Incidental Mutation 'R5015:Or1e29'
ID 385521
Institutional Source Beutler Lab
Gene Symbol Or1e29
Ensembl Gene ENSMUSG00000070383
Gene Name olfactory receptor family 1 subfamily E member 29
Synonyms MOR135-6, GA_x6K02T2P1NL-3932085-3931147, Olfr389
MMRRC Submission 042606-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R5015 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 73667213-73671415 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to G at 73668007 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 49 (V49L)
Ref Sequence ENSEMBL: ENSMUSP00000149734 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000122224] [ENSMUST00000124927] [ENSMUST00000215418]
AlphaFold Q7TRX7
Predicted Effect probably benign
Transcript: ENSMUST00000122224
AA Change: V49L

PolyPhen 2 Score 0.073 (Sensitivity: 0.93; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000113364
Gene: ENSMUSG00000070383
AA Change: V49L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.8e-56 PFAM
Pfam:7TM_GPCR_Srsx 35 305 4.2e-6 PFAM
Pfam:7tm_1 41 290 2e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000124927
AA Change: V49L

PolyPhen 2 Score 0.073 (Sensitivity: 0.93; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000115639
Gene: ENSMUSG00000070383
AA Change: V49L

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 35 221 6.6e-7 PFAM
Pfam:7tm_1 41 224 3.5e-29 PFAM
Pfam:7tm_4 139 224 1.4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215418
AA Change: V49L

PolyPhen 2 Score 0.073 (Sensitivity: 0.93; Specificity: 0.84)
Coding Region Coverage
  • 1x: 98.3%
  • 3x: 97.3%
  • 10x: 95.2%
  • 20x: 91.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam25 T A 8: 41,207,671 (GRCm39) F312L probably benign Het
Adprm A G 11: 66,932,856 (GRCm39) F18L possibly damaging Het
Ampd1 T G 3: 103,006,981 (GRCm39) N735K possibly damaging Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Atp1a4 T C 1: 172,081,649 (GRCm39) M168V probably damaging Het
Bcl6 G A 16: 23,793,600 (GRCm39) H116Y probably damaging Het
Bmpr2 T A 1: 59,890,383 (GRCm39) N338K probably damaging Het
Bms1 A T 6: 118,381,224 (GRCm39) Y697* probably null Het
Ccdc33 A C 9: 58,025,918 (GRCm39) F37C probably damaging Het
Ccdc60 T A 5: 116,426,507 (GRCm39) Q30L probably benign Het
Cndp1 C A 18: 84,650,036 (GRCm39) R219L probably damaging Het
Cstdc4 T C 16: 36,006,837 (GRCm39) probably null Het
Daam2 C A 17: 49,783,550 (GRCm39) D627Y probably damaging Het
Dffb T C 4: 154,057,416 (GRCm39) D87G possibly damaging Het
Dnah2 T G 11: 69,388,708 (GRCm39) T892P possibly damaging Het
Dqx1 A G 6: 83,043,092 (GRCm39) T610A probably benign Het
Dspp A T 5: 104,324,926 (GRCm39) I430L possibly damaging Het
Dytn T A 1: 63,672,854 (GRCm39) K516N probably benign Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fmnl2 T A 2: 52,993,773 (GRCm39) N389K possibly damaging Het
Fn1 G A 1: 71,665,336 (GRCm39) T927I probably damaging Het
Foxn1 T C 11: 78,261,989 (GRCm39) K127E probably damaging Het
Fpr-rs6 A G 17: 20,402,608 (GRCm39) F251S probably damaging Het
Frrs1 A G 3: 116,672,088 (GRCm39) D62G probably damaging Het
Fut10 T A 8: 31,726,148 (GRCm39) V301D probably damaging Het
Gk5 A G 9: 96,059,470 (GRCm39) probably null Het
Glipr1l1 T A 10: 111,914,279 (GRCm39) N213K probably benign Het
Gm1110 A G 9: 26,793,162 (GRCm39) F538S probably benign Het
Gm7347 T A 5: 26,262,366 (GRCm39) T52S probably benign Het
Gsap T C 5: 21,427,406 (GRCm39) I178T probably damaging Het
H1f9 C A 11: 94,858,928 (GRCm39) N74K probably damaging Het
Hcn1 A T 13: 117,739,556 (GRCm39) Q106L unknown Het
Isg20l2 G T 3: 87,839,288 (GRCm39) L166F possibly damaging Het
Kcnq3 T A 15: 65,876,612 (GRCm39) E510D probably damaging Het
Kif26b G T 1: 178,755,895 (GRCm39) R2003L probably damaging Het
Kiss1r T C 10: 79,754,641 (GRCm39) V45A probably damaging Het
Krt14 G A 11: 100,098,032 (GRCm39) R84* probably null Het
Mbd5 T C 2: 49,148,208 (GRCm39) M806T possibly damaging Het
Mdga1 A T 17: 30,058,847 (GRCm39) I13N possibly damaging Het
Mfsd4b5 T C 10: 39,850,758 (GRCm39) K73E probably benign Het
Mterf2 C T 10: 84,955,596 (GRCm39) G343R probably benign Het
Mto1 T A 9: 78,368,903 (GRCm39) F522I probably benign Het
Myo18b T C 5: 112,937,923 (GRCm39) E1734G probably damaging Het
Myoz1 T C 14: 20,703,787 (GRCm39) T53A probably benign Het
Naxd T C 8: 11,563,032 (GRCm39) L324P probably damaging Het
Nos1 T A 5: 118,005,334 (GRCm39) V18D probably damaging Het
Nova1 T C 12: 46,863,738 (GRCm39) T71A unknown Het
Or10v5 T C 19: 11,805,482 (GRCm39) R303G probably benign Het
Or10z1 A G 1: 174,078,448 (GRCm39) L15S possibly damaging Het
Or2j6 T C 7: 139,980,083 (GRCm39) D292G probably damaging Het
Or52b1 A G 7: 104,978,811 (GRCm39) V196A possibly damaging Het
Otof T A 5: 30,540,238 (GRCm39) Y981F probably damaging Het
Peg10 C CTCA 6: 4,756,453 (GRCm39) probably benign Het
Pex1 A G 5: 3,670,597 (GRCm39) K7E probably damaging Het
Pi4ka A G 16: 17,120,946 (GRCm39) S73P possibly damaging Het
Plxnb1 T A 9: 108,929,498 (GRCm39) I118N possibly damaging Het
Prcc T C 3: 87,779,560 (GRCm39) D158G probably damaging Het
Ptpn7 C A 1: 135,066,877 (GRCm39) R245S possibly damaging Het
Ptpre C T 7: 135,270,861 (GRCm39) H346Y probably benign Het
Pwp2 A G 10: 78,018,527 (GRCm39) C86R probably benign Het
Rfng T G 11: 120,673,876 (GRCm39) D178A probably damaging Het
Rhpn1 T C 15: 75,580,090 (GRCm39) I51T probably damaging Het
Rnasel G T 1: 153,629,843 (GRCm39) E120* probably null Het
Sall2 T G 14: 52,553,112 (GRCm39) S26R possibly damaging Het
Scn10a A G 9: 119,451,987 (GRCm39) V1312A possibly damaging Het
Sdk2 C A 11: 113,684,587 (GRCm39) R1958L probably damaging Het
Septin4 C T 11: 87,458,043 (GRCm39) S139F possibly damaging Het
Slc52a2 T A 15: 76,424,751 (GRCm39) C330S probably damaging Het
Smarca2 T A 19: 26,668,788 (GRCm39) I987N possibly damaging Het
Srrt A T 5: 137,294,271 (GRCm39) Y486N probably damaging Het
Stat5b A T 11: 100,695,831 (GRCm39) N50K possibly damaging Het
Strip2 T A 6: 29,931,265 (GRCm39) D405E probably benign Het
Tcstv6 T A 13: 120,298,474 (GRCm39) probably null Het
Tnc A T 4: 63,924,739 (GRCm39) D986E probably damaging Het
Tph2 T C 10: 114,915,621 (GRCm39) N473S probably benign Het
Tpp1 C T 7: 105,401,232 (GRCm39) probably benign Het
Trpm3 T C 19: 22,689,076 (GRCm39) Y2H probably damaging Het
Ttc21a A T 9: 119,795,195 (GRCm39) E1072V probably damaging Het
Zfat T C 15: 68,050,762 (GRCm39) D753G probably damaging Het
Zmym2 T A 14: 57,159,051 (GRCm39) S609T probably damaging Het
Other mutations in Or1e29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01458:Or1e29 APN 11 73,667,532 (GRCm39) missense probably benign 0.44
IGL01766:Or1e29 APN 11 73,667,901 (GRCm39) missense probably benign 0.41
IGL01771:Or1e29 APN 11 73,667,490 (GRCm39) missense probably damaging 1.00
IGL02535:Or1e29 APN 11 73,667,442 (GRCm39) missense probably benign 0.00
IGL02639:Or1e29 APN 11 73,667,371 (GRCm39) missense probably benign 0.21
IGL03060:Or1e29 APN 11 73,667,289 (GRCm39) missense probably damaging 1.00
IGL03075:Or1e29 APN 11 73,667,298 (GRCm39) missense probably damaging 1.00
R0081:Or1e29 UTSW 11 73,667,935 (GRCm39) missense possibly damaging 0.59
R0426:Or1e29 UTSW 11 73,667,263 (GRCm39) missense probably benign 0.13
R1140:Or1e29 UTSW 11 73,667,680 (GRCm39) missense probably benign
R1638:Or1e29 UTSW 11 73,667,974 (GRCm39) missense possibly damaging 0.95
R2001:Or1e29 UTSW 11 73,667,539 (GRCm39) missense probably benign
R2214:Or1e29 UTSW 11 73,667,655 (GRCm39) nonsense probably null
R3076:Or1e29 UTSW 11 73,667,466 (GRCm39) missense possibly damaging 0.93
R3077:Or1e29 UTSW 11 73,667,466 (GRCm39) missense possibly damaging 0.93
R3078:Or1e29 UTSW 11 73,667,466 (GRCm39) missense possibly damaging 0.93
R3081:Or1e29 UTSW 11 73,668,051 (GRCm39) missense probably damaging 1.00
R3430:Or1e29 UTSW 11 73,667,365 (GRCm39) missense probably damaging 1.00
R3731:Or1e29 UTSW 11 73,667,565 (GRCm39) missense probably benign 0.08
R4090:Or1e29 UTSW 11 73,667,667 (GRCm39) missense probably damaging 1.00
R4303:Or1e29 UTSW 11 73,667,664 (GRCm39) missense possibly damaging 0.78
R4516:Or1e29 UTSW 11 73,667,866 (GRCm39) missense probably benign 0.06
R4556:Or1e29 UTSW 11 73,667,307 (GRCm39) missense possibly damaging 0.65
R4557:Or1e29 UTSW 11 73,667,307 (GRCm39) missense possibly damaging 0.65
R4775:Or1e29 UTSW 11 73,667,377 (GRCm39) missense probably damaging 1.00
R4858:Or1e29 UTSW 11 73,667,372 (GRCm39) missense probably benign 0.44
R5087:Or1e29 UTSW 11 73,668,084 (GRCm39) missense possibly damaging 0.75
R6599:Or1e29 UTSW 11 73,667,506 (GRCm39) missense probably benign
R6701:Or1e29 UTSW 11 73,667,296 (GRCm39) missense probably damaging 1.00
R6784:Or1e29 UTSW 11 73,667,676 (GRCm39) missense probably damaging 1.00
R6916:Or1e29 UTSW 11 73,667,895 (GRCm39) missense probably benign 0.00
R7066:Or1e29 UTSW 11 73,668,018 (GRCm39) missense probably damaging 0.99
R7226:Or1e29 UTSW 11 73,667,503 (GRCm39) missense possibly damaging 0.95
R7457:Or1e29 UTSW 11 73,667,652 (GRCm39) missense probably benign 0.06
R7486:Or1e29 UTSW 11 73,667,847 (GRCm39) missense probably damaging 1.00
R7990:Or1e29 UTSW 11 73,667,497 (GRCm39) missense probably benign 0.00
R8289:Or1e29 UTSW 11 73,667,839 (GRCm39) missense probably benign
R9131:Or1e29 UTSW 11 73,668,150 (GRCm39) start codon destroyed probably null 1.00
R9160:Or1e29 UTSW 11 73,667,881 (GRCm39) missense probably benign 0.01
R9239:Or1e29 UTSW 11 73,667,346 (GRCm39) missense probably benign 0.00
R9666:Or1e29 UTSW 11 73,667,976 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TAGGCCATGACCACAAGAAG -3'
(R):5'- ATATACAGGCACAACCACTGGG -3'

Sequencing Primer
(F):5'- TGACCACAAGAAGAAAGCTTTC -3'
(R):5'- ACAACCACTGGGAATCTAAAATTATG -3'
Posted On 2016-05-10