Incidental Mutation 'R4980:Cracd'
ID 384739
Institutional Source Beutler Lab
Gene Symbol Cracd
Ensembl Gene ENSMUSG00000036377
Gene Name capping protein inhibiting regulator of actin
Synonyms C530008M17Rik
MMRRC Submission 042575-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4980 (G1)
Quality Score 175
Status Not validated
Chromosome 5
Chromosomal Location 76804359-77021401 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 77005421 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 594 (D594V)
Ref Sequence ENSEMBL: ENSMUSP00000127212 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000120639] [ENSMUST00000121160] [ENSMUST00000163347]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000120639
AA Change: D594V
SMART Domains Protein: ENSMUSP00000113796
Gene: ENSMUSG00000036377
AA Change: D594V

DomainStartEndE-ValueType
Pfam:DUF4592 44 173 1.7e-45 PFAM
low complexity region 210 220 N/A INTRINSIC
coiled coil region 224 291 N/A INTRINSIC
coiled coil region 328 482 N/A INTRINSIC
low complexity region 533 547 N/A INTRINSIC
low complexity region 580 593 N/A INTRINSIC
low complexity region 875 888 N/A INTRINSIC
internal_repeat_1 947 1025 1.47e-5 PROSPERO
low complexity region 1034 1047 N/A INTRINSIC
internal_repeat_1 1065 1122 1.47e-5 PROSPERO
low complexity region 1268 1280 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000121160
AA Change: D594V
SMART Domains Protein: ENSMUSP00000113947
Gene: ENSMUSG00000036377
AA Change: D594V

DomainStartEndE-ValueType
Pfam:DUF4592 45 172 1.8e-41 PFAM
low complexity region 210 220 N/A INTRINSIC
coiled coil region 224 291 N/A INTRINSIC
coiled coil region 328 482 N/A INTRINSIC
low complexity region 533 547 N/A INTRINSIC
low complexity region 580 593 N/A INTRINSIC
low complexity region 875 888 N/A INTRINSIC
low complexity region 1034 1047 N/A INTRINSIC
low complexity region 1271 1283 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152373
Predicted Effect unknown
Transcript: ENSMUST00000163347
AA Change: D594V
SMART Domains Protein: ENSMUSP00000127212
Gene: ENSMUSG00000036377
AA Change: D594V

DomainStartEndE-ValueType
Pfam:DUF4592 44 173 1.7e-45 PFAM
low complexity region 210 220 N/A INTRINSIC
coiled coil region 224 291 N/A INTRINSIC
coiled coil region 328 482 N/A INTRINSIC
low complexity region 533 547 N/A INTRINSIC
low complexity region 580 593 N/A INTRINSIC
low complexity region 875 888 N/A INTRINSIC
internal_repeat_1 947 1025 1.47e-5 PROSPERO
low complexity region 1034 1047 N/A INTRINSIC
internal_repeat_1 1065 1122 1.47e-5 PROSPERO
low complexity region 1268 1280 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522L14Rik A T 5: 109,885,292 (GRCm39) C189S probably damaging Het
Abcd3 A T 3: 121,562,917 (GRCm39) probably null Het
Adar T C 3: 89,638,121 (GRCm39) S2P probably benign Het
Amhr2 T A 15: 102,362,765 (GRCm39) S511T probably benign Het
Atg16l1 T C 1: 87,694,553 (GRCm39) S77P possibly damaging Het
Bltp1 T C 3: 36,997,461 (GRCm39) S1173P probably damaging Het
Cacna1i T C 15: 80,232,650 (GRCm39) F218L probably damaging Het
Cd5l A T 3: 87,274,908 (GRCm39) H149L probably benign Het
Cdc14a T A 3: 116,186,506 (GRCm39) R92* probably null Het
Col19a1 T C 1: 24,565,564 (GRCm39) T256A unknown Het
Col22a1 C T 15: 71,673,792 (GRCm39) A975T unknown Het
Cyp20a1 T C 1: 60,402,373 (GRCm39) W153R probably damaging Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Homo
Dpyd T C 3: 118,710,767 (GRCm39) S392P probably damaging Het
Dst A T 1: 34,295,369 (GRCm39) L957F probably damaging Het
Emilin2 G T 17: 71,560,066 (GRCm39) D970E possibly damaging Het
Fbn2 T C 18: 58,143,703 (GRCm39) E2784G probably benign Het
Fbxw10 T C 11: 62,738,583 (GRCm39) I159T possibly damaging Het
Fgfr2 T C 7: 129,802,810 (GRCm39) Y192C probably damaging Het
Gm7298 A G 6: 121,736,198 (GRCm39) probably null Het
Igf2r C T 17: 12,922,247 (GRCm39) probably null Het
Ints4 T C 7: 97,151,057 (GRCm39) probably null Het
Kcnf1 A G 12: 17,225,012 (GRCm39) F403S possibly damaging Het
Kif11 C T 19: 37,375,819 (GRCm39) Q211* probably null Het
Kif13a A G 13: 46,906,222 (GRCm39) S574P possibly damaging Het
Kifc3 T A 8: 95,853,177 (GRCm39) T60S probably benign Het
Krt82 T C 15: 101,453,534 (GRCm39) D284G possibly damaging Het
Lancl1 T C 1: 67,043,968 (GRCm39) Y344C probably benign Het
Ltbp3 A T 19: 5,803,955 (GRCm39) probably null Het
Map3k4 A G 17: 12,490,958 (GRCm39) F158L probably damaging Het
Mast2 A G 4: 116,174,948 (GRCm39) Y469H probably damaging Het
Mcf2l T G 8: 13,034,883 (GRCm39) F97C probably damaging Het
Mpeg1 T C 19: 12,438,904 (GRCm39) S121P probably damaging Het
Mycbp2 A T 14: 103,497,821 (GRCm39) probably null Het
Myt1l A T 12: 29,877,038 (GRCm39) T230S unknown Het
Naa15 T C 3: 51,366,173 (GRCm39) probably null Het
Nans G A 4: 46,492,764 (GRCm39) R64Q probably benign Het
Nbea C T 3: 55,554,772 (GRCm39) probably null Het
Nbea T C 3: 55,860,466 (GRCm39) E1870G probably benign Het
Ncapd3 T C 9: 26,974,591 (GRCm39) S688P probably damaging Het
Nedd4l G T 18: 65,213,131 (GRCm39) E96* probably null Het
Or56a5 T A 7: 104,793,431 (GRCm39) Y23F probably benign Het
Or5b21 A T 19: 12,839,384 (GRCm39) M82L probably benign Het
Pdxk A G 10: 78,287,318 (GRCm39) L81P probably damaging Het
Plec T A 15: 76,077,495 (GRCm39) R269* probably null Het
Plec T C 15: 76,090,065 (GRCm39) I92V probably damaging Het
Ppara T C 15: 85,671,434 (GRCm39) Y112H probably damaging Het
Ppp2r2c A T 5: 37,109,732 (GRCm39) M364L probably benign Het
Prag1 A C 8: 36,606,740 (GRCm39) H827P probably damaging Het
Ptprg A G 14: 12,154,421 (GRCm38) N714S probably benign Het
Rbp2 G A 9: 98,380,894 (GRCm39) V67I probably benign Het
Rictor T A 15: 6,811,141 (GRCm39) Y835N probably damaging Het
Ripply2 A G 9: 86,901,747 (GRCm39) Q91R probably damaging Het
Sap130 C A 18: 31,782,699 (GRCm39) H203Q possibly damaging Het
Sema4d T C 13: 51,865,270 (GRCm39) Y358C probably damaging Het
Serbp1 G A 6: 67,254,872 (GRCm39) D294N probably benign Het
Slc16a10 A G 10: 39,956,801 (GRCm39) W113R probably damaging Het
Slc6a6 A G 6: 91,703,041 (GRCm39) Y138C probably damaging Het
Spag11a T C 8: 19,207,962 (GRCm39) M1T probably null Het
Spata20 T C 11: 94,375,435 (GRCm39) M120V probably damaging Het
Stk32a A C 18: 43,447,113 (GRCm39) K357Q probably benign Het
Tasor T A 14: 27,183,382 (GRCm39) L614I probably benign Het
Trmo A T 4: 46,389,364 (GRCm39) C10* probably null Het
Tsc22d1 T G 14: 76,655,696 (GRCm39) V643G probably benign Het
Vangl2 A T 1: 171,837,132 (GRCm39) L226I probably damaging Het
Vps35l T A 7: 118,406,232 (GRCm39) D605E probably damaging Het
Wnt3a A T 11: 59,140,626 (GRCm39) C297S probably damaging Het
Wwc1 T C 11: 35,778,930 (GRCm39) K301E possibly damaging Het
Zfhx4 C T 3: 5,464,039 (GRCm39) T1399I possibly damaging Het
Zswim4 C T 8: 84,953,296 (GRCm39) probably null Het
Other mutations in Cracd
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00470:Cracd APN 5 77,013,903 (GRCm39) unclassified probably benign
IGL00660:Cracd APN 5 77,002,780 (GRCm39) critical splice acceptor site probably null
IGL00924:Cracd APN 5 77,006,833 (GRCm39) missense unknown
IGL01025:Cracd APN 5 76,805,921 (GRCm39) intron probably benign
IGL01122:Cracd APN 5 77,018,522 (GRCm39) makesense probably null
IGL01393:Cracd APN 5 77,006,818 (GRCm39) missense unknown
IGL01526:Cracd APN 5 77,005,478 (GRCm39) missense unknown
IGL01986:Cracd APN 5 77,006,457 (GRCm39) missense unknown
IGL02009:Cracd APN 5 76,996,817 (GRCm39) missense possibly damaging 0.61
IGL02724:Cracd APN 5 77,006,306 (GRCm39) missense unknown
IGL02869:Cracd APN 5 77,006,890 (GRCm39) missense unknown
IGL03030:Cracd APN 5 77,005,463 (GRCm39) missense unknown
IGL03150:Cracd APN 5 77,015,097 (GRCm39) missense probably damaging 0.99
LCD18:Cracd UTSW 5 76,806,589 (GRCm39) intron probably benign
R0975:Cracd UTSW 5 77,004,165 (GRCm39) splice site probably benign
R1329:Cracd UTSW 5 76,805,779 (GRCm39) intron probably benign
R1439:Cracd UTSW 5 76,988,757 (GRCm39) missense probably damaging 0.99
R1750:Cracd UTSW 5 77,005,522 (GRCm39) missense unknown
R1773:Cracd UTSW 5 77,015,052 (GRCm39) missense possibly damaging 0.54
R1885:Cracd UTSW 5 77,004,589 (GRCm39) missense unknown
R1924:Cracd UTSW 5 77,006,470 (GRCm39) missense unknown
R2483:Cracd UTSW 5 77,004,256 (GRCm39) missense probably damaging 0.98
R3840:Cracd UTSW 5 77,006,858 (GRCm39) missense unknown
R3841:Cracd UTSW 5 77,006,858 (GRCm39) missense unknown
R3874:Cracd UTSW 5 76,988,739 (GRCm39) missense probably damaging 1.00
R3883:Cracd UTSW 5 77,004,421 (GRCm39) missense unknown
R4033:Cracd UTSW 5 77,006,312 (GRCm39) missense unknown
R4401:Cracd UTSW 5 76,996,763 (GRCm39) missense probably damaging 0.98
R4749:Cracd UTSW 5 77,006,681 (GRCm39) missense unknown
R4884:Cracd UTSW 5 76,996,682 (GRCm39) missense probably damaging 1.00
R5010:Cracd UTSW 5 76,805,681 (GRCm39) utr 5 prime probably benign
R5086:Cracd UTSW 5 77,004,971 (GRCm39) missense unknown
R5468:Cracd UTSW 5 76,988,610 (GRCm39) intron probably benign
R5786:Cracd UTSW 5 77,014,043 (GRCm39) splice site probably null
R5813:Cracd UTSW 5 77,006,275 (GRCm39) missense unknown
R5866:Cracd UTSW 5 77,005,384 (GRCm39) missense unknown
R5928:Cracd UTSW 5 76,989,581 (GRCm39) intron probably benign
R6273:Cracd UTSW 5 77,005,568 (GRCm39) missense unknown
R6577:Cracd UTSW 5 77,013,947 (GRCm39) unclassified probably benign
R6838:Cracd UTSW 5 77,006,056 (GRCm39) missense unknown
R6849:Cracd UTSW 5 77,005,004 (GRCm39) missense unknown
R6849:Cracd UTSW 5 77,004,857 (GRCm39) missense unknown
R6914:Cracd UTSW 5 77,004,854 (GRCm39) missense unknown
R7017:Cracd UTSW 5 77,004,795 (GRCm39) small deletion probably benign
R7094:Cracd UTSW 5 77,006,879 (GRCm39) missense unknown
R7367:Cracd UTSW 5 77,004,449 (GRCm39) missense unknown
R7394:Cracd UTSW 5 77,004,801 (GRCm39) small deletion probably benign
R7436:Cracd UTSW 5 77,004,801 (GRCm39) small deletion probably benign
R7443:Cracd UTSW 5 77,004,485 (GRCm39) missense unknown
R7500:Cracd UTSW 5 76,805,905 (GRCm39) missense unknown
R7566:Cracd UTSW 5 77,014,122 (GRCm39) splice site probably null
R7633:Cracd UTSW 5 77,005,367 (GRCm39) missense unknown
R7728:Cracd UTSW 5 77,005,316 (GRCm39) missense unknown
R7930:Cracd UTSW 5 77,004,801 (GRCm39) small deletion probably benign
R7985:Cracd UTSW 5 76,805,897 (GRCm39) missense unknown
R8154:Cracd UTSW 5 76,989,644 (GRCm39) missense unknown
R8463:Cracd UTSW 5 77,004,801 (GRCm39) small deletion probably benign
R8547:Cracd UTSW 5 77,004,801 (GRCm39) small deletion probably benign
R8805:Cracd UTSW 5 77,006,489 (GRCm39) missense unknown
R8819:Cracd UTSW 5 77,004,793 (GRCm39) small deletion probably benign
R8888:Cracd UTSW 5 77,004,801 (GRCm39) small deletion probably benign
R9256:Cracd UTSW 5 76,988,757 (GRCm39) missense unknown
R9358:Cracd UTSW 5 77,002,836 (GRCm39) missense probably damaging 1.00
R9417:Cracd UTSW 5 77,004,801 (GRCm39) small deletion probably benign
R9618:Cracd UTSW 5 77,004,617 (GRCm39) missense unknown
R9628:Cracd UTSW 5 77,004,923 (GRCm39) missense unknown
R9639:Cracd UTSW 5 77,005,997 (GRCm39) missense unknown
R9762:Cracd UTSW 5 77,006,555 (GRCm39) missense unknown
R9785:Cracd UTSW 5 77,015,028 (GRCm39) missense unknown
Z1176:Cracd UTSW 5 77,005,093 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TAACGGACGATGCTGACCAG -3'
(R):5'- GACCAAAATGGCCGTGTGTG -3'

Sequencing Primer
(F):5'- CGAGAAGACCTGGAATCCGC -3'
(R):5'- ATGCTCAGCGCTGATGG -3'
Posted On 2016-05-10