Incidental Mutation 'R4972:Ptprg'
ID 384547
Institutional Source Beutler Lab
Gene Symbol Ptprg
Ensembl Gene ENSMUSG00000021745
Gene Name protein tyrosine phosphatase receptor type G
Synonyms RPTPgamma, 5430405N12Rik
MMRRC Submission 042567-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4972 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 10227722-10916220 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 12226427 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 565 (R565L)
Ref Sequence ENSEMBL: ENSMUSP00000113679 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022264] [ENSMUST00000119888] [ENSMUST00000142917]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000022264
AA Change: R1340L

PolyPhen 2 Score 0.892 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000022264
Gene: ENSMUSG00000021745
AA Change: R1340L

DomainStartEndE-ValueType
Carb_anhydrase 60 321 6.38e-109 SMART
FN3 347 433 5.4e-7 SMART
low complexity region 474 484 N/A INTRINSIC
low complexity region 515 525 N/A INTRINSIC
coiled coil region 581 617 N/A INTRINSIC
transmembrane domain 734 756 N/A INTRINSIC
PTPc 844 1118 1.76e-136 SMART
PTPc 1146 1409 1.32e-85 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000119888
AA Change: R565L

PolyPhen 2 Score 0.937 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000113679
Gene: ENSMUSG00000021745
AA Change: R565L

DomainStartEndE-ValueType
PTPc 69 343 1.76e-136 SMART
PTPc 371 634 1.32e-85 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134290
Predicted Effect probably benign
Transcript: ENSMUST00000142917
SMART Domains Protein: ENSMUSP00000121268
Gene: ENSMUSG00000021745

DomainStartEndE-ValueType
Carb_anhydrase 60 260 1.6e-50 SMART
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.2%
Validation Efficiency 93% (82/88)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele are overtly normal but exhibit minor behavioral changes including specific motor deficits, reduced latency to react in the tail flick test, enhanced sensory processing for acoustic stimuli, and reduced performance with cued fear conditioning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik A T 14: 32,383,361 (GRCm39) I868N possibly damaging Het
A730013G03Rik C G 1: 192,516,081 (GRCm39) noncoding transcript Het
Actl11 A G 9: 107,807,155 (GRCm39) T493A probably benign Het
Actn1 T C 12: 80,219,813 (GRCm39) D686G probably benign Het
Adamts1 G A 16: 85,592,833 (GRCm39) T525I probably damaging Het
Adcy10 T A 1: 165,384,431 (GRCm39) L1064H probably damaging Het
AI661453 A T 17: 47,777,324 (GRCm39) probably benign Het
Apba1 T A 19: 23,889,900 (GRCm39) S433T probably benign Het
Arid4b T A 13: 14,334,857 (GRCm39) N355K probably benign Het
Bsn A T 9: 107,992,377 (GRCm39) M1125K probably damaging Het
C2cd5 A T 6: 142,958,950 (GRCm39) M1003K probably damaging Het
Ccdc18 A G 5: 108,339,869 (GRCm39) M805V probably benign Het
Cep89 T G 7: 35,131,977 (GRCm39) L637R probably damaging Het
Col24a1 A T 3: 145,215,439 (GRCm39) I1444F probably benign Het
Commd4 A T 9: 57,062,732 (GRCm39) S175T probably benign Het
Coq7 A G 7: 118,109,340 (GRCm39) V236A unknown Het
Dctn2 C T 10: 127,112,572 (GRCm39) R176C probably damaging Het
Ddx31 T C 2: 28,750,782 (GRCm39) F389L probably damaging Het
Dgkz C T 2: 91,776,047 (GRCm39) R72H probably benign Het
Dpysl4 A G 7: 138,670,206 (GRCm39) D24G probably damaging Het
Dydc1 A G 14: 40,804,295 (GRCm39) T106A probably benign Het
F13b A G 1: 139,438,661 (GRCm39) Y355C probably damaging Het
Fcrl5 A G 3: 87,361,957 (GRCm39) M407V probably benign Het
Fzd5 C A 1: 64,775,171 (GRCm39) V197L probably benign Het
Galnt16 G T 12: 80,619,103 (GRCm39) E70* probably null Het
Gpr171 A T 3: 59,005,386 (GRCm39) F130I probably damaging Het
Grin3a T C 4: 49,770,484 (GRCm39) N763D probably damaging Het
Gsta2 A T 9: 78,244,961 (GRCm39) M51K probably damaging Het
Gvin-ps3 T C 7: 105,682,521 (GRCm39) noncoding transcript Het
Hacd3 A T 9: 64,897,718 (GRCm39) I298N probably damaging Het
Il18r1 C T 1: 40,530,224 (GRCm39) P317L probably benign Het
Iscu T A 5: 113,915,037 (GRCm39) probably benign Het
Kif6 A G 17: 50,014,647 (GRCm39) D250G probably damaging Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Lcn6 T A 2: 25,570,079 (GRCm39) C82S probably damaging Het
Mob4 C G 1: 55,190,161 (GRCm39) L135V possibly damaging Het
Mpzl3 T A 9: 44,973,554 (GRCm39) probably benign Het
Mvp T C 7: 126,588,970 (GRCm39) D599G probably damaging Het
Myo1a T C 10: 127,552,178 (GRCm39) Y766H probably benign Het
Myo5b A G 18: 74,760,264 (GRCm39) H260R probably damaging Het
Nbea C T 3: 55,992,667 (GRCm39) R313H probably damaging Het
Necab1 T A 4: 14,978,216 (GRCm39) D211V probably damaging Het
Nefl G T 14: 68,324,212 (GRCm39) probably benign Het
Nfx1 T A 4: 40,976,375 (GRCm39) D16E probably benign Het
Nlrp9a G T 7: 26,269,964 (GRCm39) C797F probably damaging Het
Or4k36 T A 2: 111,146,163 (GRCm39) V113E probably damaging Het
Or5p5 A G 7: 107,413,953 (GRCm39) Q56R probably benign Het
Pde6b A G 5: 108,573,130 (GRCm39) D500G probably benign Het
Pgs1 T C 11: 117,896,719 (GRCm39) probably null Het
Polr3b T A 10: 84,473,988 (GRCm39) I189N probably damaging Het
Ppwd1 A T 13: 104,356,616 (GRCm39) S300T probably benign Het
Prl2c2 A C 13: 13,176,755 (GRCm39) N55K possibly damaging Het
Prpf19 C T 19: 10,876,709 (GRCm39) probably benign Het
Prph2 G T 17: 47,221,733 (GRCm39) L37F possibly damaging Het
Rab8a C T 8: 72,925,119 (GRCm39) T74M probably damaging Het
Rexo1 A T 10: 80,385,527 (GRCm39) F510L probably damaging Het
Rexo2 G T 9: 48,390,689 (GRCm39) T51K probably damaging Het
Sh3d21 T C 4: 126,046,209 (GRCm39) K147R possibly damaging Het
Skint6 A G 4: 112,692,265 (GRCm39) I1062T probably benign Het
Spag16 C T 1: 70,764,087 (GRCm39) R636W probably damaging Het
Spata16 T C 3: 26,894,872 (GRCm39) I307T possibly damaging Het
Speer4f2 T G 5: 17,579,423 (GRCm39) I74S probably benign Het
Svep1 T A 4: 58,087,778 (GRCm39) Y1767F possibly damaging Het
Swt1 T C 1: 151,299,293 (GRCm39) S7G probably benign Het
Tex9 A G 9: 72,385,620 (GRCm39) probably null Het
Thsd7b C A 1: 130,116,309 (GRCm39) P1354H probably damaging Het
Ticrr A G 7: 79,319,416 (GRCm39) D467G probably damaging Het
Tmco5b A C 2: 113,127,338 (GRCm39) D303A probably damaging Het
Trpm7 A G 2: 126,665,978 (GRCm39) V876A probably damaging Het
Ttc21a G A 9: 119,774,027 (GRCm39) E245K probably benign Het
Vezt C T 10: 93,836,212 (GRCm39) probably null Het
Zscan20 G A 4: 128,486,152 (GRCm39) P183S probably benign Het
Other mutations in Ptprg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00402:Ptprg APN 14 12,215,992 (GRCm38) missense probably damaging 1.00
IGL00484:Ptprg APN 14 12,215,220 (GRCm38) missense probably damaging 0.99
IGL00847:Ptprg APN 14 12,215,265 (GRCm38) missense probably damaging 1.00
IGL01089:Ptprg APN 14 12,215,286 (GRCm38) missense probably damaging 0.97
IGL01382:Ptprg APN 14 12,237,797 (GRCm38) missense probably benign 0.16
IGL01470:Ptprg APN 14 12,213,702 (GRCm38) nonsense probably null
IGL01762:Ptprg APN 14 12,037,386 (GRCm38) missense probably benign 0.00
IGL01886:Ptprg APN 14 12,179,280 (GRCm38) missense probably benign 0.22
IGL01963:Ptprg APN 14 12,220,661 (GRCm38) missense probably damaging 1.00
IGL02015:Ptprg APN 14 12,237,782 (GRCm38) missense possibly damaging 0.46
IGL02086:Ptprg APN 14 12,110,080 (GRCm38) nonsense probably null
IGL02197:Ptprg APN 14 12,220,613 (GRCm38) missense probably damaging 0.98
IGL02341:Ptprg APN 14 12,154,360 (GRCm38) missense probably benign 0.00
IGL02732:Ptprg APN 14 12,225,617 (GRCm38) critical splice donor site probably null
IGL03011:Ptprg APN 14 12,219,029 (GRCm38) missense probably damaging 1.00
IGL03261:Ptprg APN 14 12,225,552 (GRCm38) missense probably damaging 0.99
R0038:Ptprg UTSW 14 12,213,710 (GRCm38) missense probably damaging 1.00
R0383:Ptprg UTSW 14 12,219,024 (GRCm38) missense possibly damaging 0.93
R0433:Ptprg UTSW 14 12,220,620 (GRCm38) missense probably damaging 1.00
R0488:Ptprg UTSW 14 12,220,653 (GRCm38) missense probably damaging 1.00
R0503:Ptprg UTSW 14 12,237,138 (GRCm38) missense possibly damaging 0.89
R0520:Ptprg UTSW 14 12,199,783 (GRCm38) missense possibly damaging 0.92
R0570:Ptprg UTSW 14 12,215,896 (GRCm38) missense probably damaging 1.00
R0606:Ptprg UTSW 14 12,154,131 (GRCm38) missense probably benign
R1086:Ptprg UTSW 14 11,952,706 (GRCm38) splice site probably benign
R1468:Ptprg UTSW 14 12,190,767 (GRCm38) missense probably benign 0.02
R1468:Ptprg UTSW 14 12,190,767 (GRCm38) missense probably benign 0.02
R1519:Ptprg UTSW 14 12,220,596 (GRCm38) missense probably damaging 1.00
R1662:Ptprg UTSW 14 12,207,357 (GRCm38) missense probably damaging 1.00
R1714:Ptprg UTSW 14 12,213,697 (GRCm38) missense probably damaging 1.00
R1716:Ptprg UTSW 14 12,154,360 (GRCm38) missense probably benign 0.00
R1797:Ptprg UTSW 14 12,199,743 (GRCm38) missense probably damaging 1.00
R1803:Ptprg UTSW 14 12,091,410 (GRCm38) splice site probably null
R2104:Ptprg UTSW 14 11,952,897 (GRCm38) critical splice donor site probably null
R2125:Ptprg UTSW 14 12,179,283 (GRCm38) missense possibly damaging 0.74
R2126:Ptprg UTSW 14 12,154,355 (GRCm38) missense probably benign
R2133:Ptprg UTSW 14 12,211,637 (GRCm38) missense probably damaging 1.00
R2471:Ptprg UTSW 14 12,210,327 (GRCm38) missense probably damaging 1.00
R2571:Ptprg UTSW 14 12,122,135 (GRCm38) missense probably benign
R3821:Ptprg UTSW 14 12,226,375 (GRCm38) missense probably benign 0.00
R4196:Ptprg UTSW 14 12,122,002 (GRCm38) missense possibly damaging 0.51
R4392:Ptprg UTSW 14 12,142,467 (GRCm38) missense possibly damaging 0.80
R4665:Ptprg UTSW 14 12,215,288 (GRCm38) missense possibly damaging 0.90
R4730:Ptprg UTSW 14 12,213,713 (GRCm38) missense probably damaging 1.00
R4737:Ptprg UTSW 14 12,226,314 (GRCm38) missense probably damaging 1.00
R4764:Ptprg UTSW 14 12,122,068 (GRCm38) missense probably benign 0.01
R4801:Ptprg UTSW 14 11,554,233 (GRCm38) utr 5 prime probably benign
R4825:Ptprg UTSW 14 12,220,654 (GRCm38) missense probably damaging 1.00
R4960:Ptprg UTSW 14 12,237,837 (GRCm38) missense probably benign 0.07
R4980:Ptprg UTSW 14 12,154,421 (GRCm38) missense probably benign 0.16
R5004:Ptprg UTSW 14 12,220,667 (GRCm38) missense probably damaging 1.00
R5058:Ptprg UTSW 14 12,037,387 (GRCm38) missense possibly damaging 0.82
R5182:Ptprg UTSW 14 12,154,174 (GRCm38) missense probably benign
R5258:Ptprg UTSW 14 12,142,431 (GRCm38) missense probably benign 0.11
R5338:Ptprg UTSW 14 12,154,111 (GRCm38) missense probably benign
R5353:Ptprg UTSW 14 11,554,235 (GRCm38) utr 5 prime probably benign
R5373:Ptprg UTSW 14 12,213,665 (GRCm38) missense probably benign 0.00
R5387:Ptprg UTSW 14 12,153,873 (GRCm38) missense probably damaging 1.00
R5616:Ptprg UTSW 14 12,122,120 (GRCm38) missense probably benign
R5623:Ptprg UTSW 14 12,153,857 (GRCm38) missense probably damaging 1.00
R5976:Ptprg UTSW 14 12,211,625 (GRCm38) missense probably damaging 0.96
R6027:Ptprg UTSW 14 12,220,613 (GRCm38) missense possibly damaging 0.87
R6091:Ptprg UTSW 14 12,215,979 (GRCm38) missense probably damaging 1.00
R6184:Ptprg UTSW 14 12,153,943 (GRCm38) missense probably benign 0.00
R6234:Ptprg UTSW 14 12,213,747 (GRCm38) missense probably damaging 1.00
R6318:Ptprg UTSW 14 12,237,118 (GRCm38) missense probably damaging 1.00
R6324:Ptprg UTSW 14 12,226,314 (GRCm38) missense probably damaging 1.00
R6334:Ptprg UTSW 14 12,166,832 (GRCm38) missense probably damaging 1.00
R6646:Ptprg UTSW 14 11,962,714 (GRCm38) missense probably damaging 1.00
R6647:Ptprg UTSW 14 11,962,714 (GRCm38) missense probably damaging 1.00
R6992:Ptprg UTSW 14 11,962,602 (GRCm38) missense probably damaging 1.00
R7088:Ptprg UTSW 14 12,207,365 (GRCm38) missense probably damaging 1.00
R7250:Ptprg UTSW 14 12,166,767 (GRCm38) missense probably benign 0.18
R7342:Ptprg UTSW 14 12,237,151 (GRCm38) missense possibly damaging 0.90
R7358:Ptprg UTSW 14 12,154,198 (GRCm38) missense possibly damaging 0.59
R7410:Ptprg UTSW 14 11,962,657 (GRCm38) missense probably damaging 1.00
R7448:Ptprg UTSW 14 12,142,461 (GRCm38) missense probably benign 0.12
R7514:Ptprg UTSW 14 12,179,342 (GRCm38) missense possibly damaging 0.86
R7523:Ptprg UTSW 14 12,237,130 (GRCm38) missense probably damaging 0.97
R7672:Ptprg UTSW 14 12,211,668 (GRCm38) missense probably benign 0.04
R7709:Ptprg UTSW 14 12,226,452 (GRCm38) missense probably damaging 1.00
R7720:Ptprg UTSW 14 12,211,703 (GRCm38) missense probably benign 0.31
R8860:Ptprg UTSW 14 12,213,685 (GRCm38) missense probably damaging 1.00
R8992:Ptprg UTSW 14 12,154,170 (GRCm38) missense probably benign 0.00
R9054:Ptprg UTSW 14 12,213,638 (GRCm38) missense possibly damaging 0.58
R9587:Ptprg UTSW 14 12,215,992 (GRCm38) missense probably damaging 1.00
R9621:Ptprg UTSW 14 12,237,809 (GRCm38) missense probably benign
R9625:Ptprg UTSW 14 12,152,027 (GRCm38) missense probably damaging 1.00
R9773:Ptprg UTSW 14 12,199,806 (GRCm38) missense probably damaging 0.97
X0020:Ptprg UTSW 14 12,110,070 (GRCm38) frame shift probably null
X0027:Ptprg UTSW 14 12,110,070 (GRCm38) frame shift probably null
Predicted Primers PCR Primer
(F):5'- GCGTGCTTTCTAGGGAACAG -3'
(R):5'- TCTAGGAATACTTGGAGCCCAGC -3'

Sequencing Primer
(F):5'- CTTTCTAGGGAACAGGCATTTG -3'
(R):5'- TACTTGGAGCCCAGCAAAGTTTG -3'
Posted On 2016-04-27