1 |
A |
T |
10: 93,367,463 (GRCm39) |
D230E |
probably damaging |
Het |
| Aplf |
A |
G |
6: 87,645,405 (GRCm39) |
I33T |
probably damaging |
Het |
| Aplf |
A |
T |
6: 87,623,331 (GRCm39) |
N249K |
probably benign |
Het |
| Atf4 |
T |
C |
15: 80,140,434 (GRCm39) |
|
probably benign |
Het |
| Bahcc1 |
A |
C |
11: 120,177,491 (GRCm39) |
H2068P |
probably benign |
Het |
| Bcor |
C |
T |
X: 11,906,725 (GRCm39) |
R1551Q |
probably damaging |
Het |
| Bltp1 |
A |
C |
3: 36,971,851 (GRCm39) |
H528P |
probably damaging |
Het |
| Bltp1 |
G |
A |
3: 36,974,050 (GRCm39) |
S600N |
probably benign |
Het |
| Catsper1 |
C |
A |
19: 5,391,466 (GRCm39) |
A616D |
possibly damaging |
Het |
| Cdkn3 |
A |
G |
14: 47,007,320 (GRCm39) |
D159G |
possibly damaging |
Het |
| Cep162 |
T |
C |
9: 87,108,022 (GRCm39) |
|
probably benign |
Het |
| Clca3a1 |
T |
A |
3: 144,721,414 (GRCm39) |
I386L |
probably damaging |
Het |
| Cldn10 |
G |
A |
14: 119,025,725 (GRCm39) |
G53S |
possibly damaging |
Het |
| Cmtm3 |
T |
C |
8: 105,070,460 (GRCm39) |
L73P |
probably damaging |
Het |
| Cnksr3 |
A |
C |
10: 7,102,925 (GRCm39) |
L149R |
probably benign |
Het |
| Cope |
T |
C |
8: 70,755,584 (GRCm39) |
|
probably null |
Het |
| Cpa6 |
T |
A |
1: 10,479,562 (GRCm39) |
M224L |
probably benign |
Het |
| Cyp2d41-ps |
T |
C |
15: 82,666,154 (GRCm39) |
|
noncoding transcript |
Het |
| Ddx55 |
T |
A |
5: 124,706,779 (GRCm39) |
L592* |
probably null |
Het |
| Deup1 |
T |
C |
9: 15,499,323 (GRCm39) |
M333V |
probably benign |
Het |
| Eif4a1 |
T |
C |
11: 69,558,640 (GRCm39) |
|
probably benign |
Het |
| Eif4g3 |
A |
C |
4: 137,897,876 (GRCm39) |
D1026A |
probably damaging |
Het |
| Eif5b |
T |
C |
1: 38,090,280 (GRCm39) |
V1153A |
probably damaging |
Het |
| Ercc8 |
G |
T |
13: 108,297,301 (GRCm39) |
|
probably benign |
Het |
| Fam227a |
C |
A |
15: 79,524,204 (GRCm39) |
|
probably null |
Het |
| Fat1 |
A |
G |
8: 45,489,312 (GRCm39) |
I3505V |
probably benign |
Het |
| Fat3 |
T |
G |
9: 16,286,448 (GRCm39) |
E1025A |
probably damaging |
Het |
| Fat4 |
C |
T |
3: 39,011,601 (GRCm39) |
R2234W |
probably damaging |
Het |
| Fer1l4 |
G |
T |
2: 155,887,009 (GRCm39) |
F634L |
probably damaging |
Het |
| Fetub |
G |
A |
16: 22,756,624 (GRCm39) |
V162I |
probably benign |
Het |
| Fgd4 |
T |
C |
16: 16,302,402 (GRCm39) |
Q51R |
probably benign |
Het |
| Fgfr2 |
T |
C |
7: 129,800,175 (GRCm39) |
H140R |
probably benign |
Het |
| Flt3 |
T |
A |
5: 147,293,185 (GRCm39) |
|
probably null |
Het |
| Gabrb1 |
A |
G |
5: 72,294,121 (GRCm39) |
N465S |
probably damaging |
Het |
| Gapdhs |
T |
C |
7: 30,432,691 (GRCm39) |
I206V |
probably benign |
Het |
| Gkn3 |
C |
T |
6: 87,360,507 (GRCm39) |
A163T |
probably damaging |
Het |
| Glp2r |
T |
C |
11: 67,637,529 (GRCm39) |
|
probably null |
Het |
| Gm4956 |
T |
A |
1: 21,368,306 (GRCm39) |
|
noncoding transcript |
Het |
| Gtf2a1l |
A |
T |
17: 89,022,350 (GRCm39) |
D447V |
probably damaging |
Het |
| Hsd3b5 |
A |
G |
3: 98,526,379 (GRCm39) |
W356R |
probably damaging |
Het |
| Idh2 |
A |
T |
7: 79,745,847 (GRCm39) |
V335D |
probably damaging |
Het |
| Isyna1 |
T |
C |
8: 71,048,146 (GRCm39) |
I184T |
probably damaging |
Het |
| Kcnh2 |
A |
G |
5: 24,536,085 (GRCm39) |
S320P |
probably damaging |
Het |
| Klk14 |
G |
A |
7: 43,341,501 (GRCm39) |
C51Y |
probably damaging |
Het |
| Kpna6 |
A |
G |
4: 129,541,825 (GRCm39) |
F524S |
probably damaging |
Het |
| Lap3 |
A |
T |
5: 45,663,539 (GRCm39) |
M338L |
probably benign |
Het |
| Lins1 |
T |
C |
7: 66,359,198 (GRCm39) |
|
probably benign |
Het |
| Llgl1 |
C |
T |
11: 60,600,394 (GRCm39) |
P581L |
probably benign |
Het |
| Lrrc43 |
A |
G |
5: 123,639,126 (GRCm39) |
D385G |
probably benign |
Het |
| Maf |
T |
C |
8: 116,433,532 (GRCm39) |
D24G |
unknown |
Het |
| Nell1 |
T |
C |
7: 49,712,386 (GRCm39) |
S69P |
probably benign |
Het |
| Nkapd1 |
G |
T |
9: 50,518,809 (GRCm39) |
Q268K |
probably benign |
Het |
| Or13p4 |
C |
T |
4: 118,547,089 (GRCm39) |
V187I |
possibly damaging |
Het |
| Or2h1 |
C |
T |
17: 37,404,484 (GRCm39) |
G94E |
probably damaging |
Het |
| Or2j6 |
T |
A |
7: 139,980,792 (GRCm39) |
M56L |
probably benign |
Het |
| Or51af1 |
T |
C |
7: 103,141,458 (GRCm39) |
D209G |
probably damaging |
Het |
| Or5an10 |
A |
G |
19: 12,276,260 (GRCm39) |
S79P |
possibly damaging |
Het |
| Or8g54 |
T |
C |
9: 39,707,160 (GRCm39) |
M163T |
possibly damaging |
Het |
| Oxld1 |
T |
C |
11: 120,347,862 (GRCm39) |
T112A |
probably benign |
Het |
| Parp14 |
T |
C |
16: 35,666,403 (GRCm39) |
N1210S |
probably benign |
Het |
| Pcdhb10 |
C |
A |
18: 37,545,887 (GRCm39) |
T321K |
probably benign |
Het |
| Pcdhb8 |
C |
T |
18: 37,489,059 (GRCm39) |
L246F |
probably benign |
Het |
| Pcdhga1 |
T |
A |
18: 37,795,659 (GRCm39) |
I221K |
probably benign |
Het |
| Pcdhga9 |
T |
A |
18: 37,871,185 (GRCm39) |
V338E |
probably damaging |
Het |
| Pdcd11 |
T |
C |
19: 47,108,325 (GRCm39) |
S1231P |
probably damaging |
Het |
| Pde6c |
A |
T |
19: 38,140,013 (GRCm39) |
L325F |
probably damaging |
Het |
| Pnpla7 |
T |
A |
2: 24,887,276 (GRCm39) |
|
probably null |
Het |
| Pparg |
T |
A |
6: 115,467,071 (GRCm39) |
V478E |
probably damaging |
Het |
| Ppib |
T |
C |
9: 65,967,672 (GRCm39) |
V42A |
probably benign |
Het |
| Ppox |
T |
C |
1: 171,105,166 (GRCm39) |
M341V |
probably damaging |
Het |
| Proc |
T |
C |
18: 32,258,166 (GRCm39) |
K260E |
possibly damaging |
Het |
| Ptpro |
C |
T |
6: 137,369,763 (GRCm39) |
P525L |
probably damaging |
Het |
| Rnf14 |
C |
A |
18: 38,441,435 (GRCm39) |
A275E |
probably damaging |
Het |
| Scnn1b |
C |
T |
7: 121,511,231 (GRCm39) |
P306L |
probably damaging |
Het |
| Sec14l5 |
A |
G |
16: 4,994,364 (GRCm39) |
E386G |
probably damaging |
Het |
| Sftpa1 |
T |
A |
14: 40,854,509 (GRCm39) |
I32N |
probably damaging |
Het |
| Slc26a5 |
A |
G |
5: 22,025,384 (GRCm39) |
I408T |
probably damaging |
Het |
| Slc7a13 |
A |
G |
4: 19,841,467 (GRCm39) |
Y438C |
probably damaging |
Het |
| Spire1 |
T |
C |
18: 67,652,384 (GRCm39) |
E231G |
possibly damaging |
Het |
| Stab1 |
T |
A |
14: 30,873,528 (GRCm39) |
I1014F |
probably benign |
Het |
| Steap2 |
T |
C |
5: 5,727,651 (GRCm39) |
Y228C |
probably damaging |
Het |
| Tmem131l |
T |
C |
3: 83,806,546 (GRCm39) |
T1487A |
probably benign |
Het |
| Tmem171 |
A |
G |
13: 98,828,803 (GRCm39) |
F116L |
possibly damaging |
Het |
| Tmem215 |
T |
C |
4: 40,474,520 (GRCm39) |
V199A |
probably damaging |
Het |
| Tmem45a |
T |
C |
16: 56,642,652 (GRCm39) |
N173S |
possibly damaging |
Het |
| Uqcrc2 |
C |
T |
7: 120,242,301 (GRCm39) |
R148C |
probably benign |
Het |
| Vmn2r116 |
A |
G |
17: 23,620,116 (GRCm39) |
K617E |
probably damaging |
Het |
| Xrcc6 |
T |
C |
15: 81,924,013 (GRCm39) |
L229P |
probably damaging |
Het |
| Yju2 |
A |
G |
17: 56,271,149 (GRCm39) |
D97G |
possibly damaging |
Het |
| Zfp184 |
A |
G |
13: 22,133,891 (GRCm39) |
D46G |
probably damaging |
Het |
| Zfp790 |
T |
A |
7: 29,528,916 (GRCm39) |
C534S |
possibly damaging |
Het |
| Zfp990 |
A |
T |
4: 145,263,407 (GRCm39) |
N135I |
probably damaging |
Het |
|
| Other mutations in Arap2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00481:Arap2
|
APN |
5 |
62,793,305 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00642:Arap2
|
APN |
5 |
62,890,401 (GRCm39) |
nonsense |
probably null |
|
|
IGL00705:Arap2
|
APN |
5 |
62,835,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00942:Arap2
|
APN |
5 |
62,855,732 (GRCm39) |
nonsense |
probably null |
|
|
IGL01069:Arap2
|
APN |
5 |
62,807,199 (GRCm39) |
missense |
probably benign |
|
|
IGL01601:Arap2
|
APN |
5 |
62,798,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01986:Arap2
|
APN |
5 |
62,779,265 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02032:Arap2
|
APN |
5 |
62,828,340 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02262:Arap2
|
APN |
5 |
62,800,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02331:Arap2
|
APN |
5 |
62,807,025 (GRCm39) |
splice site |
probably benign |
|
|
IGL02527:Arap2
|
APN |
5 |
62,906,650 (GRCm39) |
missense |
probably benign |
|
|
IGL02803:Arap2
|
APN |
5 |
62,906,452 (GRCm39) |
missense |
probably benign |
|
|
IGL02864:Arap2
|
APN |
5 |
62,835,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03078:Arap2
|
APN |
5 |
62,890,408 (GRCm39) |
splice site |
probably benign |
|
|
IGL03154:Arap2
|
APN |
5 |
62,800,268 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03213:Arap2
|
APN |
5 |
62,906,438 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03279:Arap2
|
APN |
5 |
62,779,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03288:Arap2
|
APN |
5 |
62,761,959 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4354001:Arap2
|
UTSW |
5 |
62,811,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0012:Arap2
|
UTSW |
5 |
62,840,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0013:Arap2
|
UTSW |
5 |
62,840,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0013:Arap2
|
UTSW |
5 |
62,840,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0166:Arap2
|
UTSW |
5 |
62,833,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0472:Arap2
|
UTSW |
5 |
62,864,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0506:Arap2
|
UTSW |
5 |
62,763,474 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0551:Arap2
|
UTSW |
5 |
62,798,666 (GRCm39) |
splice site |
probably null |
|
|
R0607:Arap2
|
UTSW |
5 |
62,763,474 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0617:Arap2
|
UTSW |
5 |
62,807,250 (GRCm39) |
splice site |
probably benign |
|
|
R0975:Arap2
|
UTSW |
5 |
62,888,229 (GRCm39) |
splice site |
probably benign |
|
|
R0976:Arap2
|
UTSW |
5 |
62,807,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1164:Arap2
|
UTSW |
5 |
62,840,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1268:Arap2
|
UTSW |
5 |
62,887,964 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1480:Arap2
|
UTSW |
5 |
62,826,472 (GRCm39) |
nonsense |
probably null |
|
|
R1502:Arap2
|
UTSW |
5 |
62,761,747 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1543:Arap2
|
UTSW |
5 |
62,763,498 (GRCm39) |
nonsense |
probably null |
|
|
R1865:Arap2
|
UTSW |
5 |
62,855,606 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1962:Arap2
|
UTSW |
5 |
62,834,007 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R2040:Arap2
|
UTSW |
5 |
62,906,259 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2118:Arap2
|
UTSW |
5 |
62,864,028 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Arap2
|
UTSW |
5 |
62,835,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2201:Arap2
|
UTSW |
5 |
62,864,028 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2215:Arap2
|
UTSW |
5 |
62,834,519 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3027:Arap2
|
UTSW |
5 |
62,827,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3053:Arap2
|
UTSW |
5 |
62,906,200 (GRCm39) |
missense |
probably benign |
0.35 |
|
R3975:Arap2
|
UTSW |
5 |
62,906,237 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4272:Arap2
|
UTSW |
5 |
62,828,322 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R4273:Arap2
|
UTSW |
5 |
62,828,322 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R4326:Arap2
|
UTSW |
5 |
62,779,206 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4327:Arap2
|
UTSW |
5 |
62,779,206 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4328:Arap2
|
UTSW |
5 |
62,779,206 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4451:Arap2
|
UTSW |
5 |
62,906,513 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4659:Arap2
|
UTSW |
5 |
62,811,469 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4665:Arap2
|
UTSW |
5 |
62,827,312 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4715:Arap2
|
UTSW |
5 |
62,906,437 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4808:Arap2
|
UTSW |
5 |
62,887,984 (GRCm39) |
missense |
probably benign |
0.23 |
|
R4983:Arap2
|
UTSW |
5 |
62,833,868 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5095:Arap2
|
UTSW |
5 |
62,811,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5156:Arap2
|
UTSW |
5 |
62,826,524 (GRCm39) |
nonsense |
probably null |
|
|
R5201:Arap2
|
UTSW |
5 |
62,840,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5346:Arap2
|
UTSW |
5 |
62,872,089 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5359:Arap2
|
UTSW |
5 |
62,840,762 (GRCm39) |
nonsense |
probably null |
|
|
R5426:Arap2
|
UTSW |
5 |
62,800,159 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5503:Arap2
|
UTSW |
5 |
62,787,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5605:Arap2
|
UTSW |
5 |
62,772,410 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5764:Arap2
|
UTSW |
5 |
62,800,197 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5813:Arap2
|
UTSW |
5 |
62,834,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5846:Arap2
|
UTSW |
5 |
62,807,116 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6084:Arap2
|
UTSW |
5 |
62,828,297 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6173:Arap2
|
UTSW |
5 |
62,906,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6175:Arap2
|
UTSW |
5 |
62,872,074 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6249:Arap2
|
UTSW |
5 |
62,803,536 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6386:Arap2
|
UTSW |
5 |
62,761,865 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6424:Arap2
|
UTSW |
5 |
62,840,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6744:Arap2
|
UTSW |
5 |
62,906,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6766:Arap2
|
UTSW |
5 |
62,834,443 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6990:Arap2
|
UTSW |
5 |
62,833,860 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7067:Arap2
|
UTSW |
5 |
62,811,387 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7098:Arap2
|
UTSW |
5 |
62,833,293 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7107:Arap2
|
UTSW |
5 |
62,763,551 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7156:Arap2
|
UTSW |
5 |
62,761,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7174:Arap2
|
UTSW |
5 |
62,761,621 (GRCm39) |
missense |
probably benign |
|
|
R7187:Arap2
|
UTSW |
5 |
62,826,396 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7197:Arap2
|
UTSW |
5 |
62,798,729 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7214:Arap2
|
UTSW |
5 |
62,906,681 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7317:Arap2
|
UTSW |
5 |
62,807,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7392:Arap2
|
UTSW |
5 |
62,855,728 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7438:Arap2
|
UTSW |
5 |
62,906,818 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7452:Arap2
|
UTSW |
5 |
62,833,892 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7495:Arap2
|
UTSW |
5 |
62,833,893 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7796:Arap2
|
UTSW |
5 |
62,888,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7936:Arap2
|
UTSW |
5 |
62,888,048 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8116:Arap2
|
UTSW |
5 |
62,887,954 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8172:Arap2
|
UTSW |
5 |
62,779,324 (GRCm39) |
splice site |
probably null |
|
|
R8277:Arap2
|
UTSW |
5 |
62,771,335 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8369:Arap2
|
UTSW |
5 |
62,761,669 (GRCm39) |
nonsense |
probably null |
|
|
R8398:Arap2
|
UTSW |
5 |
62,906,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8893:Arap2
|
UTSW |
5 |
62,888,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8973:Arap2
|
UTSW |
5 |
62,855,668 (GRCm39) |
nonsense |
probably null |
|
|
R9102:Arap2
|
UTSW |
5 |
62,906,341 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9121:Arap2
|
UTSW |
5 |
62,906,326 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9174:Arap2
|
UTSW |
5 |
62,855,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9222:Arap2
|
UTSW |
5 |
62,828,421 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R9281:Arap2
|
UTSW |
5 |
62,906,848 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9399:Arap2
|
UTSW |
5 |
62,763,455 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R9450:Arap2
|
UTSW |
5 |
62,855,762 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9467:Arap2
|
UTSW |
5 |
62,887,900 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9567:Arap2
|
UTSW |
5 |
62,761,841 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9577:Arap2
|
UTSW |
5 |
62,769,060 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9626:Arap2
|
UTSW |
5 |
62,906,878 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9688:Arap2
|
UTSW |
5 |
62,872,109 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- CGGAGACTGACAGTTTCCTTC -3'
(R):5'- CAGCGAAGTAAATGCGGACATC -3'
Sequencing Primer
(F):5'- GGAGACTGACAGTTTCCTTCACTAAG -3'
(R):5'- TGCGGACATCAGAGATTTCC -3'
|
| Posted On |
2016-04-27 |
Incidental Mutation