Incidental Mutation 'R4947:Vmn2r80'
ID 383514
Institutional Source Beutler Lab
Gene Symbol Vmn2r80
Ensembl Gene ENSMUSG00000091888
Gene Name vomeronasal 2, receptor 80
Synonyms EG624765
MMRRC Submission 042544-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R4947 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 78984650-79030767 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 79030532 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Arginine at position 786 (L786R)
Ref Sequence ENSEMBL: ENSMUSP00000132299 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165834]
AlphaFold E9Q1L0
Predicted Effect probably damaging
Transcript: ENSMUST00000165834
AA Change: L786R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000132299
Gene: ENSMUSG00000091888
AA Change: L786R

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 79 474 1.5e-36 PFAM
Pfam:NCD3G 517 570 7.9e-22 PFAM
Pfam:7tm_3 603 838 6.2e-49 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.0%
  • 20x: 87.4%
Validation Efficiency 100% (88/88)
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057M21Rik T A 7: 130,959,343 (GRCm39) H119L probably damaging Het
Acvr1c T A 2: 58,205,987 (GRCm39) Q41L probably benign Het
Adamtsl1 A T 4: 85,683,037 (GRCm39) Q36L possibly damaging Het
Bcl2a1a G A 9: 88,839,335 (GRCm39) E78K probably damaging Het
Cdk5rap2 A G 4: 70,146,829 (GRCm39) probably null Het
Copg1 C A 6: 87,880,455 (GRCm39) probably benign Het
Crb2 C T 2: 37,685,343 (GRCm39) probably benign Het
Cstdc6 T C 16: 36,142,127 (GRCm39) Y83C probably damaging Het
Ctbp2 C A 7: 132,601,012 (GRCm39) G584C probably damaging Het
Cyp11b2 T C 15: 74,723,419 (GRCm39) N415S possibly damaging Het
D630003M21Rik T A 2: 158,028,116 (GRCm39) T1095S unknown Het
D630045J12Rik C T 6: 38,125,478 (GRCm39) R1512H probably damaging Het
Dnah5 T A 15: 28,272,518 (GRCm39) V1078E probably benign Het
Donson A T 16: 91,479,439 (GRCm39) D366E probably damaging Het
Evpl T C 11: 116,114,201 (GRCm39) E1163G possibly damaging Het
Fcgbp A G 7: 27,789,237 (GRCm39) K601R probably benign Het
Fez1 A C 9: 36,780,171 (GRCm39) I323L probably damaging Het
Flacc1 T A 1: 58,715,698 (GRCm39) T173S probably benign Het
Fmnl2 T G 2: 52,963,722 (GRCm39) S285A probably benign Het
Frem1 A G 4: 82,884,371 (GRCm39) S1194P probably damaging Het
Gm10754 A T 10: 97,518,010 (GRCm39) probably benign Het
Gm14226 A T 2: 154,866,879 (GRCm39) T279S probably benign Het
Gm16332 G A 1: 139,793,730 (GRCm39) noncoding transcript Het
Gm21718 T A 14: 51,553,416 (GRCm39) noncoding transcript Het
Gm9871 A G 6: 101,773,734 (GRCm39) noncoding transcript Het
Grm1 A G 10: 10,658,377 (GRCm39) F371S probably damaging Het
Gtdc1 T C 2: 44,481,968 (GRCm39) I128V probably null Het
H2-Q3 T A 17: 35,578,708 (GRCm39) noncoding transcript Het
Ibtk T C 9: 85,592,465 (GRCm39) T998A probably benign Het
Ifi204 A G 1: 173,583,316 (GRCm39) S301P probably damaging Het
Kcnn1 C A 8: 71,297,073 (GRCm39) A545S probably benign Het
Keap1 T G 9: 21,148,849 (GRCm39) S53R probably benign Het
Lat A G 7: 125,967,110 (GRCm39) V138A probably benign Het
Lrpprc A T 17: 85,078,966 (GRCm39) N249K probably benign Het
Lrrc40 A G 3: 157,769,472 (GRCm39) I557V probably benign Het
Maml3 A G 3: 51,763,960 (GRCm39) F335L probably benign Het
Mcmbp A T 7: 128,314,420 (GRCm39) D265E probably damaging Het
Me3 A G 7: 89,282,222 (GRCm39) H35R probably benign Het
Mif4gd C A 11: 115,500,463 (GRCm39) V32L probably benign Het
Mlana T C 19: 29,677,551 (GRCm39) S18P probably damaging Het
Mpnd T A 17: 56,317,268 (GRCm39) probably benign Het
Ms4a4b T C 19: 11,432,101 (GRCm39) V74A probably benign Het
Mta2 T C 19: 8,923,655 (GRCm39) F133L possibly damaging Het
Myo5a A G 9: 75,030,330 (GRCm39) M150V probably damaging Het
Nbr1 T C 11: 101,465,903 (GRCm39) V487A probably benign Het
Nos3 G A 5: 24,582,853 (GRCm39) C660Y probably damaging Het
Ocln T C 13: 100,676,223 (GRCm39) D90G probably damaging Het
Or12d17 T C 17: 37,777,634 (GRCm39) V179A probably damaging Het
Or1e1c C T 11: 73,266,243 (GRCm39) R223* probably null Het
Or52n5 A G 7: 104,587,949 (GRCm39) D72G possibly damaging Het
Or5h18 A G 16: 58,847,808 (GRCm39) L154P probably damaging Het
Pcdh7 A G 5: 57,879,258 (GRCm39) K938E probably damaging Het
Pcgf3 T C 5: 108,635,827 (GRCm39) F166L probably benign Het
Pid1 A T 1: 84,015,981 (GRCm39) V128E possibly damaging Het
Polr3a A C 14: 24,532,532 (GRCm39) D187E probably benign Het
Prokr2 T C 2: 132,215,573 (GRCm39) D135G probably damaging Het
Rnf141 T C 7: 110,424,527 (GRCm39) T14A possibly damaging Het
Serinc1 T C 10: 57,399,141 (GRCm39) E254G probably damaging Het
Silc1 A T 12: 27,210,227 (GRCm39) noncoding transcript Het
Skint11 T C 4: 114,048,707 (GRCm39) F11L possibly damaging Het
Slc22a28 T C 19: 8,108,816 (GRCm39) T109A probably benign Het
Sntg1 C A 1: 8,853,022 (GRCm39) V43L probably damaging Het
Sp140l2 G A 1: 85,090,203 (GRCm39) A124V probably damaging Het
Strn T C 17: 78,969,208 (GRCm39) D398G probably damaging Het
Tacc2 A T 7: 130,227,629 (GRCm39) E1438V probably damaging Het
Tas2r139 A G 6: 42,118,500 (GRCm39) T211A possibly damaging Het
Tbkbp1 T C 11: 97,029,770 (GRCm39) probably benign Het
Thbs3 T C 3: 89,133,738 (GRCm39) Y897H probably damaging Het
Timm50 G T 7: 28,009,469 (GRCm39) probably benign Het
Tmem132a T C 19: 10,844,298 (GRCm39) Q100R possibly damaging Het
Ugt1a1 CAGAGAGAGAGAGA CAGAGAGAGAGA 1: 88,139,706 (GRCm39) probably benign Het
Unc93b1 C A 19: 3,985,871 (GRCm39) T90K probably benign Het
Upk3bl T C 5: 136,086,099 (GRCm39) probably benign Het
Vmn2r112 T A 17: 22,821,860 (GRCm39) H179Q probably benign Het
Vmn2r57 A T 7: 41,049,919 (GRCm39) F610Y probably damaging Het
Zc3h14 A G 12: 98,726,083 (GRCm39) T323A probably benign Het
Zfp532 T C 18: 65,758,137 (GRCm39) I690T possibly damaging Het
Zfp729b T C 13: 67,744,791 (GRCm39) N47S probably damaging Het
Other mutations in Vmn2r80
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01084:Vmn2r80 APN 10 79,030,433 (GRCm39) missense probably damaging 1.00
IGL01325:Vmn2r80 APN 10 79,030,081 (GRCm39) missense possibly damaging 0.62
IGL01611:Vmn2r80 APN 10 79,007,488 (GRCm39) missense probably damaging 1.00
IGL01799:Vmn2r80 APN 10 79,007,385 (GRCm39) missense possibly damaging 0.95
IGL01877:Vmn2r80 APN 10 79,007,334 (GRCm39) splice site probably null
IGL02673:Vmn2r80 APN 10 79,005,318 (GRCm39) missense probably benign 0.02
IGL02756:Vmn2r80 APN 10 79,030,145 (GRCm39) missense probably damaging 1.00
IGL02820:Vmn2r80 APN 10 79,007,439 (GRCm39) missense probably benign 0.04
IGL03382:Vmn2r80 APN 10 79,005,362 (GRCm39) missense probably damaging 1.00
R0071:Vmn2r80 UTSW 10 79,007,566 (GRCm39) missense possibly damaging 0.83
R0071:Vmn2r80 UTSW 10 79,007,566 (GRCm39) missense possibly damaging 0.83
R0129:Vmn2r80 UTSW 10 79,005,330 (GRCm39) missense probably damaging 1.00
R0325:Vmn2r80 UTSW 10 78,984,773 (GRCm39) missense possibly damaging 0.89
R0567:Vmn2r80 UTSW 10 79,030,665 (GRCm39) missense possibly damaging 0.89
R1510:Vmn2r80 UTSW 10 79,005,553 (GRCm39) missense possibly damaging 0.69
R1519:Vmn2r80 UTSW 10 79,030,053 (GRCm39) missense probably damaging 1.00
R1520:Vmn2r80 UTSW 10 79,030,594 (GRCm39) missense probably damaging 1.00
R1627:Vmn2r80 UTSW 10 79,030,249 (GRCm39) missense probably damaging 1.00
R1709:Vmn2r80 UTSW 10 79,030,223 (GRCm39) missense probably benign 0.04
R2116:Vmn2r80 UTSW 10 79,030,558 (GRCm39) missense probably benign 0.09
R2237:Vmn2r80 UTSW 10 79,004,104 (GRCm39) missense probably damaging 1.00
R2308:Vmn2r80 UTSW 10 79,007,455 (GRCm39) missense probably damaging 1.00
R2893:Vmn2r80 UTSW 10 78,984,699 (GRCm39) missense possibly damaging 0.63
R3408:Vmn2r80 UTSW 10 79,004,227 (GRCm39) missense possibly damaging 0.95
R4502:Vmn2r80 UTSW 10 78,984,764 (GRCm39) missense probably benign 0.00
R4685:Vmn2r80 UTSW 10 79,030,162 (GRCm39) missense possibly damaging 0.95
R4851:Vmn2r80 UTSW 10 79,030,156 (GRCm39) missense possibly damaging 0.68
R5112:Vmn2r80 UTSW 10 79,030,292 (GRCm39) missense possibly damaging 0.61
R5217:Vmn2r80 UTSW 10 79,004,980 (GRCm39) missense possibly damaging 0.62
R5226:Vmn2r80 UTSW 10 79,029,874 (GRCm39) missense probably benign 0.36
R5512:Vmn2r80 UTSW 10 79,004,066 (GRCm39) missense probably benign 0.00
R5618:Vmn2r80 UTSW 10 78,984,755 (GRCm39) missense probably benign
R5959:Vmn2r80 UTSW 10 79,005,313 (GRCm39) missense probably benign 0.00
R6104:Vmn2r80 UTSW 10 78,984,854 (GRCm39) missense probably benign 0.00
R6110:Vmn2r80 UTSW 10 79,017,837 (GRCm39) missense probably damaging 1.00
R6270:Vmn2r80 UTSW 10 79,030,159 (GRCm39) missense probably benign 0.00
R6508:Vmn2r80 UTSW 10 79,030,290 (GRCm39) missense probably benign 0.03
R6843:Vmn2r80 UTSW 10 79,005,502 (GRCm39) missense probably benign 0.08
R6894:Vmn2r80 UTSW 10 79,005,438 (GRCm39) missense probably benign 0.06
R7048:Vmn2r80 UTSW 10 79,030,153 (GRCm39) missense probably damaging 1.00
R7149:Vmn2r80 UTSW 10 79,030,654 (GRCm39) missense probably benign 0.00
R7262:Vmn2r80 UTSW 10 79,005,579 (GRCm39) missense probably damaging 0.98
R7559:Vmn2r80 UTSW 10 79,030,459 (GRCm39) missense probably benign 0.00
R7622:Vmn2r80 UTSW 10 79,030,097 (GRCm39) missense probably damaging 1.00
R8003:Vmn2r80 UTSW 10 78,984,711 (GRCm39) missense probably benign 0.16
R8207:Vmn2r80 UTSW 10 79,030,150 (GRCm39) nonsense probably null
R8330:Vmn2r80 UTSW 10 79,007,550 (GRCm39) missense probably damaging 1.00
R8337:Vmn2r80 UTSW 10 78,984,707 (GRCm39) missense probably benign 0.00
R8354:Vmn2r80 UTSW 10 78,984,710 (GRCm39) missense probably benign
R8688:Vmn2r80 UTSW 10 79,004,069 (GRCm39) missense probably damaging 1.00
R8903:Vmn2r80 UTSW 10 79,017,928 (GRCm39) missense probably damaging 1.00
R9088:Vmn2r80 UTSW 10 79,005,378 (GRCm39) missense probably benign 0.05
R9125:Vmn2r80 UTSW 10 78,984,760 (GRCm39) missense probably benign 0.12
R9147:Vmn2r80 UTSW 10 79,030,687 (GRCm39) missense probably damaging 0.98
R9148:Vmn2r80 UTSW 10 79,030,687 (GRCm39) missense probably damaging 0.98
R9187:Vmn2r80 UTSW 10 79,030,438 (GRCm39) missense probably benign 0.20
R9218:Vmn2r80 UTSW 10 79,030,270 (GRCm39) missense possibly damaging 0.61
R9553:Vmn2r80 UTSW 10 78,984,743 (GRCm39) missense probably benign
R9612:Vmn2r80 UTSW 10 79,030,712 (GRCm39) missense probably damaging 1.00
R9677:Vmn2r80 UTSW 10 78,984,672 (GRCm39) missense probably benign 0.15
R9769:Vmn2r80 UTSW 10 79,005,443 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r80 UTSW 10 79,030,441 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r80 UTSW 10 79,030,232 (GRCm39) missense possibly damaging 0.65
Z1176:Vmn2r80 UTSW 10 79,005,311 (GRCm39) missense not run
Z1176:Vmn2r80 UTSW 10 79,030,605 (GRCm39) missense probably damaging 1.00
Z1177:Vmn2r80 UTSW 10 79,005,311 (GRCm39) missense not run
Predicted Primers PCR Primer
(F):5'- TCTCTGGTATATGGCTGGGAAC -3'
(R):5'- TGAGTAAGTGTGTTCACCTCTG -3'

Sequencing Primer
(F):5'- GTATATGGCTGGGAACATCTCCTC -3'
(R):5'- AGTGTGTTCACCTCTGGCCTAAAC -3'
Posted On 2016-04-27