Incidental Mutation 'R4982:Or1j14'
ID 384888
Institutional Source Beutler Lab
Gene Symbol Or1j14
Ensembl Gene ENSMUSG00000111869
Gene Name olfactory receptor family 1 subfamily J member 14
Synonyms GA_x6K02T2NLDC-33222024-33222962, MOR136-4, Olfr342
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.290) question?
Stock # R4982 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 36415010-36420802 bp(+) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) A to T at 36417409 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000149751 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074192] [ENSMUST00000216275] [ENSMUST00000216275]
AlphaFold Q8VGK7
Predicted Effect probably null
Transcript: ENSMUST00000074192
SMART Domains Protein: ENSMUSP00000073818
Gene: ENSMUSG00000111869

Pfam:7tm_4 31 308 4.7e-56 PFAM
Pfam:7tm_1 41 290 2e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213794
Predicted Effect probably null
Transcript: ENSMUST00000216275
Predicted Effect probably null
Transcript: ENSMUST00000216275
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A T 11: 9,242,348 (GRCm39) I1404L possibly damaging Het
Adra1b A G 11: 43,726,057 (GRCm39) S287P probably damaging Het
Atxn2 G T 5: 121,952,406 (GRCm39) A1280S possibly damaging Het
Bbip1 T C 19: 53,920,639 (GRCm39) probably null Het
Bbs2 A G 8: 94,808,982 (GRCm39) probably null Het
Bcl11b A T 12: 107,932,031 (GRCm39) C180* probably null Het
Bltp3a T C 17: 28,105,580 (GRCm39) F702S probably benign Het
Bod1l A G 5: 41,977,816 (GRCm39) V1166A probably benign Het
Bora C T 14: 99,284,788 (GRCm39) P13S probably damaging Het
C2cd4c T C 10: 79,449,075 (GRCm39) E24G probably benign Het
Ccne1 A T 7: 37,799,996 (GRCm39) I196N probably damaging Het
Chsy3 C T 18: 59,542,647 (GRCm39) S595L probably benign Het
Chsy3 T A 18: 59,542,839 (GRCm39) I659N possibly damaging Het
Cntrob T A 11: 69,202,188 (GRCm39) probably null Het
Col5a2 G A 1: 45,428,618 (GRCm39) P983S possibly damaging Het
Crat T A 2: 30,297,148 (GRCm39) probably null Het
Ctnnbl1 C T 2: 157,678,473 (GRCm39) H359Y probably benign Het
D430041D05Rik A G 2: 104,085,732 (GRCm39) V83A possibly damaging Het
Dixdc1 A G 9: 50,593,902 (GRCm39) S488P possibly damaging Het
Dmrta1 T C 4: 89,576,801 (GRCm39) C86R probably damaging Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Homo
Fam171a1 G A 2: 3,179,505 (GRCm39) probably null Het
Fam222b T C 11: 78,045,569 (GRCm39) C249R probably damaging Het
Fbxw18 T A 9: 109,531,719 (GRCm39) probably benign Het
Fes T C 7: 80,036,952 (GRCm39) Y44C probably damaging Het
Gimap6 A G 6: 48,684,933 (GRCm39) V51A probably benign Het
Gpr75 C T 11: 30,841,463 (GRCm39) L123F possibly damaging Het
Gpr75 C A 11: 30,841,462 (GRCm39) H122Q probably damaging Het
Greb1 A G 12: 16,774,762 (GRCm39) S212P probably damaging Het
Grin3a T C 4: 49,665,512 (GRCm39) H1041R probably benign Het
Ifna5 A G 4: 88,753,861 (GRCm39) N34D probably damaging Het
Ift140 A T 17: 25,255,968 (GRCm39) H221L probably damaging Het
Igsf3 T C 3: 101,342,983 (GRCm39) V540A probably benign Het
Il10ra A G 9: 45,180,357 (GRCm39) L5S probably damaging Het
Klra2 A T 6: 131,197,152 (GRCm39) D282E probably benign Het
Lyst T A 13: 13,900,539 (GRCm39) H3138Q probably damaging Het
Malrd1 A G 2: 16,046,940 (GRCm39) T1689A probably benign Het
Mon2 A T 10: 122,831,694 (GRCm39) L1671M probably damaging Het
Mpped1 T C 15: 83,720,528 (GRCm39) F71S probably damaging Het
Mtpap C A 18: 4,396,332 (GRCm39) H541Q probably benign Het
Muc5ac T A 7: 141,363,193 (GRCm39) probably benign Het
Mybbp1a T C 11: 72,336,040 (GRCm39) I451T probably damaging Het
Myh7 T A 14: 55,210,224 (GRCm39) E1827V probably damaging Het
Or2h15 A T 17: 38,441,468 (GRCm39) I205N probably damaging Het
Or5p75-ps1 T A 7: 108,107,855 (GRCm39) Y197* probably null Het
Or8b8 C A 9: 37,808,811 (GRCm39) T37N probably damaging Het
Os9 C T 10: 126,956,920 (GRCm39) R23H possibly damaging Het
Otud6b A G 4: 14,815,607 (GRCm39) L261P probably damaging Het
Pcdhga2 A G 18: 37,802,476 (GRCm39) N107D probably benign Het
Pclo C T 5: 14,729,308 (GRCm39) probably benign Het
Peg10 T TCCG 6: 4,756,451 (GRCm39) probably benign Het
Phtf1 T A 3: 103,906,024 (GRCm39) S524T probably damaging Het
Pkdrej A C 15: 85,703,197 (GRCm39) L913R probably damaging Het
Pld1 C A 3: 28,085,447 (GRCm39) A201D probably damaging Het
Rorb T A 19: 18,955,052 (GRCm39) Q103L probably benign Het
Sec24d C T 3: 123,093,255 (GRCm39) T284M probably benign Het
Serpinb3b T C 1: 107,085,484 (GRCm39) I86V probably benign Het
Serpinb6a A T 13: 34,102,857 (GRCm39) M201K probably damaging Het
Snx8 A G 5: 140,337,989 (GRCm39) S219P probably benign Het
Sp8 C T 12: 118,812,160 (GRCm39) T5I probably damaging Het
Tanc1 A G 2: 59,630,287 (GRCm39) N749D probably damaging Het
Tarm1 G C 7: 3,537,612 (GRCm39) P284A probably damaging Het
Tbx15 A T 3: 99,161,390 (GRCm39) E65V probably benign Het
Ticam1 T A 17: 56,579,020 (GRCm39) H25L probably benign Het
Tmprss11g T A 5: 86,640,674 (GRCm39) L170F probably damaging Het
Tnfsf9 A G 17: 57,414,504 (GRCm39) *310W probably null Het
Tsks C T 7: 44,593,418 (GRCm39) T128I possibly damaging Het
Vmn1r175 A T 7: 23,508,494 (GRCm39) N44K possibly damaging Het
Vmn1r45 A G 6: 89,910,847 (GRCm39) I41T probably damaging Het
Ythdc2 A G 18: 45,004,532 (GRCm39) N1102S probably benign Het
Zswim4 C T 8: 84,953,296 (GRCm39) probably null Het
Other mutations in Or1j14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Or1j14 APN 2 36,418,005 (GRCm39) missense probably benign 0.22
IGL01372:Or1j14 APN 2 36,417,463 (GRCm39) missense probably benign 0.00
IGL01747:Or1j14 APN 2 36,417,844 (GRCm39) missense probably damaging 1.00
IGL01836:Or1j14 APN 2 36,417,837 (GRCm39) nonsense probably null
IGL02409:Or1j14 APN 2 36,418,165 (GRCm39) missense probably damaging 1.00
IGL02578:Or1j14 APN 2 36,418,156 (GRCm39) missense probably damaging 1.00
IGL03344:Or1j14 APN 2 36,418,140 (GRCm39) missense probably damaging 1.00
IGL03396:Or1j14 APN 2 36,417,692 (GRCm39) missense probably benign 0.00
R0086:Or1j14 UTSW 2 36,417,462 (GRCm39) missense possibly damaging 0.69
R0427:Or1j14 UTSW 2 36,417,994 (GRCm39) missense probably damaging 1.00
R0973:Or1j14 UTSW 2 36,418,020 (GRCm39) missense probably benign 0.13
R0973:Or1j14 UTSW 2 36,418,020 (GRCm39) missense probably benign 0.13
R0974:Or1j14 UTSW 2 36,418,020 (GRCm39) missense probably benign 0.13
R2183:Or1j14 UTSW 2 36,417,723 (GRCm39) nonsense probably null
R2437:Or1j14 UTSW 2 36,418,258 (GRCm39) missense probably damaging 1.00
R4060:Or1j14 UTSW 2 36,417,426 (GRCm39) start codon destroyed probably null 0.01
R5070:Or1j14 UTSW 2 36,417,778 (GRCm39) missense probably damaging 1.00
R6244:Or1j14 UTSW 2 36,418,353 (GRCm39) missense probably benign 0.00
R8350:Or1j14 UTSW 2 36,418,176 (GRCm39) missense probably damaging 1.00
R8690:Or1j14 UTSW 2 36,418,207 (GRCm39) missense probably benign 0.22
R9105:Or1j14 UTSW 2 36,418,294 (GRCm39) missense probably damaging 1.00
R9224:Or1j14 UTSW 2 36,417,838 (GRCm39) missense probably benign 0.00
R9249:Or1j14 UTSW 2 36,417,559 (GRCm39) missense probably damaging 1.00
R9274:Or1j14 UTSW 2 36,417,559 (GRCm39) missense probably damaging 1.00
R9465:Or1j14 UTSW 2 36,417,898 (GRCm39) missense probably benign 0.02
R9644:Or1j14 UTSW 2 36,417,777 (GRCm39) missense probably damaging 1.00
R9700:Or1j14 UTSW 2 36,418,313 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2016-05-10