Incidental Mutation 'R4965:Nav2'
| ID |
383908 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nav2
|
| Ensembl Gene |
ENSMUSG00000052512 |
| Gene Name |
neuron navigator 2 |
| Synonyms |
Rainb1, HELAD1, Unc53H2, RAINB2, 5330421F07Rik, POMFIL2 |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.483)
|
| Stock # |
R4965 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
48908716-49610090 bp(+) (GRCm38) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 49552877 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Stop codon
at position 1470
(R1470*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139045
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000064395]
[ENSMUST00000183659]
[ENSMUST00000184109]
[ENSMUST00000184945]
|
| AlphaFold |
E9Q842 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000064395
AA Change: R1470*
|
| SMART Domains |
Protein: ENSMUSP00000067448
Gene: ENSMUSG00000052512
AA Change: R1470*
| Domain | Start | End | E-Value | Type |
|---|
|
CH
|
84 |
187 |
1.58e-13 |
SMART |
|
low complexity region
|
202 |
210 |
N/A |
INTRINSIC |
|
low complexity region
|
297 |
310 |
N/A |
INTRINSIC |
|
low complexity region
|
337 |
348 |
N/A |
INTRINSIC |
|
low complexity region
|
412 |
424 |
N/A |
INTRINSIC |
|
coiled coil region
|
486 |
516 |
N/A |
INTRINSIC |
|
low complexity region
|
580 |
591 |
N/A |
INTRINSIC |
|
low complexity region
|
613 |
625 |
N/A |
INTRINSIC |
|
low complexity region
|
640 |
662 |
N/A |
INTRINSIC |
|
low complexity region
|
846 |
857 |
N/A |
INTRINSIC |
|
low complexity region
|
920 |
944 |
N/A |
INTRINSIC |
|
low complexity region
|
947 |
967 |
N/A |
INTRINSIC |
|
low complexity region
|
990 |
1004 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1074 |
N/A |
INTRINSIC |
|
low complexity region
|
1343 |
1360 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1385 |
N/A |
INTRINSIC |
|
low complexity region
|
1417 |
1432 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1526 |
1540 |
N/A |
INTRINSIC |
|
low complexity region
|
1614 |
1628 |
N/A |
INTRINSIC |
|
coiled coil region
|
1630 |
1717 |
N/A |
INTRINSIC |
|
low complexity region
|
1789 |
1800 |
N/A |
INTRINSIC |
|
coiled coil region
|
1841 |
1909 |
N/A |
INTRINSIC |
|
AAA
|
2093 |
2247 |
1.69e-5 |
SMART |
|
low complexity region
|
2404 |
2430 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000183659
AA Change: R1409*
|
| SMART Domains |
Protein: ENSMUSP00000139309
Gene: ENSMUSG00000052512
AA Change: R1409*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
11 |
N/A |
INTRINSIC |
|
CH
|
23 |
126 |
6.19e-16 |
SMART |
|
low complexity region
|
141 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
236 |
249 |
N/A |
INTRINSIC |
|
low complexity region
|
276 |
287 |
N/A |
INTRINSIC |
|
low complexity region
|
351 |
363 |
N/A |
INTRINSIC |
|
coiled coil region
|
425 |
455 |
N/A |
INTRINSIC |
|
low complexity region
|
519 |
530 |
N/A |
INTRINSIC |
|
low complexity region
|
552 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
579 |
601 |
N/A |
INTRINSIC |
|
low complexity region
|
785 |
796 |
N/A |
INTRINSIC |
|
low complexity region
|
859 |
883 |
N/A |
INTRINSIC |
|
low complexity region
|
886 |
906 |
N/A |
INTRINSIC |
|
low complexity region
|
929 |
943 |
N/A |
INTRINSIC |
|
low complexity region
|
1001 |
1013 |
N/A |
INTRINSIC |
|
low complexity region
|
1282 |
1299 |
N/A |
INTRINSIC |
|
low complexity region
|
1307 |
1324 |
N/A |
INTRINSIC |
|
low complexity region
|
1356 |
1371 |
N/A |
INTRINSIC |
|
low complexity region
|
1393 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1465 |
1479 |
N/A |
INTRINSIC |
|
low complexity region
|
1553 |
1567 |
N/A |
INTRINSIC |
|
coiled coil region
|
1569 |
1656 |
N/A |
INTRINSIC |
|
low complexity region
|
1728 |
1739 |
N/A |
INTRINSIC |
|
coiled coil region
|
1780 |
1848 |
N/A |
INTRINSIC |
|
AAA
|
2032 |
2186 |
1.69e-5 |
SMART |
|
low complexity region
|
2343 |
2369 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000184109
|
| SMART Domains |
Protein: ENSMUSP00000138846
Gene: ENSMUSG00000052512
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
154 |
171 |
N/A |
INTRINSIC |
|
low complexity region
|
179 |
196 |
N/A |
INTRINSIC |
|
low complexity region
|
228 |
243 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000184544
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000184945
AA Change: R1470*
|
| SMART Domains |
Protein: ENSMUSP00000139045
Gene: ENSMUSG00000052512
AA Change: R1470*
| Domain | Start | End | E-Value | Type |
|---|
|
CH
|
84 |
187 |
1.58e-13 |
SMART |
|
low complexity region
|
202 |
210 |
N/A |
INTRINSIC |
|
low complexity region
|
297 |
310 |
N/A |
INTRINSIC |
|
low complexity region
|
337 |
348 |
N/A |
INTRINSIC |
|
low complexity region
|
412 |
424 |
N/A |
INTRINSIC |
|
coiled coil region
|
486 |
516 |
N/A |
INTRINSIC |
|
low complexity region
|
580 |
591 |
N/A |
INTRINSIC |
|
low complexity region
|
613 |
625 |
N/A |
INTRINSIC |
|
low complexity region
|
640 |
662 |
N/A |
INTRINSIC |
|
low complexity region
|
846 |
857 |
N/A |
INTRINSIC |
|
low complexity region
|
920 |
944 |
N/A |
INTRINSIC |
|
low complexity region
|
947 |
967 |
N/A |
INTRINSIC |
|
low complexity region
|
990 |
1004 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1074 |
N/A |
INTRINSIC |
|
low complexity region
|
1343 |
1360 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1385 |
N/A |
INTRINSIC |
|
low complexity region
|
1417 |
1432 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1526 |
1540 |
N/A |
INTRINSIC |
|
low complexity region
|
1614 |
1628 |
N/A |
INTRINSIC |
|
coiled coil region
|
1630 |
1717 |
N/A |
INTRINSIC |
|
low complexity region
|
1789 |
1800 |
N/A |
INTRINSIC |
|
coiled coil region
|
1841 |
1909 |
N/A |
INTRINSIC |
|
AAA
|
2093 |
2247 |
1.69e-5 |
SMART |
|
low complexity region
|
2404 |
2430 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.2%
- 10x: 95.7%
- 20x: 90.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous null mice display impaired olfaction and hearing, increased latency in a hot plate test, degeneration of the optic nerve, decreased exploration in new environments, and weight loss. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 117 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
A |
G |
3: 138,069,672 (GRCm38) |
T1541A |
probably benign |
Het |
| 2810474O19Rik |
G |
T |
6: 149,328,398 (GRCm38) |
G981* |
probably null |
Het |
| 4931423N10Rik |
C |
A |
2: 23,245,115 (GRCm38) |
T312K |
probably benign |
Het |
| 9530002B09Rik |
T |
C |
4: 122,700,492 (GRCm38) |
M59T |
probably benign |
Het |
| Adam18 |
C |
T |
8: 24,641,811 (GRCm38) |
C428Y |
probably damaging |
Het |
| Adcy5 |
A |
G |
16: 35,278,502 (GRCm38) |
E700G |
possibly damaging |
Het |
| Adprh |
G |
T |
16: 38,445,780 (GRCm38) |
Y333* |
probably null |
Het |
| Agfg2 |
C |
A |
5: 137,667,177 (GRCm38) |
|
probably null |
Het |
| Akip1 |
A |
T |
7: 109,711,754 (GRCm38) |
E167V |
probably damaging |
Het |
| Akr1c21 |
A |
T |
13: 4,580,305 (GRCm38) |
Q199L |
probably damaging |
Het |
| Aldh9a1 |
C |
A |
1: 167,365,789 (GRCm38) |
A455E |
probably damaging |
Het |
| Amph |
G |
A |
13: 19,137,699 (GRCm38) |
S520N |
probably benign |
Het |
| Ankrd52 |
A |
G |
10: 128,390,507 (GRCm38) |
D1006G |
probably benign |
Het |
| Ap5z1 |
A |
C |
5: 142,467,676 (GRCm38) |
Q133P |
probably damaging |
Het |
| Babam1 |
C |
T |
8: 71,404,388 (GRCm38) |
A331V |
possibly damaging |
Het |
| Btc |
T |
C |
5: 91,362,301 (GRCm38) |
|
probably null |
Het |
| Cacna2d3 |
A |
G |
14: 28,982,332 (GRCm38) |
F831L |
probably benign |
Het |
| Cadm3 |
G |
A |
1: 173,337,097 (GRCm38) |
P372L |
probably damaging |
Het |
| Capn5 |
A |
T |
7: 98,126,417 (GRCm38) |
M439K |
probably damaging |
Het |
| Carf |
T |
C |
1: 60,150,637 (GRCm38) |
S639P |
probably damaging |
Het |
| Casp12 |
C |
T |
9: 5,352,250 (GRCm38) |
R81C |
probably benign |
Het |
| Ces2e |
G |
T |
8: 104,933,698 (GRCm38) |
R555M |
probably benign |
Het |
| Cfap54 |
T |
A |
10: 93,066,799 (GRCm38) |
I164F |
probably benign |
Het |
| Cltc |
C |
T |
11: 86,707,501 (GRCm38) |
V1012I |
probably damaging |
Het |
| Cmya5 |
G |
A |
13: 93,095,787 (GRCm38) |
T931I |
possibly damaging |
Het |
| Cntn6 |
A |
G |
6: 104,774,474 (GRCm38) |
I364V |
probably damaging |
Het |
| Cntnap1 |
A |
T |
11: 101,177,425 (GRCm38) |
I59F |
possibly damaging |
Het |
| Cop1 |
T |
C |
1: 159,239,597 (GRCm38) |
M80T |
probably damaging |
Het |
| Cplx2 |
A |
G |
13: 54,379,647 (GRCm38) |
S115G |
possibly damaging |
Het |
| Crtac1 |
A |
G |
19: 42,318,740 (GRCm38) |
Y195H |
probably damaging |
Het |
| Csn1s2a |
A |
C |
5: 87,781,838 (GRCm38) |
S99R |
possibly damaging |
Het |
| Csn1s2b |
T |
A |
5: 87,813,961 (GRCm38) |
D41E |
possibly damaging |
Het |
| Cul9 |
C |
T |
17: 46,538,525 (GRCm38) |
D565N |
probably damaging |
Het |
| Cux1 |
A |
T |
5: 136,311,556 (GRCm38) |
N625K |
possibly damaging |
Het |
| Cyp2c37 |
A |
T |
19: 40,011,762 (GRCm38) |
M443L |
possibly damaging |
Het |
| Cyp2s1 |
G |
A |
7: 25,809,285 (GRCm38) |
T244I |
possibly damaging |
Het |
| Dgkh |
C |
T |
14: 78,624,421 (GRCm38) |
V135M |
probably damaging |
Het |
| Dtl |
T |
C |
1: 191,546,565 (GRCm38) |
E395G |
possibly damaging |
Het |
| Dyrk1a |
G |
T |
16: 94,691,995 (GRCm38) |
G658* |
probably null |
Het |
| Erlin2 |
T |
C |
8: 27,029,595 (GRCm38) |
F117S |
probably damaging |
Het |
| Fkbp8 |
A |
G |
8: 70,531,523 (GRCm38) |
|
probably null |
Het |
| Fras1 |
T |
C |
5: 96,726,580 (GRCm38) |
F2288S |
possibly damaging |
Het |
| Frmd3 |
A |
G |
4: 74,153,600 (GRCm38) |
T240A |
probably damaging |
Het |
| H2-D1 |
A |
G |
17: 35,263,905 (GRCm38) |
Y137C |
probably damaging |
Het |
| Helz2 |
A |
G |
2: 181,240,916 (GRCm38) |
V28A |
possibly damaging |
Het |
| Hydin |
A |
G |
8: 110,398,095 (GRCm38) |
I579V |
probably benign |
Het |
| Il6 |
A |
T |
5: 30,013,493 (GRCm38) |
Y29F |
possibly damaging |
Het |
| Ildr2 |
A |
G |
1: 166,307,840 (GRCm38) |
D368G |
probably damaging |
Het |
| Junb |
T |
A |
8: 84,978,159 (GRCm38) |
I91F |
probably damaging |
Het |
| Kat2a |
A |
T |
11: 100,712,204 (GRCm38) |
|
probably benign |
Het |
| Kat2a |
C |
A |
11: 100,712,203 (GRCm38) |
|
probably benign |
Het |
| Kcnh5 |
T |
A |
12: 74,965,151 (GRCm38) |
T665S |
probably benign |
Het |
| Kdm1b |
A |
T |
13: 47,074,367 (GRCm38) |
D608V |
probably damaging |
Het |
| Krcc1 |
A |
G |
6: 71,284,637 (GRCm38) |
K218E |
probably damaging |
Het |
| Krt8 |
C |
T |
15: 101,996,951 (GRCm38) |
V488M |
probably benign |
Het |
| Lzts1 |
C |
T |
8: 69,138,762 (GRCm38) |
A245T |
probably benign |
Het |
| Mcm6 |
T |
A |
1: 128,359,486 (GRCm38) |
Q27L |
probably damaging |
Het |
| Mfsd4b3 |
G |
T |
10: 39,947,690 (GRCm38) |
Y191* |
probably null |
Het |
| Mgme1 |
C |
T |
2: 144,276,404 (GRCm38) |
Q199* |
probably null |
Het |
| Mgme1 |
T |
C |
2: 144,279,620 (GRCm38) |
L332P |
probably benign |
Het |
| Morc3 |
G |
T |
16: 93,860,587 (GRCm38) |
E25* |
probably null |
Het |
| Mroh7 |
G |
A |
4: 106,690,987 (GRCm38) |
A1098V |
possibly damaging |
Het |
| Mtrf1 |
G |
A |
14: 79,406,587 (GRCm38) |
R174H |
probably benign |
Het |
| Mybpc3 |
G |
A |
2: 91,119,247 (GRCm38) |
G45D |
possibly damaging |
Het |
| Mycbpap |
A |
T |
11: 94,504,938 (GRCm38) |
N733K |
probably damaging |
Het |
| N4bp1 |
T |
C |
8: 86,851,686 (GRCm38) |
I684V |
possibly damaging |
Het |
| Ndufa9 |
A |
T |
6: 126,822,063 (GRCm38) |
S364T |
probably benign |
Het |
| Nipal4 |
C |
A |
11: 46,162,010 (GRCm38) |
A43S |
possibly damaging |
Het |
| Nlrp1a |
T |
A |
11: 71,092,315 (GRCm38) |
Y1275F |
possibly damaging |
Het |
| Nova1 |
A |
T |
12: 46,720,835 (GRCm38) |
L8* |
probably null |
Het |
| Odam |
G |
T |
5: 87,890,108 (GRCm38) |
G181* |
probably null |
Het |
| Olfr1111 |
T |
A |
2: 87,150,659 (GRCm38) |
M1L |
possibly damaging |
Het |
| Olfr1297 |
T |
C |
2: 111,621,534 (GRCm38) |
D180G |
probably damaging |
Het |
| Olfr15 |
T |
C |
16: 3,839,570 (GRCm38) |
L199P |
probably damaging |
Het |
| Olfr186 |
A |
T |
16: 59,027,333 (GRCm38) |
D191E |
probably damaging |
Het |
| Olfr283 |
T |
C |
15: 98,379,149 (GRCm38) |
|
probably benign |
Het |
| Olfr33 |
A |
T |
7: 102,713,495 (GRCm38) |
I306N |
probably damaging |
Het |
| Olfr723 |
C |
T |
14: 49,928,897 (GRCm38) |
V216I |
probably benign |
Het |
| Optn |
T |
A |
2: 5,021,379 (GRCm38) |
Q576L |
probably benign |
Het |
| Patl2 |
G |
T |
2: 122,128,848 (GRCm38) |
S45* |
probably null |
Het |
| Pde2a |
G |
A |
7: 101,502,933 (GRCm38) |
G349E |
probably benign |
Het |
| Pdlim2 |
T |
A |
14: 70,168,015 (GRCm38) |
|
probably benign |
Het |
| Per1 |
T |
C |
11: 69,104,401 (GRCm38) |
V653A |
probably benign |
Het |
| Phlda2 |
A |
G |
7: 143,502,268 (GRCm38) |
S75P |
probably damaging |
Het |
| Poldip3 |
A |
T |
15: 83,137,505 (GRCm38) |
M167K |
possibly damaging |
Het |
| Prpf38a |
T |
C |
4: 108,579,081 (GRCm38) |
I12V |
probably benign |
Het |
| Prrc1 |
G |
A |
18: 57,374,550 (GRCm38) |
V259I |
possibly damaging |
Het |
| Ptges3l |
A |
T |
11: 101,424,622 (GRCm38) |
M1K |
probably null |
Het |
| Rdh5 |
A |
G |
10: 128,913,784 (GRCm38) |
Y296H |
probably damaging |
Het |
| Rnf2 |
T |
A |
1: 151,473,217 (GRCm38) |
K51* |
probably null |
Het |
| Rpusd3 |
C |
A |
6: 113,416,848 (GRCm38) |
R215L |
probably benign |
Het |
| Rsph4a |
A |
T |
10: 33,909,240 (GRCm38) |
E382D |
probably damaging |
Het |
| S1pr2 |
G |
A |
9: 20,968,449 (GRCm38) |
Q28* |
probably null |
Het |
| Sesn1 |
A |
T |
10: 41,895,009 (GRCm38) |
I179F |
probably damaging |
Het |
| Setd3 |
T |
A |
12: 108,113,371 (GRCm38) |
E291V |
probably benign |
Het |
| Shc1 |
G |
T |
3: 89,426,996 (GRCm38) |
R323L |
probably damaging |
Het |
| Slc22a5 |
T |
C |
11: 53,891,526 (GRCm38) |
D5G |
possibly damaging |
Het |
| Slc6a19 |
T |
C |
13: 73,700,558 (GRCm38) |
K26E |
probably benign |
Het |
| Slc9a3 |
A |
G |
13: 74,164,293 (GRCm38) |
N670D |
possibly damaging |
Het |
| Spata19 |
A |
T |
9: 27,400,465 (GRCm38) |
I127L |
probably benign |
Het |
| Speg |
G |
T |
1: 75,427,703 (GRCm38) |
V2751L |
probably damaging |
Het |
| Sptbn2 |
A |
G |
19: 4,729,309 (GRCm38) |
D298G |
probably benign |
Het |
| Srm |
T |
C |
4: 148,594,183 (GRCm38) |
V289A |
possibly damaging |
Het |
| Stip1 |
C |
T |
19: 7,035,570 (GRCm38) |
A49T |
probably benign |
Het |
| Tas2r118 |
C |
A |
6: 23,969,628 (GRCm38) |
V145F |
probably benign |
Het |
| Tbc1d12 |
A |
T |
19: 38,865,725 (GRCm38) |
K284* |
probably null |
Het |
| Tfcp2 |
T |
C |
15: 100,525,650 (GRCm38) |
H125R |
probably damaging |
Het |
| Tfdp1 |
T |
C |
8: 13,373,073 (GRCm38) |
V206A |
probably damaging |
Het |
| Tgtp2 |
A |
G |
11: 49,059,410 (GRCm38) |
W112R |
probably damaging |
Het |
| Tmem71 |
T |
G |
15: 66,538,861 (GRCm38) |
M221L |
probably benign |
Het |
| Tpcn1 |
T |
C |
5: 120,547,487 (GRCm38) |
N436S |
possibly damaging |
Het |
| Usp4 |
C |
T |
9: 108,362,620 (GRCm38) |
L183F |
probably damaging |
Het |
| Vmn2r55 |
A |
T |
7: 12,670,551 (GRCm38) |
N308K |
possibly damaging |
Het |
| Zfp106 |
T |
A |
2: 120,533,919 (GRCm38) |
D669V |
probably damaging |
Het |
| Zfp108 |
A |
T |
7: 24,260,148 (GRCm38) |
I55L |
probably benign |
Het |
| Zfp512b |
A |
T |
2: 181,586,338 (GRCm38) |
S8R |
probably damaging |
Het |
| Zfp827 |
T |
C |
8: 79,061,281 (GRCm38) |
S359P |
probably benign |
Het |
|
| Other mutations in Nav2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01097:Nav2
|
APN |
7 |
49,571,194 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01150:Nav2
|
APN |
7 |
49,452,521 (GRCm38) |
missense |
probably benign |
0.17 |
|
IGL01649:Nav2
|
APN |
7 |
49,575,729 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01662:Nav2
|
APN |
7 |
49,571,209 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02297:Nav2
|
APN |
7 |
49,594,229 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL02313:Nav2
|
APN |
7 |
49,558,773 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02441:Nav2
|
APN |
7 |
49,452,512 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02472:Nav2
|
APN |
7 |
49,546,041 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02477:Nav2
|
APN |
7 |
49,582,875 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02725:Nav2
|
APN |
7 |
49,565,095 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02944:Nav2
|
APN |
7 |
49,420,256 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02953:Nav2
|
APN |
7 |
49,548,423 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03105:Nav2
|
APN |
7 |
49,464,879 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03234:Nav2
|
APN |
7 |
49,462,008 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL03274:Nav2
|
APN |
7 |
49,362,099 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03294:Nav2
|
APN |
7 |
49,491,457 (GRCm38) |
nonsense |
probably null |
|
|
R0006:Nav2
|
UTSW |
7 |
49,453,230 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
R0070:Nav2
|
UTSW |
7 |
49,570,714 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0113:Nav2
|
UTSW |
7 |
49,535,953 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0306:Nav2
|
UTSW |
7 |
49,545,903 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0346:Nav2
|
UTSW |
7 |
49,604,585 (GRCm38) |
missense |
probably benign |
0.11 |
|
R0539:Nav2
|
UTSW |
7 |
49,461,938 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0669:Nav2
|
UTSW |
7 |
49,408,683 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0785:Nav2
|
UTSW |
7 |
49,420,333 (GRCm38) |
missense |
probably benign |
0.06 |
|
R0970:Nav2
|
UTSW |
7 |
49,584,153 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1162:Nav2
|
UTSW |
7 |
49,536,040 (GRCm38) |
splice site |
probably benign |
|
|
R1274:Nav2
|
UTSW |
7 |
49,604,430 (GRCm38) |
nonsense |
probably null |
|
|
R1463:Nav2
|
UTSW |
7 |
49,535,962 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1464:Nav2
|
UTSW |
7 |
49,362,204 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1464:Nav2
|
UTSW |
7 |
49,362,204 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1536:Nav2
|
UTSW |
7 |
49,545,934 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1612:Nav2
|
UTSW |
7 |
49,571,211 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1638:Nav2
|
UTSW |
7 |
49,452,465 (GRCm38) |
missense |
probably benign |
|
|
R1731:Nav2
|
UTSW |
7 |
49,548,174 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1734:Nav2
|
UTSW |
7 |
49,575,720 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1865:Nav2
|
UTSW |
7 |
49,548,195 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1945:Nav2
|
UTSW |
7 |
49,464,872 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1997:Nav2
|
UTSW |
7 |
49,548,471 (GRCm38) |
missense |
probably benign |
0.16 |
|
R2061:Nav2
|
UTSW |
7 |
49,598,897 (GRCm38) |
splice site |
probably benign |
|
|
R2117:Nav2
|
UTSW |
7 |
49,464,580 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2174:Nav2
|
UTSW |
7 |
49,452,663 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2182:Nav2
|
UTSW |
7 |
49,597,254 (GRCm38) |
missense |
probably benign |
0.38 |
|
R2251:Nav2
|
UTSW |
7 |
49,453,277 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2283:Nav2
|
UTSW |
7 |
49,491,404 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2343:Nav2
|
UTSW |
7 |
49,598,817 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R2472:Nav2
|
UTSW |
7 |
49,408,884 (GRCm38) |
missense |
probably benign |
|
|
R2568:Nav2
|
UTSW |
7 |
49,597,564 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2656:Nav2
|
UTSW |
7 |
49,545,942 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2964:Nav2
|
UTSW |
7 |
49,557,032 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2966:Nav2
|
UTSW |
7 |
49,557,032 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3817:Nav2
|
UTSW |
7 |
49,464,562 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3834:Nav2
|
UTSW |
7 |
49,545,858 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4207:Nav2
|
UTSW |
7 |
49,597,231 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4207:Nav2
|
UTSW |
7 |
49,572,298 (GRCm38) |
splice site |
probably null |
|
|
R4411:Nav2
|
UTSW |
7 |
49,398,109 (GRCm38) |
missense |
probably benign |
0.37 |
|
R4413:Nav2
|
UTSW |
7 |
49,398,109 (GRCm38) |
missense |
probably benign |
0.37 |
|
R4440:Nav2
|
UTSW |
7 |
49,575,263 (GRCm38) |
splice site |
probably benign |
|
|
R4440:Nav2
|
UTSW |
7 |
49,552,037 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R4454:Nav2
|
UTSW |
7 |
49,548,544 (GRCm38) |
splice site |
probably null |
|
|
R4729:Nav2
|
UTSW |
7 |
49,452,819 (GRCm38) |
missense |
probably benign |
0.17 |
|
R4801:Nav2
|
UTSW |
7 |
49,545,852 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R4802:Nav2
|
UTSW |
7 |
49,545,852 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R4824:Nav2
|
UTSW |
7 |
49,409,001 (GRCm38) |
intron |
probably benign |
|
|
R4887:Nav2
|
UTSW |
7 |
49,548,434 (GRCm38) |
nonsense |
probably null |
|
|
R4908:Nav2
|
UTSW |
7 |
49,604,510 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4952:Nav2
|
UTSW |
7 |
49,304,540 (GRCm38) |
intron |
probably benign |
|
|
R5169:Nav2
|
UTSW |
7 |
49,548,483 (GRCm38) |
nonsense |
probably null |
|
|
R5224:Nav2
|
UTSW |
7 |
49,551,725 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5249:Nav2
|
UTSW |
7 |
49,535,913 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5285:Nav2
|
UTSW |
7 |
49,548,234 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5314:Nav2
|
UTSW |
7 |
49,408,692 (GRCm38) |
small deletion |
probably benign |
|
|
R5320:Nav2
|
UTSW |
7 |
49,491,373 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5377:Nav2
|
UTSW |
7 |
49,589,160 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5471:Nav2
|
UTSW |
7 |
49,548,169 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5754:Nav2
|
UTSW |
7 |
49,557,046 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5832:Nav2
|
UTSW |
7 |
49,548,069 (GRCm38) |
splice site |
probably null |
|
|
R5884:Nav2
|
UTSW |
7 |
49,597,169 (GRCm38) |
nonsense |
probably null |
|
|
R5921:Nav2
|
UTSW |
7 |
49,304,576 (GRCm38) |
intron |
probably benign |
|
|
R6180:Nav2
|
UTSW |
7 |
49,458,167 (GRCm38) |
missense |
probably benign |
0.39 |
|
R6208:Nav2
|
UTSW |
7 |
49,564,103 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6373:Nav2
|
UTSW |
7 |
49,453,175 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6450:Nav2
|
UTSW |
7 |
49,594,366 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6522:Nav2
|
UTSW |
7 |
49,597,533 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6626:Nav2
|
UTSW |
7 |
49,594,352 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6695:Nav2
|
UTSW |
7 |
49,464,904 (GRCm38) |
missense |
probably benign |
0.04 |
|
R6705:Nav2
|
UTSW |
7 |
49,551,916 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6842:Nav2
|
UTSW |
7 |
49,458,169 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R6847:Nav2
|
UTSW |
7 |
49,491,456 (GRCm38) |
missense |
probably benign |
0.14 |
|
R7287:Nav2
|
UTSW |
7 |
49,420,328 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7312:Nav2
|
UTSW |
7 |
49,461,924 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
R7315:Nav2
|
UTSW |
7 |
49,548,289 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
R7337:Nav2
|
UTSW |
7 |
49,551,773 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
R7366:Nav2
|
UTSW |
7 |
49,554,203 (GRCm38) |
splice site |
probably null |
|
|
R7451:Nav2
|
UTSW |
7 |
49,552,829 (GRCm38) |
splice site |
probably null |
|
|
R7545:Nav2
|
UTSW |
7 |
49,582,857 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7706:Nav2
|
UTSW |
7 |
49,594,319 (GRCm38) |
missense |
probably benign |
0.35 |
|
R7730:Nav2
|
UTSW |
7 |
49,572,397 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7812:Nav2
|
UTSW |
7 |
49,597,173 (GRCm38) |
missense |
probably benign |
0.13 |
|
R8097:Nav2
|
UTSW |
7 |
49,587,777 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8110:Nav2
|
UTSW |
7 |
49,551,950 (GRCm38) |
nonsense |
probably null |
|
|
R8119:Nav2
|
UTSW |
7 |
49,453,484 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8298:Nav2
|
UTSW |
7 |
49,554,261 (GRCm38) |
critical splice donor site |
probably null |
|
|
R8306:Nav2
|
UTSW |
7 |
49,546,017 (GRCm38) |
missense |
probably benign |
0.33 |
|
R8331:Nav2
|
UTSW |
7 |
49,452,623 (GRCm38) |
missense |
probably benign |
|
|
R8402:Nav2
|
UTSW |
7 |
49,453,437 (GRCm38) |
missense |
probably benign |
0.43 |
|
R8421:Nav2
|
UTSW |
7 |
49,452,521 (GRCm38) |
missense |
probably benign |
|
|
R8478:Nav2
|
UTSW |
7 |
49,461,985 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8724:Nav2
|
UTSW |
7 |
49,491,436 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R8753:Nav2
|
UTSW |
7 |
49,452,572 (GRCm38) |
missense |
probably benign |
|
|
R8835:Nav2
|
UTSW |
7 |
49,598,803 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R8933:Nav2
|
UTSW |
7 |
49,461,957 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8957:Nav2
|
UTSW |
7 |
49,571,216 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9069:Nav2
|
UTSW |
7 |
49,558,813 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9095:Nav2
|
UTSW |
7 |
49,604,545 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9223:Nav2
|
UTSW |
7 |
49,552,851 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9261:Nav2
|
UTSW |
7 |
49,597,156 (GRCm38) |
missense |
probably damaging |
1.00 |
|
X0023:Nav2
|
UTSW |
7 |
49,547,899 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
Z1177:Nav2
|
UTSW |
7 |
49,594,223 (GRCm38) |
missense |
probably benign |
0.01 |
|
Z1177:Nav2
|
UTSW |
7 |
49,452,761 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCAGTCTGCTACAGTCTTGGG -3'
(R):5'- TTTAGCAGACAGTGGAGCAG -3'
Sequencing Primer
(F):5'- CTGCTACAGTCTTGGGGTGTGTC -3'
(R):5'- AGCAGGTCCTCACTGGCATG -3'
|
| Posted On |
2016-04-27 |
Incidental Mutation