Incidental Mutation 'R4968:Vmn2r61'
| ID |
384183 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r61
|
| Ensembl Gene |
ENSMUSG00000090967 |
| Gene Name |
vomeronasal 2, receptor 61 |
| Synonyms |
Gprc2a-rs2, Casr-rs2, EG637873 |
| MMRRC Submission |
042564-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.101)
|
| Stock # |
R4968 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
41909477-41950179 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 41949478 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 633
(T633A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129576
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166131]
|
| AlphaFold |
L7N2B8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000166131
AA Change: T633A
PolyPhen 2
Score 0.135 (Sensitivity: 0.92; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000129576
Gene: ENSMUSG00000090967
AA Change: T633A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
4e-42 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
1.9e-21 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
6.2e-52 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000173044
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 93.6%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 69 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2810021J22Rik |
A |
T |
11: 58,769,616 (GRCm39) |
K53* |
probably null |
Het |
| 4921513D11Rik |
T |
C |
17: 79,935,651 (GRCm39) |
S255P |
probably benign |
Het |
| Ace |
A |
G |
11: 105,872,679 (GRCm39) |
N367S |
possibly damaging |
Het |
| Agl |
A |
T |
3: 116,582,175 (GRCm39) |
N282K |
probably benign |
Het |
| Ahnak |
C |
A |
19: 8,992,464 (GRCm39) |
P4583T |
probably damaging |
Het |
| Alpi |
T |
C |
1: 87,029,247 (GRCm39) |
D4G |
probably benign |
Het |
| Anks6 |
C |
T |
4: 47,030,795 (GRCm39) |
G601S |
probably damaging |
Het |
| Aplnr |
T |
C |
2: 84,967,289 (GRCm39) |
Y105H |
probably damaging |
Het |
| Arhgap9 |
G |
A |
10: 127,162,875 (GRCm39) |
R395K |
possibly damaging |
Het |
| Asah1 |
A |
G |
8: 41,807,067 (GRCm39) |
M119T |
|
Het |
| Atp5f1b |
T |
C |
10: 127,919,856 (GRCm39) |
F75L |
probably damaging |
Het |
| B4galt6 |
G |
T |
18: 20,861,026 (GRCm39) |
N75K |
possibly damaging |
Het |
| Bco1 |
A |
T |
8: 117,857,833 (GRCm39) |
H486L |
probably benign |
Het |
| Btaf1 |
T |
A |
19: 36,947,351 (GRCm39) |
L480Q |
probably null |
Het |
| Ccdc34 |
G |
T |
2: 109,871,078 (GRCm39) |
|
probably null |
Het |
| Cdh19 |
T |
C |
1: 110,852,958 (GRCm39) |
S326G |
probably benign |
Het |
| Cep89 |
A |
G |
7: 35,109,055 (GRCm39) |
D178G |
possibly damaging |
Het |
| Cyp11b2 |
A |
T |
15: 74,725,854 (GRCm39) |
|
probably null |
Het |
| Cyp21a1 |
A |
G |
17: 35,022,383 (GRCm39) |
I157T |
possibly damaging |
Het |
| Dcbld2 |
A |
G |
16: 58,245,074 (GRCm39) |
D116G |
probably damaging |
Het |
| Ddx5 |
T |
C |
11: 106,674,953 (GRCm39) |
Q377R |
probably damaging |
Het |
| Deup1 |
T |
C |
9: 15,503,724 (GRCm39) |
D279G |
probably damaging |
Het |
| F11 |
G |
A |
8: 45,698,770 (GRCm39) |
A458V |
probably benign |
Het |
| Fhad1 |
C |
A |
4: 141,645,618 (GRCm39) |
G326W |
probably damaging |
Het |
| Fhit |
C |
T |
14: 10,421,522 (GRCm38) |
V26M |
probably damaging |
Het |
| Gjb5 |
A |
T |
4: 127,250,015 (GRCm39) |
V43E |
probably damaging |
Het |
| Grtp1 |
A |
T |
8: 13,242,184 (GRCm39) |
I75N |
probably damaging |
Het |
| Hmcn1 |
A |
G |
1: 150,533,221 (GRCm39) |
I3022T |
possibly damaging |
Het |
| Hsp90ab1 |
T |
C |
17: 45,881,962 (GRCm39) |
T166A |
probably benign |
Het |
| Ift70b |
T |
C |
2: 75,768,391 (GRCm39) |
I121V |
probably benign |
Het |
| Iho1 |
C |
T |
9: 108,289,713 (GRCm39) |
V170M |
probably benign |
Het |
| Ikbke |
GCC |
G |
1: 131,203,004 (GRCm39) |
|
probably null |
Het |
| Kcnk10 |
T |
C |
12: 98,401,161 (GRCm39) |
I491V |
probably benign |
Het |
| Kcp |
A |
T |
6: 29,497,628 (GRCm39) |
C519* |
probably null |
Het |
| Lcmt2 |
T |
C |
2: 120,970,217 (GRCm39) |
T69A |
probably benign |
Het |
| Lmf1 |
A |
G |
17: 25,804,592 (GRCm39) |
Y90C |
probably damaging |
Het |
| Lpp |
A |
G |
16: 24,798,064 (GRCm39) |
D612G |
probably damaging |
Het |
| Lrfn5 |
C |
A |
12: 61,886,461 (GRCm39) |
S83Y |
probably damaging |
Het |
| Lrp1b |
T |
C |
2: 40,592,719 (GRCm39) |
|
probably null |
Het |
| Lrp1b |
C |
T |
2: 41,679,074 (GRCm39) |
C6Y |
probably damaging |
Het |
| Lrrc8c |
A |
G |
5: 105,754,993 (GRCm39) |
D256G |
probably damaging |
Het |
| Mphosph10 |
A |
G |
7: 64,032,656 (GRCm39) |
Y478H |
probably damaging |
Het |
| Mpp2 |
T |
C |
11: 101,955,124 (GRCm39) |
H167R |
probably benign |
Het |
| Mtss1 |
A |
G |
15: 58,815,767 (GRCm39) |
S598P |
probably damaging |
Het |
| Myh10 |
A |
G |
11: 68,684,049 (GRCm39) |
E1154G |
probably damaging |
Het |
| Myo10 |
T |
C |
15: 25,808,270 (GRCm39) |
V1218A |
probably damaging |
Het |
| Myo19 |
A |
G |
11: 84,792,328 (GRCm39) |
K599R |
probably damaging |
Het |
| Neurl4 |
T |
C |
11: 69,798,134 (GRCm39) |
M771T |
probably damaging |
Het |
| Nlrc4 |
A |
G |
17: 74,753,936 (GRCm39) |
V149A |
probably benign |
Het |
| Nup133 |
A |
T |
8: 124,641,935 (GRCm39) |
S843T |
probably benign |
Het |
| Or2y1c |
T |
C |
11: 49,361,358 (GRCm39) |
C127R |
probably damaging |
Het |
| Or51k1 |
T |
C |
7: 103,661,777 (GRCm39) |
N44S |
probably damaging |
Het |
| P3h2 |
A |
G |
16: 25,811,412 (GRCm39) |
|
probably null |
Het |
| Piezo2 |
A |
T |
18: 63,278,042 (GRCm39) |
Y287* |
probably null |
Het |
| Prob1 |
T |
C |
18: 35,785,605 (GRCm39) |
Y883C |
probably damaging |
Het |
| Pxdn |
T |
A |
12: 30,050,011 (GRCm39) |
H506Q |
probably benign |
Het |
| Ripor3 |
T |
C |
2: 167,827,037 (GRCm39) |
D658G |
probably benign |
Het |
| Rufy1 |
T |
A |
11: 50,301,434 (GRCm39) |
I333L |
probably benign |
Het |
| Selenok |
T |
A |
14: 29,692,064 (GRCm39) |
V34E |
probably benign |
Het |
| Selplg |
T |
C |
5: 113,957,787 (GRCm39) |
E173G |
possibly damaging |
Het |
| Septin10 |
A |
G |
10: 59,016,943 (GRCm39) |
F194L |
probably damaging |
Het |
| Sptbn2 |
A |
T |
19: 4,779,230 (GRCm39) |
|
probably null |
Het |
| St6galnac6 |
C |
T |
2: 32,498,098 (GRCm39) |
P6S |
probably benign |
Het |
| Syngr2 |
T |
C |
11: 117,704,296 (GRCm39) |
Y194H |
probably damaging |
Het |
| Thbs4 |
A |
G |
13: 92,894,576 (GRCm39) |
I649T |
possibly damaging |
Het |
| Triobp |
T |
A |
15: 78,850,816 (GRCm39) |
N323K |
probably benign |
Het |
| Tuba8 |
T |
A |
6: 121,197,548 (GRCm39) |
L70Q |
probably damaging |
Het |
| Zfp280b |
G |
T |
10: 75,875,188 (GRCm39) |
V356L |
probably damaging |
Het |
| Zswim4 |
A |
T |
8: 84,944,001 (GRCm39) |
V746D |
probably benign |
Het |
|
| Other mutations in Vmn2r61 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00158:Vmn2r61
|
APN |
7 |
41,950,175 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL00824:Vmn2r61
|
APN |
7 |
41,916,438 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00903:Vmn2r61
|
APN |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01125:Vmn2r61
|
APN |
7 |
41,909,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01393:Vmn2r61
|
APN |
7 |
41,916,258 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01712:Vmn2r61
|
APN |
7 |
41,909,661 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01822:Vmn2r61
|
APN |
7 |
41,950,130 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01835:Vmn2r61
|
APN |
7 |
41,950,015 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL01844:Vmn2r61
|
APN |
7 |
41,909,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01953:Vmn2r61
|
APN |
7 |
41,949,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02032:Vmn2r61
|
APN |
7 |
41,949,466 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02054:Vmn2r61
|
APN |
7 |
41,926,158 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02569:Vmn2r61
|
APN |
7 |
41,926,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02697:Vmn2r61
|
APN |
7 |
41,924,892 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL02958:Vmn2r61
|
APN |
7 |
41,949,361 (GRCm39) |
missense |
probably benign |
|
|
IGL03290:Vmn2r61
|
APN |
7 |
41,915,408 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03337:Vmn2r61
|
APN |
7 |
41,916,509 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
IGL03369:Vmn2r61
|
APN |
7 |
41,909,517 (GRCm39) |
missense |
probably benign |
|
|
IGL03402:Vmn2r61
|
APN |
7 |
41,909,679 (GRCm39) |
missense |
probably benign |
|
|
R0026:Vmn2r61
|
UTSW |
7 |
41,924,898 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0319:Vmn2r61
|
UTSW |
7 |
41,949,941 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0433:Vmn2r61
|
UTSW |
7 |
41,915,335 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0555:Vmn2r61
|
UTSW |
7 |
41,915,442 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0691:Vmn2r61
|
UTSW |
7 |
41,949,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1701:Vmn2r61
|
UTSW |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1718:Vmn2r61
|
UTSW |
7 |
41,950,121 (GRCm39) |
missense |
probably benign |
|
|
R1835:Vmn2r61
|
UTSW |
7 |
41,916,076 (GRCm39) |
nonsense |
probably null |
|
|
R1920:Vmn2r61
|
UTSW |
7 |
41,949,710 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2069:Vmn2r61
|
UTSW |
7 |
41,949,425 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2326:Vmn2r61
|
UTSW |
7 |
41,916,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2402:Vmn2r61
|
UTSW |
7 |
41,949,529 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3103:Vmn2r61
|
UTSW |
7 |
41,916,067 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3107:Vmn2r61
|
UTSW |
7 |
41,916,491 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4426:Vmn2r61
|
UTSW |
7 |
41,950,159 (GRCm39) |
missense |
probably benign |
|
|
R4426:Vmn2r61
|
UTSW |
7 |
41,950,157 (GRCm39) |
missense |
probably benign |
|
|
R4484:Vmn2r61
|
UTSW |
7 |
41,950,120 (GRCm39) |
missense |
probably benign |
|
|
R4748:Vmn2r61
|
UTSW |
7 |
41,916,565 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4835:Vmn2r61
|
UTSW |
7 |
41,916,459 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R4863:Vmn2r61
|
UTSW |
7 |
41,950,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4923:Vmn2r61
|
UTSW |
7 |
41,916,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5114:Vmn2r61
|
UTSW |
7 |
41,949,953 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5297:Vmn2r61
|
UTSW |
7 |
41,909,646 (GRCm39) |
missense |
probably benign |
|
|
R5497:Vmn2r61
|
UTSW |
7 |
41,924,906 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5508:Vmn2r61
|
UTSW |
7 |
41,916,242 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5587:Vmn2r61
|
UTSW |
7 |
41,949,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5615:Vmn2r61
|
UTSW |
7 |
41,949,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5615:Vmn2r61
|
UTSW |
7 |
41,916,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5782:Vmn2r61
|
UTSW |
7 |
41,949,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6136:Vmn2r61
|
UTSW |
7 |
41,916,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6207:Vmn2r61
|
UTSW |
7 |
41,909,616 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6265:Vmn2r61
|
UTSW |
7 |
41,915,915 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6272:Vmn2r61
|
UTSW |
7 |
41,949,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6355:Vmn2r61
|
UTSW |
7 |
41,916,659 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6469:Vmn2r61
|
UTSW |
7 |
41,915,283 (GRCm39) |
nonsense |
probably null |
|
|
R6554:Vmn2r61
|
UTSW |
7 |
41,926,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6699:Vmn2r61
|
UTSW |
7 |
41,949,580 (GRCm39) |
missense |
probably benign |
|
|
R6768:Vmn2r61
|
UTSW |
7 |
41,949,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6824:Vmn2r61
|
UTSW |
7 |
41,949,403 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6930:Vmn2r61
|
UTSW |
7 |
41,949,364 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7053:Vmn2r61
|
UTSW |
7 |
41,916,557 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7238:Vmn2r61
|
UTSW |
7 |
41,916,629 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7332:Vmn2r61
|
UTSW |
7 |
41,909,534 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7359:Vmn2r61
|
UTSW |
7 |
41,915,407 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7553:Vmn2r61
|
UTSW |
7 |
41,916,205 (GRCm39) |
missense |
not run |
|
|
R7710:Vmn2r61
|
UTSW |
7 |
41,916,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7732:Vmn2r61
|
UTSW |
7 |
41,916,097 (GRCm39) |
missense |
probably benign |
|
|
R7839:Vmn2r61
|
UTSW |
7 |
41,916,032 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7916:Vmn2r61
|
UTSW |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8026:Vmn2r61
|
UTSW |
7 |
41,916,141 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8440:Vmn2r61
|
UTSW |
7 |
41,916,080 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8499:Vmn2r61
|
UTSW |
7 |
41,949,700 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8771:Vmn2r61
|
UTSW |
7 |
41,916,194 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8847:Vmn2r61
|
UTSW |
7 |
41,950,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8986:Vmn2r61
|
UTSW |
7 |
41,915,325 (GRCm39) |
nonsense |
probably null |
|
|
R9290:Vmn2r61
|
UTSW |
7 |
41,915,385 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9311:Vmn2r61
|
UTSW |
7 |
41,950,092 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9324:Vmn2r61
|
UTSW |
7 |
41,916,619 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9476:Vmn2r61
|
UTSW |
7 |
41,949,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9521:Vmn2r61
|
UTSW |
7 |
41,916,626 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9619:Vmn2r61
|
UTSW |
7 |
41,926,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9729:Vmn2r61
|
UTSW |
7 |
41,949,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r61
|
UTSW |
7 |
41,949,388 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
Z1176:Vmn2r61
|
UTSW |
7 |
41,916,166 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn2r61
|
UTSW |
7 |
41,909,585 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGTGAAGTGTTCAGAAAGTCAC -3'
(R):5'- ACCATCTCACCATTCTAGCTGG -3'
Sequencing Primer
(F):5'- TTACTGCCTCCAGAAATCTGTGAG -3'
(R):5'- TTCTAGCTGGAACAATGGCC -3'
|
| Posted On |
2016-04-27 |
Incidental Mutation