Incidental Mutation 'R4963:Tpp2'
| ID |
383690 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tpp2
|
| Ensembl Gene |
ENSMUSG00000041763 |
| Gene Name |
tripeptidyl peptidase II |
| Synonyms |
TppII |
| MMRRC Submission |
042560-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.589)
|
| Stock # |
R4963 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
43973130-44042160 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 44031428 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Glutamine
at position 1069
(R1069Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139918
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087933]
[ENSMUST00000188302]
[ENSMUST00000188313]
[ENSMUST00000189388]
[ENSMUST00000190207]
|
| AlphaFold |
Q64514 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000087933
AA Change: R1082Q
PolyPhen 2
Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000085244
Gene: ENSMUSG00000041763
AA Change: R1082Q
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
35 |
500 |
1.4e-96 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
777 |
964 |
2.4e-80 |
PFAM |
|
low complexity region
|
1017 |
1033 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1034 |
1262 |
1e-20 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000188302
|
| SMART Domains |
Protein: ENSMUSP00000140474
Gene: ENSMUSG00000041763
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
4.3e-84 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000188313
AA Change: R1069Q
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000139918
Gene: ENSMUSG00000041763
AA Change: R1069Q
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
5.1e-83 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
966 |
2.7e-93 |
PFAM |
|
low complexity region
|
1004 |
1020 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1021 |
1249 |
1e-20 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189388
|
| SMART Domains |
Protein: ENSMUSP00000140562
Gene: ENSMUSG00000041763
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
2.3e-81 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
880 |
7.8e-49 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000190207
AA Change: R135Q
PolyPhen 2
Score 0.781 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000140313
Gene: ENSMUSG00000041763
AA Change: R135Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
70 |
86 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
87 |
281 |
3e-19 |
PDB |
|
| Meta Mutation Damage Score |
0.0652 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.3%
|
| Validation Efficiency |
97% (74/76) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
PHENOTYPE: Engineered mutations of this gene result in decreased lifespan and symptoms of immunohematopoietic senescence. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A530064D06Rik |
A |
T |
17: 48,470,582 (GRCm39) |
I133N |
probably benign |
Het |
| Abca15 |
T |
C |
7: 119,960,142 (GRCm39) |
S642P |
probably damaging |
Het |
| Abcg5 |
G |
T |
17: 84,967,569 (GRCm39) |
Y410* |
probably null |
Het |
| Anapc7 |
T |
A |
5: 122,560,669 (GRCm39) |
M10K |
probably damaging |
Het |
| Ank2 |
G |
A |
3: 126,825,745 (GRCm39) |
T418M |
probably benign |
Het |
| Arhgap17 |
T |
C |
7: 122,907,583 (GRCm39) |
R260G |
possibly damaging |
Het |
| Atp1a3 |
T |
C |
7: 24,694,051 (GRCm39) |
T381A |
probably damaging |
Het |
| Cep89 |
T |
G |
7: 35,102,577 (GRCm39) |
S97A |
probably benign |
Het |
| Cyp2j11 |
T |
C |
4: 96,204,619 (GRCm39) |
D309G |
probably damaging |
Het |
| Dcbld2 |
T |
C |
16: 58,286,145 (GRCm39) |
I768T |
probably benign |
Het |
| Defa41 |
C |
T |
8: 21,691,774 (GRCm39) |
S52F |
probably damaging |
Het |
| Dgke |
A |
G |
11: 88,941,628 (GRCm39) |
V249A |
possibly damaging |
Het |
| Dnah9 |
T |
C |
11: 65,975,437 (GRCm39) |
|
probably null |
Het |
| Dnajc3 |
C |
A |
14: 119,215,585 (GRCm39) |
H502N |
probably benign |
Het |
| Dsp |
A |
G |
13: 38,381,846 (GRCm39) |
T2265A |
probably damaging |
Het |
| Enpp6 |
A |
G |
8: 47,518,496 (GRCm39) |
D208G |
probably benign |
Het |
| Evc |
C |
T |
5: 37,479,393 (GRCm39) |
|
probably null |
Het |
| Fam98a |
A |
G |
17: 75,845,977 (GRCm39) |
S285P |
probably damaging |
Het |
| Glp2r |
G |
T |
11: 67,648,419 (GRCm39) |
Y94* |
probably null |
Het |
| Gsdmc |
A |
G |
15: 63,676,229 (GRCm39) |
|
probably null |
Het |
| Gtpbp4 |
C |
A |
13: 9,035,253 (GRCm39) |
D369Y |
probably damaging |
Het |
| H2-M1 |
A |
G |
17: 36,982,630 (GRCm39) |
Y77H |
probably benign |
Het |
| Irx2 |
T |
C |
13: 72,780,729 (GRCm39) |
V466A |
possibly damaging |
Het |
| Kcnh4 |
C |
A |
11: 100,643,079 (GRCm39) |
W396L |
probably damaging |
Het |
| Kif27 |
T |
C |
13: 58,476,808 (GRCm39) |
D614G |
possibly damaging |
Het |
| Kirrel2 |
C |
A |
7: 30,150,226 (GRCm39) |
|
probably null |
Het |
| Lcn5 |
A |
G |
2: 25,551,426 (GRCm39) |
I182V |
probably benign |
Het |
| Ldb3 |
T |
G |
14: 34,288,815 (GRCm39) |
S252R |
probably damaging |
Het |
| Marchf8 |
G |
A |
6: 116,363,232 (GRCm39) |
|
probably benign |
Het |
| Mdn1 |
C |
A |
4: 32,756,512 (GRCm39) |
Q4735K |
probably benign |
Het |
| Mfrp |
A |
T |
9: 44,014,561 (GRCm39) |
H236L |
probably benign |
Het |
| Mlph |
A |
G |
1: 90,867,112 (GRCm39) |
D378G |
probably damaging |
Het |
| Msi1 |
T |
A |
5: 115,588,944 (GRCm39) |
Y320N |
probably damaging |
Het |
| Mtmr11 |
T |
C |
3: 96,070,567 (GRCm39) |
|
probably benign |
Het |
| Mtpap |
T |
C |
18: 4,375,638 (GRCm39) |
V6A |
probably benign |
Het |
| Nedd1 |
C |
A |
10: 92,530,893 (GRCm39) |
D399Y |
probably damaging |
Het |
| Ninl |
A |
G |
2: 150,781,829 (GRCm39) |
Y234H |
probably benign |
Het |
| Nkx3-1 |
G |
A |
14: 69,428,367 (GRCm39) |
G72S |
probably benign |
Het |
| Nle1 |
A |
G |
11: 82,795,763 (GRCm39) |
V228A |
probably benign |
Het |
| Npy4r |
T |
A |
14: 33,868,973 (GRCm39) |
D105V |
probably damaging |
Het |
| Or1f12 |
A |
G |
13: 21,722,152 (GRCm39) |
Y8H |
probably damaging |
Het |
| Palld |
C |
T |
8: 62,156,244 (GRCm39) |
V464M |
probably damaging |
Het |
| Pclo |
T |
C |
5: 14,719,235 (GRCm39) |
V1124A |
unknown |
Het |
| Pex1 |
T |
A |
5: 3,659,924 (GRCm39) |
M476K |
probably benign |
Het |
| Pkhd1l1 |
G |
A |
15: 44,367,421 (GRCm39) |
S773N |
probably benign |
Het |
| Polrmt |
A |
G |
10: 79,582,385 (GRCm39) |
M1T |
probably null |
Het |
| Prmt9 |
A |
G |
8: 78,282,358 (GRCm39) |
D85G |
probably damaging |
Het |
| Ptpn12 |
T |
A |
5: 21,220,706 (GRCm39) |
|
probably null |
Het |
| Rbm19 |
T |
A |
5: 120,279,631 (GRCm39) |
M766K |
probably damaging |
Het |
| Rdh11 |
A |
G |
12: 79,235,380 (GRCm39) |
V72A |
probably benign |
Het |
| Rxfp3 |
A |
G |
15: 11,036,367 (GRCm39) |
V335A |
probably damaging |
Het |
| Sema6a |
T |
C |
18: 47,431,318 (GRCm39) |
K127E |
possibly damaging |
Het |
| Slc5a1 |
C |
T |
5: 33,318,126 (GRCm39) |
T593I |
probably benign |
Het |
| Slco1a1 |
A |
G |
6: 141,868,825 (GRCm39) |
F380L |
probably benign |
Het |
| Smc2 |
T |
C |
4: 52,450,826 (GRCm39) |
S215P |
probably damaging |
Het |
| Smyd2 |
A |
T |
1: 189,614,385 (GRCm39) |
V381E |
probably damaging |
Het |
| Smyd4 |
C |
T |
11: 75,273,120 (GRCm39) |
S60L |
probably benign |
Het |
| Spata18 |
T |
A |
5: 73,836,336 (GRCm39) |
V419E |
probably damaging |
Het |
| Terb1 |
A |
G |
8: 105,208,950 (GRCm39) |
L376S |
probably damaging |
Het |
| Timd2 |
T |
C |
11: 46,573,617 (GRCm39) |
E129G |
possibly damaging |
Het |
| Topbp1 |
C |
A |
9: 103,197,804 (GRCm39) |
T461K |
probably benign |
Het |
| Ttn |
A |
G |
2: 76,584,289 (GRCm39) |
V22273A |
probably damaging |
Het |
| Tulp4 |
G |
A |
17: 6,249,088 (GRCm39) |
E36K |
probably damaging |
Het |
| Uqcrfs1 |
A |
T |
13: 30,724,746 (GRCm39) |
F265I |
probably damaging |
Het |
| Vmn2r107 |
A |
T |
17: 20,595,403 (GRCm39) |
Q652L |
probably damaging |
Het |
| Vwf |
C |
T |
6: 125,644,446 (GRCm39) |
R2434* |
probably null |
Het |
| Wdhd1 |
A |
G |
14: 47,506,146 (GRCm39) |
V256A |
possibly damaging |
Het |
| Zfp442 |
A |
T |
2: 150,250,415 (GRCm39) |
C439S |
probably damaging |
Het |
| Zfp709 |
A |
G |
8: 72,643,632 (GRCm39) |
T354A |
probably benign |
Het |
| Zswim2 |
A |
T |
2: 83,755,454 (GRCm39) |
I149N |
probably damaging |
Het |
|
| Other mutations in Tpp2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00977:Tpp2
|
APN |
1 |
44,022,451 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01021:Tpp2
|
APN |
1 |
43,973,347 (GRCm39) |
nonsense |
probably null |
|
|
IGL01096:Tpp2
|
APN |
1 |
44,000,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01344:Tpp2
|
APN |
1 |
44,022,422 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01642:Tpp2
|
APN |
1 |
43,993,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02719:Tpp2
|
APN |
1 |
43,979,391 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02890:Tpp2
|
APN |
1 |
44,038,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03102:Tpp2
|
APN |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03175:Tpp2
|
APN |
1 |
44,012,671 (GRCm39) |
missense |
probably benign |
0.35 |
|
beaver
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
|
billingsly
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
cleaver
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
|
dow
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
|
Eddie
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
jerry
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
|
June
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
landers
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
mathers
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
recurrentis
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
|
state
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
wally
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
Ward
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
wilson
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
BB010:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB020:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0001:Tpp2
|
UTSW |
1 |
44,010,886 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0003:Tpp2
|
UTSW |
1 |
43,999,299 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Tpp2
|
UTSW |
1 |
44,020,908 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0110:Tpp2
|
UTSW |
1 |
44,017,664 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0110:Tpp2
|
UTSW |
1 |
44,038,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0167:Tpp2
|
UTSW |
1 |
44,009,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0441:Tpp2
|
UTSW |
1 |
44,029,722 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0520:Tpp2
|
UTSW |
1 |
44,029,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0639:Tpp2
|
UTSW |
1 |
44,014,607 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1118:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1119:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1593:Tpp2
|
UTSW |
1 |
44,014,593 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1702:Tpp2
|
UTSW |
1 |
44,029,708 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1756:Tpp2
|
UTSW |
1 |
44,017,885 (GRCm39) |
splice site |
probably null |
|
|
R2066:Tpp2
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R2171:Tpp2
|
UTSW |
1 |
43,996,606 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2378:Tpp2
|
UTSW |
1 |
44,038,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2394:Tpp2
|
UTSW |
1 |
44,022,346 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2507:Tpp2
|
UTSW |
1 |
44,040,609 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2879:Tpp2
|
UTSW |
1 |
44,010,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3436:Tpp2
|
UTSW |
1 |
43,979,304 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4106:Tpp2
|
UTSW |
1 |
44,040,617 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4658:Tpp2
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4760:Tpp2
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5049:Tpp2
|
UTSW |
1 |
44,040,633 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5073:Tpp2
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6010:Tpp2
|
UTSW |
1 |
43,990,373 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6118:Tpp2
|
UTSW |
1 |
43,979,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6155:Tpp2
|
UTSW |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6169:Tpp2
|
UTSW |
1 |
44,022,739 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6236:Tpp2
|
UTSW |
1 |
44,016,477 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6695:Tpp2
|
UTSW |
1 |
44,022,436 (GRCm39) |
missense |
probably benign |
|
|
R6845:Tpp2
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
|
R7054:Tpp2
|
UTSW |
1 |
44,022,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7094:Tpp2
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7223:Tpp2
|
UTSW |
1 |
44,008,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7316:Tpp2
|
UTSW |
1 |
44,009,591 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7324:Tpp2
|
UTSW |
1 |
44,017,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7363:Tpp2
|
UTSW |
1 |
44,024,582 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7454:Tpp2
|
UTSW |
1 |
43,993,819 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7496:Tpp2
|
UTSW |
1 |
44,022,677 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7699:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
|
R7700:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
|
R7804:Tpp2
|
UTSW |
1 |
44,022,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7933:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7979:Tpp2
|
UTSW |
1 |
43,979,297 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8032:Tpp2
|
UTSW |
1 |
44,014,628 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8101:Tpp2
|
UTSW |
1 |
44,009,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8245:Tpp2
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8314:Tpp2
|
UTSW |
1 |
43,973,387 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8518:Tpp2
|
UTSW |
1 |
44,019,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8519:Tpp2
|
UTSW |
1 |
44,016,365 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8529:Tpp2
|
UTSW |
1 |
44,022,300 (GRCm39) |
missense |
probably benign |
|
|
R8756:Tpp2
|
UTSW |
1 |
43,999,295 (GRCm39) |
nonsense |
probably null |
|
|
R8765:Tpp2
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8773:Tpp2
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
|
R8915:Tpp2
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9049:Tpp2
|
UTSW |
1 |
43,992,502 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9090:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9176:Tpp2
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
|
R9214:Tpp2
|
UTSW |
1 |
44,031,514 (GRCm39) |
missense |
probably benign |
|
|
R9271:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9316:Tpp2
|
UTSW |
1 |
44,017,604 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9371:Tpp2
|
UTSW |
1 |
43,999,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9422:Tpp2
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9488:Tpp2
|
UTSW |
1 |
44,041,272 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9513:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9514:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9516:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAGGTCTCTCAAAAGCAGTTTG -3'
(R):5'- GGGACTTTTGGGATAGCATTAGAAATG -3'
Sequencing Primer
(F):5'- AAATGAGGATTTGGGGGAATTTTAC -3'
(R):5'- GGGTCAGTCTTCATTGCA -3'
|
| Posted On |
2016-04-27 |
Incidental Mutation