Incidental Mutation 'R5015:Dqx1'
ID 385496
Institutional Source Beutler Lab
Gene Symbol Dqx1
Ensembl Gene ENSMUSG00000009145
Gene Name DEAQ RNA-dependent ATPase
Synonyms 2310066E11Rik
MMRRC Submission 042606-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R5015 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 83034825-83044299 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 83043092 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 610 (T610A)
Ref Sequence ENSEMBL: ENSMUSP00000076708 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077502] [ENSMUST00000089641] [ENSMUST00000174674]
AlphaFold Q924H9
Predicted Effect probably benign
Transcript: ENSMUST00000077502
AA Change: T610A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000076708
Gene: ENSMUSG00000009145
AA Change: T610A

DomainStartEndE-ValueType
low complexity region 2 19 N/A INTRINSIC
DEXDc 30 236 5.01e-4 SMART
low complexity region 268 280 N/A INTRINSIC
low complexity region 288 301 N/A INTRINSIC
HA2 441 530 4e-19 SMART
Pfam:OB_NTP_bind 555 674 2.2e-11 PFAM
low complexity region 695 708 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000089641
SMART Domains Protein: ENSMUSP00000087069
Gene: ENSMUSG00000068327

DomainStartEndE-ValueType
low complexity region 2 16 N/A INTRINSIC
low complexity region 25 61 N/A INTRINSIC
low complexity region 82 116 N/A INTRINSIC
HOX 157 219 1.66e-23 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000174674
SMART Domains Protein: ENSMUSP00000133420
Gene: ENSMUSG00000068327

DomainStartEndE-ValueType
low complexity region 2 16 N/A INTRINSIC
low complexity region 25 61 N/A INTRINSIC
low complexity region 82 116 N/A INTRINSIC
HOX 157 213 2.43e-16 SMART
Coding Region Coverage
  • 1x: 98.3%
  • 3x: 97.3%
  • 10x: 95.2%
  • 20x: 91.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam25 T A 8: 41,207,671 (GRCm39) F312L probably benign Het
Adprm A G 11: 66,932,856 (GRCm39) F18L possibly damaging Het
Ampd1 T G 3: 103,006,981 (GRCm39) N735K possibly damaging Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Atp1a4 T C 1: 172,081,649 (GRCm39) M168V probably damaging Het
Bcl6 G A 16: 23,793,600 (GRCm39) H116Y probably damaging Het
Bmpr2 T A 1: 59,890,383 (GRCm39) N338K probably damaging Het
Bms1 A T 6: 118,381,224 (GRCm39) Y697* probably null Het
Ccdc33 A C 9: 58,025,918 (GRCm39) F37C probably damaging Het
Ccdc60 T A 5: 116,426,507 (GRCm39) Q30L probably benign Het
Cndp1 C A 18: 84,650,036 (GRCm39) R219L probably damaging Het
Cstdc4 T C 16: 36,006,837 (GRCm39) probably null Het
Daam2 C A 17: 49,783,550 (GRCm39) D627Y probably damaging Het
Dffb T C 4: 154,057,416 (GRCm39) D87G possibly damaging Het
Dnah2 T G 11: 69,388,708 (GRCm39) T892P possibly damaging Het
Dspp A T 5: 104,324,926 (GRCm39) I430L possibly damaging Het
Dytn T A 1: 63,672,854 (GRCm39) K516N probably benign Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fmnl2 T A 2: 52,993,773 (GRCm39) N389K possibly damaging Het
Fn1 G A 1: 71,665,336 (GRCm39) T927I probably damaging Het
Foxn1 T C 11: 78,261,989 (GRCm39) K127E probably damaging Het
Fpr-rs6 A G 17: 20,402,608 (GRCm39) F251S probably damaging Het
Frrs1 A G 3: 116,672,088 (GRCm39) D62G probably damaging Het
Fut10 T A 8: 31,726,148 (GRCm39) V301D probably damaging Het
Gk5 A G 9: 96,059,470 (GRCm39) probably null Het
Glipr1l1 T A 10: 111,914,279 (GRCm39) N213K probably benign Het
Gm1110 A G 9: 26,793,162 (GRCm39) F538S probably benign Het
Gm7347 T A 5: 26,262,366 (GRCm39) T52S probably benign Het
Gsap T C 5: 21,427,406 (GRCm39) I178T probably damaging Het
H1f9 C A 11: 94,858,928 (GRCm39) N74K probably damaging Het
Hcn1 A T 13: 117,739,556 (GRCm39) Q106L unknown Het
Isg20l2 G T 3: 87,839,288 (GRCm39) L166F possibly damaging Het
Kcnq3 T A 15: 65,876,612 (GRCm39) E510D probably damaging Het
Kif26b G T 1: 178,755,895 (GRCm39) R2003L probably damaging Het
Kiss1r T C 10: 79,754,641 (GRCm39) V45A probably damaging Het
Krt14 G A 11: 100,098,032 (GRCm39) R84* probably null Het
Mbd5 T C 2: 49,148,208 (GRCm39) M806T possibly damaging Het
Mdga1 A T 17: 30,058,847 (GRCm39) I13N possibly damaging Het
Mfsd4b5 T C 10: 39,850,758 (GRCm39) K73E probably benign Het
Mterf2 C T 10: 84,955,596 (GRCm39) G343R probably benign Het
Mto1 T A 9: 78,368,903 (GRCm39) F522I probably benign Het
Myo18b T C 5: 112,937,923 (GRCm39) E1734G probably damaging Het
Myoz1 T C 14: 20,703,787 (GRCm39) T53A probably benign Het
Naxd T C 8: 11,563,032 (GRCm39) L324P probably damaging Het
Nos1 T A 5: 118,005,334 (GRCm39) V18D probably damaging Het
Nova1 T C 12: 46,863,738 (GRCm39) T71A unknown Het
Or10v5 T C 19: 11,805,482 (GRCm39) R303G probably benign Het
Or10z1 A G 1: 174,078,448 (GRCm39) L15S possibly damaging Het
Or1e29 C G 11: 73,668,007 (GRCm39) V49L probably benign Het
Or2j6 T C 7: 139,980,083 (GRCm39) D292G probably damaging Het
Or52b1 A G 7: 104,978,811 (GRCm39) V196A possibly damaging Het
Otof T A 5: 30,540,238 (GRCm39) Y981F probably damaging Het
Peg10 C CTCA 6: 4,756,453 (GRCm39) probably benign Het
Pex1 A G 5: 3,670,597 (GRCm39) K7E probably damaging Het
Pi4ka A G 16: 17,120,946 (GRCm39) S73P possibly damaging Het
Plxnb1 T A 9: 108,929,498 (GRCm39) I118N possibly damaging Het
Prcc T C 3: 87,779,560 (GRCm39) D158G probably damaging Het
Ptpn7 C A 1: 135,066,877 (GRCm39) R245S possibly damaging Het
Ptpre C T 7: 135,270,861 (GRCm39) H346Y probably benign Het
Pwp2 A G 10: 78,018,527 (GRCm39) C86R probably benign Het
Rfng T G 11: 120,673,876 (GRCm39) D178A probably damaging Het
Rhpn1 T C 15: 75,580,090 (GRCm39) I51T probably damaging Het
Rnasel G T 1: 153,629,843 (GRCm39) E120* probably null Het
Sall2 T G 14: 52,553,112 (GRCm39) S26R possibly damaging Het
Scn10a A G 9: 119,451,987 (GRCm39) V1312A possibly damaging Het
Sdk2 C A 11: 113,684,587 (GRCm39) R1958L probably damaging Het
Septin4 C T 11: 87,458,043 (GRCm39) S139F possibly damaging Het
Slc52a2 T A 15: 76,424,751 (GRCm39) C330S probably damaging Het
Smarca2 T A 19: 26,668,788 (GRCm39) I987N possibly damaging Het
Srrt A T 5: 137,294,271 (GRCm39) Y486N probably damaging Het
Stat5b A T 11: 100,695,831 (GRCm39) N50K possibly damaging Het
Strip2 T A 6: 29,931,265 (GRCm39) D405E probably benign Het
Tcstv6 T A 13: 120,298,474 (GRCm39) probably null Het
Tnc A T 4: 63,924,739 (GRCm39) D986E probably damaging Het
Tph2 T C 10: 114,915,621 (GRCm39) N473S probably benign Het
Tpp1 C T 7: 105,401,232 (GRCm39) probably benign Het
Trpm3 T C 19: 22,689,076 (GRCm39) Y2H probably damaging Het
Ttc21a A T 9: 119,795,195 (GRCm39) E1072V probably damaging Het
Zfat T C 15: 68,050,762 (GRCm39) D753G probably damaging Het
Zmym2 T A 14: 57,159,051 (GRCm39) S609T probably damaging Het
Other mutations in Dqx1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01796:Dqx1 APN 6 83,043,408 (GRCm39) unclassified probably benign
IGL02158:Dqx1 APN 6 83,035,891 (GRCm39) splice site probably benign
IGL02288:Dqx1 APN 6 83,037,309 (GRCm39) missense probably damaging 0.98
IGL02801:Dqx1 APN 6 83,037,476 (GRCm39) splice site probably null
IGL02929:Dqx1 APN 6 83,037,465 (GRCm39) unclassified probably benign
R0396:Dqx1 UTSW 6 83,035,986 (GRCm39) missense probably benign 0.00
R0448:Dqx1 UTSW 6 83,037,326 (GRCm39) missense probably damaging 1.00
R0471:Dqx1 UTSW 6 83,036,407 (GRCm39) splice site probably benign
R1022:Dqx1 UTSW 6 83,038,070 (GRCm39) missense probably damaging 1.00
R1023:Dqx1 UTSW 6 83,038,070 (GRCm39) missense probably damaging 1.00
R1024:Dqx1 UTSW 6 83,038,070 (GRCm39) missense probably damaging 1.00
R1480:Dqx1 UTSW 6 83,036,433 (GRCm39) missense possibly damaging 0.61
R1804:Dqx1 UTSW 6 83,037,303 (GRCm39) missense probably damaging 1.00
R1848:Dqx1 UTSW 6 83,043,088 (GRCm39) missense probably damaging 1.00
R1982:Dqx1 UTSW 6 83,035,558 (GRCm39) missense probably damaging 1.00
R2064:Dqx1 UTSW 6 83,035,524 (GRCm39) unclassified probably benign
R2350:Dqx1 UTSW 6 83,036,068 (GRCm39) nonsense probably null
R3110:Dqx1 UTSW 6 83,035,953 (GRCm39) missense probably damaging 0.99
R3112:Dqx1 UTSW 6 83,035,953 (GRCm39) missense probably damaging 0.99
R3119:Dqx1 UTSW 6 83,043,216 (GRCm39) nonsense probably null
R4179:Dqx1 UTSW 6 83,036,460 (GRCm39) missense probably benign 0.03
R4180:Dqx1 UTSW 6 83,036,460 (GRCm39) missense probably benign 0.03
R4873:Dqx1 UTSW 6 83,037,993 (GRCm39) missense probably benign 0.25
R4875:Dqx1 UTSW 6 83,037,993 (GRCm39) missense probably benign 0.25
R4882:Dqx1 UTSW 6 83,043,069 (GRCm39) critical splice acceptor site probably null
R5128:Dqx1 UTSW 6 83,037,548 (GRCm39) missense probably damaging 0.96
R5346:Dqx1 UTSW 6 83,036,700 (GRCm39) missense possibly damaging 0.87
R5480:Dqx1 UTSW 6 83,041,784 (GRCm39) missense probably damaging 0.98
R6939:Dqx1 UTSW 6 83,036,446 (GRCm39) missense probably damaging 0.99
R6979:Dqx1 UTSW 6 83,037,992 (GRCm39) missense probably damaging 1.00
R7059:Dqx1 UTSW 6 83,041,790 (GRCm39) missense probably benign 0.18
R7084:Dqx1 UTSW 6 83,043,436 (GRCm39) missense probably damaging 1.00
R7354:Dqx1 UTSW 6 83,037,957 (GRCm39) nonsense probably null
R7389:Dqx1 UTSW 6 83,041,775 (GRCm39) missense probably null 0.99
R7497:Dqx1 UTSW 6 83,036,028 (GRCm39) missense probably damaging 1.00
R7632:Dqx1 UTSW 6 83,036,680 (GRCm39) missense probably benign
R7762:Dqx1 UTSW 6 83,038,013 (GRCm39) missense probably damaging 1.00
R8002:Dqx1 UTSW 6 83,035,558 (GRCm39) missense probably damaging 1.00
R8036:Dqx1 UTSW 6 83,036,788 (GRCm39) missense probably damaging 1.00
R8147:Dqx1 UTSW 6 83,037,222 (GRCm39) missense probably benign 0.41
R8776:Dqx1 UTSW 6 83,035,619 (GRCm39) missense probably damaging 0.99
R8776-TAIL:Dqx1 UTSW 6 83,035,619 (GRCm39) missense probably damaging 0.99
R9090:Dqx1 UTSW 6 83,036,024 (GRCm39) missense probably benign 0.13
R9139:Dqx1 UTSW 6 83,036,759 (GRCm39) missense possibly damaging 0.76
R9271:Dqx1 UTSW 6 83,036,024 (GRCm39) missense probably benign 0.13
Predicted Primers PCR Primer
(F):5'- TCCTATGGTGAAGCAGGAGC -3'
(R):5'- ACATCTCAGGCTGGATCTCAG -3'

Sequencing Primer
(F):5'- GACAAGGTCTCATGTTGTCCAAGC -3'
(R):5'- CTCAGGCTGGATCTCAGAGACAATG -3'
Posted On 2016-05-10