Incidental Mutation 'R4980:Kif11'
ID 384788
Institutional Source Beutler Lab
Gene Symbol Kif11
Ensembl Gene ENSMUSG00000012443
Gene Name kinesin family member 11
Synonyms Eg5, Knsl1, Kifl1
MMRRC Submission 042575-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4980 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 37364851-37410307 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 37375819 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 211 (Q211*)
Ref Sequence ENSEMBL: ENSMUSP00000012587 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000012587]
AlphaFold Q6P9P6
Predicted Effect probably null
Transcript: ENSMUST00000012587
AA Change: Q211*
SMART Domains Protein: ENSMUSP00000012587
Gene: ENSMUSG00000012443
AA Change: Q211*

DomainStartEndE-ValueType
KISc 15 366 8.21e-180 SMART
Blast:KISc 372 417 1e-16 BLAST
low complexity region 453 465 N/A INTRINSIC
Pfam:Microtub_bind 915 1049 1.2e-44 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Deletion of Kif11 results in early embryonic lethality of homozygotes, with developmental growth arrest at E3.5. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522L14Rik A T 5: 109,885,292 (GRCm39) C189S probably damaging Het
Abcd3 A T 3: 121,562,917 (GRCm39) probably null Het
Adar T C 3: 89,638,121 (GRCm39) S2P probably benign Het
Amhr2 T A 15: 102,362,765 (GRCm39) S511T probably benign Het
Atg16l1 T C 1: 87,694,553 (GRCm39) S77P possibly damaging Het
Bltp1 T C 3: 36,997,461 (GRCm39) S1173P probably damaging Het
Cacna1i T C 15: 80,232,650 (GRCm39) F218L probably damaging Het
Cd5l A T 3: 87,274,908 (GRCm39) H149L probably benign Het
Cdc14a T A 3: 116,186,506 (GRCm39) R92* probably null Het
Col19a1 T C 1: 24,565,564 (GRCm39) T256A unknown Het
Col22a1 C T 15: 71,673,792 (GRCm39) A975T unknown Het
Cracd A T 5: 77,005,421 (GRCm39) D594V unknown Het
Cyp20a1 T C 1: 60,402,373 (GRCm39) W153R probably damaging Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Homo
Dpyd T C 3: 118,710,767 (GRCm39) S392P probably damaging Het
Dst A T 1: 34,295,369 (GRCm39) L957F probably damaging Het
Emilin2 G T 17: 71,560,066 (GRCm39) D970E possibly damaging Het
Fbn2 T C 18: 58,143,703 (GRCm39) E2784G probably benign Het
Fbxw10 T C 11: 62,738,583 (GRCm39) I159T possibly damaging Het
Fgfr2 T C 7: 129,802,810 (GRCm39) Y192C probably damaging Het
Gm7298 A G 6: 121,736,198 (GRCm39) probably null Het
Igf2r C T 17: 12,922,247 (GRCm39) probably null Het
Ints4 T C 7: 97,151,057 (GRCm39) probably null Het
Kcnf1 A G 12: 17,225,012 (GRCm39) F403S possibly damaging Het
Kif13a A G 13: 46,906,222 (GRCm39) S574P possibly damaging Het
Kifc3 T A 8: 95,853,177 (GRCm39) T60S probably benign Het
Krt82 T C 15: 101,453,534 (GRCm39) D284G possibly damaging Het
Lancl1 T C 1: 67,043,968 (GRCm39) Y344C probably benign Het
Ltbp3 A T 19: 5,803,955 (GRCm39) probably null Het
Map3k4 A G 17: 12,490,958 (GRCm39) F158L probably damaging Het
Mast2 A G 4: 116,174,948 (GRCm39) Y469H probably damaging Het
Mcf2l T G 8: 13,034,883 (GRCm39) F97C probably damaging Het
Mpeg1 T C 19: 12,438,904 (GRCm39) S121P probably damaging Het
Mycbp2 A T 14: 103,497,821 (GRCm39) probably null Het
Myt1l A T 12: 29,877,038 (GRCm39) T230S unknown Het
Naa15 T C 3: 51,366,173 (GRCm39) probably null Het
Nans G A 4: 46,492,764 (GRCm39) R64Q probably benign Het
Nbea C T 3: 55,554,772 (GRCm39) probably null Het
Nbea T C 3: 55,860,466 (GRCm39) E1870G probably benign Het
Ncapd3 T C 9: 26,974,591 (GRCm39) S688P probably damaging Het
Nedd4l G T 18: 65,213,131 (GRCm39) E96* probably null Het
Or56a5 T A 7: 104,793,431 (GRCm39) Y23F probably benign Het
Or5b21 A T 19: 12,839,384 (GRCm39) M82L probably benign Het
Pdxk A G 10: 78,287,318 (GRCm39) L81P probably damaging Het
Plec T A 15: 76,077,495 (GRCm39) R269* probably null Het
Plec T C 15: 76,090,065 (GRCm39) I92V probably damaging Het
Ppara T C 15: 85,671,434 (GRCm39) Y112H probably damaging Het
Ppp2r2c A T 5: 37,109,732 (GRCm39) M364L probably benign Het
Prag1 A C 8: 36,606,740 (GRCm39) H827P probably damaging Het
Ptprg A G 14: 12,154,421 (GRCm38) N714S probably benign Het
Rbp2 G A 9: 98,380,894 (GRCm39) V67I probably benign Het
Rictor T A 15: 6,811,141 (GRCm39) Y835N probably damaging Het
Ripply2 A G 9: 86,901,747 (GRCm39) Q91R probably damaging Het
Sap130 C A 18: 31,782,699 (GRCm39) H203Q possibly damaging Het
Sema4d T C 13: 51,865,270 (GRCm39) Y358C probably damaging Het
Serbp1 G A 6: 67,254,872 (GRCm39) D294N probably benign Het
Slc16a10 A G 10: 39,956,801 (GRCm39) W113R probably damaging Het
Slc6a6 A G 6: 91,703,041 (GRCm39) Y138C probably damaging Het
Spag11a T C 8: 19,207,962 (GRCm39) M1T probably null Het
Spata20 T C 11: 94,375,435 (GRCm39) M120V probably damaging Het
Stk32a A C 18: 43,447,113 (GRCm39) K357Q probably benign Het
Tasor T A 14: 27,183,382 (GRCm39) L614I probably benign Het
Trmo A T 4: 46,389,364 (GRCm39) C10* probably null Het
Tsc22d1 T G 14: 76,655,696 (GRCm39) V643G probably benign Het
Vangl2 A T 1: 171,837,132 (GRCm39) L226I probably damaging Het
Vps35l T A 7: 118,406,232 (GRCm39) D605E probably damaging Het
Wnt3a A T 11: 59,140,626 (GRCm39) C297S probably damaging Het
Wwc1 T C 11: 35,778,930 (GRCm39) K301E possibly damaging Het
Zfhx4 C T 3: 5,464,039 (GRCm39) T1399I possibly damaging Het
Zswim4 C T 8: 84,953,296 (GRCm39) probably null Het
Other mutations in Kif11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00434:Kif11 APN 19 37,399,857 (GRCm39) missense possibly damaging 0.82
IGL00785:Kif11 APN 19 37,392,746 (GRCm39) missense probably damaging 0.99
IGL00785:Kif11 APN 19 37,392,745 (GRCm39) missense probably benign 0.01
IGL01586:Kif11 APN 19 37,372,681 (GRCm39) splice site probably benign
IGL01883:Kif11 APN 19 37,372,791 (GRCm39) missense probably benign 0.01
IGL02138:Kif11 APN 19 37,373,057 (GRCm39) missense probably damaging 1.00
IGL03197:Kif11 APN 19 37,395,475 (GRCm39) missense probably benign 0.00
PIT4151001:Kif11 UTSW 19 37,373,045 (GRCm39) missense probably damaging 1.00
R0027:Kif11 UTSW 19 37,395,431 (GRCm39) splice site probably benign
R0027:Kif11 UTSW 19 37,395,431 (GRCm39) splice site probably benign
R0104:Kif11 UTSW 19 37,401,663 (GRCm39) missense probably benign 0.00
R0254:Kif11 UTSW 19 37,399,957 (GRCm39) missense probably benign 0.00
R0631:Kif11 UTSW 19 37,401,565 (GRCm39) splice site probably benign
R1607:Kif11 UTSW 19 37,375,648 (GRCm39) nonsense probably null
R1895:Kif11 UTSW 19 37,375,847 (GRCm39) missense probably damaging 1.00
R1983:Kif11 UTSW 19 37,379,224 (GRCm39) missense possibly damaging 0.78
R2056:Kif11 UTSW 19 37,390,660 (GRCm39) missense probably benign 0.17
R2158:Kif11 UTSW 19 37,399,062 (GRCm39) missense probably benign
R2291:Kif11 UTSW 19 37,395,451 (GRCm39) missense probably benign
R2300:Kif11 UTSW 19 37,399,987 (GRCm39) missense probably benign 0.01
R2850:Kif11 UTSW 19 37,397,941 (GRCm39) missense probably benign
R2904:Kif11 UTSW 19 37,392,103 (GRCm39) splice site probably benign
R3035:Kif11 UTSW 19 37,395,501 (GRCm39) missense possibly damaging 0.92
R3908:Kif11 UTSW 19 37,379,169 (GRCm39) missense probably damaging 1.00
R4319:Kif11 UTSW 19 37,373,033 (GRCm39) missense probably damaging 0.99
R4356:Kif11 UTSW 19 37,399,883 (GRCm39) missense probably benign 0.00
R4469:Kif11 UTSW 19 37,404,940 (GRCm39) missense probably benign 0.05
R4623:Kif11 UTSW 19 37,398,195 (GRCm39) missense probably benign
R4779:Kif11 UTSW 19 37,406,397 (GRCm39) missense probably benign 0.00
R4911:Kif11 UTSW 19 37,406,385 (GRCm39) missense probably benign 0.00
R5109:Kif11 UTSW 19 37,373,063 (GRCm39) missense possibly damaging 0.81
R5770:Kif11 UTSW 19 37,379,313 (GRCm39) missense probably benign 0.03
R6023:Kif11 UTSW 19 37,379,158 (GRCm39) missense probably damaging 1.00
R6666:Kif11 UTSW 19 37,398,214 (GRCm39) missense probably benign
R6755:Kif11 UTSW 19 37,398,199 (GRCm39) missense probably benign 0.01
R6845:Kif11 UTSW 19 37,392,565 (GRCm39) missense probably damaging 1.00
R7052:Kif11 UTSW 19 37,373,040 (GRCm39) nonsense probably null
R7367:Kif11 UTSW 19 37,408,789 (GRCm39) missense probably benign
R7387:Kif11 UTSW 19 37,398,204 (GRCm39) missense probably damaging 1.00
R7485:Kif11 UTSW 19 37,399,072 (GRCm39) missense possibly damaging 0.94
R7502:Kif11 UTSW 19 37,398,255 (GRCm39) missense possibly damaging 0.53
R7591:Kif11 UTSW 19 37,372,711 (GRCm39) missense probably damaging 1.00
R7618:Kif11 UTSW 19 37,400,008 (GRCm39) missense probably benign 0.32
R7809:Kif11 UTSW 19 37,373,057 (GRCm39) missense probably damaging 1.00
R8181:Kif11 UTSW 19 37,379,095 (GRCm39) critical splice acceptor site probably null
R8274:Kif11 UTSW 19 37,391,994 (GRCm39) missense probably damaging 0.99
R8323:Kif11 UTSW 19 37,372,692 (GRCm39) missense possibly damaging 0.77
R8948:Kif11 UTSW 19 37,386,602 (GRCm39) missense probably damaging 0.96
R9372:Kif11 UTSW 19 37,399,892 (GRCm39) missense probably benign 0.00
Z1177:Kif11 UTSW 19 37,401,735 (GRCm39) missense possibly damaging 0.62
Predicted Primers PCR Primer
(F):5'- GTTTCTGAAAGGCTGCAGATG -3'
(R):5'- GAATCTGAGTACCAAGGACTCCC -3'

Sequencing Primer
(F):5'- CAGATGTTTGATGATCCCCGGAAC -3'
(R):5'- TGAGTACCAAGGACTCCCCGTATAG -3'
Posted On 2016-05-10