Incidental Mutation 'R4949:Vmn2r32'
ID 383665
Institutional Source Beutler Lab
Gene Symbol Vmn2r32
Ensembl Gene ENSMUSG00000096743
Gene Name vomeronasal 2, receptor 32
Synonyms V2r5
MMRRC Submission 042546-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.249) question?
Stock # R4949 (G1)
Quality Score 164
Status Not validated
Chromosome 7
Chromosomal Location 7466968-7482972 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 7467083 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 815 (I815T)
Ref Sequence ENSEMBL: ENSMUSP00000092462 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094866]
AlphaFold K7N686
Predicted Effect probably benign
Transcript: ENSMUST00000094866
AA Change: I815T

PolyPhen 2 Score 0.218 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000092462
Gene: ENSMUSG00000096743
AA Change: I815T

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 470 3.6e-33 PFAM
Pfam:NCD3G 512 565 8.1e-21 PFAM
Pfam:7tm_3 598 833 9.5e-55 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 91.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acox3 T C 5: 35,769,450 (GRCm39) V692A probably benign Het
Bcl2l13 G T 6: 120,864,191 (GRCm39) G382W probably damaging Het
Cdhr5 T A 7: 140,852,557 (GRCm39) N353I probably damaging Het
Chil4 A G 3: 106,113,408 (GRCm39) S170P possibly damaging Het
Clp1 A C 2: 84,554,086 (GRCm39) M361R possibly damaging Het
Cylc2 A G 4: 51,229,804 (GRCm39) K382R unknown Het
Dsg2 T A 18: 20,723,241 (GRCm39) D422E probably damaging Het
Dync1h1 C A 12: 110,624,560 (GRCm39) T3700N probably damaging Het
Gm14295 A C 2: 176,501,469 (GRCm39) T320P probably damaging Het
Ido2 T G 8: 25,023,970 (GRCm39) probably null Het
Ift140 T A 17: 25,313,639 (GRCm39) S1357T probably benign Het
Insr T G 8: 3,235,059 (GRCm39) E145A probably benign Het
Itpripl1 A G 2: 126,983,327 (GRCm39) M265T probably benign Het
Kcnb1 G T 2: 166,947,521 (GRCm39) N442K probably damaging Het
Kifc5b C A 17: 27,144,488 (GRCm39) R536S probably damaging Het
Klf6 A T 13: 5,914,947 (GRCm39) S129C probably benign Het
Lpin2 C G 17: 71,538,334 (GRCm39) P327A probably damaging Het
Lsm1 T C 8: 26,292,065 (GRCm39) V114A probably benign Het
Map7d1 C T 4: 126,128,846 (GRCm39) W218* probably null Het
N4bp2 T A 5: 65,979,142 (GRCm39) probably null Het
Nt5el T A 13: 105,246,214 (GRCm39) S258R probably damaging Het
Rheb A T 5: 25,008,729 (GRCm39) I163K possibly damaging Het
Rph3a T C 5: 121,101,897 (GRCm39) D113G probably damaging Het
Scn8a A G 15: 100,927,663 (GRCm39) N1381D probably damaging Het
Sdsl T A 5: 120,597,870 (GRCm39) N208Y possibly damaging Het
Serpinb9e A G 13: 33,435,591 (GRCm39) N8S possibly damaging Het
Sox18 G A 2: 181,313,017 (GRCm39) Q100* probably null Het
Taar8b C T 10: 23,967,825 (GRCm39) C123Y probably damaging Het
Tas2r124 A G 6: 132,731,858 (GRCm39) I56V possibly damaging Het
Tes C A 6: 17,100,359 (GRCm39) H331N probably benign Het
Tmbim1 T G 1: 74,334,524 (GRCm39) D12A probably damaging Het
Tmprss4 T C 9: 45,086,841 (GRCm39) I307V possibly damaging Het
Ttll1 A T 15: 83,386,374 (GRCm39) M77K probably null Het
Ttpal G A 2: 163,455,671 (GRCm39) R220Q probably damaging Het
Vmn1r230 T A 17: 21,067,625 (GRCm39) H271Q probably benign Het
Other mutations in Vmn2r32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02140:Vmn2r32 APN 7 7,479,696 (GRCm39) missense probably damaging 0.97
IGL02333:Vmn2r32 APN 7 7,467,143 (GRCm39) missense probably damaging 1.00
IGL02406:Vmn2r32 APN 7 7,479,709 (GRCm39) missense probably benign
IGL02428:Vmn2r32 APN 7 7,477,283 (GRCm39) missense probably benign 0.02
IGL02484:Vmn2r32 APN 7 7,467,116 (GRCm39) missense probably damaging 1.00
IGL03277:Vmn2r32 APN 7 7,477,251 (GRCm39) missense probably benign 0.23
IGL03366:Vmn2r32 APN 7 7,467,029 (GRCm39) missense probably damaging 0.99
R1055:Vmn2r32 UTSW 7 7,477,326 (GRCm39) nonsense probably null
R1695:Vmn2r32 UTSW 7 7,466,991 (GRCm39) missense probably benign 0.01
R2172:Vmn2r32 UTSW 7 7,477,614 (GRCm39) missense probably damaging 0.99
R2262:Vmn2r32 UTSW 7 7,477,618 (GRCm39) missense probably benign
R3150:Vmn2r32 UTSW 7 7,475,554 (GRCm39) missense probably benign
R4362:Vmn2r32 UTSW 7 7,482,857 (GRCm39) nonsense probably null
R4432:Vmn2r32 UTSW 7 7,482,918 (GRCm39) missense probably damaging 0.98
R4851:Vmn2r32 UTSW 7 7,482,953 (GRCm39) missense possibly damaging 0.59
R5990:Vmn2r32 UTSW 7 7,482,809 (GRCm39) missense probably damaging 0.97
R6083:Vmn2r32 UTSW 7 7,467,209 (GRCm39) missense probably benign 0.15
R6084:Vmn2r32 UTSW 7 7,467,209 (GRCm39) missense probably benign 0.15
R6116:Vmn2r32 UTSW 7 7,467,092 (GRCm39) missense probably damaging 1.00
R6263:Vmn2r32 UTSW 7 7,479,691 (GRCm39) missense possibly damaging 0.90
R6889:Vmn2r32 UTSW 7 7,475,573 (GRCm39) missense possibly damaging 0.82
R7286:Vmn2r32 UTSW 7 7,482,807 (GRCm39) missense probably benign 0.21
R7390:Vmn2r32 UTSW 7 7,482,851 (GRCm39) missense probably benign 0.00
R7412:Vmn2r32 UTSW 7 7,477,212 (GRCm39) missense possibly damaging 0.53
R7508:Vmn2r32 UTSW 7 7,470,373 (GRCm39) missense possibly damaging 0.87
R8812:Vmn2r32 UTSW 7 7,477,669 (GRCm39) missense probably damaging 1.00
R8968:Vmn2r32 UTSW 7 7,477,204 (GRCm39) missense probably benign 0.00
R9331:Vmn2r32 UTSW 7 7,467,402 (GRCm39) nonsense probably null
R9358:Vmn2r32 UTSW 7 7,477,197 (GRCm39) missense probably damaging 1.00
Z1177:Vmn2r32 UTSW 7 7,477,160 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TTTTATCACTAGAGCAACCAGTGAG -3'
(R):5'- CACTGGGAAGCTTCACTTTGG -3'

Sequencing Primer
(F):5'- CTAGAGCAACCAGTGAGAGTGATTC -3'
(R):5'- GGAAGCTTCACTTTGGCTTTC -3'
Posted On 2016-04-27