Incidental Mutation 'R4948:Dock3'
| ID |
383589 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dock3
|
| Ensembl Gene |
ENSMUSG00000039716 |
| Gene Name |
dedicator of cyto-kinesis 3 |
| Synonyms |
Moca, PBP |
| MMRRC Submission |
042545-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.549)
|
| Stock # |
R4948 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
106770024-107109108 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 106868354 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 643
(D643E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000047652
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044532]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000044532
AA Change: D643E
PolyPhen 2
Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000047652
Gene: ENSMUSG00000039716
AA Change: D643E
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
9 |
66 |
3.85e-9 |
SMART |
|
Pfam:DOCK_N
|
69 |
412 |
1.4e-120 |
PFAM |
|
Pfam:DOCK-C2
|
417 |
608 |
7.7e-56 |
PFAM |
|
low complexity region
|
854 |
867 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
916 |
N/A |
INTRINSIC |
|
Pfam:DHR-2
|
1121 |
1628 |
9e-133 |
PFAM |
|
low complexity region
|
1679 |
1690 |
N/A |
INTRINSIC |
|
low complexity region
|
1693 |
1704 |
N/A |
INTRINSIC |
|
low complexity region
|
1730 |
1754 |
N/A |
INTRINSIC |
|
low complexity region
|
1880 |
1902 |
N/A |
INTRINSIC |
|
low complexity region
|
1963 |
1977 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.3%
- 20x: 92.2%
|
| Validation Efficiency |
94% (103/109) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit abnormal behaviors and muscular weakness associated with axonal dystrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2610318N02Rik |
A |
T |
16: 16,936,154 (GRCm39) |
|
probably null |
Het |
| Adcy4 |
C |
T |
14: 56,016,486 (GRCm39) |
D322N |
probably damaging |
Het |
| Alas1 |
A |
T |
9: 106,124,077 (GRCm39) |
L27* |
probably null |
Het |
| Aldh1a7 |
A |
G |
19: 20,704,374 (GRCm39) |
V40A |
possibly damaging |
Het |
| Appbp2 |
A |
T |
11: 85,085,409 (GRCm39) |
I499K |
possibly damaging |
Het |
| B3gnt5 |
A |
C |
16: 19,587,894 (GRCm39) |
M38L |
probably benign |
Het |
| Brd8 |
A |
G |
18: 34,747,585 (GRCm39) |
V92A |
probably damaging |
Het |
| Btla |
A |
T |
16: 45,063,091 (GRCm39) |
E151D |
probably benign |
Het |
| Cd79b |
T |
A |
11: 106,203,687 (GRCm39) |
T67S |
probably benign |
Het |
| Cep192 |
A |
G |
18: 67,949,875 (GRCm39) |
R320G |
probably benign |
Het |
| Chad |
A |
C |
11: 94,456,528 (GRCm39) |
D202A |
probably damaging |
Het |
| Chil6 |
A |
G |
3: 106,295,988 (GRCm39) |
|
probably benign |
Het |
| Cpz |
T |
C |
5: 35,674,748 (GRCm39) |
E167G |
possibly damaging |
Het |
| Crisp2 |
T |
G |
17: 41,076,159 (GRCm39) |
H225P |
probably damaging |
Het |
| Cyp2c23 |
T |
C |
19: 44,010,138 (GRCm39) |
Y69C |
possibly damaging |
Het |
| Dcp1a |
T |
A |
14: 30,201,724 (GRCm39) |
L49H |
probably damaging |
Het |
| Dnah6 |
T |
A |
6: 73,030,672 (GRCm39) |
H3380L |
probably benign |
Het |
| Dnai3 |
T |
A |
3: 145,788,820 (GRCm39) |
K254* |
probably null |
Het |
| Dnm2 |
A |
G |
9: 21,415,829 (GRCm39) |
D721G |
possibly damaging |
Het |
| Dnpep |
G |
T |
1: 75,293,404 (GRCm39) |
T15K |
probably benign |
Het |
| Ear6 |
C |
T |
14: 52,091,573 (GRCm39) |
T40I |
possibly damaging |
Het |
| Fancm |
A |
G |
12: 65,137,748 (GRCm39) |
D313G |
probably damaging |
Het |
| Fbxw16 |
T |
A |
9: 109,267,415 (GRCm39) |
E272V |
probably damaging |
Het |
| Frmd4b |
T |
A |
6: 97,283,691 (GRCm39) |
E393D |
probably benign |
Het |
| Fryl |
T |
A |
5: 73,246,473 (GRCm39) |
M1100L |
probably benign |
Het |
| Gjd3 |
T |
C |
11: 102,691,247 (GRCm39) |
H252R |
probably damaging |
Het |
| Gm10518 |
T |
C |
1: 179,631,477 (GRCm39) |
|
probably benign |
Het |
| Gna14 |
A |
G |
19: 16,580,656 (GRCm39) |
M165V |
probably benign |
Het |
| Hells |
C |
A |
19: 38,923,966 (GRCm39) |
Q72K |
probably damaging |
Het |
| Herc1 |
A |
G |
9: 66,392,184 (GRCm39) |
I4031V |
probably benign |
Het |
| Hspa2 |
C |
T |
12: 76,452,761 (GRCm39) |
A485V |
probably damaging |
Het |
| Ighv1-54 |
T |
A |
12: 115,157,438 (GRCm39) |
I70F |
probably benign |
Het |
| Il20rb |
A |
T |
9: 100,343,592 (GRCm39) |
|
probably benign |
Het |
| Irag1 |
A |
G |
7: 110,487,236 (GRCm39) |
V498A |
probably damaging |
Het |
| Krt1 |
C |
A |
15: 101,754,376 (GRCm39) |
V625L |
unknown |
Het |
| Lamc3 |
T |
C |
2: 31,830,748 (GRCm39) |
I1495T |
probably benign |
Het |
| Larp6 |
A |
G |
9: 60,645,063 (GRCm39) |
E401G |
possibly damaging |
Het |
| Ldha |
A |
T |
7: 46,496,805 (GRCm39) |
H19L |
probably benign |
Het |
| Lrba |
A |
G |
3: 86,192,335 (GRCm39) |
N83S |
probably damaging |
Het |
| Lrp4 |
G |
T |
2: 91,316,231 (GRCm39) |
R783L |
probably benign |
Het |
| Lrrk2 |
T |
G |
15: 91,687,592 (GRCm39) |
I2227S |
probably benign |
Het |
| Lvrn |
T |
C |
18: 47,013,803 (GRCm39) |
L495P |
probably damaging |
Het |
| Macf1 |
T |
C |
4: 123,391,548 (GRCm39) |
N1077S |
probably damaging |
Het |
| Mboat1 |
A |
G |
13: 30,425,213 (GRCm39) |
T425A |
probably damaging |
Het |
| Mcam |
A |
G |
9: 44,047,863 (GRCm39) |
E36G |
probably damaging |
Het |
| Meis1 |
T |
A |
11: 18,966,308 (GRCm39) |
T22S |
probably benign |
Het |
| Micu1 |
A |
G |
10: 59,699,076 (GRCm39) |
K451R |
possibly damaging |
Het |
| Nat8 |
A |
T |
6: 85,807,505 (GRCm39) |
D209E |
probably benign |
Het |
| Nek10 |
T |
A |
14: 14,860,986 (GRCm38) |
L513M |
possibly damaging |
Het |
| Nmral1 |
G |
A |
16: 4,534,274 (GRCm39) |
R56* |
probably null |
Het |
| Ofcc1 |
G |
A |
13: 40,168,864 (GRCm39) |
T841I |
probably damaging |
Het |
| Or10j27 |
A |
G |
1: 172,958,526 (GRCm39) |
V86A |
probably benign |
Het |
| Or5b99 |
A |
T |
19: 12,977,195 (GRCm39) |
T282S |
probably benign |
Het |
| Or5g25 |
T |
C |
2: 85,477,916 (GRCm39) |
I250V |
probably benign |
Het |
| Or5h24 |
G |
A |
16: 58,919,340 (GRCm39) |
T5I |
probably damaging |
Het |
| Palm3 |
A |
T |
8: 84,753,708 (GRCm39) |
R132* |
probably null |
Het |
| Pax2 |
A |
G |
19: 44,804,479 (GRCm39) |
Y272C |
probably damaging |
Het |
| Phc2 |
G |
A |
4: 128,616,908 (GRCm39) |
A394T |
probably benign |
Het |
| Phf2 |
C |
A |
13: 48,961,198 (GRCm39) |
G831C |
unknown |
Het |
| Pik3c2b |
G |
A |
1: 133,027,453 (GRCm39) |
|
probably null |
Het |
| Plin2 |
T |
A |
4: 86,580,228 (GRCm39) |
I178F |
probably benign |
Het |
| Pramel32 |
A |
T |
4: 88,547,185 (GRCm39) |
L162H |
probably damaging |
Het |
| Prdm14 |
T |
A |
1: 13,192,855 (GRCm39) |
I295F |
probably damaging |
Het |
| Psmd5 |
C |
T |
2: 34,760,795 (GRCm39) |
R47H |
probably benign |
Het |
| Ptchd3 |
T |
A |
11: 121,733,342 (GRCm39) |
I744K |
probably damaging |
Het |
| Ptrh1 |
T |
A |
2: 32,666,557 (GRCm39) |
|
probably benign |
Het |
| Rab6a |
A |
G |
7: 100,277,627 (GRCm39) |
D49G |
probably damaging |
Het |
| Radil |
A |
T |
5: 142,470,994 (GRCm39) |
D1062E |
probably benign |
Het |
| Robo2 |
A |
G |
16: 74,149,726 (GRCm39) |
V34A |
possibly damaging |
Het |
| Sall3 |
G |
A |
18: 81,014,626 (GRCm39) |
P1029S |
probably benign |
Het |
| Sec14l3 |
A |
G |
11: 4,018,101 (GRCm39) |
D127G |
possibly damaging |
Het |
| Sel1l2 |
A |
G |
2: 140,086,086 (GRCm39) |
Y502H |
probably damaging |
Het |
| Serpina1f |
A |
G |
12: 103,656,010 (GRCm39) |
V406A |
probably damaging |
Het |
| Sf3b3 |
T |
C |
8: 111,540,301 (GRCm39) |
D1040G |
probably damaging |
Het |
| Sgcd |
A |
G |
11: 46,870,262 (GRCm39) |
I233T |
possibly damaging |
Het |
| Slc15a3 |
A |
G |
19: 10,820,410 (GRCm39) |
Q9R |
probably benign |
Het |
| Slc25a46 |
A |
G |
18: 31,716,336 (GRCm39) |
F389L |
probably damaging |
Het |
| Slc26a2 |
G |
T |
18: 61,331,330 (GRCm39) |
C700* |
probably null |
Het |
| Slc4a7 |
A |
G |
14: 14,771,283 (GRCm38) |
Y671C |
possibly damaging |
Het |
| Slc5a10 |
A |
T |
11: 61,610,708 (GRCm39) |
I22N |
probably damaging |
Het |
| Slc5a9 |
C |
A |
4: 111,748,941 (GRCm39) |
|
probably null |
Het |
| Slc6a12 |
A |
G |
6: 121,332,281 (GRCm39) |
D205G |
probably benign |
Het |
| Tas2r115 |
G |
A |
6: 132,714,124 (GRCm39) |
H276Y |
probably damaging |
Het |
| Tdpoz4 |
T |
A |
3: 93,704,318 (GRCm39) |
I205N |
probably damaging |
Het |
| Tfeb |
C |
T |
17: 48,096,904 (GRCm39) |
T33I |
probably benign |
Het |
| Tgm3 |
A |
G |
2: 129,890,240 (GRCm39) |
T668A |
probably benign |
Het |
| Tnpo3 |
A |
G |
6: 29,582,259 (GRCm39) |
V201A |
probably benign |
Het |
| Tpcn1 |
T |
A |
5: 120,694,596 (GRCm39) |
M158L |
probably benign |
Het |
| Trim47 |
A |
C |
11: 115,996,918 (GRCm39) |
L612R |
probably damaging |
Het |
| Trmt10c |
A |
T |
16: 55,854,438 (GRCm39) |
L399* |
probably null |
Het |
| Trpm2 |
A |
T |
10: 77,753,626 (GRCm39) |
S1293T |
probably benign |
Het |
| Ttn |
C |
T |
2: 76,582,941 (GRCm39) |
V22651I |
probably damaging |
Het |
| Tubgcp5 |
A |
G |
7: 55,455,871 (GRCm39) |
I300V |
probably benign |
Het |
| Uty |
T |
A |
Y: 1,136,883 (GRCm39) |
Q844L |
probably damaging |
Het |
| Vmn2r85 |
C |
T |
10: 130,254,990 (GRCm39) |
E565K |
probably damaging |
Het |
| Vmn2r97 |
T |
C |
17: 19,167,561 (GRCm39) |
V605A |
possibly damaging |
Het |
| Vwa3a |
T |
C |
7: 120,375,487 (GRCm39) |
V399A |
probably damaging |
Het |
| Wnk4 |
G |
A |
11: 101,159,107 (GRCm39) |
R508Q |
probably damaging |
Het |
| Zfp217 |
A |
G |
2: 169,961,130 (GRCm39) |
V399A |
probably damaging |
Het |
| Zfp616 |
T |
A |
11: 73,974,830 (GRCm39) |
N457K |
possibly damaging |
Het |
|
| Other mutations in Dock3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00940:Dock3
|
APN |
9 |
106,788,576 (GRCm39) |
splice site |
probably benign |
|
|
IGL01067:Dock3
|
APN |
9 |
106,959,572 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01160:Dock3
|
APN |
9 |
106,783,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01290:Dock3
|
APN |
9 |
106,835,599 (GRCm39) |
splice site |
probably benign |
|
|
IGL01291:Dock3
|
APN |
9 |
106,835,599 (GRCm39) |
splice site |
probably benign |
|
|
IGL01391:Dock3
|
APN |
9 |
106,784,433 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL01399:Dock3
|
APN |
9 |
106,870,670 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01660:Dock3
|
APN |
9 |
106,909,563 (GRCm39) |
splice site |
probably benign |
|
|
IGL01752:Dock3
|
APN |
9 |
106,902,512 (GRCm39) |
splice site |
probably benign |
|
|
IGL01820:Dock3
|
APN |
9 |
106,773,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01908:Dock3
|
APN |
9 |
106,783,861 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02191:Dock3
|
APN |
9 |
106,815,340 (GRCm39) |
missense |
probably benign |
|
|
IGL02227:Dock3
|
APN |
9 |
106,939,254 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02309:Dock3
|
APN |
9 |
106,790,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Dock3
|
APN |
9 |
106,790,298 (GRCm39) |
splice site |
probably benign |
|
|
IGL02469:Dock3
|
APN |
9 |
106,863,215 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02545:Dock3
|
APN |
9 |
106,939,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02894:Dock3
|
APN |
9 |
106,807,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02934:Dock3
|
APN |
9 |
106,900,944 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03027:Dock3
|
APN |
9 |
106,870,677 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03068:Dock3
|
APN |
9 |
106,841,958 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL03128:Dock3
|
APN |
9 |
106,909,491 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03161:Dock3
|
APN |
9 |
106,900,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03263:Dock3
|
APN |
9 |
106,807,330 (GRCm39) |
splice site |
probably benign |
|
|
IGL03279:Dock3
|
APN |
9 |
106,788,447 (GRCm39) |
splice site |
probably benign |
|
|
IGL03366:Dock3
|
APN |
9 |
106,882,632 (GRCm39) |
missense |
probably benign |
0.01 |
|
Implosion
|
UTSW |
9 |
106,815,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
Squeeze
|
UTSW |
9 |
106,807,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Tight
|
UTSW |
9 |
106,872,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
ANU05:Dock3
|
UTSW |
9 |
106,772,862 (GRCm39) |
missense |
probably benign |
|
|
R0025:Dock3
|
UTSW |
9 |
106,790,467 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0025:Dock3
|
UTSW |
9 |
106,790,467 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0030:Dock3
|
UTSW |
9 |
106,789,512 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0076:Dock3
|
UTSW |
9 |
106,788,685 (GRCm39) |
splice site |
probably benign |
|
|
R0076:Dock3
|
UTSW |
9 |
106,788,685 (GRCm39) |
splice site |
probably benign |
|
|
R0206:Dock3
|
UTSW |
9 |
106,874,195 (GRCm39) |
nonsense |
probably null |
|
|
R0208:Dock3
|
UTSW |
9 |
106,874,195 (GRCm39) |
nonsense |
probably null |
|
|
R0384:Dock3
|
UTSW |
9 |
106,779,094 (GRCm39) |
splice site |
probably benign |
|
|
R0610:Dock3
|
UTSW |
9 |
106,900,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0731:Dock3
|
UTSW |
9 |
106,847,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1184:Dock3
|
UTSW |
9 |
106,846,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1350:Dock3
|
UTSW |
9 |
106,791,831 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1393:Dock3
|
UTSW |
9 |
106,788,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1424:Dock3
|
UTSW |
9 |
106,790,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Dock3
|
UTSW |
9 |
106,832,908 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1469:Dock3
|
UTSW |
9 |
106,832,908 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1539:Dock3
|
UTSW |
9 |
106,874,112 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1539:Dock3
|
UTSW |
9 |
106,829,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1571:Dock3
|
UTSW |
9 |
106,815,158 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1682:Dock3
|
UTSW |
9 |
106,851,040 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1795:Dock3
|
UTSW |
9 |
106,902,534 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1987:Dock3
|
UTSW |
9 |
106,985,620 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2000:Dock3
|
UTSW |
9 |
106,870,160 (GRCm39) |
splice site |
probably benign |
|
|
R2074:Dock3
|
UTSW |
9 |
106,870,662 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R2114:Dock3
|
UTSW |
9 |
106,870,743 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2265:Dock3
|
UTSW |
9 |
106,818,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Dock3
|
UTSW |
9 |
106,818,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2370:Dock3
|
UTSW |
9 |
106,829,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2377:Dock3
|
UTSW |
9 |
106,773,090 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2385:Dock3
|
UTSW |
9 |
106,868,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Dock3
|
UTSW |
9 |
106,791,740 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R3076:Dock3
|
UTSW |
9 |
106,818,725 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3122:Dock3
|
UTSW |
9 |
106,788,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4052:Dock3
|
UTSW |
9 |
106,850,995 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4294:Dock3
|
UTSW |
9 |
106,807,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4623:Dock3
|
UTSW |
9 |
106,939,244 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4664:Dock3
|
UTSW |
9 |
106,870,743 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4705:Dock3
|
UTSW |
9 |
106,902,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Dock3
|
UTSW |
9 |
106,829,557 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4898:Dock3
|
UTSW |
9 |
106,870,171 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4898:Dock3
|
UTSW |
9 |
106,807,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4961:Dock3
|
UTSW |
9 |
106,818,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4986:Dock3
|
UTSW |
9 |
106,809,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5054:Dock3
|
UTSW |
9 |
106,815,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5065:Dock3
|
UTSW |
9 |
106,832,883 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5081:Dock3
|
UTSW |
9 |
106,868,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5101:Dock3
|
UTSW |
9 |
106,846,980 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5135:Dock3
|
UTSW |
9 |
106,810,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5227:Dock3
|
UTSW |
9 |
106,863,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5257:Dock3
|
UTSW |
9 |
106,874,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5258:Dock3
|
UTSW |
9 |
106,874,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5273:Dock3
|
UTSW |
9 |
106,777,904 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5322:Dock3
|
UTSW |
9 |
106,779,028 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5482:Dock3
|
UTSW |
9 |
106,855,937 (GRCm39) |
nonsense |
probably null |
|
|
R5553:Dock3
|
UTSW |
9 |
106,868,309 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5631:Dock3
|
UTSW |
9 |
106,832,898 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5739:Dock3
|
UTSW |
9 |
106,850,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5838:Dock3
|
UTSW |
9 |
106,772,687 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R5888:Dock3
|
UTSW |
9 |
106,901,002 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5960:Dock3
|
UTSW |
9 |
106,788,554 (GRCm39) |
nonsense |
probably null |
|
|
R5974:Dock3
|
UTSW |
9 |
106,871,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6116:Dock3
|
UTSW |
9 |
106,809,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6162:Dock3
|
UTSW |
9 |
106,841,998 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6176:Dock3
|
UTSW |
9 |
106,790,147 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6219:Dock3
|
UTSW |
9 |
106,872,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6238:Dock3
|
UTSW |
9 |
106,790,147 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6266:Dock3
|
UTSW |
9 |
106,841,952 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6291:Dock3
|
UTSW |
9 |
106,785,631 (GRCm39) |
missense |
probably benign |
|
|
R6531:Dock3
|
UTSW |
9 |
106,844,415 (GRCm39) |
missense |
probably benign |
|
|
R6567:Dock3
|
UTSW |
9 |
106,773,946 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6572:Dock3
|
UTSW |
9 |
106,866,674 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6620:Dock3
|
UTSW |
9 |
106,815,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6726:Dock3
|
UTSW |
9 |
107,036,651 (GRCm39) |
nonsense |
probably null |
|
|
R7085:Dock3
|
UTSW |
9 |
106,779,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7151:Dock3
|
UTSW |
9 |
106,841,916 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7320:Dock3
|
UTSW |
9 |
106,772,723 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7357:Dock3
|
UTSW |
9 |
106,882,568 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7423:Dock3
|
UTSW |
9 |
106,844,370 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7426:Dock3
|
UTSW |
9 |
106,772,782 (GRCm39) |
missense |
probably benign |
|
|
R7439:Dock3
|
UTSW |
9 |
106,900,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7452:Dock3
|
UTSW |
9 |
106,866,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7470:Dock3
|
UTSW |
9 |
106,882,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7879:Dock3
|
UTSW |
9 |
106,785,700 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8047:Dock3
|
UTSW |
9 |
106,870,208 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8308:Dock3
|
UTSW |
9 |
106,790,371 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8837:Dock3
|
UTSW |
9 |
106,774,539 (GRCm39) |
missense |
probably benign |
|
|
R8862:Dock3
|
UTSW |
9 |
106,855,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8952:Dock3
|
UTSW |
9 |
106,850,958 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9230:Dock3
|
UTSW |
9 |
106,807,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9269:Dock3
|
UTSW |
9 |
106,818,522 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9272:Dock3
|
UTSW |
9 |
106,774,569 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9344:Dock3
|
UTSW |
9 |
106,870,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9757:Dock3
|
UTSW |
9 |
106,901,035 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9764:Dock3
|
UTSW |
9 |
106,959,713 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9766:Dock3
|
UTSW |
9 |
106,788,483 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0023:Dock3
|
UTSW |
9 |
106,863,197 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGAAGCCTGGCTCTTTTCTAAG -3'
(R):5'- CTTAGCTAGGCAGAGACAGATAC -3'
Sequencing Primer
(F):5'- CCTGGCTCTTTTCTAAGGCTAGAAG -3'
(R):5'- GCAGAGACAGATACTAGATGTTTTTG -3'
|
| Posted On |
2016-04-27 |
Incidental Mutation