Mutagenetix > Incidental Mutation

Incidental Mutation 'R4995:Tenm3'

385179

Institutional Source

Beutler Lab

Gene Symbol

Tenm3

Ensembl Gene

ENSMUSG00000031561

Gene Name

teneurin transmembrane protein 3

Synonyms

Odz3, Ten-m3, 2610100B16Rik

MMRRC Submission

042589-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.472) question?

Stock #

R4995 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

48680717-49296986 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 48682172 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 2486 (M2486K)

Ref Sequence

ENSEMBL: ENSMUSP00000033965 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033965] [ENSMUST00000190840]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000033965
AA Change: M2486K

PolyPhen 2 Score 0.865 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000033965
Gene: ENSMUSG00000031561
AA Change: M2486K

Domain	Start	End	E-Value	Type
Pfam:Ten_N	11	177	6.9e-91	PFAM
Pfam:Ten_N	171	308	1e-72	PFAM
transmembrane domain	309	331	N/A	INTRINSIC
EGF	517	545	2.32e-1	SMART
EGF_like	548	576	4.11e1	SMART
EGF	581	610	1.69e1	SMART
EGF	613	642	1.35e-2	SMART
EGF	647	677	6.11e-1	SMART
EGF	680	708	7.95e0	SMART
EGF	711	739	1.28e1	SMART
EGF	751	783	1.64e-1	SMART
PDB:1RWL\|A	1276	1511	9e-6	PDB
low complexity region	2593	2602	N/A	INTRINSIC
Pfam:Tox-GHH	2631	2708	1.5e-34	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000129821
AA Change: M2124K

PolyPhen 2 Score 0.846 (Sensitivity: 0.83; Specificity: 0.93)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000190840
AA Change: M2470K

PolyPhen 2 Score 0.663 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000140141
Gene: ENSMUSG00000031561
AA Change: M2470K

Domain	Start	End	E-Value	Type
Pfam:Ten_N	10	182	7.6e-77	PFAM
Pfam:Ten_N	168	308	6.6e-50	PFAM
transmembrane domain	309	331	N/A	INTRINSIC
EGF	517	545	2.32e-1	SMART
EGF_like	548	576	4.11e1	SMART
EGF	581	610	1.69e1	SMART
EGF	613	642	1.35e-2	SMART
EGF	647	677	6.11e-1	SMART
EGF	680	708	7.95e0	SMART
EGF	711	739	1.28e1	SMART
EGF	751	783	1.64e-1	SMART
PDB:1RWL\|A	1276	1511	9e-6	PDB
low complexity region	2593	2602	N/A	INTRINSIC
Pfam:Tox-GHH	2630	2708	3.2e-35	PFAM

Meta Mutation Damage Score

0.1509

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.7%
20x: 93.6%

Validation Efficiency

99% (86/87)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large transmembrane protein that may be involved in the regulation of neuronal development. Mutation in this gene causes microphthalmia. [provided by RefSeq, Aug 2015]
PHENOTYPE: Mice homozygous for a null mutation display abnormal ipsilateral retinal ganglion cell projections and impaired performance in visually mediated behavioral tasks. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 79 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921504E06Rik	G	A	2: 19,498,995 (GRCm39)	Q333*	probably null	Het
4930505A04Rik	C	T	11: 30,376,349 (GRCm39)	V173M	probably damaging	Het
Acvrl1	G	A	15: 101,033,741 (GRCm39)	R141H	probably benign	Het
Adprm	A	G	11: 66,932,436 (GRCm39)	F158L	possibly damaging	Het
Aldoart2	C	T	12: 55,613,038 (GRCm39)	T321M	probably benign	Het
Ap3m2	A	G	8: 23,293,792 (GRCm39)	V86A	probably benign	Het
Arhgef19	T	A	4: 140,974,826 (GRCm39)		probably null	Het
Bcl2l12	T	G	7: 44,643,615 (GRCm39)		probably null	Het
Bptf	T	C	11: 106,945,391 (GRCm39)	Q2501R	probably damaging	Het
C230029F24Rik	A	T	1: 49,377,295 (GRCm39)		noncoding transcript	Het
C7	C	T	15: 5,079,074 (GRCm39)	G78D	probably damaging	Het
Caly	T	C	7: 139,650,538 (GRCm39)	T135A	probably benign	Het
Cbl	A	G	9: 44,065,108 (GRCm39)	M740T	possibly damaging	Het
Cbx4	A	G	11: 118,972,037 (GRCm39)	V446A	probably benign	Het
Celsr1	C	A	15: 85,822,112 (GRCm39)	R1735L	probably damaging	Het
Cep250	A	G	2: 155,830,236 (GRCm39)	D135G	probably damaging	Het
Cgn	T	C	3: 94,687,246 (GRCm39)	T19A	probably damaging	Het
Chic2	A	T	5: 75,204,865 (GRCm39)	V32D	probably damaging	Het
Cntln	A	G	4: 84,968,120 (GRCm39)	K780E	probably benign	Het
Col8a2	A	T	4: 126,204,581 (GRCm39)	D197V	probably damaging	Het
Crot	A	T	5: 9,024,000 (GRCm39)	V372E	probably damaging	Het
Cyb561d2	C	T	9: 107,418,747 (GRCm39)	V26M	probably damaging	Het
Ddx5	G	A	11: 106,676,062 (GRCm39)	T237I	probably damaging	Het
Dmxl2	G	T	9: 54,408,725 (GRCm39)		probably benign	Het
Dock8	T	A	19: 25,135,747 (GRCm39)	S1188R	probably benign	Het
Ehbp1	T	A	11: 22,051,073 (GRCm39)	H493L	probably damaging	Het
Eif5b	T	A	1: 38,090,792 (GRCm39)	*1217K	probably null	Het
Eprs1	A	G	1: 185,142,336 (GRCm39)		probably benign	Het
Etfdh	T	C	3: 79,513,095 (GRCm39)	D376G	probably benign	Het
Fam186a	T	C	15: 99,842,980 (GRCm39)	Q1088R	probably benign	Het
Fbxw16	G	T	9: 109,270,318 (GRCm39)	T141N	probably damaging	Het
Fgf11	G	A	11: 69,689,585 (GRCm39)	H138Y	probably damaging	Het
Htra3	T	C	5: 35,828,418 (GRCm39)	E154G	probably damaging	Het
Hydin	T	A	8: 111,296,274 (GRCm39)	V3601D	probably damaging	Het
Jup	G	T	11: 100,270,367 (GRCm39)	S380*	probably null	Het
Klrg1	T	A	6: 122,255,234 (GRCm39)	D66V	probably benign	Het
Llgl1	C	T	11: 60,600,550 (GRCm39)	A633V	probably benign	Het
Lmln	T	A	16: 32,894,467 (GRCm39)	Y203*	probably null	Het
Lrrc58	T	G	16: 37,697,418 (GRCm39)	C165G	probably benign	Het
Lss	T	C	10: 76,383,371 (GRCm39)	V557A	probably benign	Het
Mast4	T	C	13: 103,042,262 (GRCm39)		probably benign	Het
Med13l	C	A	5: 118,869,014 (GRCm39)	P754Q	possibly damaging	Het
Mga	C	T	2: 119,763,063 (GRCm39)	R1240*	probably null	Het
Mgat5b	T	A	11: 116,865,025 (GRCm39)		probably null	Het
Mtor	A	G	4: 148,610,209 (GRCm39)	D1572G	probably damaging	Het
Muc4	T	A	16: 32,754,214 (GRCm38)	S1363T	probably benign	Het
Muc4	T	A	16: 32,575,332 (GRCm39)	S1306T	probably benign	Het
Myo18b	A	G	5: 112,908,258 (GRCm39)	V2005A	probably damaging	Het
Myo1e	G	A	9: 70,260,554 (GRCm39)	D571N	probably benign	Het
Mypn	T	C	10: 62,955,747 (GRCm39)		probably null	Het
Ndufb10	T	C	17: 24,941,731 (GRCm39)		probably null	Het
Nelfb	G	T	2: 25,096,208 (GRCm39)	D300E	probably benign	Het
Nicol1	G	A	5: 34,142,270 (GRCm39)	R79H	probably damaging	Het
Odad2	G	A	18: 7,223,663 (GRCm39)	T460M	probably damaging	Het
Or2y1d	T	A	11: 49,321,482 (GRCm39)	Y60N	probably damaging	Het
Or4e5	A	T	14: 52,727,988 (GRCm39)	C61*	probably null	Het
Or52n2c	T	A	7: 104,574,942 (GRCm39)	T10S	probably benign	Het
Or52z15	T	A	7: 103,332,574 (GRCm39)	D206E	probably damaging	Het
Pcdha11	C	T	18: 37,144,080 (GRCm39)	T57M	probably benign	Het
Pkp1	A	T	1: 135,808,593 (GRCm39)	I458N	possibly damaging	Het
Prr12	T	A	7: 44,700,653 (GRCm39)		probably benign	Het
Prrc2c	A	T	1: 162,532,879 (GRCm39)		probably benign	Het
Psd4	T	C	2: 24,287,259 (GRCm39)	F397S	probably benign	Het
Pygm	T	C	19: 6,448,169 (GRCm39)	I737T	probably damaging	Het
Rfx1	T	A	8: 84,806,743 (GRCm39)		probably null	Het
Rsl1	A	G	13: 67,330,313 (GRCm39)	T254A	possibly damaging	Het
Sh3rf3	A	G	10: 58,922,646 (GRCm39)	Q574R	probably benign	Het
Spire1	T	C	18: 67,685,849 (GRCm39)		probably null	Het
St6galnac4	G	A	2: 32,484,075 (GRCm39)	G91D	probably damaging	Het
Sytl2	T	C	7: 90,031,465 (GRCm39)		probably benign	Het
Tbpl2	T	A	2: 23,983,872 (GRCm39)	K188N	possibly damaging	Het
Tgoln1	A	C	6: 72,593,123 (GRCm39)	V119G	possibly damaging	Het
Tpgs1	A	T	10: 79,505,325 (GRCm39)	N28Y	probably benign	Het
U2surp	A	C	9: 95,344,847 (GRCm39)		probably benign	Het
Vmn2r103	A	G	17: 19,993,773 (GRCm39)	H50R	probably benign	Het
Vmn2r19	A	G	6: 123,306,869 (GRCm39)	N459S	probably benign	Het
Vmn2r72	T	C	7: 85,387,693 (GRCm39)	S624G	probably damaging	Het
Vps13c	A	G	9: 67,826,603 (GRCm39)	T1415A	probably benign	Het
Vwa5b1	G	A	4: 138,336,154 (GRCm39)	P147S	probably damaging	Het

Other mutations in Tenm3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00272:Tenm3	APN	8	48,870,095 (GRCm39)	missense	probably damaging	1.00
IGL00538:Tenm3	APN	8	48,689,060 (GRCm39)	missense	probably damaging	1.00
IGL00719:Tenm3	APN	8	48,732,077 (GRCm39)	missense	probably benign	0.39
IGL00720:Tenm3	APN	8	48,729,456 (GRCm39)	missense	probably damaging	0.98
IGL00870:Tenm3	APN	8	48,870,167 (GRCm39)	missense	probably benign	0.00
IGL00976:Tenm3	APN	8	48,709,876 (GRCm39)	missense	probably benign	0.14
IGL01469:Tenm3	APN	8	48,689,458 (GRCm39)	missense	probably damaging	1.00
IGL01508:Tenm3	APN	8	48,729,680 (GRCm39)	missense	probably benign	0.09
IGL01590:Tenm3	APN	8	48,681,837 (GRCm39)	missense	probably damaging	1.00
IGL01610:Tenm3	APN	8	48,707,512 (GRCm39)	missense	probably damaging	1.00
IGL01874:Tenm3	APN	8	48,689,793 (GRCm39)	nonsense	probably null
IGL01892:Tenm3	APN	8	48,729,431 (GRCm39)	missense	probably benign	0.09
IGL02098:Tenm3	APN	8	48,729,611 (GRCm39)	missense	possibly damaging	0.94
IGL02382:Tenm3	APN	8	48,688,511 (GRCm39)	missense	probably damaging	1.00
IGL02397:Tenm3	APN	8	48,689,729 (GRCm39)	missense	possibly damaging	0.94
IGL02475:Tenm3	APN	8	48,732,233 (GRCm39)	splice site	probably benign
IGL02502:Tenm3	APN	8	48,741,051 (GRCm39)	missense	probably damaging	1.00
IGL02508:Tenm3	APN	8	48,752,674 (GRCm39)	missense	probably benign	0.30
IGL02543:Tenm3	APN	8	48,751,991 (GRCm39)	missense	probably damaging	1.00
IGL02723:Tenm3	APN	8	48,729,938 (GRCm39)	missense	probably benign	0.02
IGL03037:Tenm3	APN	8	48,751,913 (GRCm39)	missense	possibly damaging	0.90
IGL03160:Tenm3	APN	8	49,099,453 (GRCm39)	missense	probably benign	0.05
IGL03268:Tenm3	APN	8	48,688,558 (GRCm39)	missense	probably damaging	1.00
IGL02988:Tenm3	UTSW	8	48,688,381 (GRCm39)	missense	probably damaging	0.99
PIT4431001:Tenm3	UTSW	8	48,688,642 (GRCm39)	missense	probably damaging	1.00
PIT4504001:Tenm3	UTSW	8	48,746,692 (GRCm39)	missense	probably damaging	1.00
R0079:Tenm3	UTSW	8	48,796,380 (GRCm39)	missense	possibly damaging	0.90
R0121:Tenm3	UTSW	8	48,795,694 (GRCm39)	missense	probably damaging	0.99
R0123:Tenm3	UTSW	8	49,127,507 (GRCm39)	missense	probably damaging	1.00
R0134:Tenm3	UTSW	8	49,127,507 (GRCm39)	missense	probably damaging	1.00
R0147:Tenm3	UTSW	8	48,689,755 (GRCm39)	missense	probably damaging	1.00
R0148:Tenm3	UTSW	8	48,689,755 (GRCm39)	missense	probably damaging	1.00
R0309:Tenm3	UTSW	8	48,794,069 (GRCm39)	missense	probably damaging	1.00
R0322:Tenm3	UTSW	8	48,689,947 (GRCm39)	splice site	probably benign
R0335:Tenm3	UTSW	8	48,685,140 (GRCm39)	missense	probably damaging	1.00
R0355:Tenm3	UTSW	8	48,682,010 (GRCm39)	missense	probably damaging	1.00
R0411:Tenm3	UTSW	8	48,740,826 (GRCm39)	missense	possibly damaging	0.61
R0505:Tenm3	UTSW	8	48,794,195 (GRCm39)	splice site	probably benign
R0573:Tenm3	UTSW	8	49,127,434 (GRCm39)	splice site	probably benign
R0599:Tenm3	UTSW	8	48,730,745 (GRCm39)	missense	probably damaging	1.00
R0616:Tenm3	UTSW	8	48,729,191 (GRCm39)	missense	possibly damaging	0.76
R0637:Tenm3	UTSW	8	48,689,560 (GRCm39)	missense	probably damaging	1.00
R0726:Tenm3	UTSW	8	48,689,629 (GRCm39)	missense	probably damaging	1.00
R0840:Tenm3	UTSW	8	48,788,777 (GRCm39)	missense	probably damaging	0.99
R0981:Tenm3	UTSW	8	48,752,000 (GRCm39)	missense	probably damaging	1.00
R1006:Tenm3	UTSW	8	48,681,577 (GRCm39)	missense	probably damaging	1.00
R1199:Tenm3	UTSW	8	48,688,617 (GRCm39)	missense	probably damaging	0.99
R1223:Tenm3	UTSW	8	48,693,431 (GRCm39)	missense	possibly damaging	0.72
R1240:Tenm3	UTSW	8	48,740,928 (GRCm39)	missense	possibly damaging	0.74
R1394:Tenm3	UTSW	8	48,729,435 (GRCm39)	missense	probably benign
R1455:Tenm3	UTSW	8	48,732,083 (GRCm39)	missense	possibly damaging	0.87
R1459:Tenm3	UTSW	8	48,689,006 (GRCm39)	missense	probably damaging	1.00
R1473:Tenm3	UTSW	8	48,763,660 (GRCm39)	missense	probably damaging	1.00
R1501:Tenm3	UTSW	8	48,796,351 (GRCm39)	missense	probably damaging	0.99
R1507:Tenm3	UTSW	8	48,740,857 (GRCm39)	missense	probably benign	0.01
R1522:Tenm3	UTSW	8	48,848,611 (GRCm39)	missense	probably damaging	1.00
R1524:Tenm3	UTSW	8	48,682,016 (GRCm39)	missense	possibly damaging	0.92
R1553:Tenm3	UTSW	8	48,689,456 (GRCm39)	missense	probably damaging	1.00
R1572:Tenm3	UTSW	8	48,682,028 (GRCm39)	missense	possibly damaging	0.94
R1583:Tenm3	UTSW	8	48,732,109 (GRCm39)	missense	probably benign	0.09
R1676:Tenm3	UTSW	8	48,870,154 (GRCm39)	missense	possibly damaging	0.83
R1732:Tenm3	UTSW	8	48,763,669 (GRCm39)	missense	probably damaging	1.00
R1768:Tenm3	UTSW	8	48,685,139 (GRCm39)	missense	probably damaging	1.00
R1777:Tenm3	UTSW	8	48,870,214 (GRCm39)	missense	probably benign	0.05
R1793:Tenm3	UTSW	8	49,127,579 (GRCm39)	missense	probably damaging	0.98
R1801:Tenm3	UTSW	8	48,729,291 (GRCm39)	missense	probably benign	0.39
R1863:Tenm3	UTSW	8	48,729,381 (GRCm39)	missense	probably benign	0.20
R1898:Tenm3	UTSW	8	48,763,796 (GRCm39)	missense	probably damaging	1.00
R1971:Tenm3	UTSW	8	48,689,348 (GRCm39)	missense	probably damaging	1.00
R1972:Tenm3	UTSW	8	48,681,626 (GRCm39)	missense	probably damaging	1.00
R1996:Tenm3	UTSW	8	48,681,703 (GRCm39)	missense	probably damaging	1.00
R2061:Tenm3	UTSW	8	48,795,291 (GRCm39)	critical splice donor site	probably null
R2109:Tenm3	UTSW	8	48,796,384 (GRCm39)	missense	possibly damaging	0.94
R2124:Tenm3	UTSW	8	48,870,041 (GRCm39)	critical splice donor site	probably null
R2190:Tenm3	UTSW	8	48,848,579 (GRCm39)	missense	probably damaging	1.00
R2204:Tenm3	UTSW	8	49,127,585 (GRCm39)	missense	probably benign	0.17
R2233:Tenm3	UTSW	8	48,729,204 (GRCm39)	missense	probably benign	0.04
R2234:Tenm3	UTSW	8	48,729,204 (GRCm39)	missense	probably benign	0.04
R2235:Tenm3	UTSW	8	48,729,204 (GRCm39)	missense	probably benign	0.04
R2237:Tenm3	UTSW	8	48,795,372 (GRCm39)	missense	probably damaging	1.00
R2418:Tenm3	UTSW	8	48,729,693 (GRCm39)	missense	possibly damaging	0.87
R2419:Tenm3	UTSW	8	48,729,693 (GRCm39)	missense	possibly damaging	0.87
R2435:Tenm3	UTSW	8	48,740,988 (GRCm39)	missense	probably damaging	1.00
R2483:Tenm3	UTSW	8	48,693,305 (GRCm39)	missense	probably damaging	0.99
R3406:Tenm3	UTSW	8	48,681,590 (GRCm39)	missense	probably damaging	1.00
R3724:Tenm3	UTSW	8	48,730,781 (GRCm39)	missense	probably damaging	0.97
R4009:Tenm3	UTSW	8	48,802,258 (GRCm39)	missense	probably damaging	1.00
R4210:Tenm3	UTSW	8	48,802,439 (GRCm39)	missense	probably damaging	1.00
R4293:Tenm3	UTSW	8	48,848,693 (GRCm39)	missense	probably damaging	1.00
R4656:Tenm3	UTSW	8	48,746,761 (GRCm39)	missense	probably damaging	1.00
R4663:Tenm3	UTSW	8	48,689,005 (GRCm39)	missense	probably damaging	1.00
R4835:Tenm3	UTSW	8	48,766,271 (GRCm39)	critical splice donor site	probably null
R4851:Tenm3	UTSW	8	48,763,656 (GRCm39)	critical splice donor site	probably null
R4867:Tenm3	UTSW	8	48,688,856 (GRCm39)	missense	probably damaging	1.00
R4892:Tenm3	UTSW	8	48,729,896 (GRCm39)	missense	probably damaging	0.99
R4895:Tenm3	UTSW	8	48,754,006 (GRCm39)	missense	probably damaging	1.00
R4962:Tenm3	UTSW	8	48,731,996 (GRCm39)	nonsense	probably null
R4996:Tenm3	UTSW	8	48,688,861 (GRCm39)	missense	probably damaging	0.97
R5091:Tenm3	UTSW	8	48,795,343 (GRCm39)	missense	probably benign	0.14
R5228:Tenm3	UTSW	8	48,689,390 (GRCm39)	missense	probably damaging	1.00
R5253:Tenm3	UTSW	8	48,682,233 (GRCm39)	missense	possibly damaging	0.92
R5260:Tenm3	UTSW	8	48,689,890 (GRCm39)	missense	probably damaging	1.00
R5363:Tenm3	UTSW	8	48,740,866 (GRCm39)	missense	possibly damaging	0.55
R5414:Tenm3	UTSW	8	48,689,390 (GRCm39)	missense	probably damaging	1.00
R5427:Tenm3	UTSW	8	48,689,599 (GRCm39)	missense	probably damaging	1.00
R5431:Tenm3	UTSW	8	48,820,412 (GRCm39)	nonsense	probably null
R5566:Tenm3	UTSW	8	48,732,041 (GRCm39)	missense	probably damaging	1.00
R5579:Tenm3	UTSW	8	48,689,799 (GRCm39)	missense	probably damaging	1.00
R5656:Tenm3	UTSW	8	48,681,797 (GRCm39)	missense	probably damaging	1.00
R5931:Tenm3	UTSW	8	49,099,533 (GRCm39)	missense	probably benign	0.00
R5959:Tenm3	UTSW	8	49,099,482 (GRCm39)	nonsense	probably null
R5965:Tenm3	UTSW	8	48,681,543 (GRCm39)	nonsense	probably null
R6062:Tenm3	UTSW	8	48,796,441 (GRCm39)	missense	possibly damaging	0.46
R6151:Tenm3	UTSW	8	48,848,608 (GRCm39)	missense	probably damaging	1.00
R6157:Tenm3	UTSW	8	48,751,843 (GRCm39)	missense	probably damaging	0.96
R6167:Tenm3	UTSW	8	48,707,657 (GRCm39)	missense	possibly damaging	0.46
R6217:Tenm3	UTSW	8	48,746,700 (GRCm39)	missense	probably damaging	0.99
R6233:Tenm3	UTSW	8	48,870,094 (GRCm39)	missense	probably damaging	1.00
R6270:Tenm3	UTSW	8	48,820,429 (GRCm39)	missense	probably damaging	0.98
R6329:Tenm3	UTSW	8	48,729,884 (GRCm39)	missense	probably damaging	0.99
R6466:Tenm3	UTSW	8	48,689,098 (GRCm39)	missense	probably damaging	0.97
R6515:Tenm3	UTSW	8	48,870,257 (GRCm39)	missense	probably benign
R6516:Tenm3	UTSW	8	48,870,257 (GRCm39)	missense	probably benign
R6747:Tenm3	UTSW	8	48,796,278 (GRCm39)	missense	probably damaging	1.00
R6782:Tenm3	UTSW	8	49,099,291 (GRCm39)	critical splice donor site	probably null
R6788:Tenm3	UTSW	8	49,127,528 (GRCm39)	missense	probably damaging	1.00
R6823:Tenm3	UTSW	8	48,709,872 (GRCm39)	missense	probably damaging	0.99
R6846:Tenm3	UTSW	8	48,729,773 (GRCm39)	missense	probably benign	0.39
R6913:Tenm3	UTSW	8	48,751,972 (GRCm39)	missense	probably damaging	0.99
R6941:Tenm3	UTSW	8	49,127,451 (GRCm39)	missense	probably damaging	0.99
R6950:Tenm3	UTSW	8	48,693,514 (GRCm39)	nonsense	probably null
R6968:Tenm3	UTSW	8	48,689,474 (GRCm39)	missense	probably damaging	1.00
R6970:Tenm3	UTSW	8	48,689,474 (GRCm39)	missense	probably damaging	1.00
R6993:Tenm3	UTSW	8	48,689,474 (GRCm39)	missense	probably damaging	1.00
R7003:Tenm3	UTSW	8	48,693,479 (GRCm39)	missense	probably damaging	1.00
R7125:Tenm3	UTSW	8	49,127,588 (GRCm39)	missense	probably benign	0.00
R7140:Tenm3	UTSW	8	48,745,271 (GRCm39)	missense	probably damaging	1.00
R7222:Tenm3	UTSW	8	48,754,004 (GRCm39)	missense	probably damaging	1.00
R7232:Tenm3	UTSW	8	48,688,970 (GRCm39)	missense	probably damaging	1.00
R7336:Tenm3	UTSW	8	48,689,212 (GRCm39)	missense	possibly damaging	0.93
R7417:Tenm3	UTSW	8	48,689,218 (GRCm39)	missense	probably damaging	1.00
R7526:Tenm3	UTSW	8	48,740,847 (GRCm39)	missense	probably damaging	0.96
R7527:Tenm3	UTSW	8	48,729,635 (GRCm39)	missense	possibly damaging	0.60
R7616:Tenm3	UTSW	8	48,794,084 (GRCm39)	missense	possibly damaging	0.56
R7662:Tenm3	UTSW	8	48,788,762 (GRCm39)	missense	probably benign	0.27
R7734:Tenm3	UTSW	8	49,099,368 (GRCm39)	missense	probably damaging	1.00
R7802:Tenm3	UTSW	8	48,689,500 (GRCm39)	missense	probably damaging	1.00
R7812:Tenm3	UTSW	8	48,729,335 (GRCm39)	missense	probably benign	0.01
R7843:Tenm3	UTSW	8	48,682,146 (GRCm39)	nonsense	probably null
R7951:Tenm3	UTSW	8	48,763,738 (GRCm39)	missense	possibly damaging	0.86
R8293:Tenm3	UTSW	8	48,820,457 (GRCm39)	missense	possibly damaging	0.91
R8336:Tenm3	UTSW	8	48,746,808 (GRCm39)	missense	probably damaging	1.00
R8351:Tenm3	UTSW	8	48,740,907 (GRCm39)	missense	probably damaging	0.96
R8387:Tenm3	UTSW	8	48,740,883 (GRCm39)	missense	probably damaging	0.98
R8414:Tenm3	UTSW	8	48,746,544 (GRCm39)	missense	probably damaging	1.00
R8451:Tenm3	UTSW	8	48,740,907 (GRCm39)	missense	probably damaging	0.96
R8465:Tenm3	UTSW	8	48,682,216 (GRCm39)	missense	probably damaging	1.00
R8528:Tenm3	UTSW	8	48,795,668 (GRCm39)	missense	probably damaging	1.00
R8717:Tenm3	UTSW	8	48,752,680 (GRCm39)	missense	possibly damaging	0.77
R8734:Tenm3	UTSW	8	48,802,391 (GRCm39)	missense	probably benign	0.16
R8781:Tenm3	UTSW	8	48,795,484 (GRCm39)	frame shift	probably null
R8820:Tenm3	UTSW	8	48,763,759 (GRCm39)	missense	probably damaging	0.96
R8821:Tenm3	UTSW	8	48,729,417 (GRCm39)	missense
R8831:Tenm3	UTSW	8	48,729,417 (GRCm39)	missense
R8853:Tenm3	UTSW	8	48,795,382 (GRCm39)	missense	probably damaging	1.00
R8900:Tenm3	UTSW	8	48,689,437 (GRCm39)	missense	probably damaging	1.00
R8931:Tenm3	UTSW	8	48,688,637 (GRCm39)	missense	probably damaging	1.00
R8933:Tenm3	UTSW	8	48,732,095 (GRCm39)	missense	possibly damaging	0.53
R8989:Tenm3	UTSW	8	48,688,383 (GRCm39)	nonsense	probably null
R8998:Tenm3	UTSW	8	48,729,722 (GRCm39)	missense	probably damaging	1.00
R9008:Tenm3	UTSW	8	48,795,688 (GRCm39)	missense	probably damaging	0.98
R9017:Tenm3	UTSW	8	48,707,668 (GRCm39)	missense	probably damaging	0.99
R9101:Tenm3	UTSW	8	48,745,186 (GRCm39)	missense	probably damaging	1.00
R9108:Tenm3	UTSW	8	48,766,271 (GRCm39)	critical splice donor site	probably null
R9142:Tenm3	UTSW	8	48,788,548 (GRCm39)	missense	unknown
R9231:Tenm3	UTSW	8	48,689,231 (GRCm39)	missense	probably damaging	1.00
R9309:Tenm3	UTSW	8	48,751,972 (GRCm39)	missense	probably damaging	0.99
R9310:Tenm3	UTSW	8	49,008,935 (GRCm39)	unclassified	probably benign
R9336:Tenm3	UTSW	8	48,870,115 (GRCm39)	missense	probably damaging	1.00
R9373:Tenm3	UTSW	8	48,752,690 (GRCm39)	missense	probably damaging	1.00
R9393:Tenm3	UTSW	8	49,127,559 (GRCm39)	missense	probably damaging	0.99
R9509:Tenm3	UTSW	8	48,766,292 (GRCm39)	nonsense	probably null
R9575:Tenm3	UTSW	8	48,688,796 (GRCm39)	missense	possibly damaging	0.94
R9698:Tenm3	UTSW	8	48,689,246 (GRCm39)	missense	probably damaging	1.00
R9722:Tenm3	UTSW	8	48,753,849 (GRCm39)	missense	probably benign	0.00
R9788:Tenm3	UTSW	8	48,788,596 (GRCm39)	missense	probably benign	0.02
X0010:Tenm3	UTSW	8	48,740,864 (GRCm39)	missense	probably damaging	0.98
X0025:Tenm3	UTSW	8	48,689,512 (GRCm39)	missense	probably damaging	1.00
Z1177:Tenm3	UTSW	8	48,729,815 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACGTTGATCCCGTTCTCCAG -3'
(R):5'- TTATGTGTAGTCAAGACCGGG -3'

Sequencing Primer
(F):5'- AAGGCGTTGTTGAGCACC -3'
(R):5'- GAAGGTACACCAGCAAGCATG -3'

Posted On

2016-05-10