Mutagenetix > Incidental Mutation

Incidental Mutation 'R4941:Ptpro'

383084

Institutional Source

Beutler Lab

Gene Symbol

Ptpro

Ensembl Gene

ENSMUSG00000030223

Gene Name

protein tyrosine phosphatase, receptor type, O

Synonyms

Ptpn15, PTP-oc, GLEPP1, PTP-U2, PTP-BK, PTP-phi, D28, PTPROt

MMRRC Submission

042539-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4941 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

137252319-137463233 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 137392765 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Proline to Leucine at position 525 (P525L)

Ref Sequence

ENSEMBL: ENSMUSP00000127112 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077115] [ENSMUST00000167679]

AlphaFold

E9Q612

Predicted Effect

probably damaging
Transcript: ENSMUST00000077115
AA Change: P525L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000076364
Gene: ENSMUSG00000030223
AA Change: P525L

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
low complexity region	269	291	N/A	INTRINSIC
FN3	443	528	1.07e-1	SMART
FN3	540	626	7.07e-2	SMART
FN3	642	722	4.47e1	SMART
FN3	733	812	5.92e-4	SMART
transmembrane domain	831	853	N/A	INTRINSIC
transmembrane domain	890	912	N/A	INTRINSIC
PTPc	947	1207	1.43e-127	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000167679
AA Change: P525L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000127112
Gene: ENSMUSG00000030223
AA Change: P525L

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
low complexity region	269	291	N/A	INTRINSIC
FN3	443	528	1.07e-1	SMART
FN3	540	626	7.07e-2	SMART
FN3	642	722	4.47e1	SMART
FN3	733	812	5.92e-4	SMART
transmembrane domain	831	853	N/A	INTRINSIC
PTPc	919	1179	1.43e-127	SMART

Meta Mutation Damage Score

0.2790

Coding Region Coverage

1x: 98.9%
3x: 98.0%
10x: 95.4%
20x: 89.0%

Validation Efficiency

97% (112/116)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]
PHENOTYPE: Mice homozygous for one allele display impaired glomerular filtration due to podocyte structural anomalies and a predisposition for hypertension. Mice homozygous for a second allele exhibit susceptibility to pharmacologically induced seizures. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 98 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	A	C	3: 36,917,702 (GRCm38)	H528P	probably damaging	Het
4932438A13Rik	G	A	3: 36,919,901 (GRCm38)	S600N	probably benign	Het
A4galt	T	A	15: 83,228,328 (GRCm38)	I85F	probably damaging	Het
Abcc6	T	A	7: 46,012,523 (GRCm38)	I435F	probably benign	Het
Adam3	T	C	8: 24,677,316 (GRCm38)		probably benign	Het
Adrb3	T	C	8: 27,227,422 (GRCm38)	Y333C	probably damaging	Het
Ago4	A	T	4: 126,526,054 (GRCm38)	D43E	probably benign	Het
Agt	T	A	8: 124,556,988 (GRCm38)	Q464L	probably benign	Het
Amdhd1	A	T	10: 93,531,601 (GRCm38)	D230E	probably damaging	Het
Aplf	A	T	6: 87,646,349 (GRCm38)	N249K	probably benign	Het
Aplf	A	G	6: 87,668,423 (GRCm38)	I33T	probably damaging	Het
Arap2	A	G	5: 62,749,478 (GRCm38)	M66T	probably benign	Het
Atf4	T	C	15: 80,256,233 (GRCm38)		probably benign	Het
AU019823	G	T	9: 50,607,509 (GRCm38)	Q268K	probably benign	Het
Bahcc1	A	C	11: 120,286,665 (GRCm38)	H2068P	probably benign	Het
Bcor	C	T	X: 12,040,486 (GRCm38)	R1551Q	probably damaging	Het
Catsper1	C	A	19: 5,341,438 (GRCm38)	A616D	possibly damaging	Het
Ccdc94	A	G	17: 55,964,149 (GRCm38)	D97G	possibly damaging	Het
Cdkn3	A	G	14: 46,769,863 (GRCm38)	D159G	possibly damaging	Het
Cep162	T	C	9: 87,225,969 (GRCm38)		probably benign	Het
Clca1	T	A	3: 145,015,653 (GRCm38)	I386L	probably damaging	Het
Cldn10	G	A	14: 118,788,313 (GRCm38)	G53S	possibly damaging	Het
Cmtm3	T	C	8: 104,343,828 (GRCm38)	L73P	probably damaging	Het
Cnksr3	A	C	10: 7,152,925 (GRCm38)	L149R	probably benign	Het
Cope	T	C	8: 70,302,934 (GRCm38)		probably null	Het
Cpa6	T	A	1: 10,409,337 (GRCm38)	M224L	probably benign	Het
Cyp2d41-ps	T	C	15: 82,781,953 (GRCm38)		noncoding transcript	Het
Ddx55	T	A	5: 124,568,716 (GRCm38)	L592*	probably null	Het
Deup1	T	C	9: 15,588,027 (GRCm38)	M333V	probably benign	Het
Eif4a1	T	C	11: 69,667,814 (GRCm38)		probably benign	Het
Eif4g3	A	C	4: 138,170,565 (GRCm38)	D1026A	probably damaging	Het
Eif5b	T	C	1: 38,051,199 (GRCm38)	V1153A	probably damaging	Het
Ercc8	G	T	13: 108,160,767 (GRCm38)		probably benign	Het
Fam227a	C	A	15: 79,640,003 (GRCm38)		probably null	Het
Fat1	A	G	8: 45,036,275 (GRCm38)	I3505V	probably benign	Het
Fat3	T	G	9: 16,375,152 (GRCm38)	E1025A	probably damaging	Het
Fat4	C	T	3: 38,957,452 (GRCm38)	R2234W	probably damaging	Het
Fer1l4	G	T	2: 156,045,089 (GRCm38)	F634L	probably damaging	Het
Fetub	G	A	16: 22,937,874 (GRCm38)	V162I	probably benign	Het
Fgd4	T	C	16: 16,484,538 (GRCm38)	Q51R	probably benign	Het
Fgfr2	T	C	7: 130,198,445 (GRCm38)	H140R	probably benign	Het
Flt3	T	A	5: 147,356,375 (GRCm38)		probably null	Het
Gabrb1	A	G	5: 72,136,778 (GRCm38)	N465S	probably damaging	Het
Gapdhs	T	C	7: 30,733,266 (GRCm38)	I206V	probably benign	Het
Gkn3	C	T	6: 87,383,525 (GRCm38)	A163T	probably damaging	Het
Glp2r	T	C	11: 67,746,703 (GRCm38)		probably null	Het
Gm4956	T	A	1: 21,298,082 (GRCm38)		noncoding transcript	Het
Gtf2a1l	A	T	17: 88,714,922 (GRCm38)	D447V	probably damaging	Het
Hsd3b5	A	G	3: 98,619,063 (GRCm38)	W356R	probably damaging	Het
Idh2	A	T	7: 80,096,099 (GRCm38)	V335D	probably damaging	Het
Isyna1	T	C	8: 70,595,496 (GRCm38)	I184T	probably damaging	Het
Kcnh2	A	G	5: 24,331,087 (GRCm38)	S320P	probably damaging	Het
Klk14	G	A	7: 43,692,077 (GRCm38)	C51Y	probably damaging	Het
Kpna6	A	G	4: 129,648,032 (GRCm38)	F524S	probably damaging	Het
Lap3	A	T	5: 45,506,197 (GRCm38)	M338L	probably benign	Het
Lins1	T	C	7: 66,709,450 (GRCm38)		probably benign	Het
Llgl1	C	T	11: 60,709,568 (GRCm38)	P581L	probably benign	Het
Lrrc43	A	G	5: 123,501,063 (GRCm38)	D385G	probably benign	Het
Maf	T	C	8: 115,706,793 (GRCm38)	D24G	unknown	Het
Nell1	T	C	7: 50,062,638 (GRCm38)	S69P	probably benign	Het
Olfr1342	C	T	4: 118,689,892 (GRCm38)	V187I	possibly damaging	Het
Olfr1436	A	G	19: 12,298,896 (GRCm38)	S79P	possibly damaging	Het
Olfr531	T	A	7: 140,400,879 (GRCm38)	M56L	probably benign	Het
Olfr609	T	C	7: 103,492,251 (GRCm38)	D209G	probably damaging	Het
Olfr91	C	T	17: 37,093,592 (GRCm38)	G94E	probably damaging	Het
Olfr969	T	C	9: 39,795,864 (GRCm38)	M163T	possibly damaging	Het
Oxld1	T	C	11: 120,457,036 (GRCm38)	T112A	probably benign	Het
Parp14	T	C	16: 35,846,033 (GRCm38)	N1210S	probably benign	Het
Pcdhb10	C	A	18: 37,412,834 (GRCm38)	T321K	probably benign	Het
Pcdhb8	C	T	18: 37,356,006 (GRCm38)	L246F	probably benign	Het
Pcdhga1	T	A	18: 37,662,606 (GRCm38)	I221K	probably benign	Het
Pcdhga9	T	A	18: 37,738,132 (GRCm38)	V338E	probably damaging	Het
Pdcd11	T	C	19: 47,119,886 (GRCm38)	S1231P	probably damaging	Het
Pde6c	A	T	19: 38,151,565 (GRCm38)	L325F	probably damaging	Het
Pnpla7	T	A	2: 24,997,264 (GRCm38)		probably null	Het
Pparg	T	A	6: 115,490,110 (GRCm38)	V478E	probably damaging	Het
Ppib	T	C	9: 66,060,390 (GRCm38)	V42A	probably benign	Het
Ppox	T	C	1: 171,277,593 (GRCm38)	M341V	probably damaging	Het
Proc	T	C	18: 32,125,113 (GRCm38)	K260E	possibly damaging	Het
Rnf14	C	A	18: 38,308,382 (GRCm38)	A275E	probably damaging	Het
Scnn1b	C	T	7: 121,912,008 (GRCm38)	P306L	probably damaging	Het
Sec14l5	A	G	16: 5,176,500 (GRCm38)	E386G	probably damaging	Het
Sftpa1	T	A	14: 41,132,552 (GRCm38)	I32N	probably damaging	Het
Slc26a5	A	G	5: 21,820,386 (GRCm38)	I408T	probably damaging	Het
Slc7a13	A	G	4: 19,841,467 (GRCm38)	Y438C	probably damaging	Het
Spire1	T	C	18: 67,519,314 (GRCm38)	E231G	possibly damaging	Het
Stab1	T	A	14: 31,151,571 (GRCm38)	I1014F	probably benign	Het
Steap2	T	C	5: 5,677,651 (GRCm38)	Y228C	probably damaging	Het
Tmem131l	T	C	3: 83,899,239 (GRCm38)	T1487A	probably benign	Het
Tmem171	A	G	13: 98,692,295 (GRCm38)	F116L	possibly damaging	Het
Tmem215	T	C	4: 40,474,520 (GRCm38)	V199A	probably damaging	Het
Tmem45a	T	C	16: 56,822,289 (GRCm38)	N173S	possibly damaging	Het
Uqcrc2	C	T	7: 120,643,078 (GRCm38)	R148C	probably benign	Het
Vmn2r116	A	G	17: 23,401,142 (GRCm38)	K617E	probably damaging	Het
Xrcc6	T	C	15: 82,039,812 (GRCm38)	L229P	probably damaging	Het
Zfp184	A	G	13: 21,949,721 (GRCm38)	D46G	probably damaging	Het
Zfp790	T	A	7: 29,829,491 (GRCm38)	C534S	possibly damaging	Het
Zfp990	A	T	4: 145,536,837 (GRCm38)	N135I	probably damaging	Het

Other mutations in Ptpro

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00334:Ptpro	APN	6	137,394,909 (GRCm38)	critical splice donor site	probably null
IGL00844:Ptpro	APN	6	137,414,239 (GRCm38)	missense	probably damaging	1.00
IGL00983:Ptpro	APN	6	137,418,248 (GRCm38)	missense	probably benign	0.01
IGL01073:Ptpro	APN	6	137,377,088 (GRCm38)	missense	probably damaging	1.00
IGL01832:Ptpro	APN	6	137,393,668 (GRCm38)	missense	possibly damaging	0.93
IGL02308:Ptpro	APN	6	137,454,700 (GRCm38)	missense	probably benign	0.37
IGL02387:Ptpro	APN	6	137,410,980 (GRCm38)	missense	probably damaging	0.96
IGL02605:Ptpro	APN	6	137,380,318 (GRCm38)	missense	probably benign	0.02
IGL02666:Ptpro	APN	6	137,378,059 (GRCm38)	missense	probably damaging	0.96
IGL03275:Ptpro	APN	6	137,450,006 (GRCm38)	missense	probably damaging	1.00
Brau	UTSW	6	137,454,598 (GRCm38)	missense	probably damaging	1.00
court	UTSW	6	137,393,675 (GRCm38)	nonsense	probably null
Hoff	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
Jester	UTSW	6	137,449,917 (GRCm38)	missense	probably damaging	1.00
mann	UTSW	6	137,411,116 (GRCm38)	splice site	probably null
R0017:Ptpro	UTSW	6	137,416,827 (GRCm38)	missense	probably benign	0.03
R0017:Ptpro	UTSW	6	137,416,827 (GRCm38)	missense	probably benign	0.03
R0020:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0022:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0023:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0024:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0094:Ptpro	UTSW	6	137,386,352 (GRCm38)	missense	probably benign	0.08
R0094:Ptpro	UTSW	6	137,386,352 (GRCm38)	missense	probably benign	0.08
R0103:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0106:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0316:Ptpro	UTSW	6	137,376,989 (GRCm38)	missense	possibly damaging	0.81
R0427:Ptpro	UTSW	6	137,368,296 (GRCm38)	missense	possibly damaging	0.81
R0456:Ptpro	UTSW	6	137,414,230 (GRCm38)	missense	probably benign	0.04
R0536:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0537:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0552:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0555:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0664:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0708:Ptpro	UTSW	6	137,386,253 (GRCm38)	missense	probably benign	0.26
R0730:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0735:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0738:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0786:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0811:Ptpro	UTSW	6	137,368,079 (GRCm38)	missense	probably benign	0.00
R0812:Ptpro	UTSW	6	137,368,079 (GRCm38)	missense	probably benign	0.00
R0881:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0973:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1145:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1145:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1146:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1146:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1147:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1147:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1259:Ptpro	UTSW	6	137,392,741 (GRCm38)	missense	probably damaging	0.98
R1340:Ptpro	UTSW	6	137,441,081 (GRCm38)	missense	possibly damaging	0.95
R1381:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1382:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1385:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1396:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1401:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1416:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1422:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1448:Ptpro	UTSW	6	137,441,116 (GRCm38)	missense	probably damaging	1.00
R1513:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1518:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1526:Ptpro	UTSW	6	137,461,726 (GRCm38)	missense	probably damaging	1.00
R1540:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1571:Ptpro	UTSW	6	137,378,130 (GRCm38)	missense	probably benign
R1573:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1587:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1588:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1649:Ptpro	UTSW	6	137,444,017 (GRCm38)	nonsense	probably null
R1700:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1701:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1745:Ptpro	UTSW	6	137,400,645 (GRCm38)	missense	probably benign	0.03
R1772:Ptpro	UTSW	6	137,430,743 (GRCm38)	missense	probably damaging	1.00
R1911:Ptpro	UTSW	6	137,400,619 (GRCm38)	splice site	probably benign
R1958:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1967:Ptpro	UTSW	6	137,416,865 (GRCm38)	missense	probably benign	0.38
R2025:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2026:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2040:Ptpro	UTSW	6	137,386,164 (GRCm38)	splice site	probably benign
R2115:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2117:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2130:Ptpro	UTSW	6	137,411,116 (GRCm38)	splice site	probably null
R2161:Ptpro	UTSW	6	137,449,887 (GRCm38)	missense	probably benign	0.01
R2431:Ptpro	UTSW	6	137,443,585 (GRCm38)	nonsense	probably null
R2915:Ptpro	UTSW	6	137,414,241 (GRCm38)	start gained	probably benign
R2988:Ptpro	UTSW	6	137,443,599 (GRCm38)	nonsense	probably null
R3772:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3773:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3795:Ptpro	UTSW	6	137,380,309 (GRCm38)	missense	probably benign
R3885:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3886:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3887:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3888:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3893:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R4032:Ptpro	UTSW	6	137,461,742 (GRCm38)	missense	probably damaging	1.00
R4133:Ptpro	UTSW	6	137,420,372 (GRCm38)	missense	probably damaging	1.00
R4377:Ptpro	UTSW	6	137,380,266 (GRCm38)	missense	probably benign	0.26
R4455:Ptpro	UTSW	6	137,393,659 (GRCm38)	missense	probably damaging	1.00
R4613:Ptpro	UTSW	6	137,416,836 (GRCm38)	nonsense	probably null
R4827:Ptpro	UTSW	6	137,442,710 (GRCm38)	missense	probably damaging	1.00
R4863:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R4870:Ptpro	UTSW	6	137,377,132 (GRCm38)	missense	probably damaging	0.96
R4910:Ptpro	UTSW	6	137,368,338 (GRCm38)	missense	probably damaging	0.99
R4932:Ptpro	UTSW	6	137,411,105 (GRCm38)	nonsense	probably null
R4989:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5009:Ptpro	UTSW	6	137,377,132 (GRCm38)	missense	probably damaging	0.96
R5032:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5033:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5162:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5393:Ptpro	UTSW	6	137,380,224 (GRCm38)	missense	probably benign	0.04
R5423:Ptpro	UTSW	6	137,442,707 (GRCm38)	missense	probably damaging	1.00
R5782:Ptpro	UTSW	6	137,399,498 (GRCm38)	missense	possibly damaging	0.80
R6103:Ptpro	UTSW	6	137,400,706 (GRCm38)	missense	possibly damaging	0.76
R6239:Ptpro	UTSW	6	137,380,608 (GRCm38)	missense	probably benign	0.28
R6488:Ptpro	UTSW	6	137,393,675 (GRCm38)	nonsense	probably null
R6494:Ptpro	UTSW	6	137,382,642 (GRCm38)	missense	probably benign	0.20
R6746:Ptpro	UTSW	6	137,394,823 (GRCm38)	missense	probably damaging	1.00
R6763:Ptpro	UTSW	6	137,418,281 (GRCm38)	splice site	probably null
R6888:Ptpro	UTSW	6	137,380,200 (GRCm38)	missense	probably benign	0.30
R6983:Ptpro	UTSW	6	137,449,917 (GRCm38)	missense	probably damaging	1.00
R7019:Ptpro	UTSW	6	137,380,478 (GRCm38)	missense	probably benign
R7218:Ptpro	UTSW	6	137,454,598 (GRCm38)	missense	probably damaging	1.00
R7236:Ptpro	UTSW	6	137,368,337 (GRCm38)	missense	probably damaging	1.00
R7299:Ptpro	UTSW	6	137,441,144 (GRCm38)	critical splice donor site	probably null
R7381:Ptpro	UTSW	6	137,399,561 (GRCm38)	missense	possibly damaging	0.93
R7493:Ptpro	UTSW	6	137,382,649 (GRCm38)	missense	probably benign	0.01
R7733:Ptpro	UTSW	6	137,414,286 (GRCm38)	nonsense	probably null
R7793:Ptpro	UTSW	6	137,416,820 (GRCm38)	missense	probably damaging	0.99
R7804:Ptpro	UTSW	6	137,399,601 (GRCm38)	splice site	probably null
R7833:Ptpro	UTSW	6	137,416,863 (GRCm38)	nonsense	probably null
R7859:Ptpro	UTSW	6	137,392,807 (GRCm38)	critical splice donor site	probably null
R7873:Ptpro	UTSW	6	137,430,739 (GRCm38)	missense	probably benign	0.44
R8042:Ptpro	UTSW	6	137,416,883 (GRCm38)	missense	possibly damaging	0.71
R8859:Ptpro	UTSW	6	137,426,784 (GRCm38)	nonsense	probably null
R8979:Ptpro	UTSW	6	137,368,142 (GRCm38)	missense	probably benign
R9138:Ptpro	UTSW	6	137,411,115 (GRCm38)	critical splice donor site	probably null
R9309:Ptpro	UTSW	6	137,454,658 (GRCm38)	missense	probably damaging	1.00
R9420:Ptpro	UTSW	6	137,443,935 (GRCm38)	missense	probably benign	0.08
R9612:Ptpro	UTSW	6	137,414,320 (GRCm38)	missense	probably benign	0.31
R9625:Ptpro	UTSW	6	137,394,875 (GRCm38)	missense	probably damaging	1.00
R9697:Ptpro	UTSW	6	137,386,290 (GRCm38)	missense	probably damaging	1.00
R9715:Ptpro	UTSW	6	137,368,110 (GRCm38)	missense	probably damaging	0.96
Z1177:Ptpro	UTSW	6	137,378,140 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGAATTTCAATGCCCTGGATCTC -3'
(R):5'- GGAGCACAGCCTCATGATTC -3'

Sequencing Primer
(F):5'- CATGAGTCAAAGATGCCGGATTTC -3'
(R):5'- GCACAGCCTCATGATTCTTCCG -3'

Posted On

2016-04-27