Incidental Mutation 'R4981:Ephb2'
| ID |
384809 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ephb2
|
| Ensembl Gene |
ENSMUSG00000028664 |
| Gene Name |
Eph receptor B2 |
| Synonyms |
eteck, Cek5, Qek5, Sek3, Hek5, Drt, Prkm5, Nuk, Erk, Tyro5 |
| MMRRC Submission |
042576-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.760)
|
| Stock # |
R4981 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
136374850-136563299 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 136423321 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Threonine
at position 319
(M319T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101472
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000059287]
[ENSMUST00000105845]
[ENSMUST00000105846]
|
| AlphaFold |
P54763 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000059287
AA Change: M319T
PolyPhen 2
Score 0.085 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000058135
Gene: ENSMUSG00000028664
AA Change: M319T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
EPH_lbd
|
20 |
197 |
7.37e-130 |
SMART |
|
Pfam:GCC2_GCC3
|
261 |
304 |
8.1e-10 |
PFAM |
|
FN3
|
325 |
417 |
1.75e-6 |
SMART |
|
FN3
|
436 |
518 |
1.23e-10 |
SMART |
|
Pfam:EphA2_TM
|
545 |
619 |
6e-25 |
PFAM |
|
TyrKc
|
622 |
881 |
1.34e-138 |
SMART |
|
SAM
|
911 |
978 |
1.18e-23 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105845
AA Change: M319T
PolyPhen 2
Score 0.085 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000101471
Gene: ENSMUSG00000028664
AA Change: M319T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
EPH_lbd
|
20 |
197 |
7.37e-130 |
SMART |
|
Pfam:GCC2_GCC3
|
259 |
305 |
2.2e-10 |
PFAM |
|
FN3
|
325 |
417 |
1.75e-6 |
SMART |
|
FN3
|
436 |
517 |
1.41e-10 |
SMART |
|
Pfam:EphA2_TM
|
543 |
618 |
2.1e-30 |
PFAM |
|
TyrKc
|
621 |
880 |
1.34e-138 |
SMART |
|
SAM
|
910 |
977 |
1.18e-23 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105846
AA Change: M319T
PolyPhen 2
Score 0.085 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000101472
Gene: ENSMUSG00000028664
AA Change: M319T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
EPH_lbd
|
20 |
197 |
7.37e-130 |
SMART |
|
Pfam:GCC2_GCC3
|
259 |
305 |
2.2e-10 |
PFAM |
|
FN3
|
325 |
417 |
1.75e-6 |
SMART |
|
FN3
|
436 |
517 |
1.41e-10 |
SMART |
|
Pfam:EphA2_TM
|
543 |
619 |
1e-30 |
PFAM |
|
TyrKc
|
622 |
881 |
1.34e-138 |
SMART |
|
SAM
|
911 |
978 |
1.18e-23 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156558
|
| SMART Domains |
Protein: ENSMUSP00000116350
Gene: ENSMUSG00000028664
| Domain | Start | End | E-Value | Type |
|---|
|
FN3
|
1 |
85 |
6.48e1 |
SMART |
|
FN3
|
104 |
186 |
1.23e-10 |
SMART |
|
Pfam:EphA2_TM
|
213 |
276 |
2.5e-16 |
PFAM |
|
| Meta Mutation Damage Score |
0.1891 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.2%
- 10x: 96.0%
- 20x: 91.3%
|
| Validation Efficiency |
100% (105/105) |
| MGI Phenotype |
FUNCTION: This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors consist of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. The encoded receptor preferentially binds membrane-bound ephrin-B ligands and is involved in nervous system and vascular development. This gene is used as a marker of intestinal stem cells. Homozygous knockout mice for this gene exhibit impaired axon guidance and vestibular function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit abnormal axon guidance, circling, head bobbing, and hyperactivity. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700097O09Rik |
A |
T |
12: 55,095,772 (GRCm39) |
|
probably null |
Het |
| Aatf |
T |
C |
11: 84,402,323 (GRCm39) |
D121G |
probably benign |
Het |
| Amer2 |
T |
A |
14: 60,617,176 (GRCm39) |
L331H |
probably damaging |
Het |
| Ang4 |
T |
G |
14: 52,001,829 (GRCm39) |
K40Q |
probably benign |
Het |
| Aspm |
A |
C |
1: 139,398,498 (GRCm39) |
|
probably null |
Het |
| Cacna1c |
A |
T |
6: 118,728,432 (GRCm39) |
D337E |
probably benign |
Het |
| Ccdc124 |
T |
C |
8: 71,321,429 (GRCm39) |
E134G |
probably benign |
Het |
| Ccdc7a |
G |
T |
8: 129,711,464 (GRCm39) |
A312E |
probably benign |
Het |
| Cd209g |
A |
G |
8: 4,186,845 (GRCm39) |
D130G |
probably damaging |
Het |
| Cd320 |
T |
C |
17: 34,066,549 (GRCm39) |
S96P |
probably benign |
Het |
| Cenatac |
A |
T |
9: 44,329,245 (GRCm39) |
F14Y |
probably damaging |
Het |
| Clu |
C |
G |
14: 66,210,815 (GRCm39) |
Q134E |
probably damaging |
Het |
| Cnksr3 |
T |
A |
10: 7,110,777 (GRCm39) |
H28L |
probably benign |
Het |
| Cntnap1 |
T |
C |
11: 101,067,159 (GRCm39) |
|
probably null |
Het |
| Col22a1 |
C |
T |
15: 71,732,915 (GRCm39) |
C546Y |
unknown |
Het |
| Col6a3 |
C |
T |
1: 90,706,565 (GRCm39) |
V2183I |
unknown |
Het |
| Cop1 |
A |
G |
1: 159,152,638 (GRCm39) |
|
probably benign |
Het |
| Cpne8 |
T |
C |
15: 90,563,438 (GRCm39) |
I24V |
probably benign |
Het |
| Cspp1 |
T |
A |
1: 10,196,688 (GRCm39) |
N900K |
probably damaging |
Het |
| Dennd5b |
G |
A |
6: 148,911,270 (GRCm39) |
L978F |
possibly damaging |
Het |
| Depdc1a |
G |
T |
3: 159,229,550 (GRCm39) |
M627I |
probably benign |
Het |
| Dnah3 |
A |
T |
7: 119,555,424 (GRCm39) |
N2721K |
probably benign |
Het |
| Dnase1l1 |
C |
T |
X: 73,320,644 (GRCm39) |
|
probably null |
Homo |
| Dsg1b |
A |
G |
18: 20,541,925 (GRCm39) |
T811A |
possibly damaging |
Het |
| Emilin1 |
C |
G |
5: 31,076,695 (GRCm39) |
Q847E |
probably benign |
Het |
| Epha3 |
A |
T |
16: 63,472,775 (GRCm39) |
V370D |
probably benign |
Het |
| Epha5 |
T |
A |
5: 84,298,342 (GRCm39) |
T406S |
probably damaging |
Het |
| Ephb1 |
A |
T |
9: 101,918,159 (GRCm39) |
I450N |
probably benign |
Het |
| Eps15l1 |
A |
G |
8: 73,132,833 (GRCm39) |
|
probably null |
Het |
| Fbxo9 |
G |
A |
9: 77,993,168 (GRCm39) |
|
probably benign |
Het |
| Fgd5 |
T |
C |
6: 91,966,281 (GRCm39) |
I838T |
probably damaging |
Het |
| Fnbp4 |
T |
C |
2: 90,596,174 (GRCm39) |
F582L |
probably damaging |
Het |
| Frs3 |
T |
C |
17: 48,000,187 (GRCm39) |
|
probably null |
Het |
| Fscb |
C |
T |
12: 64,520,393 (GRCm39) |
V358I |
possibly damaging |
Het |
| Fus |
G |
T |
7: 127,566,727 (GRCm39) |
|
probably benign |
Het |
| Fyb1 |
CCTCTCTCTCTCTCTCTCTCT |
CCTCTCTCTCTCTCTCTCT |
15: 6,676,092 (GRCm39) |
|
probably benign |
Het |
| Glra3 |
A |
T |
8: 56,444,270 (GRCm39) |
I77F |
possibly damaging |
Het |
| Gm4454 |
C |
T |
7: 38,269,860 (GRCm39) |
|
noncoding transcript |
Het |
| Gng3 |
G |
A |
19: 8,815,625 (GRCm39) |
A37V |
possibly damaging |
Het |
| Grin3b |
T |
A |
10: 79,812,191 (GRCm39) |
|
probably benign |
Het |
| Herpud1 |
A |
G |
8: 95,118,422 (GRCm39) |
Y41C |
probably damaging |
Het |
| Igkv4-92 |
G |
C |
6: 68,732,028 (GRCm39) |
S115R |
possibly damaging |
Het |
| Ikbip |
T |
A |
10: 90,931,848 (GRCm39) |
I164N |
probably benign |
Het |
| Kank1 |
A |
G |
19: 25,388,759 (GRCm39) |
T783A |
probably benign |
Het |
| Kcnq3 |
A |
T |
15: 65,903,254 (GRCm39) |
V152E |
possibly damaging |
Het |
| Kif23 |
C |
T |
9: 61,839,153 (GRCm39) |
R314H |
probably damaging |
Het |
| Klc4 |
T |
C |
17: 46,955,287 (GRCm39) |
H49R |
probably benign |
Het |
| Klhl20 |
A |
T |
1: 160,930,575 (GRCm39) |
I309N |
possibly damaging |
Het |
| Lgals4 |
A |
G |
7: 28,540,701 (GRCm39) |
Y268C |
probably damaging |
Het |
| Lingo4 |
A |
G |
3: 94,306,761 (GRCm39) |
Q13R |
probably benign |
Het |
| Lmtk2 |
C |
A |
5: 144,113,265 (GRCm39) |
F1328L |
probably damaging |
Het |
| Mapk14 |
A |
G |
17: 28,960,765 (GRCm39) |
R179G |
probably damaging |
Het |
| Mbd3l1 |
A |
T |
9: 18,396,201 (GRCm39) |
T109S |
probably benign |
Het |
| Megf6 |
T |
C |
4: 154,351,907 (GRCm39) |
F1169L |
possibly damaging |
Het |
| Mrgpra1 |
A |
T |
7: 46,984,959 (GRCm39) |
V240D |
probably damaging |
Het |
| Muc6 |
G |
A |
7: 141,218,313 (GRCm39) |
S2120F |
possibly damaging |
Het |
| Myh1 |
T |
C |
11: 67,115,300 (GRCm39) |
|
probably benign |
Het |
| Nav3 |
T |
C |
10: 109,716,553 (GRCm39) |
I172V |
probably benign |
Het |
| Nemp1 |
T |
A |
10: 127,529,399 (GRCm39) |
L178Q |
probably damaging |
Het |
| Numa1 |
T |
C |
7: 101,641,881 (GRCm39) |
S110P |
probably damaging |
Het |
| Or4a75 |
A |
G |
2: 89,447,769 (GRCm39) |
Y256H |
probably damaging |
Het |
| Or4c117 |
T |
C |
2: 88,955,845 (GRCm39) |
T77A |
probably benign |
Het |
| Or51k1 |
A |
G |
7: 103,661,312 (GRCm39) |
I199T |
probably damaging |
Het |
| Or5ak25 |
A |
G |
2: 85,268,813 (GRCm39) |
S230P |
probably damaging |
Het |
| Or8k30 |
T |
C |
2: 86,339,171 (GRCm39) |
Y123H |
probably damaging |
Het |
| Or9q1 |
A |
T |
19: 13,805,458 (GRCm39) |
F101I |
probably damaging |
Het |
| Pard3b |
T |
G |
1: 62,383,219 (GRCm39) |
M771R |
probably damaging |
Het |
| Phkg2 |
A |
G |
7: 127,181,551 (GRCm39) |
I245V |
probably damaging |
Het |
| Pik3cg |
A |
T |
12: 32,254,103 (GRCm39) |
M628K |
possibly damaging |
Het |
| Poln |
A |
G |
5: 34,264,429 (GRCm39) |
|
probably null |
Het |
| Ppip5k1 |
A |
T |
2: 121,142,871 (GRCm39) |
S1172T |
probably damaging |
Het |
| Prdm5 |
A |
T |
6: 65,847,446 (GRCm39) |
H363L |
probably damaging |
Het |
| Prkdc |
A |
G |
16: 15,496,173 (GRCm39) |
Y788C |
probably damaging |
Het |
| Prrc2c |
T |
A |
1: 162,520,116 (GRCm39) |
R2076S |
probably damaging |
Het |
| Sh2d2a |
A |
G |
3: 87,756,728 (GRCm39) |
Y191C |
probably damaging |
Het |
| Slc20a1 |
T |
C |
2: 129,041,919 (GRCm39) |
I94T |
probably damaging |
Het |
| Sptbn2 |
T |
C |
19: 4,801,686 (GRCm39) |
V2366A |
probably benign |
Het |
| Stab2 |
T |
A |
10: 86,796,087 (GRCm39) |
M387L |
probably benign |
Het |
| Syne2 |
T |
G |
12: 75,987,993 (GRCm39) |
M1718R |
probably damaging |
Het |
| Synm |
G |
T |
7: 67,384,235 (GRCm39) |
F700L |
probably benign |
Het |
| Tmco4 |
T |
C |
4: 138,718,012 (GRCm39) |
F51L |
possibly damaging |
Het |
| Tmem104 |
C |
A |
11: 115,095,962 (GRCm39) |
P168T |
probably damaging |
Het |
| Tril |
G |
T |
6: 53,795,905 (GRCm39) |
T439K |
probably benign |
Het |
| Trim2 |
A |
G |
3: 84,085,042 (GRCm39) |
L559P |
probably damaging |
Het |
| Trim3 |
A |
G |
7: 105,268,335 (GRCm39) |
V149A |
probably damaging |
Het |
| Triml2 |
A |
G |
8: 43,640,717 (GRCm39) |
N191S |
probably benign |
Het |
| Usp4 |
A |
G |
9: 108,258,617 (GRCm39) |
D16G |
probably benign |
Het |
| Vmn2r58 |
G |
A |
7: 41,486,885 (GRCm39) |
T670I |
probably damaging |
Het |
| Vmn2r97 |
G |
T |
17: 19,160,436 (GRCm39) |
G524* |
probably null |
Het |
| Xpo5 |
C |
A |
17: 46,531,743 (GRCm39) |
F426L |
probably damaging |
Het |
| Zfp800 |
A |
G |
6: 28,247,190 (GRCm39) |
L84S |
probably damaging |
Het |
| Zranb2 |
T |
G |
3: 157,252,378 (GRCm39) |
|
probably benign |
Het |
| Zswim4 |
C |
T |
8: 84,953,296 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Ephb2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00336:Ephb2
|
APN |
4 |
136,384,795 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00963:Ephb2
|
APN |
4 |
136,386,262 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01111:Ephb2
|
APN |
4 |
136,384,721 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01462:Ephb2
|
APN |
4 |
136,498,681 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
IGL01863:Ephb2
|
APN |
4 |
136,387,088 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02149:Ephb2
|
APN |
4 |
136,421,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02232:Ephb2
|
APN |
4 |
136,384,762 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02269:Ephb2
|
APN |
4 |
136,498,360 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL02828:Ephb2
|
APN |
4 |
136,498,461 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03109:Ephb2
|
APN |
4 |
136,498,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03284:Ephb2
|
APN |
4 |
136,388,827 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Zimbalist
|
UTSW |
4 |
136,387,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB006:Ephb2
|
UTSW |
4 |
136,388,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB016:Ephb2
|
UTSW |
4 |
136,388,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4453001:Ephb2
|
UTSW |
4 |
136,388,121 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0004:Ephb2
|
UTSW |
4 |
136,384,835 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0121:Ephb2
|
UTSW |
4 |
136,498,368 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0539:Ephb2
|
UTSW |
4 |
136,383,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Ephb2
|
UTSW |
4 |
136,400,676 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0988:Ephb2
|
UTSW |
4 |
136,387,019 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R1471:Ephb2
|
UTSW |
4 |
136,386,262 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1473:Ephb2
|
UTSW |
4 |
136,421,369 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1546:Ephb2
|
UTSW |
4 |
136,498,320 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1639:Ephb2
|
UTSW |
4 |
136,421,216 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1725:Ephb2
|
UTSW |
4 |
136,387,089 (GRCm39) |
nonsense |
probably null |
|
|
R1779:Ephb2
|
UTSW |
4 |
136,421,136 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R1818:Ephb2
|
UTSW |
4 |
136,382,647 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2099:Ephb2
|
UTSW |
4 |
136,388,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2916:Ephb2
|
UTSW |
4 |
136,411,256 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3885:Ephb2
|
UTSW |
4 |
136,498,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4572:Ephb2
|
UTSW |
4 |
136,383,251 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4709:Ephb2
|
UTSW |
4 |
136,423,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4893:Ephb2
|
UTSW |
4 |
136,387,064 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4992:Ephb2
|
UTSW |
4 |
136,388,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5004:Ephb2
|
UTSW |
4 |
136,387,010 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R5307:Ephb2
|
UTSW |
4 |
136,421,098 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5370:Ephb2
|
UTSW |
4 |
136,498,881 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5561:Ephb2
|
UTSW |
4 |
136,388,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5643:Ephb2
|
UTSW |
4 |
136,498,923 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5826:Ephb2
|
UTSW |
4 |
136,388,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5858:Ephb2
|
UTSW |
4 |
136,399,756 (GRCm39) |
missense |
probably benign |
|
|
R5867:Ephb2
|
UTSW |
4 |
136,402,733 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5990:Ephb2
|
UTSW |
4 |
136,423,366 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6000:Ephb2
|
UTSW |
4 |
136,411,341 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R6156:Ephb2
|
UTSW |
4 |
136,388,816 (GRCm39) |
missense |
probably benign |
0.44 |
|
R6413:Ephb2
|
UTSW |
4 |
136,498,433 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6577:Ephb2
|
UTSW |
4 |
136,384,861 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6633:Ephb2
|
UTSW |
4 |
136,411,307 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6720:Ephb2
|
UTSW |
4 |
136,384,813 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6795:Ephb2
|
UTSW |
4 |
136,400,646 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7235:Ephb2
|
UTSW |
4 |
136,421,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7260:Ephb2
|
UTSW |
4 |
136,498,885 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7328:Ephb2
|
UTSW |
4 |
136,386,245 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7404:Ephb2
|
UTSW |
4 |
136,498,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7466:Ephb2
|
UTSW |
4 |
136,386,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7524:Ephb2
|
UTSW |
4 |
136,387,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7605:Ephb2
|
UTSW |
4 |
136,498,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7611:Ephb2
|
UTSW |
4 |
136,388,212 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7777:Ephb2
|
UTSW |
4 |
136,498,947 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7889:Ephb2
|
UTSW |
4 |
136,498,353 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7929:Ephb2
|
UTSW |
4 |
136,388,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8191:Ephb2
|
UTSW |
4 |
136,386,256 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8370:Ephb2
|
UTSW |
4 |
136,383,302 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8444:Ephb2
|
UTSW |
4 |
136,388,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8724:Ephb2
|
UTSW |
4 |
136,498,368 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8988:Ephb2
|
UTSW |
4 |
136,402,769 (GRCm39) |
missense |
probably benign |
0.42 |
|
R9410:Ephb2
|
UTSW |
4 |
136,386,948 (GRCm39) |
missense |
probably null |
1.00 |
|
R9722:Ephb2
|
UTSW |
4 |
136,384,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCCCAATGTGAGTCAAGACC -3'
(R):5'- GGGCTATCTCCTCATACTACAGC -3'
Sequencing Primer
(F):5'- AAGACCTTGACTTTATCCTCACATG -3'
(R):5'- TGGGCTCCTTGGTGACC -3'
|
| Posted On |
2016-05-10 |
Incidental Mutation