Incidental Mutation 'R4994:Trappc11'
ID 385104
Institutional Source Beutler Lab
Gene Symbol Trappc11
Ensembl Gene ENSMUSG00000038102
Gene Name trafficking protein particle complex 11
Synonyms D030016E14Rik
MMRRC Submission 042588-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4994 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 47490115-47533470 bp(-) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 47522441 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 247 (Y247*)
Ref Sequence ENSEMBL: ENSMUSP00000047562 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039061]
AlphaFold B2RXC1
Predicted Effect probably null
Transcript: ENSMUST00000039061
AA Change: Y247*
SMART Domains Protein: ENSMUSP00000047562
Gene: ENSMUSG00000038102
AA Change: Y247*

DomainStartEndE-ValueType
Pfam:Foie-gras_1 263 522 3e-78 PFAM
Pfam:Gryzun 978 1114 3.9e-10 PFAM
Pfam:Gryzun-like 1036 1095 2.4e-28 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123958
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125065
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131551
Meta Mutation Damage Score 0.9701 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.0%
Validation Efficiency 100% (79/79)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplasmic reticulum-to-Golgi vesicle transport. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik A G 8: 72,455,118 (GRCm38) E364G probably benign Het
4930505A04Rik C T 11: 30,426,349 (GRCm38) V173M probably damaging Het
Abcb4 A G 5: 8,928,524 (GRCm38) T557A probably damaging Het
Acadm C T 3: 153,929,584 (GRCm38) E298K probably damaging Het
Adrb3 T C 8: 27,227,827 (GRCm38) probably null Het
Aldh1b1 A G 4: 45,803,128 (GRCm38) Y222C possibly damaging Het
Ankrd6 A G 4: 32,860,387 (GRCm38) Y19H probably damaging Het
Arhgap21 T A 2: 20,849,890 (GRCm38) T1554S probably benign Het
BC043934 T C 9: 96,437,120 (GRCm38) noncoding transcript Het
Birc6 A G 17: 74,594,324 (GRCm38) probably benign Het
Blm A C 7: 80,458,825 (GRCm38) F1357C probably benign Het
Cd209a T C 8: 3,747,713 (GRCm38) probably null Het
Cdk7 G A 13: 100,717,595 (GRCm38) H129Y probably damaging Het
Clec14a G T 12: 58,268,284 (GRCm38) P184Q probably damaging Het
Cma1 T A 14: 55,941,671 (GRCm38) I243F probably damaging Het
Cntnap3 G T 13: 64,761,984 (GRCm38) T769K possibly damaging Het
Col5a1 A C 2: 28,032,739 (GRCm38) K273T possibly damaging Het
Csnk1e A G 15: 79,424,929 (GRCm38) Y266H probably damaging Het
Cyb5d1 A G 11: 69,393,771 (GRCm38) L185S probably damaging Het
Dennd5b T C 6: 149,041,500 (GRCm38) probably null Het
Dipk2a C A 9: 94,537,433 (GRCm38) R148L probably benign Het
Drp2 G A X: 134,441,316 (GRCm38) R567H probably damaging Homo
Dzank1 T G 2: 144,522,566 (GRCm38) D37A probably damaging Het
Echdc2 A G 4: 108,165,628 (GRCm38) I34V probably benign Het
Esm1 A T 13: 113,213,431 (GRCm38) R128S probably benign Het
Fbh1 T A 2: 11,764,230 (GRCm38) I251F probably damaging Het
Fbrsl1 A G 5: 110,447,951 (GRCm38) S73P probably damaging Het
Fbxo6 A T 4: 148,149,491 (GRCm38) S49R probably damaging Het
Gm17093 A T 14: 44,519,322 (GRCm38) Q82L probably damaging Het
Hmcn2 T C 2: 31,458,055 (GRCm38) probably null Het
Hspa4l C A 3: 40,745,649 (GRCm38) probably benign Het
Il3ra G A 14: 14,351,080 (GRCm38) A201T probably benign Het
Irx5 T A 8: 92,360,781 (GRCm38) V447E probably damaging Het
Kif14 G T 1: 136,482,959 (GRCm38) L668F probably damaging Het
Lag3 T A 6: 124,904,453 (GRCm38) R519W unknown Het
Lgr4 A G 2: 110,011,938 (GRCm38) N756S probably damaging Het
Lingo4 T A 3: 94,403,001 (GRCm38) H415Q probably benign Het
Lingo4 A G 3: 94,402,541 (GRCm38) H262R probably benign Het
Lkaaear1 C A 2: 181,697,583 (GRCm38) G25* probably null Het
Maco1 A G 4: 134,828,299 (GRCm38) Y288H probably damaging Het
Marf1 T C 16: 14,114,231 (GRCm38) K1641E probably benign Het
Mtfmt T C 9: 65,443,851 (GRCm38) probably benign Het
Mtif3 G A 5: 146,956,788 (GRCm38) T203M probably benign Het
Mycbp2 A G 14: 103,169,994 (GRCm38) I2740T probably benign Het
Nrdc A G 4: 109,046,612 (GRCm38) T720A probably benign Het
Or2d2 T C 7: 107,129,064 (GRCm38) T110A probably benign Het
Peak1 T A 9: 56,241,276 (GRCm38) D32V possibly damaging Het
Pigr G A 1: 130,841,817 (GRCm38) D122N probably benign Het
Plekhg3 A G 12: 76,565,537 (GRCm38) R391G possibly damaging Het
Ppfia3 T C 7: 45,341,118 (GRCm38) D919G probably damaging Het
Pramel23 T A 4: 143,698,369 (GRCm38) Q168L possibly damaging Het
Rnase2b T A 14: 51,162,751 (GRCm38) D96E possibly damaging Het
Rsf1 CGGCGGC CGGCGGCCGCGGCGGC 7: 97,579,923 (GRCm38) probably benign Het
Rsf1 G GACGGCGGCT 7: 97,579,909 (GRCm38) probably benign Het
Serpina3f A G 12: 104,220,356 (GRCm38) T394A probably benign Het
Six3 A G 17: 85,621,292 (GRCm38) N18S possibly damaging Het
Slc12a5 T A 2: 164,983,365 (GRCm38) probably null Het
Slc35f6 A G 5: 30,648,083 (GRCm38) N21S probably damaging Het
Slc39a6 A T 18: 24,596,294 (GRCm38) I454N probably damaging Het
Slc40a1 T A 1: 45,909,664 (GRCm38) E485D probably damaging Het
Sort1 G A 3: 108,328,069 (GRCm38) C255Y probably damaging Het
Stab2 T A 10: 86,949,907 (GRCm38) T624S probably benign Het
Stk33 T A 7: 109,340,398 (GRCm38) I99L probably benign Het
Taf4b T A 18: 14,898,043 (GRCm38) I828N probably damaging Het
Terf2 T C 8: 107,076,478 (GRCm38) probably benign Het
Timd4 C T 11: 46,815,517 (GRCm38) R49C probably damaging Het
Tpte T C 8: 22,318,346 (GRCm38) S166P probably benign Het
Trabd2b T C 4: 114,406,855 (GRCm38) L13P probably benign Het
Trnt1 C T 6: 106,778,892 (GRCm38) Q303* probably null Het
Tspyl5 T A 15: 33,687,055 (GRCm38) Q248L possibly damaging Het
Ubxn7 A T 16: 32,381,504 (GRCm38) K337N probably damaging Het
Unc13a T A 8: 71,643,172 (GRCm38) I1234F probably benign Het
Vmn1r127 A T 7: 21,319,018 (GRCm38) F282I probably damaging Het
Wdhd1 A T 14: 47,268,654 (GRCm38) probably null Het
Zfp605 A G 5: 110,127,486 (GRCm38) K157E probably damaging Het
Zhx2 T A 15: 57,821,359 (GRCm38) D41E probably benign Het
Other mutations in Trappc11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00324:Trappc11 APN 8 47,503,302 (GRCm38) unclassified probably benign
IGL01300:Trappc11 APN 8 47,501,868 (GRCm38) missense probably benign
IGL01312:Trappc11 APN 8 47,505,677 (GRCm38) missense possibly damaging 0.95
IGL01344:Trappc11 APN 8 47,519,704 (GRCm38) missense probably damaging 1.00
IGL01518:Trappc11 APN 8 47,501,869 (GRCm38) splice site probably null
IGL01747:Trappc11 APN 8 47,519,621 (GRCm38) missense probably benign 0.41
IGL01781:Trappc11 APN 8 47,514,128 (GRCm38) missense possibly damaging 0.95
IGL01908:Trappc11 APN 8 47,503,994 (GRCm38) missense probably damaging 1.00
IGL01956:Trappc11 APN 8 47,528,001 (GRCm38) missense possibly damaging 0.86
IGL02266:Trappc11 APN 8 47,505,731 (GRCm38) missense probably damaging 1.00
IGL02377:Trappc11 APN 8 47,530,650 (GRCm38) critical splice donor site probably null
IGL02530:Trappc11 APN 8 47,507,582 (GRCm38) missense probably damaging 1.00
IGL02676:Trappc11 APN 8 47,493,413 (GRCm38) splice site probably benign
IGL03030:Trappc11 APN 8 47,513,929 (GRCm38) missense probably damaging 0.98
IGL03393:Trappc11 APN 8 47,510,877 (GRCm38) missense possibly damaging 0.95
bantu UTSW 8 47,498,666 (GRCm38) missense probably benign 0.44
bunyoro UTSW 8 47,512,285 (GRCm38) splice site probably null
nyoro UTSW 8 47,526,979 (GRCm38) missense possibly damaging 0.73
serval UTSW 8 47,503,965 (GRCm38) missense probably damaging 1.00
R0009:Trappc11 UTSW 8 47,503,320 (GRCm38) missense possibly damaging 0.70
R0009:Trappc11 UTSW 8 47,503,320 (GRCm38) missense possibly damaging 0.70
R0043:Trappc11 UTSW 8 47,505,575 (GRCm38) splice site probably benign
R0180:Trappc11 UTSW 8 47,527,974 (GRCm38) missense possibly damaging 0.86
R0529:Trappc11 UTSW 8 47,526,979 (GRCm38) missense possibly damaging 0.73
R0538:Trappc11 UTSW 8 47,503,412 (GRCm38) missense probably benign 0.01
R0740:Trappc11 UTSW 8 47,524,588 (GRCm38) missense probably damaging 0.99
R1352:Trappc11 UTSW 8 47,525,046 (GRCm38) missense possibly damaging 0.90
R1469:Trappc11 UTSW 8 47,503,965 (GRCm38) missense probably damaging 1.00
R1469:Trappc11 UTSW 8 47,503,965 (GRCm38) missense probably damaging 1.00
R1502:Trappc11 UTSW 8 47,530,827 (GRCm38) missense possibly damaging 0.94
R1589:Trappc11 UTSW 8 47,501,680 (GRCm38) missense probably damaging 1.00
R1741:Trappc11 UTSW 8 47,529,327 (GRCm38) critical splice donor site probably null
R2292:Trappc11 UTSW 8 47,505,736 (GRCm38) missense probably damaging 1.00
R2303:Trappc11 UTSW 8 47,503,416 (GRCm38) missense probably damaging 0.99
R2931:Trappc11 UTSW 8 47,503,942 (GRCm38) missense probably damaging 0.99
R3522:Trappc11 UTSW 8 47,498,673 (GRCm38) missense possibly damaging 0.93
R3714:Trappc11 UTSW 8 47,505,316 (GRCm38) intron probably benign
R3739:Trappc11 UTSW 8 47,514,103 (GRCm38) missense probably damaging 0.98
R4165:Trappc11 UTSW 8 47,524,968 (GRCm38) splice site probably benign
R4581:Trappc11 UTSW 8 47,493,345 (GRCm38) missense probably damaging 0.97
R4598:Trappc11 UTSW 8 47,513,766 (GRCm38) missense probably damaging 0.98
R4939:Trappc11 UTSW 8 47,519,665 (GRCm38) missense probably damaging 1.00
R4990:Trappc11 UTSW 8 47,490,895 (GRCm38) missense probably benign 0.41
R5091:Trappc11 UTSW 8 47,512,604 (GRCm38) missense probably benign 0.00
R5123:Trappc11 UTSW 8 47,513,402 (GRCm38) missense probably damaging 0.99
R5176:Trappc11 UTSW 8 47,510,963 (GRCm38) missense possibly damaging 0.79
R5279:Trappc11 UTSW 8 47,505,304 (GRCm38) intron probably benign
R5293:Trappc11 UTSW 8 47,493,342 (GRCm38) missense possibly damaging 0.83
R5294:Trappc11 UTSW 8 47,530,731 (GRCm38) missense possibly damaging 0.88
R5661:Trappc11 UTSW 8 47,512,607 (GRCm38) missense probably damaging 0.99
R5838:Trappc11 UTSW 8 47,512,559 (GRCm38) critical splice donor site probably null
R5889:Trappc11 UTSW 8 47,519,578 (GRCm38) missense probably benign 0.40
R5952:Trappc11 UTSW 8 47,496,917 (GRCm38) critical splice donor site probably null
R5959:Trappc11 UTSW 8 47,501,558 (GRCm38) missense probably damaging 0.97
R6239:Trappc11 UTSW 8 47,529,494 (GRCm38) missense possibly damaging 0.73
R6322:Trappc11 UTSW 8 47,530,773 (GRCm38) missense possibly damaging 0.95
R6369:Trappc11 UTSW 8 47,512,285 (GRCm38) splice site probably null
R7541:Trappc11 UTSW 8 47,505,582 (GRCm38) splice site probably null
R7544:Trappc11 UTSW 8 47,522,414 (GRCm38) missense possibly damaging 0.73
R7762:Trappc11 UTSW 8 47,522,376 (GRCm38) missense probably damaging 0.99
R7964:Trappc11 UTSW 8 47,526,944 (GRCm38) missense possibly damaging 0.54
R8183:Trappc11 UTSW 8 47,529,356 (GRCm38) missense possibly damaging 0.93
R8282:Trappc11 UTSW 8 47,516,589 (GRCm38) missense probably damaging 0.97
R8733:Trappc11 UTSW 8 47,501,848 (GRCm38) missense probably damaging 1.00
R8782:Trappc11 UTSW 8 47,498,666 (GRCm38) missense probably benign 0.44
R8853:Trappc11 UTSW 8 47,529,404 (GRCm38) missense probably damaging 0.98
R9544:Trappc11 UTSW 8 47,519,678 (GRCm38) missense possibly damaging 0.94
R9709:Trappc11 UTSW 8 47,493,313 (GRCm38) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- ACCACCTTTATGGATCAAGAAACTG -3'
(R):5'- CAATAGGATGGGTCTTCTGCTG -3'

Sequencing Primer
(F):5'- AAATCCTGCCATCGTCTT -3'
(R):5'- CTGTATATGCCCCAGTACAGG -3'
Posted On 2016-05-10