Mutagenetix > Incidental Mutation

Incidental Mutation 'R4995:Myo18b'

385165

Institutional Source

Beutler Lab

Gene Symbol

Myo18b

Ensembl Gene

ENSMUSG00000072720

Gene Name

myosin XVIIIb

Synonyms

4932408L24Rik, 4933411E19Rik

MMRRC Submission

042589-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R4995 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

112688876-112896362 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 112760392 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 2005 (V2005A)

Ref Sequence

ENSEMBL: ENSMUSP00000083810 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086617]

AlphaFold

E9PV66

Predicted Effect

probably damaging
Transcript: ENSMUST00000086617
AA Change: V2005A

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000083810
Gene: ENSMUSG00000072720
AA Change: V2005A

Domain	Start	End	E-Value	Type
low complexity region	20	28	N/A	INTRINSIC
low complexity region	43	59	N/A	INTRINSIC
low complexity region	86	100	N/A	INTRINSIC
low complexity region	185	200	N/A	INTRINSIC
low complexity region	273	290	N/A	INTRINSIC
low complexity region	291	304	N/A	INTRINSIC
low complexity region	355	372	N/A	INTRINSIC
low complexity region	377	419	N/A	INTRINSIC
MYSc	605	1374	8.78e-30	SMART
IQ	1375	1397	5.92e-4	SMART
Pfam:Myosin_tail_1	1423	1875	5e-12	PFAM
low complexity region	1965	1985	N/A	INTRINSIC
coiled coil region	2052	2126	N/A	INTRINSIC
low complexity region	2184	2199	N/A	INTRINSIC
low complexity region	2325	2336	N/A	INTRINSIC
low complexity region	2408	2424	N/A	INTRINSIC
low complexity region	2544	2558	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000182189

Meta Mutation Damage Score

0.0714

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.7%
20x: 93.6%

Validation Efficiency

99% (86/87)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null mutation display embryonic lethality during organogenesis with internal hemorrhage, pericaridal effusion, enlargement of the right atrium, and cardiac myofibril abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 79 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921504E06Rik	G	A	2: 19,494,184 (GRCm38)	Q333*	probably null	Het
4930505A04Rik	C	T	11: 30,426,349 (GRCm38)	V173M	probably damaging	Het
Acvrl1	G	A	15: 101,135,860 (GRCm38)	R141H	probably benign	Het
Adprm	A	G	11: 67,041,610 (GRCm38)	F158L	possibly damaging	Het
Aldoart2	C	T	12: 55,566,253 (GRCm38)	T321M	probably benign	Het
Ap3m2	A	G	8: 22,803,776 (GRCm38)	V86A	probably benign	Het
Arhgef19	T	A	4: 141,247,515 (GRCm38)		probably null	Het
Armc4	G	A	18: 7,223,663 (GRCm38)	T460M	probably damaging	Het
Bcl2l12	T	G	7: 44,994,191 (GRCm38)		probably null	Het
Bptf	T	C	11: 107,054,565 (GRCm38)	Q2501R	probably damaging	Het
C230029F24Rik	A	T	1: 49,338,136 (GRCm38)		noncoding transcript	Het
C7	C	T	15: 5,049,592 (GRCm38)	G78D	probably damaging	Het
Caly	T	C	7: 140,070,625 (GRCm38)	T135A	probably benign	Het
Cbl	A	G	9: 44,153,811 (GRCm38)	M740T	possibly damaging	Het
Cbx4	A	G	11: 119,081,211 (GRCm38)	V446A	probably benign	Het
Celsr1	C	A	15: 85,937,911 (GRCm38)	R1735L	probably damaging	Het
Cep250	A	G	2: 155,988,316 (GRCm38)	D135G	probably damaging	Het
Cgn	T	C	3: 94,779,936 (GRCm38)	T19A	probably damaging	Het
Chic2	A	T	5: 75,044,204 (GRCm38)	V32D	probably damaging	Het
Cntln	A	G	4: 85,049,883 (GRCm38)	K780E	probably benign	Het
Col8a2	A	T	4: 126,310,788 (GRCm38)	D197V	probably damaging	Het
Crot	A	T	5: 8,974,000 (GRCm38)	V372E	probably damaging	Het
Cyb561d2	C	T	9: 107,541,548 (GRCm38)	V26M	probably damaging	Het
Ddx5	G	A	11: 106,785,236 (GRCm38)	T237I	probably damaging	Het
Dmxl2	G	T	9: 54,501,441 (GRCm38)		probably benign	Het
Dock8	T	A	19: 25,158,383 (GRCm38)	S1188R	probably benign	Het
Ehbp1	T	A	11: 22,101,073 (GRCm38)	H493L	probably damaging	Het
Eif5b	T	A	1: 38,051,711 (GRCm38)	*1217K	probably null	Het
Eprs	A	G	1: 185,410,139 (GRCm38)		probably benign	Het
Etfdh	T	C	3: 79,605,788 (GRCm38)	D376G	probably benign	Het
Fam186a	T	C	15: 99,945,099 (GRCm38)	Q1088R	probably benign	Het
Fbxw16	G	T	9: 109,441,250 (GRCm38)	T141N	probably damaging	Het
Fgf11	G	A	11: 69,798,759 (GRCm38)	H138Y	probably damaging	Het
Gm1673	G	A	5: 33,984,926 (GRCm38)	R79H	probably damaging	Het
Htra3	T	C	5: 35,671,074 (GRCm38)	E154G	probably damaging	Het
Hydin	T	A	8: 110,569,642 (GRCm38)	V3601D	probably damaging	Het
Jup	G	T	11: 100,379,541 (GRCm38)	S380*	probably null	Het
Klrg1	T	A	6: 122,278,275 (GRCm38)	D66V	probably benign	Het
Llgl1	C	T	11: 60,709,724 (GRCm38)	A633V	probably benign	Het
Lmln	T	A	16: 33,074,097 (GRCm38)	Y203*	probably null	Het
Lrrc58	T	G	16: 37,877,056 (GRCm38)	C165G	probably benign	Het
Lss	T	C	10: 76,547,537 (GRCm38)	V557A	probably benign	Het
Mast4	T	C	13: 102,905,754 (GRCm38)		probably benign	Het
Med13l	C	A	5: 118,730,949 (GRCm38)	P754Q	possibly damaging	Het
Mga	C	T	2: 119,932,582 (GRCm38)	R1240*	probably null	Het
Mgat5b	T	A	11: 116,974,199 (GRCm38)		probably null	Het
Mtor	A	G	4: 148,525,752 (GRCm38)	D1572G	probably damaging	Het
Muc4	T	A	16: 32,754,041 (GRCm38)	S1306T	probably benign	Het
Muc4	T	A	16: 32,754,214 (GRCm38)	S1363T	probably benign	Het
Myo1e	G	A	9: 70,353,272 (GRCm38)	D571N	probably benign	Het
Mypn	T	C	10: 63,119,968 (GRCm38)		probably null	Het
Ndufb10	T	C	17: 24,722,757 (GRCm38)		probably null	Het
Nelfb	G	T	2: 25,206,196 (GRCm38)	D300E	probably benign	Het
Olfr1389	T	A	11: 49,430,655 (GRCm38)	Y60N	probably damaging	Het
Olfr1507	A	T	14: 52,490,531 (GRCm38)	C61*	probably null	Het
Olfr625-ps1	T	A	7: 103,683,367 (GRCm38)	D206E	probably damaging	Het
Olfr668	T	A	7: 104,925,735 (GRCm38)	T10S	probably benign	Het
Pcdha11	C	T	18: 37,011,027 (GRCm38)	T57M	probably benign	Het
Pkp1	A	T	1: 135,880,855 (GRCm38)	I458N	possibly damaging	Het
Prr12	T	A	7: 45,051,229 (GRCm38)		probably benign	Het
Prrc2c	A	T	1: 162,705,310 (GRCm38)		probably benign	Het
Psd4	T	C	2: 24,397,247 (GRCm38)	F397S	probably benign	Het
Pygm	T	C	19: 6,398,139 (GRCm38)	I737T	probably damaging	Het
Rfx1	T	A	8: 84,080,114 (GRCm38)		probably null	Het
Rsl1	A	G	13: 67,182,249 (GRCm38)	T254A	possibly damaging	Het
Sh3rf3	A	G	10: 59,086,824 (GRCm38)	Q574R	probably benign	Het
Spire1	T	C	18: 67,552,779 (GRCm38)		probably null	Het
St6galnac4	G	A	2: 32,594,063 (GRCm38)	G91D	probably damaging	Het
Sytl2	T	C	7: 90,382,257 (GRCm38)		probably benign	Het
Tbpl2	T	A	2: 24,093,860 (GRCm38)	K188N	possibly damaging	Het
Tenm3	A	T	8: 48,229,137 (GRCm38)	M2486K	possibly damaging	Het
Tgoln1	A	C	6: 72,616,140 (GRCm38)	V119G	possibly damaging	Het
Tpgs1	A	T	10: 79,669,491 (GRCm38)	N28Y	probably benign	Het
U2surp	A	C	9: 95,462,794 (GRCm38)		probably benign	Het
Vmn2r103	A	G	17: 19,773,511 (GRCm38)	H50R	probably benign	Het
Vmn2r19	A	G	6: 123,329,910 (GRCm38)	N459S	probably benign	Het
Vmn2r72	T	C	7: 85,738,485 (GRCm38)	S624G	probably damaging	Het
Vps13c	A	G	9: 67,919,321 (GRCm38)	T1415A	probably benign	Het
Vwa5b1	G	A	4: 138,608,843 (GRCm38)	P147S	probably damaging	Het

Other mutations in Myo18b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00159:Myo18b	APN	5	112,874,131 (GRCm38)	missense	probably benign	0.05
IGL00847:Myo18b	APN	5	112,830,389 (GRCm38)	splice site	probably benign
IGL00848:Myo18b	APN	5	112,871,485 (GRCm38)	missense	probably damaging	1.00
IGL00969:Myo18b	APN	5	112,875,007 (GRCm38)	unclassified	probably benign
IGL01018:Myo18b	APN	5	112,809,747 (GRCm38)	missense	probably damaging	1.00
IGL01448:Myo18b	APN	5	112,811,704 (GRCm38)	missense	probably damaging	1.00
IGL01490:Myo18b	APN	5	112,809,700 (GRCm38)	missense	possibly damaging	0.84
IGL01556:Myo18b	APN	5	112,757,449 (GRCm38)	splice site	probably benign
IGL01637:Myo18b	APN	5	112,840,629 (GRCm38)	missense	possibly damaging	0.82
IGL01819:Myo18b	APN	5	112,878,050 (GRCm38)	missense	unknown
IGL02007:Myo18b	APN	5	112,874,972 (GRCm38)	unclassified	probably benign
IGL02146:Myo18b	APN	5	112,843,285 (GRCm38)	missense	probably damaging	1.00
IGL02229:Myo18b	APN	5	112,878,110 (GRCm38)	missense	unknown
IGL02319:Myo18b	APN	5	112,791,139 (GRCm38)	missense	probably damaging	0.99
IGL02398:Myo18b	APN	5	112,830,312 (GRCm38)	missense	possibly damaging	0.92
IGL02420:Myo18b	APN	5	112,827,986 (GRCm38)	missense	possibly damaging	0.64
IGL02626:Myo18b	APN	5	112,878,085 (GRCm38)	missense	unknown
IGL02815:Myo18b	APN	5	112,809,735 (GRCm38)	missense	probably damaging	1.00
IGL02822:Myo18b	APN	5	112,775,345 (GRCm38)	missense	probably damaging	1.00
IGL02852:Myo18b	APN	5	112,715,511 (GRCm38)	missense	probably benign	0.03
IGL02995:Myo18b	APN	5	112,775,413 (GRCm38)	splice site	probably benign
IGL03019:Myo18b	APN	5	112,692,397 (GRCm38)	missense	probably benign	0.21
IGL03039:Myo18b	APN	5	112,840,771 (GRCm38)	missense	probably damaging	1.00
IGL03112:Myo18b	APN	5	112,873,990 (GRCm38)	missense	probably benign	0.02
IGL03123:Myo18b	APN	5	112,874,938 (GRCm38)	unclassified	probably benign
IGL03288:Myo18b	APN	5	112,789,997 (GRCm38)	missense	probably damaging	1.00
IGL03391:Myo18b	APN	5	112,874,479 (GRCm38)	unclassified	probably benign
klippel	UTSW	5	112,757,453 (GRCm38)	critical splice donor site	probably null
PIT4651001:Myo18b	UTSW	5	112,834,435 (GRCm38)	missense	probably benign	0.01
R0271:Myo18b	UTSW	5	112,809,685 (GRCm38)	missense	possibly damaging	0.91
R0277:Myo18b	UTSW	5	112,693,347 (GRCm38)	splice site	probably benign
R0352:Myo18b	UTSW	5	112,874,523 (GRCm38)	unclassified	probably benign
R0504:Myo18b	UTSW	5	112,873,576 (GRCm38)	unclassified	probably benign
R0539:Myo18b	UTSW	5	112,723,868 (GRCm38)	missense	probably damaging	0.99
R0599:Myo18b	UTSW	5	112,865,750 (GRCm38)	missense	probably damaging	1.00
R0627:Myo18b	UTSW	5	112,798,834 (GRCm38)	missense	probably benign	0.38
R0659:Myo18b	UTSW	5	112,760,327 (GRCm38)	missense	possibly damaging	0.66
R0671:Myo18b	UTSW	5	112,692,766 (GRCm38)	missense	probably benign	0.00
R0847:Myo18b	UTSW	5	112,874,488 (GRCm38)	unclassified	probably benign
R1082:Myo18b	UTSW	5	112,760,414 (GRCm38)	missense	probably damaging	1.00
R1116:Myo18b	UTSW	5	112,803,279 (GRCm38)	missense	probably damaging	1.00
R1264:Myo18b	UTSW	5	112,830,319 (GRCm38)	missense	probably benign	0.12
R1280:Myo18b	UTSW	5	112,723,805 (GRCm38)	critical splice donor site	probably null
R1444:Myo18b	UTSW	5	112,775,251 (GRCm38)	critical splice donor site	probably null
R1446:Myo18b	UTSW	5	112,757,559 (GRCm38)	missense	probably damaging	1.00
R1470:Myo18b	UTSW	5	112,693,033 (GRCm38)	missense	probably damaging	1.00
R1470:Myo18b	UTSW	5	112,693,033 (GRCm38)	missense	probably damaging	1.00
R1590:Myo18b	UTSW	5	112,875,266 (GRCm38)	nonsense	probably null
R1601:Myo18b	UTSW	5	112,871,498 (GRCm38)	missense	possibly damaging	0.73
R1903:Myo18b	UTSW	5	112,692,758 (GRCm38)	missense	probably damaging	1.00
R1935:Myo18b	UTSW	5	112,760,356 (GRCm38)	missense	probably benign	0.04
R1936:Myo18b	UTSW	5	112,760,356 (GRCm38)	missense	probably benign	0.04
R2008:Myo18b	UTSW	5	112,873,557 (GRCm38)	missense	probably benign
R2127:Myo18b	UTSW	5	112,831,078 (GRCm38)	missense	probably damaging	1.00
R2129:Myo18b	UTSW	5	112,831,078 (GRCm38)	missense	probably damaging	1.00
R2141:Myo18b	UTSW	5	112,874,026 (GRCm38)	missense	probably benign	0.01
R2170:Myo18b	UTSW	5	112,723,858 (GRCm38)	missense	probably benign	0.23
R2258:Myo18b	UTSW	5	112,874,663 (GRCm38)	unclassified	probably benign
R2265:Myo18b	UTSW	5	112,782,673 (GRCm38)	missense	probably damaging	1.00
R2483:Myo18b	UTSW	5	112,858,408 (GRCm38)	missense	probably damaging	1.00
R2931:Myo18b	UTSW	5	112,693,127 (GRCm38)	missense	probably benign	0.01
R3160:Myo18b	UTSW	5	112,692,728 (GRCm38)	missense	probably damaging	0.99
R3162:Myo18b	UTSW	5	112,692,728 (GRCm38)	missense	probably damaging	0.99
R3777:Myo18b	UTSW	5	112,757,596 (GRCm38)	missense	probably damaging	0.99
R4240:Myo18b	UTSW	5	112,803,187 (GRCm38)	critical splice donor site	probably null
R4243:Myo18b	UTSW	5	112,692,395 (GRCm38)	missense	possibly damaging	0.95
R4245:Myo18b	UTSW	5	112,692,395 (GRCm38)	missense	possibly damaging	0.95
R4533:Myo18b	UTSW	5	112,693,025 (GRCm38)	missense	probably damaging	1.00
R4631:Myo18b	UTSW	5	112,846,400 (GRCm38)	missense	probably damaging	1.00
R4661:Myo18b	UTSW	5	112,875,175 (GRCm38)	unclassified	probably benign
R4755:Myo18b	UTSW	5	112,874,474 (GRCm38)	nonsense	probably null
R4771:Myo18b	UTSW	5	112,692,227 (GRCm38)	nonsense	probably null
R4812:Myo18b	UTSW	5	112,809,718 (GRCm38)	missense	possibly damaging	0.95
R4840:Myo18b	UTSW	5	112,874,029 (GRCm38)	missense	probably benign	0.02
R4888:Myo18b	UTSW	5	112,874,480 (GRCm38)	unclassified	probably benign
R5001:Myo18b	UTSW	5	112,761,340 (GRCm38)	missense	probably damaging	0.99
R5015:Myo18b	UTSW	5	112,790,057 (GRCm38)	missense	probably damaging	1.00
R5055:Myo18b	UTSW	5	112,875,217 (GRCm38)	unclassified	probably benign
R5070:Myo18b	UTSW	5	112,761,346 (GRCm38)	missense	probably damaging	1.00
R5105:Myo18b	UTSW	5	112,840,778 (GRCm38)	missense	probably damaging	1.00
R5121:Myo18b	UTSW	5	112,874,480 (GRCm38)	unclassified	probably benign
R5130:Myo18b	UTSW	5	112,873,903 (GRCm38)	missense	probably benign	0.06
R5186:Myo18b	UTSW	5	112,871,470 (GRCm38)	missense	probably damaging	1.00
R5437:Myo18b	UTSW	5	112,757,573 (GRCm38)	missense	possibly damaging	0.73
R5535:Myo18b	UTSW	5	112,790,042 (GRCm38)	missense	probably damaging	1.00
R5560:Myo18b	UTSW	5	112,868,295 (GRCm38)	missense	probably damaging	0.96
R5810:Myo18b	UTSW	5	112,834,450 (GRCm38)	missense	probably damaging	1.00
R5898:Myo18b	UTSW	5	112,802,330 (GRCm38)	splice site	probably null
R6065:Myo18b	UTSW	5	112,692,781 (GRCm38)	missense	probably benign	0.00
R6104:Myo18b	UTSW	5	112,874,291 (GRCm38)	unclassified	probably benign
R6113:Myo18b	UTSW	5	112,866,385 (GRCm38)	missense	probably damaging	1.00
R6158:Myo18b	UTSW	5	112,874,172 (GRCm38)	missense	probably benign	0.01
R6167:Myo18b	UTSW	5	112,872,507 (GRCm38)	splice site	probably null
R6220:Myo18b	UTSW	5	112,757,507 (GRCm38)	missense	possibly damaging	0.93
R6276:Myo18b	UTSW	5	112,811,642 (GRCm38)	missense	probably benign	0.31
R6290:Myo18b	UTSW	5	112,865,735 (GRCm38)	missense	possibly damaging	0.69
R6291:Myo18b	UTSW	5	112,865,735 (GRCm38)	missense	possibly damaging	0.69
R6795:Myo18b	UTSW	5	112,846,364 (GRCm38)	missense	probably damaging	0.99
R6798:Myo18b	UTSW	5	112,761,386 (GRCm38)	missense	probably damaging	0.98
R6817:Myo18b	UTSW	5	112,830,238 (GRCm38)	missense	probably benign	0.00
R6937:Myo18b	UTSW	5	112,802,392 (GRCm38)	missense	probably benign	0.12
R7034:Myo18b	UTSW	5	112,723,904 (GRCm38)	nonsense	probably null
R7097:Myo18b	UTSW	5	112,874,405 (GRCm38)	missense	unknown
R7145:Myo18b	UTSW	5	112,817,679 (GRCm38)	nonsense	probably null
R7201:Myo18b	UTSW	5	112,715,459 (GRCm38)	missense	probably damaging	1.00
R7260:Myo18b	UTSW	5	112,775,288 (GRCm38)	missense	probably benign	0.01
R7265:Myo18b	UTSW	5	112,812,072 (GRCm38)	missense	probably damaging	1.00
R7409:Myo18b	UTSW	5	112,874,105 (GRCm38)	missense	probably benign	0.25
R7466:Myo18b	UTSW	5	112,723,892 (GRCm38)	missense	probably benign	0.02
R7487:Myo18b	UTSW	5	112,834,433 (GRCm38)	missense	possibly damaging	0.93
R7571:Myo18b	UTSW	5	112,830,328 (GRCm38)	missense	probably damaging	1.00
R7600:Myo18b	UTSW	5	112,878,103 (GRCm38)	missense	unknown
R7612:Myo18b	UTSW	5	112,865,302 (GRCm38)	missense	possibly damaging	0.82
R7617:Myo18b	UTSW	5	112,757,453 (GRCm38)	critical splice donor site	probably null
R7696:Myo18b	UTSW	5	112,692,292 (GRCm38)	missense	probably damaging	1.00
R7710:Myo18b	UTSW	5	112,875,025 (GRCm38)	missense	unknown
R8047:Myo18b	UTSW	5	112,723,815 (GRCm38)	missense	possibly damaging	0.91
R8070:Myo18b	UTSW	5	112,791,120 (GRCm38)	missense	probably benign	0.01
R8088:Myo18b	UTSW	5	112,879,510 (GRCm38)	start gained	probably benign
R8247:Myo18b	UTSW	5	112,692,196 (GRCm38)	missense	probably damaging	1.00
R8276:Myo18b	UTSW	5	112,795,407 (GRCm38)	missense	possibly damaging	0.50
R8313:Myo18b	UTSW	5	112,875,179 (GRCm38)	missense	unknown
R8375:Myo18b	UTSW	5	112,760,393 (GRCm38)	missense	possibly damaging	0.85
R8432:Myo18b	UTSW	5	112,764,512 (GRCm38)	missense	probably benign	0.00
R8475:Myo18b	UTSW	5	112,873,556 (GRCm38)	nonsense	probably null
R8482:Myo18b	UTSW	5	112,871,623 (GRCm38)	nonsense	probably null
R8671:Myo18b	UTSW	5	112,874,743 (GRCm38)	missense	unknown
R8681:Myo18b	UTSW	5	112,873,563 (GRCm38)	critical splice acceptor site	probably null
R8918:Myo18b	UTSW	5	112,875,007 (GRCm38)	unclassified	probably benign
R8941:Myo18b	UTSW	5	112,874,929 (GRCm38)	unclassified	probably benign
R8962:Myo18b	UTSW	5	112,858,480 (GRCm38)	missense	probably benign	0.24
R8972:Myo18b	UTSW	5	112,693,298 (GRCm38)	missense	probably benign	0.00
R9116:Myo18b	UTSW	5	112,827,996 (GRCm38)	missense	probably damaging	1.00
R9209:Myo18b	UTSW	5	112,875,061 (GRCm38)	missense	unknown
R9358:Myo18b	UTSW	5	112,795,403 (GRCm38)	missense	possibly damaging	0.93
R9469:Myo18b	UTSW	5	112,846,381 (GRCm38)	missense	probably benign	0.15
R9607:Myo18b	UTSW	5	112,874,678 (GRCm38)	missense	unknown
R9659:Myo18b	UTSW	5	112,874,516 (GRCm38)	missense	unknown
Z1088:Myo18b	UTSW	5	112,757,484 (GRCm38)	missense	probably benign	0.25
Z1088:Myo18b	UTSW	5	112,692,943 (GRCm38)	missense	possibly damaging	0.89
Z1176:Myo18b	UTSW	5	112,831,190 (GRCm38)	missense	probably damaging	1.00
Z1176:Myo18b	UTSW	5	112,809,738 (GRCm38)	missense	possibly damaging	0.87
Z1176:Myo18b	UTSW	5	112,762,721 (GRCm38)	missense	not run
Z1177:Myo18b	UTSW	5	112,873,541 (GRCm38)	nonsense	probably null
Z1177:Myo18b	UTSW	5	112,762,721 (GRCm38)	missense	not run
Z1177:Myo18b	UTSW	5	112,692,899 (GRCm38)	missense	probably damaging	1.00
Z1177:Myo18b	UTSW	5	112,875,152 (GRCm38)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- GGCAGCCATGAGAACAACTG -3'
(R):5'- AAGACCCAGGACTTGTCACC -3'

Sequencing Primer
(F):5'- TGAGAACAACTGCTGACCTG -3'
(R):5'- CCAGTGTGAGGGTTAGCAGTAC -3'

Posted On

2016-05-10