Mutagenetix > Incidental Mutation

Incidental Mutation 'R4986:Gpr137c'

385886

Institutional Source

Beutler Lab

Gene Symbol

Gpr137c

Ensembl Gene

ENSMUSG00000049092

Gene Name

G protein-coupled receptor 137C

Synonyms

TM7SF1L2, LOC380893, 6330416L11Rik

MMRRC Submission

042580-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

R4986 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

45457174-45520182 bp(+) (GRCm39)

Type of Mutation

critical splice acceptor site

DNA Base Change (assembly)

A to T at 45483743 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000120015 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000146150]

AlphaFold

E9Q343

Predicted Effect

probably null
Transcript: ENSMUST00000146150

SMART Domains

Protein: ENSMUSP00000120015
Gene: ENSMUSG00000049092

Domain	Start	End	E-Value	Type
low complexity region	4	17	N/A	INTRINSIC
low complexity region	23	39	N/A	INTRINSIC
transmembrane domain	44	66	N/A	INTRINSIC
transmembrane domain	78	100	N/A	INTRINSIC
Blast:G_alpha	121	286	9e-17	BLAST
transmembrane domain	294	316	N/A	INTRINSIC
low complexity region	376	389	N/A	INTRINSIC

Meta Mutation Damage Score

0.9492

Coding Region Coverage

1x: 99.0%
3x: 98.1%
10x: 95.5%
20x: 89.2%

Validation Efficiency

95% (41/43)

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc9	A	T	6: 142,573,317 (GRCm39)	C1005S	probably benign	Het
Armh4	A	T	14: 49,989,111 (GRCm39)	D619E	probably damaging	Het
Ccdc34	T	C	2: 109,848,214 (GRCm39)	M1T	probably null	Het
Ceacam5	T	A	7: 17,491,758 (GRCm39)	N709K	possibly damaging	Het
Ces2f	G	A	8: 105,678,657 (GRCm39)	S298N	probably benign	Het
Defa30	T	A	8: 21,625,432 (GRCm39)	Y65*	probably null	Het
Dock3	A	C	9: 106,809,182 (GRCm39)	C1314G	probably damaging	Het
Emc2	A	G	15: 43,375,180 (GRCm39)	M226V	probably benign	Het
Fat3	T	C	9: 15,909,636 (GRCm39)	Y2122C	probably damaging	Het
Gad1	A	G	2: 70,431,037 (GRCm39)	D560G	probably benign	Het
Gm9944	T	C	4: 144,179,760 (GRCm39)		probably benign	Het
Igf2bp2	C	T	16: 21,889,056 (GRCm39)		probably null	Het
Igsf10	T	C	3: 59,236,027 (GRCm39)	T1385A	probably benign	Het
Itpr2	T	A	6: 146,141,840 (GRCm39)	N1734I	probably damaging	Het
Kbtbd6	A	G	14: 79,690,049 (GRCm39)	H248R	probably damaging	Het
Macf1	C	T	4: 123,284,914 (GRCm39)	R5650Q	probably damaging	Het
Mdh1	A	G	11: 21,508,545 (GRCm39)	F266L	possibly damaging	Het
Mecom	G	T	3: 30,034,848 (GRCm39)	P466Q	probably damaging	Het
Muc20	A	G	16: 32,598,009 (GRCm39)		probably benign	Het
Or4x11	A	T	2: 89,867,772 (GRCm39)	N170Y	probably damaging	Het
Or5w8	T	A	2: 87,687,858 (GRCm39)	L113Q	probably damaging	Het
Osmr	A	G	15: 6,846,061 (GRCm39)		probably null	Het
Rrs1	G	A	1: 9,615,992 (GRCm39)	E82K	probably damaging	Het
Sacs	T	A	14: 61,450,492 (GRCm39)	Y4179*	probably null	Het
Septin11	T	C	5: 93,309,100 (GRCm39)	V203A	probably damaging	Het
Skint9	T	A	4: 112,248,910 (GRCm39)	T173S	probably benign	Het
Slain1	A	T	14: 103,925,541 (GRCm39)	R296S	probably damaging	Het
Slc36a3	T	A	11: 55,037,592 (GRCm39)	*93C	probably null	Het
Sp110	G	A	1: 85,519,481 (GRCm39)	P116S	probably benign	Het
Srl	T	C	16: 4,314,646 (GRCm39)	Y332C	probably benign	Het
Ubtf	G	A	11: 102,205,000 (GRCm39)	H95Y	probably benign	Het
Ugt1a1	CAGAGAGAGAGAGA	CAGAGAGAGAGA	1: 88,139,706 (GRCm39)		probably benign	Het
Wdfy3	C	T	5: 102,090,985 (GRCm39)	D532N	probably benign	Het
Ybx1	C	T	4: 119,139,627 (GRCm39)	V123I	probably damaging	Het
Zfp944	A	T	17: 22,558,211 (GRCm39)	H345Q	probably damaging	Het
Zfp993	T	A	4: 146,742,014 (GRCm39)	F113I	probably benign	Het

Other mutations in Gpr137c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00478:Gpr137c	APN	14	45,516,202 (GRCm39)	missense	probably damaging	0.97
IGL02167:Gpr137c	APN	14	45,517,412 (GRCm39)	missense	probably damaging	0.98
IGL02203:Gpr137c	APN	14	45,514,944 (GRCm39)	missense	possibly damaging	0.86
IGL02960:Gpr137c	APN	14	45,483,890 (GRCm39)	missense	possibly damaging	0.92
R0731:Gpr137c	UTSW	14	45,483,806 (GRCm39)	missense	probably damaging	1.00
R1162:Gpr137c	UTSW	14	45,481,615 (GRCm39)	missense	possibly damaging	0.89
R1245:Gpr137c	UTSW	14	45,516,522 (GRCm39)	utr 3 prime	probably benign
R1983:Gpr137c	UTSW	14	45,517,428 (GRCm39)	missense	probably benign	0.01
R2060:Gpr137c	UTSW	14	45,481,616 (GRCm39)	missense	probably damaging	1.00
R2428:Gpr137c	UTSW	14	45,516,420 (GRCm39)	missense	probably damaging	1.00
R3034:Gpr137c	UTSW	14	45,457,733 (GRCm39)	missense	probably damaging	0.99
R3911:Gpr137c	UTSW	14	45,516,392 (GRCm39)	missense	probably benign	0.31
R4037:Gpr137c	UTSW	14	45,457,687 (GRCm39)	missense	probably damaging	0.99
R4038:Gpr137c	UTSW	14	45,457,687 (GRCm39)	missense	probably damaging	0.99
R4213:Gpr137c	UTSW	14	45,483,965 (GRCm39)	missense	probably damaging	0.99
R5521:Gpr137c	UTSW	14	45,516,151 (GRCm39)	missense	possibly damaging	0.92
R6028:Gpr137c	UTSW	14	45,514,938 (GRCm39)	missense	probably damaging	0.96
R7117:Gpr137c	UTSW	14	45,516,484 (GRCm39)	missense	probably damaging	1.00
R7238:Gpr137c	UTSW	14	45,516,148 (GRCm39)	missense	probably damaging	1.00
R7365:Gpr137c	UTSW	14	45,516,471 (GRCm39)	missense	probably damaging	1.00
R9515:Gpr137c	UTSW	14	45,516,229 (GRCm39)	nonsense	probably null
R9539:Gpr137c	UTSW	14	45,516,187 (GRCm39)	missense	probably damaging	0.97
X0027:Gpr137c	UTSW	14	45,516,126 (GRCm39)	missense	probably benign	0.14

Predicted Primers

PCR Primer
(F):5'- CTAGCATGCCAAGTAACTATGGG -3'
(R):5'- TGTAGCTAACTAAAGAGATGGCAC -3'

Sequencing Primer
(F):5'- TAGGCCATCTGCTACATATGCAG -3'
(R):5'- TGGCACAGAGAATAAACAGGCTATC -3'

Posted On

2016-05-10