Incidental Mutation 'R4972:Actl11'
ID 384534
Institutional Source Beutler Lab
Gene Symbol Actl11
Ensembl Gene ENSMUSG00000066368
Gene Name actin-like 11
Synonyms 4921517D21Rik
MMRRC Submission 042567-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R4972 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 107805668-107809660 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 107807155 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 493 (T493A)
Ref Sequence ENSEMBL: ENSMUSP00000082150 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085073]
AlphaFold Q9D5V1
Predicted Effect probably benign
Transcript: ENSMUST00000085073
AA Change: T493A

PolyPhen 2 Score 0.073 (Sensitivity: 0.93; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000082150
Gene: ENSMUSG00000066368
AA Change: T493A

DomainStartEndE-ValueType
low complexity region 223 239 N/A INTRINSIC
low complexity region 301 309 N/A INTRINSIC
low complexity region 374 391 N/A INTRINSIC
low complexity region 492 507 N/A INTRINSIC
low complexity region 697 710 N/A INTRINSIC
ACTIN 858 1207 4.26e-81 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.2%
Validation Efficiency 93% (82/88)
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik A T 14: 32,383,361 (GRCm39) I868N possibly damaging Het
A730013G03Rik C G 1: 192,516,081 (GRCm39) noncoding transcript Het
Actn1 T C 12: 80,219,813 (GRCm39) D686G probably benign Het
Adamts1 G A 16: 85,592,833 (GRCm39) T525I probably damaging Het
Adcy10 T A 1: 165,384,431 (GRCm39) L1064H probably damaging Het
AI661453 A T 17: 47,777,324 (GRCm39) probably benign Het
Apba1 T A 19: 23,889,900 (GRCm39) S433T probably benign Het
Arid4b T A 13: 14,334,857 (GRCm39) N355K probably benign Het
Bsn A T 9: 107,992,377 (GRCm39) M1125K probably damaging Het
C2cd5 A T 6: 142,958,950 (GRCm39) M1003K probably damaging Het
Ccdc18 A G 5: 108,339,869 (GRCm39) M805V probably benign Het
Cep89 T G 7: 35,131,977 (GRCm39) L637R probably damaging Het
Col24a1 A T 3: 145,215,439 (GRCm39) I1444F probably benign Het
Commd4 A T 9: 57,062,732 (GRCm39) S175T probably benign Het
Coq7 A G 7: 118,109,340 (GRCm39) V236A unknown Het
Dctn2 C T 10: 127,112,572 (GRCm39) R176C probably damaging Het
Ddx31 T C 2: 28,750,782 (GRCm39) F389L probably damaging Het
Dgkz C T 2: 91,776,047 (GRCm39) R72H probably benign Het
Dpysl4 A G 7: 138,670,206 (GRCm39) D24G probably damaging Het
Dydc1 A G 14: 40,804,295 (GRCm39) T106A probably benign Het
F13b A G 1: 139,438,661 (GRCm39) Y355C probably damaging Het
Fcrl5 A G 3: 87,361,957 (GRCm39) M407V probably benign Het
Fzd5 C A 1: 64,775,171 (GRCm39) V197L probably benign Het
Galnt16 G T 12: 80,619,103 (GRCm39) E70* probably null Het
Gpr171 A T 3: 59,005,386 (GRCm39) F130I probably damaging Het
Grin3a T C 4: 49,770,484 (GRCm39) N763D probably damaging Het
Gsta2 A T 9: 78,244,961 (GRCm39) M51K probably damaging Het
Gvin-ps3 T C 7: 105,682,521 (GRCm39) noncoding transcript Het
Hacd3 A T 9: 64,897,718 (GRCm39) I298N probably damaging Het
Il18r1 C T 1: 40,530,224 (GRCm39) P317L probably benign Het
Iscu T A 5: 113,915,037 (GRCm39) probably benign Het
Kif6 A G 17: 50,014,647 (GRCm39) D250G probably damaging Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Lcn6 T A 2: 25,570,079 (GRCm39) C82S probably damaging Het
Mob4 C G 1: 55,190,161 (GRCm39) L135V possibly damaging Het
Mpzl3 T A 9: 44,973,554 (GRCm39) probably benign Het
Mvp T C 7: 126,588,970 (GRCm39) D599G probably damaging Het
Myo1a T C 10: 127,552,178 (GRCm39) Y766H probably benign Het
Myo5b A G 18: 74,760,264 (GRCm39) H260R probably damaging Het
Nbea C T 3: 55,992,667 (GRCm39) R313H probably damaging Het
Necab1 T A 4: 14,978,216 (GRCm39) D211V probably damaging Het
Nefl G T 14: 68,324,212 (GRCm39) probably benign Het
Nfx1 T A 4: 40,976,375 (GRCm39) D16E probably benign Het
Nlrp9a G T 7: 26,269,964 (GRCm39) C797F probably damaging Het
Or4k36 T A 2: 111,146,163 (GRCm39) V113E probably damaging Het
Or5p5 A G 7: 107,413,953 (GRCm39) Q56R probably benign Het
Pde6b A G 5: 108,573,130 (GRCm39) D500G probably benign Het
Pgs1 T C 11: 117,896,719 (GRCm39) probably null Het
Polr3b T A 10: 84,473,988 (GRCm39) I189N probably damaging Het
Ppwd1 A T 13: 104,356,616 (GRCm39) S300T probably benign Het
Prl2c2 A C 13: 13,176,755 (GRCm39) N55K possibly damaging Het
Prpf19 C T 19: 10,876,709 (GRCm39) probably benign Het
Prph2 G T 17: 47,221,733 (GRCm39) L37F possibly damaging Het
Ptprg G T 14: 12,226,427 (GRCm38) R565L possibly damaging Het
Rab8a C T 8: 72,925,119 (GRCm39) T74M probably damaging Het
Rexo1 A T 10: 80,385,527 (GRCm39) F510L probably damaging Het
Rexo2 G T 9: 48,390,689 (GRCm39) T51K probably damaging Het
Sh3d21 T C 4: 126,046,209 (GRCm39) K147R possibly damaging Het
Skint6 A G 4: 112,692,265 (GRCm39) I1062T probably benign Het
Spag16 C T 1: 70,764,087 (GRCm39) R636W probably damaging Het
Spata16 T C 3: 26,894,872 (GRCm39) I307T possibly damaging Het
Speer4f2 T G 5: 17,579,423 (GRCm39) I74S probably benign Het
Svep1 T A 4: 58,087,778 (GRCm39) Y1767F possibly damaging Het
Swt1 T C 1: 151,299,293 (GRCm39) S7G probably benign Het
Tex9 A G 9: 72,385,620 (GRCm39) probably null Het
Thsd7b C A 1: 130,116,309 (GRCm39) P1354H probably damaging Het
Ticrr A G 7: 79,319,416 (GRCm39) D467G probably damaging Het
Tmco5b A C 2: 113,127,338 (GRCm39) D303A probably damaging Het
Trpm7 A G 2: 126,665,978 (GRCm39) V876A probably damaging Het
Ttc21a G A 9: 119,774,027 (GRCm39) E245K probably benign Het
Vezt C T 10: 93,836,212 (GRCm39) probably null Het
Zscan20 G A 4: 128,486,152 (GRCm39) P183S probably benign Het
Other mutations in Actl11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01081:Actl11 APN 9 107,806,181 (GRCm39) missense possibly damaging 0.49
IGL01396:Actl11 APN 9 107,805,964 (GRCm39) missense possibly damaging 0.71
IGL01622:Actl11 APN 9 107,805,775 (GRCm39) missense probably benign 0.03
IGL01623:Actl11 APN 9 107,805,775 (GRCm39) missense probably benign 0.03
IGL01660:Actl11 APN 9 107,806,247 (GRCm39) missense probably benign
IGL01912:Actl11 APN 9 107,806,844 (GRCm39) missense probably damaging 0.98
IGL02002:Actl11 APN 9 107,806,529 (GRCm39) missense probably benign 0.08
IGL02266:Actl11 APN 9 107,808,382 (GRCm39) missense possibly damaging 0.76
IGL02535:Actl11 APN 9 107,807,136 (GRCm39) missense possibly damaging 0.71
IGL02692:Actl11 APN 9 107,806,507 (GRCm39) missense probably benign 0.06
IGL02744:Actl11 APN 9 107,807,061 (GRCm39) missense probably benign 0.04
IGL02864:Actl11 APN 9 107,806,186 (GRCm39) missense probably benign 0.25
IGL03037:Actl11 APN 9 107,807,294 (GRCm39) missense probably damaging 0.99
IGL03085:Actl11 APN 9 107,806,749 (GRCm39) missense probably damaging 0.98
R0167:Actl11 UTSW 9 107,806,969 (GRCm39) missense probably damaging 1.00
R0304:Actl11 UTSW 9 107,806,967 (GRCm39) missense probably damaging 1.00
R0959:Actl11 UTSW 9 107,808,434 (GRCm39) missense probably damaging 1.00
R1499:Actl11 UTSW 9 107,808,682 (GRCm39) missense probably damaging 1.00
R1616:Actl11 UTSW 9 107,809,135 (GRCm39) missense probably benign 0.39
R1694:Actl11 UTSW 9 107,807,207 (GRCm39) missense probably damaging 1.00
R1927:Actl11 UTSW 9 107,806,736 (GRCm39) missense possibly damaging 0.88
R2081:Actl11 UTSW 9 107,807,396 (GRCm39) missense probably benign
R2939:Actl11 UTSW 9 107,808,409 (GRCm39) missense possibly damaging 0.84
R3427:Actl11 UTSW 9 107,806,969 (GRCm39) missense probably damaging 1.00
R4812:Actl11 UTSW 9 107,808,329 (GRCm39) missense probably damaging 0.99
R4843:Actl11 UTSW 9 107,806,691 (GRCm39) missense possibly damaging 0.61
R4989:Actl11 UTSW 9 107,808,615 (GRCm39) missense probably damaging 1.00
R4996:Actl11 UTSW 9 107,808,934 (GRCm39) missense possibly damaging 0.77
R5320:Actl11 UTSW 9 107,808,203 (GRCm39) missense possibly damaging 0.73
R5546:Actl11 UTSW 9 107,806,832 (GRCm39) missense probably benign 0.00
R5810:Actl11 UTSW 9 107,806,420 (GRCm39) missense probably benign 0.23
R6302:Actl11 UTSW 9 107,806,772 (GRCm39) missense probably benign 0.12
R6412:Actl11 UTSW 9 107,807,116 (GRCm39) missense probably benign 0.01
R6835:Actl11 UTSW 9 107,807,761 (GRCm39) missense probably benign
R6891:Actl11 UTSW 9 107,806,346 (GRCm39) missense probably benign 0.03
R7195:Actl11 UTSW 9 107,806,069 (GRCm39) nonsense probably null
R7212:Actl11 UTSW 9 107,805,856 (GRCm39) missense probably damaging 0.99
R8478:Actl11 UTSW 9 107,805,844 (GRCm39) missense possibly damaging 0.81
R8670:Actl11 UTSW 9 107,805,959 (GRCm39) missense possibly damaging 0.76
R8683:Actl11 UTSW 9 107,806,065 (GRCm39) missense probably benign 0.15
R9114:Actl11 UTSW 9 107,808,509 (GRCm39) missense possibly damaging 0.62
R9233:Actl11 UTSW 9 107,807,900 (GRCm39) missense possibly damaging 0.91
R9280:Actl11 UTSW 9 107,808,573 (GRCm39) missense probably damaging 1.00
R9361:Actl11 UTSW 9 107,805,824 (GRCm39) missense probably damaging 1.00
R9565:Actl11 UTSW 9 107,808,121 (GRCm39) missense possibly damaging 0.92
X0024:Actl11 UTSW 9 107,807,704 (GRCm39) missense probably benign 0.01
Z1176:Actl11 UTSW 9 107,808,899 (GRCm39) missense probably benign 0.20
Predicted Primers PCR Primer
(F):5'- GCTGGTATTTGATATGGCCACAG -3'
(R):5'- CTAGGATCAGGAACTTGGGCTG -3'

Sequencing Primer
(F):5'- CCACAGGCAATACAAGGATGG -3'
(R):5'- ATCAGGAACTTGGGCTGATATC -3'
Posted On 2016-04-27