Incidental Mutation 'R4982:Vmn1r175'
ID 384914
Institutional Source Beutler Lab
Gene Symbol Vmn1r175
Ensembl Gene ENSMUSG00000095632
Gene Name vomeronasal 1 receptor 175
Synonyms Gm6299
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R4982 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 23507711-23508625 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 23508494 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 44 (N44K)
Ref Sequence ENSEMBL: ENSMUSP00000154170 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166141] [ENSMUST00000228383]
AlphaFold K7N6T9
Predicted Effect possibly damaging
Transcript: ENSMUST00000166141
AA Change: N44K

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000126357
Gene: ENSMUSG00000095632
AA Change: N44K

DomainStartEndE-ValueType
Pfam:TAS2R 8 296 8.8e-15 PFAM
Pfam:7tm_1 13 285 2.5e-6 PFAM
Pfam:V1R 41 295 4.4e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000228383
AA Change: N44K

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A T 11: 9,242,348 (GRCm39) I1404L possibly damaging Het
Adra1b A G 11: 43,726,057 (GRCm39) S287P probably damaging Het
Atxn2 G T 5: 121,952,406 (GRCm39) A1280S possibly damaging Het
Bbip1 T C 19: 53,920,639 (GRCm39) probably null Het
Bbs2 A G 8: 94,808,982 (GRCm39) probably null Het
Bcl11b A T 12: 107,932,031 (GRCm39) C180* probably null Het
Bltp3a T C 17: 28,105,580 (GRCm39) F702S probably benign Het
Bod1l A G 5: 41,977,816 (GRCm39) V1166A probably benign Het
Bora C T 14: 99,284,788 (GRCm39) P13S probably damaging Het
C2cd4c T C 10: 79,449,075 (GRCm39) E24G probably benign Het
Ccne1 A T 7: 37,799,996 (GRCm39) I196N probably damaging Het
Chsy3 C T 18: 59,542,647 (GRCm39) S595L probably benign Het
Chsy3 T A 18: 59,542,839 (GRCm39) I659N possibly damaging Het
Cntrob T A 11: 69,202,188 (GRCm39) probably null Het
Col5a2 G A 1: 45,428,618 (GRCm39) P983S possibly damaging Het
Crat T A 2: 30,297,148 (GRCm39) probably null Het
Ctnnbl1 C T 2: 157,678,473 (GRCm39) H359Y probably benign Het
D430041D05Rik A G 2: 104,085,732 (GRCm39) V83A possibly damaging Het
Dixdc1 A G 9: 50,593,902 (GRCm39) S488P possibly damaging Het
Dmrta1 T C 4: 89,576,801 (GRCm39) C86R probably damaging Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Homo
Fam171a1 G A 2: 3,179,505 (GRCm39) probably null Het
Fam222b T C 11: 78,045,569 (GRCm39) C249R probably damaging Het
Fbxw18 T A 9: 109,531,719 (GRCm39) probably benign Het
Fes T C 7: 80,036,952 (GRCm39) Y44C probably damaging Het
Gimap6 A G 6: 48,684,933 (GRCm39) V51A probably benign Het
Gpr75 C T 11: 30,841,463 (GRCm39) L123F possibly damaging Het
Gpr75 C A 11: 30,841,462 (GRCm39) H122Q probably damaging Het
Greb1 A G 12: 16,774,762 (GRCm39) S212P probably damaging Het
Grin3a T C 4: 49,665,512 (GRCm39) H1041R probably benign Het
Ifna5 A G 4: 88,753,861 (GRCm39) N34D probably damaging Het
Ift140 A T 17: 25,255,968 (GRCm39) H221L probably damaging Het
Igsf3 T C 3: 101,342,983 (GRCm39) V540A probably benign Het
Il10ra A G 9: 45,180,357 (GRCm39) L5S probably damaging Het
Klra2 A T 6: 131,197,152 (GRCm39) D282E probably benign Het
Lyst T A 13: 13,900,539 (GRCm39) H3138Q probably damaging Het
Malrd1 A G 2: 16,046,940 (GRCm39) T1689A probably benign Het
Mon2 A T 10: 122,831,694 (GRCm39) L1671M probably damaging Het
Mpped1 T C 15: 83,720,528 (GRCm39) F71S probably damaging Het
Mtpap C A 18: 4,396,332 (GRCm39) H541Q probably benign Het
Muc5ac T A 7: 141,363,193 (GRCm39) probably benign Het
Mybbp1a T C 11: 72,336,040 (GRCm39) I451T probably damaging Het
Myh7 T A 14: 55,210,224 (GRCm39) E1827V probably damaging Het
Or1j14 A T 2: 36,417,409 (GRCm39) probably null Het
Or2h15 A T 17: 38,441,468 (GRCm39) I205N probably damaging Het
Or5p75-ps1 T A 7: 108,107,855 (GRCm39) Y197* probably null Het
Or8b8 C A 9: 37,808,811 (GRCm39) T37N probably damaging Het
Os9 C T 10: 126,956,920 (GRCm39) R23H possibly damaging Het
Otud6b A G 4: 14,815,607 (GRCm39) L261P probably damaging Het
Pcdhga2 A G 18: 37,802,476 (GRCm39) N107D probably benign Het
Pclo C T 5: 14,729,308 (GRCm39) probably benign Het
Peg10 T TCCG 6: 4,756,451 (GRCm39) probably benign Het
Phtf1 T A 3: 103,906,024 (GRCm39) S524T probably damaging Het
Pkdrej A C 15: 85,703,197 (GRCm39) L913R probably damaging Het
Pld1 C A 3: 28,085,447 (GRCm39) A201D probably damaging Het
Rorb T A 19: 18,955,052 (GRCm39) Q103L probably benign Het
Sec24d C T 3: 123,093,255 (GRCm39) T284M probably benign Het
Serpinb3b T C 1: 107,085,484 (GRCm39) I86V probably benign Het
Serpinb6a A T 13: 34,102,857 (GRCm39) M201K probably damaging Het
Snx8 A G 5: 140,337,989 (GRCm39) S219P probably benign Het
Sp8 C T 12: 118,812,160 (GRCm39) T5I probably damaging Het
Tanc1 A G 2: 59,630,287 (GRCm39) N749D probably damaging Het
Tarm1 G C 7: 3,537,612 (GRCm39) P284A probably damaging Het
Tbx15 A T 3: 99,161,390 (GRCm39) E65V probably benign Het
Ticam1 T A 17: 56,579,020 (GRCm39) H25L probably benign Het
Tmprss11g T A 5: 86,640,674 (GRCm39) L170F probably damaging Het
Tnfsf9 A G 17: 57,414,504 (GRCm39) *310W probably null Het
Tsks C T 7: 44,593,418 (GRCm39) T128I possibly damaging Het
Vmn1r45 A G 6: 89,910,847 (GRCm39) I41T probably damaging Het
Ythdc2 A G 18: 45,004,532 (GRCm39) N1102S probably benign Het
Zswim4 C T 8: 84,953,296 (GRCm39) probably null Het
Other mutations in Vmn1r175
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02944:Vmn1r175 APN 7 23,508,591 (GRCm39) missense probably damaging 0.97
PIT4531001:Vmn1r175 UTSW 7 23,508,603 (GRCm39) missense possibly damaging 0.62
R1163:Vmn1r175 UTSW 7 23,507,937 (GRCm39) missense probably benign 0.30
R1901:Vmn1r175 UTSW 7 23,508,218 (GRCm39) missense probably benign 0.00
R1926:Vmn1r175 UTSW 7 23,508,466 (GRCm39) missense possibly damaging 0.81
R1957:Vmn1r175 UTSW 7 23,507,808 (GRCm39) missense probably benign 0.21
R2163:Vmn1r175 UTSW 7 23,508,352 (GRCm39) missense probably benign 0.29
R2381:Vmn1r175 UTSW 7 23,508,093 (GRCm39) missense probably benign 0.31
R3109:Vmn1r175 UTSW 7 23,508,393 (GRCm39) missense probably benign 0.00
R3419:Vmn1r175 UTSW 7 23,508,075 (GRCm39) missense probably damaging 0.96
R3941:Vmn1r175 UTSW 7 23,508,393 (GRCm39) missense probably benign 0.00
R5191:Vmn1r175 UTSW 7 23,508,447 (GRCm39) missense possibly damaging 0.91
R5326:Vmn1r175 UTSW 7 23,508,531 (GRCm39) missense possibly damaging 0.88
R5333:Vmn1r175 UTSW 7 23,508,004 (GRCm39) missense possibly damaging 0.69
R5476:Vmn1r175 UTSW 7 23,508,556 (GRCm39) missense possibly damaging 0.82
R5542:Vmn1r175 UTSW 7 23,508,531 (GRCm39) missense possibly damaging 0.88
R5761:Vmn1r175 UTSW 7 23,507,905 (GRCm39) missense probably benign 0.01
R5918:Vmn1r175 UTSW 7 23,508,372 (GRCm39) missense probably damaging 1.00
R6163:Vmn1r175 UTSW 7 23,508,591 (GRCm39) missense possibly damaging 0.71
R6563:Vmn1r175 UTSW 7 23,508,030 (GRCm39) missense possibly damaging 0.61
R7476:Vmn1r175 UTSW 7 23,507,847 (GRCm39) missense probably benign 0.01
R7616:Vmn1r175 UTSW 7 23,508,031 (GRCm39) missense possibly damaging 0.79
R8100:Vmn1r175 UTSW 7 23,508,012 (GRCm39) missense probably damaging 1.00
R8157:Vmn1r175 UTSW 7 23,508,523 (GRCm39) missense probably benign 0.00
R8699:Vmn1r175 UTSW 7 23,508,234 (GRCm39) missense probably benign 0.01
R8744:Vmn1r175 UTSW 7 23,508,403 (GRCm39) missense probably benign 0.00
R9595:Vmn1r175 UTSW 7 23,508,508 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TTCGAGCCACCAGCCAAATG -3'
(R):5'- AAAGTAGAGCTGCCCTTCGTG -3'

Sequencing Primer
(F):5'- GCCAAATGAAGTACCCAAGTTTAC -3'
(R):5'- CCTTCGTGGGGGAAAATGTC -3'
Posted On 2016-05-10