Incidental Mutation 'R4986:Or4x11'
ID 385865
Institutional Source Beutler Lab
Gene Symbol Or4x11
Ensembl Gene ENSMUSG00000059910
Gene Name olfactory receptor family 4 subfamily X member 11
Synonyms MOR228-2, GA_x6K02T2Q125-51469027-51469956, Olfr1265
MMRRC Submission 042580-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R4986 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 89867265-89868194 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 89867772 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Tyrosine at position 170 (N170Y)
Ref Sequence ENSEMBL: ENSMUSP00000149684 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080311] [ENSMUST00000214855]
AlphaFold Q8VEZ3
Predicted Effect probably damaging
Transcript: ENSMUST00000080311
AA Change: N170Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000079190
Gene: ENSMUSG00000059910
AA Change: N170Y

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 1.9e-49 PFAM
Pfam:7tm_1 39 285 1.4e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214855
AA Change: N170Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.1589 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.5%
  • 20x: 89.2%
Validation Efficiency 95% (41/43)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 A T 6: 142,573,317 (GRCm39) C1005S probably benign Het
Armh4 A T 14: 49,989,111 (GRCm39) D619E probably damaging Het
Ccdc34 T C 2: 109,848,214 (GRCm39) M1T probably null Het
Ceacam5 T A 7: 17,491,758 (GRCm39) N709K possibly damaging Het
Ces2f G A 8: 105,678,657 (GRCm39) S298N probably benign Het
Defa30 T A 8: 21,625,432 (GRCm39) Y65* probably null Het
Dock3 A C 9: 106,809,182 (GRCm39) C1314G probably damaging Het
Emc2 A G 15: 43,375,180 (GRCm39) M226V probably benign Het
Fat3 T C 9: 15,909,636 (GRCm39) Y2122C probably damaging Het
Gad1 A G 2: 70,431,037 (GRCm39) D560G probably benign Het
Gm9944 T C 4: 144,179,760 (GRCm39) probably benign Het
Gpr137c A T 14: 45,483,743 (GRCm39) probably null Het
Igf2bp2 C T 16: 21,889,056 (GRCm39) probably null Het
Igsf10 T C 3: 59,236,027 (GRCm39) T1385A probably benign Het
Itpr2 T A 6: 146,141,840 (GRCm39) N1734I probably damaging Het
Kbtbd6 A G 14: 79,690,049 (GRCm39) H248R probably damaging Het
Macf1 C T 4: 123,284,914 (GRCm39) R5650Q probably damaging Het
Mdh1 A G 11: 21,508,545 (GRCm39) F266L possibly damaging Het
Mecom G T 3: 30,034,848 (GRCm39) P466Q probably damaging Het
Muc20 A G 16: 32,598,009 (GRCm39) probably benign Het
Or5w8 T A 2: 87,687,858 (GRCm39) L113Q probably damaging Het
Osmr A G 15: 6,846,061 (GRCm39) probably null Het
Rrs1 G A 1: 9,615,992 (GRCm39) E82K probably damaging Het
Sacs T A 14: 61,450,492 (GRCm39) Y4179* probably null Het
Septin11 T C 5: 93,309,100 (GRCm39) V203A probably damaging Het
Skint9 T A 4: 112,248,910 (GRCm39) T173S probably benign Het
Slain1 A T 14: 103,925,541 (GRCm39) R296S probably damaging Het
Slc36a3 T A 11: 55,037,592 (GRCm39) *93C probably null Het
Sp110 G A 1: 85,519,481 (GRCm39) P116S probably benign Het
Srl T C 16: 4,314,646 (GRCm39) Y332C probably benign Het
Ubtf G A 11: 102,205,000 (GRCm39) H95Y probably benign Het
Ugt1a1 CAGAGAGAGAGAGA CAGAGAGAGAGA 1: 88,139,706 (GRCm39) probably benign Het
Wdfy3 C T 5: 102,090,985 (GRCm39) D532N probably benign Het
Ybx1 C T 4: 119,139,627 (GRCm39) V123I probably damaging Het
Zfp944 A T 17: 22,558,211 (GRCm39) H345Q probably damaging Het
Zfp993 T A 4: 146,742,014 (GRCm39) F113I probably benign Het
Other mutations in Or4x11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01154:Or4x11 APN 2 89,867,812 (GRCm39) missense probably damaging 1.00
IGL01470:Or4x11 APN 2 89,868,162 (GRCm39) missense possibly damaging 0.81
IGL01878:Or4x11 APN 2 89,867,478 (GRCm39) missense probably damaging 0.97
IGL02716:Or4x11 APN 2 89,868,138 (GRCm39) missense probably benign 0.05
IGL03066:Or4x11 APN 2 89,867,778 (GRCm39) missense probably damaging 0.99
R1310:Or4x11 UTSW 2 89,868,047 (GRCm39) missense probably benign 0.02
R5101:Or4x11 UTSW 2 89,867,391 (GRCm39) missense probably benign 0.00
R6149:Or4x11 UTSW 2 89,867,860 (GRCm39) missense probably benign 0.01
R6400:Or4x11 UTSW 2 89,867,739 (GRCm39) missense probably benign 0.00
R7367:Or4x11 UTSW 2 89,868,156 (GRCm39) missense probably benign 0.02
R7432:Or4x11 UTSW 2 89,867,528 (GRCm39) missense probably damaging 0.99
R7645:Or4x11 UTSW 2 89,868,091 (GRCm39) missense possibly damaging 0.90
R7849:Or4x11 UTSW 2 89,867,626 (GRCm39) missense probably damaging 1.00
R9265:Or4x11 UTSW 2 89,867,842 (GRCm39) missense probably benign 0.01
R9634:Or4x11 UTSW 2 89,867,907 (GRCm39) missense probably damaging 1.00
R9756:Or4x11 UTSW 2 89,867,674 (GRCm39) missense probably benign 0.02
X0019:Or4x11 UTSW 2 89,867,988 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TGCTCACAGTGATGGCCTATG -3'
(R):5'- ACCACAGTGACATGGGATCC -3'

Sequencing Primer
(F):5'- ATGACCGTTATGTGGCCATC -3'
(R):5'- CACAGGTGGACAGAGCTTTGC -3'
Posted On 2016-05-10