Mutagenetix > Incidental Mutations

Incidental Mutation 'R4995:Olfr1507'

385206

Institutional Source

Beutler Lab

Gene Symbol

Olfr1507

Ensembl Gene

ENSMUSG00000059887

Gene Name

olfactory receptor 1507

Synonyms

MOR244-1, MOR28, GA_x6K02T2RJGY-491851-492792

MMRRC Submission

042589-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R4995 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

52488791-52495749 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 52490531 bp

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 61 (C61*)

Ref Sequence

ENSEMBL: ENSMUSP00000145718 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073571] [ENSMUST00000205963] [ENSMUST00000206062] [ENSMUST00000206069] [ENSMUST00000206931]

Predicted Effect

probably null
Transcript: ENSMUST00000073571
AA Change: C144*

SMART Domains

Protein: ENSMUSP00000073260
Gene: ENSMUSG00000059887
AA Change: C144*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	34	308	1.1e-47	PFAM
Pfam:7TM_GPCR_Srsx	38	305	3.6e-9	PFAM
Pfam:7tm_1	44	290	9.1e-22	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000205963
AA Change: C117*

Predicted Effect

probably null
Transcript: ENSMUST00000206062
AA Change: C144*

Predicted Effect

probably null
Transcript: ENSMUST00000206069
AA Change: C61*

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206087
AA Change: C144*

Predicted Effect

probably benign
Transcript: ENSMUST00000206931

Meta Mutation Damage Score

0.9376

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.7%
20x: 93.6%

Validation Efficiency

99% (86/87)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 79 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921504E06Rik	G	A	2: 19,494,184	Q333*	probably null	Het
4930505A04Rik	C	T	11: 30,426,349	V173M	probably damaging	Het
Acvrl1	G	A	15: 101,135,860	R141H	probably benign	Het
Adprm	A	G	11: 67,041,610	F158L	possibly damaging	Het
Aldoart2	C	T	12: 55,566,253	T321M	probably benign	Het
Ap3m2	A	G	8: 22,803,776	V86A	probably benign	Het
Arhgef19	T	A	4: 141,247,515		probably null	Het
Armc4	G	A	18: 7,223,663	T460M	probably damaging	Het
Bcl2l12	T	G	7: 44,994,191		probably null	Het
Bptf	T	C	11: 107,054,565	Q2501R	probably damaging	Het
C230029F24Rik	A	T	1: 49,338,136		noncoding transcript	Het
C7	C	T	15: 5,049,592	G78D	probably damaging	Het
Caly	T	C	7: 140,070,625	T135A	probably benign	Het
Cbl	A	G	9: 44,153,811	M740T	possibly damaging	Het
Cbx4	A	G	11: 119,081,211	V446A	probably benign	Het
Celsr1	C	A	15: 85,937,911	R1735L	probably damaging	Het
Cep250	A	G	2: 155,988,316	D135G	probably damaging	Het
Cgn	T	C	3: 94,779,936	T19A	probably damaging	Het
Chic2	A	T	5: 75,044,204	V32D	probably damaging	Het
Cntln	A	G	4: 85,049,883	K780E	probably benign	Het
Col8a2	A	T	4: 126,310,788	D197V	probably damaging	Het
Crot	A	T	5: 8,974,000	V372E	probably damaging	Het
Cyb561d2	C	T	9: 107,541,548	V26M	probably damaging	Het
Ddx5	G	A	11: 106,785,236	T237I	probably damaging	Het
Dmxl2	G	T	9: 54,501,441		probably benign	Het
Dock8	T	A	19: 25,158,383	S1188R	probably benign	Het
Ehbp1	T	A	11: 22,101,073	H493L	probably damaging	Het
Eif5b	T	A	1: 38,051,711	*1217K	probably null	Het
Eprs	A	G	1: 185,410,139		probably benign	Het
Etfdh	T	C	3: 79,605,788	D376G	probably benign	Het
Fam186a	T	C	15: 99,945,099	Q1088R	probably benign	Het
Fbxw16	G	T	9: 109,441,250	T141N	probably damaging	Het
Fgf11	G	A	11: 69,798,759	H138Y	probably damaging	Het
Gm1673	G	A	5: 33,984,926	R79H	probably damaging	Het
Htra3	T	C	5: 35,671,074	E154G	probably damaging	Het
Hydin	T	A	8: 110,569,642	V3601D	probably damaging	Het
Jup	G	T	11: 100,379,541	S380*	probably null	Het
Klrg1	T	A	6: 122,278,275	D66V	probably benign	Het
Llgl1	C	T	11: 60,709,724	A633V	probably benign	Het
Lmln	T	A	16: 33,074,097	Y203*	probably null	Het
Lrrc58	T	G	16: 37,877,056	C165G	probably benign	Het
Lss	T	C	10: 76,547,537	V557A	probably benign	Het
Mast4	T	C	13: 102,905,754		probably benign	Het
Med13l	C	A	5: 118,730,949	P754Q	possibly damaging	Het
Mga	C	T	2: 119,932,582	R1240*	probably null	Het
Mgat5b	T	A	11: 116,974,199		probably null	Het
Mtor	A	G	4: 148,525,752	D1572G	probably damaging	Het
Muc4	T	A	16: 32,754,214	S1363T	probably benign	Het
Muc4	T	A	16: 32,754,041	S1306T	probably benign	Het
Myo18b	A	G	5: 112,760,392	V2005A	probably damaging	Het
Myo1e	G	A	9: 70,353,272	D571N	probably benign	Het
Mypn	T	C	10: 63,119,968		probably null	Het
Ndufb10	T	C	17: 24,722,757		probably null	Het
Nelfb	G	T	2: 25,206,196	D300E	probably benign	Het
Olfr1389	T	A	11: 49,430,655	Y60N	probably damaging	Het
Olfr625-ps1	T	A	7: 103,683,367	D206E	probably damaging	Het
Olfr668	T	A	7: 104,925,735	T10S	probably benign	Het
Pcdha11	C	T	18: 37,011,027	T57M	probably benign	Het
Pkp1	A	T	1: 135,880,855	I458N	possibly damaging	Het
Prr12	T	A	7: 45,051,229		probably benign	Het
Prrc2c	A	T	1: 162,705,310		probably benign	Het
Psd4	T	C	2: 24,397,247	F397S	probably benign	Het
Pygm	T	C	19: 6,398,139	I737T	probably damaging	Het
Rfx1	T	A	8: 84,080,114		probably null	Het
Rsl1	A	G	13: 67,182,249	T254A	possibly damaging	Het
Sh3rf3	A	G	10: 59,086,824	Q574R	probably benign	Het
Spire1	T	C	18: 67,552,779		probably null	Het
St6galnac4	G	A	2: 32,594,063	G91D	probably damaging	Het
Sytl2	T	C	7: 90,382,257		probably benign	Het
Tbpl2	T	A	2: 24,093,860	K188N	possibly damaging	Het
Tenm3	A	T	8: 48,229,137	M2486K	possibly damaging	Het
Tgoln1	A	C	6: 72,616,140	V119G	possibly damaging	Het
Tpgs1	A	T	10: 79,669,491	N28Y	probably benign	Het
U2surp	A	C	9: 95,462,794		probably benign	Het
Vmn2r103	A	G	17: 19,773,511	H50R	probably benign	Het
Vmn2r19	A	G	6: 123,329,910	N459S	probably benign	Het
Vmn2r72	T	C	7: 85,738,485	S624G	probably damaging	Het
Vps13c	A	G	9: 67,919,321	T1415A	probably benign	Het
Vwa5b1	G	A	4: 138,608,843	P147S	probably damaging	Het

Other mutations in Olfr1507

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01336:Olfr1507	APN	14	52490748	missense	probably damaging	1.00
IGL01367:Olfr1507	APN	14	52490167	missense	probably benign	0.42
IGL01664:Olfr1507	APN	14	52490545	missense	probably benign	0.01
IGL02890:Olfr1507	APN	14	52490911	missense	probably benign
IGL03108:Olfr1507	APN	14	52490076	missense	probably damaging	0.97
IGL03184:Olfr1507	APN	14	52490923	missense	probably benign	0.20
R0563:Olfr1507	UTSW	14	52490257	nonsense	probably null
R1080:Olfr1507	UTSW	14	52490585	nonsense	probably null
R1558:Olfr1507	UTSW	14	52490146	missense	probably benign	0.26
R1653:Olfr1507	UTSW	14	52490772	missense	probably damaging	1.00
R1714:Olfr1507	UTSW	14	52490414	unclassified	probably null
R1720:Olfr1507	UTSW	14	52490594	nonsense	probably null
R3430:Olfr1507	UTSW	14	52490425	missense	possibly damaging	0.92
R5954:Olfr1507	UTSW	14	52490167	missense	probably benign	0.42
R6183:Olfr1507	UTSW	14	52490731	missense	probably benign	0.05
R6518:Olfr1507	UTSW	14	52490620	missense	probably damaging	1.00
R6651:Olfr1507	UTSW	14	52490793	missense	probably benign	0.07
R6652:Olfr1507	UTSW	14	52490793	missense	probably benign	0.07
R6653:Olfr1507	UTSW	14	52490793	missense	probably benign	0.07
R7385:Olfr1507	UTSW	14	52490181	missense	probably damaging	1.00
R7524:Olfr1507	UTSW	14	52490293	missense	probably damaging	1.00
X0025:Olfr1507	UTSW	14	52490466	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- ACCATAGAGATCATCCCACTGTTG -3'
(R):5'- CACTGTCACTGTCCCAAAGATG -3'

Sequencing Primer
(F):5'- TGGAGACAACGAGAATCTCAGTG -3'
(R):5'- GTCACTGTCCCAAAGATGCTAAGTG -3'

Posted On

2016-05-10