Incidental Mutation 'R4989:Or5k3'
ID 386086
Institutional Source Beutler Lab
Gene Symbol Or5k3
Ensembl Gene ENSMUSG00000062608
Gene Name olfactory receptor family 5 subfamily K member 3
Synonyms MOR184-5, GA_x54KRFPKG5P-55369823-55370749, Olfr195
MMRRC Submission 042583-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R4989 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 58969215-58970141 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58969981 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 256 (L256P)
Ref Sequence ENSEMBL: ENSMUSP00000150249 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075381] [ENSMUST00000216957]
AlphaFold Q8VGQ6
Predicted Effect probably damaging
Transcript: ENSMUST00000075381
AA Change: L256P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073737
Gene: ENSMUSG00000062608
AA Change: L256P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.1e-53 PFAM
Pfam:7TM_GPCR_Srsx 35 161 2.7e-8 PFAM
Pfam:7tm_1 41 307 9.4e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208239
Predicted Effect probably damaging
Transcript: ENSMUST00000216957
AA Change: L256P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.2811 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency 100% (115/115)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 114 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
Acot6 A G 12: 84,155,789 (GRCm39) K246E probably benign Het
Actl11 T A 9: 107,808,615 (GRCm39) H979Q probably damaging Het
Adal T A 2: 120,986,030 (GRCm39) probably benign Het
Add2 G A 6: 86,087,840 (GRCm39) V596I probably benign Het
Adrb3 A C 8: 27,717,798 (GRCm39) M217R probably damaging Het
Ank1 T C 8: 23,631,134 (GRCm39) probably benign Het
Ank2 A T 3: 126,757,094 (GRCm39) N1054K possibly damaging Het
Ankib1 T C 5: 3,763,217 (GRCm39) Y504C probably damaging Het
Ankrd29 T C 18: 12,395,242 (GRCm39) K217R probably damaging Het
Ankrd45 T C 1: 160,982,876 (GRCm39) V129A probably damaging Het
Aox4 A T 1: 58,275,835 (GRCm39) D389V probably benign Het
Aph1a G T 3: 95,802,843 (GRCm39) G148W probably damaging Het
Arhgef26 G A 3: 62,247,806 (GRCm39) D297N possibly damaging Het
Atxn7l3b C A 10: 112,764,649 (GRCm39) probably benign Het
Auh A G 13: 52,995,065 (GRCm39) S167P probably damaging Het
Bach1 A T 16: 87,515,888 (GRCm39) K143I possibly damaging Het
Bbx T A 16: 50,045,101 (GRCm39) T487S probably damaging Het
Bche T G 3: 73,609,177 (GRCm39) D83A probably benign Het
Bri3bp G T 5: 125,518,760 (GRCm39) probably benign Het
Cd3d A T 9: 44,896,296 (GRCm39) E28D probably damaging Het
Cdc42bpa A G 1: 179,965,366 (GRCm39) T1028A probably damaging Het
Ceacam23 A G 7: 17,639,143 (GRCm39) probably null Het
Celsr2 T C 3: 108,319,945 (GRCm39) I956V possibly damaging Het
Cep95 A T 11: 106,707,480 (GRCm39) probably null Het
Cic G T 7: 24,986,535 (GRCm39) G1289C probably damaging Het
Cndp1 A G 18: 84,650,025 (GRCm39) Y223H probably damaging Het
Cops8 A G 1: 90,538,724 (GRCm39) D51G probably damaging Het
Csgalnact1 T C 8: 68,913,623 (GRCm39) E194G probably benign Het
Ctsm A G 13: 61,686,776 (GRCm39) Y39H probably damaging Het
Dhrs2 T C 14: 55,474,722 (GRCm39) V119A probably damaging Het
Drosha T A 15: 12,935,093 (GRCm39) M1336K probably benign Het
Dsp G A 13: 38,381,678 (GRCm39) D2808N possibly damaging Het
Ehmt1 G T 2: 24,767,509 (GRCm39) P135T probably damaging Het
Epas1 A G 17: 87,116,882 (GRCm39) N184S probably damaging Het
Erich3 C T 3: 154,454,025 (GRCm39) T597I possibly damaging Het
F10 T C 8: 13,105,698 (GRCm39) V421A probably damaging Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fam227b G A 2: 125,958,043 (GRCm39) P241S probably damaging Het
Fcgrt C T 7: 44,751,372 (GRCm39) G192D probably benign Het
Fras1 A G 5: 96,798,541 (GRCm39) E1184G possibly damaging Het
Garre1 A C 7: 33,945,225 (GRCm39) Y552D probably damaging Het
Grn C A 11: 102,321,380 (GRCm39) probably benign Het
Gvin-ps5 A T 7: 105,928,664 (GRCm39) noncoding transcript Het
Hadh A T 3: 131,029,197 (GRCm39) L274* probably null Het
Hus1 T C 11: 8,956,027 (GRCm39) S169G probably damaging Het
Hydin A T 8: 111,290,554 (GRCm39) I3338F possibly damaging Het
Ighv11-1 T G 12: 113,945,768 (GRCm39) E28D probably benign Het
Kctd9 C T 14: 67,966,805 (GRCm39) T106I probably damaging Het
Krit1 A T 5: 3,872,238 (GRCm39) N421I probably damaging Het
Lamb1 A G 12: 31,376,677 (GRCm39) D1619G probably damaging Het
Lpar6 G A 14: 73,476,147 (GRCm39) C36Y probably damaging Het
Lrrc37a G C 11: 103,347,565 (GRCm39) F3043L unknown Het
Lrrc46 A T 11: 96,931,765 (GRCm39) V19D probably damaging Het
Mapkap1 G T 2: 34,471,303 (GRCm39) S197I probably damaging Het
Mrps35 A C 6: 146,961,645 (GRCm39) K173N possibly damaging Het
Mtf2 A G 5: 108,220,894 (GRCm39) probably benign Het
Ncf1 A C 5: 134,252,267 (GRCm39) D261E probably damaging Het
Notch1 C T 2: 26,371,193 (GRCm39) E298K probably damaging Het
Nrxn1 A T 17: 90,928,274 (GRCm39) probably benign Het
Or13a18 C A 7: 140,190,304 (GRCm39) A75E possibly damaging Het
Or4x13 T A 2: 90,231,107 (GRCm39) M34K probably benign Het
Or52a33 A G 7: 103,289,308 (GRCm39) F13S probably damaging Het
Or5v1 G T 17: 37,810,017 (GRCm39) L158F probably benign Het
Otud4 G A 8: 80,382,318 (GRCm39) V176I probably damaging Het
Pakap T A 4: 57,856,552 (GRCm39) V668E probably benign Het
Papolg T C 11: 23,823,919 (GRCm39) probably null Het
Pgk2 A G 17: 40,518,402 (GRCm39) V342A probably damaging Het
Phf2 G A 13: 48,961,320 (GRCm39) A790V unknown Het
Prkdc T C 16: 15,491,861 (GRCm39) I602T possibly damaging Het
Prl3d3 T C 13: 27,343,072 (GRCm39) I86T possibly damaging Het
Prss8 G T 7: 127,525,635 (GRCm39) Q295K probably benign Het
Ptpre C T 7: 135,270,861 (GRCm39) H346Y probably benign Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Pwwp3a T C 10: 80,068,702 (GRCm39) L282P probably benign Het
Qrfpr A G 3: 36,276,285 (GRCm39) V35A probably damaging Het
Rpf1 A G 3: 146,212,293 (GRCm39) L349S probably damaging Het
Rpl41 G T 10: 128,384,652 (GRCm39) probably null Het
Rprd2 G C 3: 95,672,632 (GRCm39) R924G probably benign Het
Serpini1 T A 3: 75,521,795 (GRCm39) N95K probably benign Het
Sfxn1 A T 13: 54,242,933 (GRCm39) T64S probably benign Het
Siae T G 9: 37,557,816 (GRCm39) I541S possibly damaging Het
Slc25a4 T A 8: 46,660,509 (GRCm39) K296N probably benign Het
Slc37a1 A G 17: 31,541,120 (GRCm39) N204S probably damaging Het
Slc9c1 A G 16: 45,413,800 (GRCm39) N976S probably benign Het
Smarcal1 T C 1: 72,672,019 (GRCm39) S847P possibly damaging Het
Smg1 A T 7: 117,757,323 (GRCm39) probably benign Het
Smg1 C T 7: 117,807,274 (GRCm39) A168T probably benign Het
Sptlc1 A G 13: 53,505,692 (GRCm39) I242T probably damaging Het
St8sia2 T C 7: 73,616,709 (GRCm39) I89V possibly damaging Het
Supt20 A T 3: 54,602,555 (GRCm39) probably benign Het
Tep1 T C 14: 51,076,457 (GRCm39) D1659G probably benign Het
Tex10 C A 4: 48,458,525 (GRCm39) probably benign Het
Thbs3 CAGAAG CAG 3: 89,130,409 (GRCm39) probably benign Het
Tmbim6 C A 15: 99,299,950 (GRCm39) S22* probably null Het
Tmc2 A T 2: 130,043,961 (GRCm39) K65M possibly damaging Het
Tmod1 A G 4: 46,090,872 (GRCm39) S142G probably damaging Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Trmt6 T C 2: 132,650,191 (GRCm39) R349G possibly damaging Het
Ttn T A 2: 76,537,586 (GRCm39) T26454S possibly damaging Het
Ttn C T 2: 76,605,122 (GRCm39) V16555I probably benign Het
Tut4 T A 4: 108,384,042 (GRCm39) probably benign Het
Ubr3 T C 2: 69,850,790 (GRCm39) probably benign Het
Vmn1r17 A C 6: 57,337,460 (GRCm39) F253V possibly damaging Het
Vmn1r201 G T 13: 22,659,622 (GRCm39) A279S possibly damaging Het
Vmn2r17 A T 5: 109,575,739 (GRCm39) R203S probably benign Het
Vwa5a A G 9: 38,633,926 (GRCm39) E43G probably benign Het
Wdr86 C T 5: 24,917,843 (GRCm39) probably null Het
Wdsub1 A T 2: 59,700,758 (GRCm39) probably benign Het
Zcchc7 T C 4: 44,931,039 (GRCm39) L76P probably damaging Het
Zfp108 G T 7: 23,960,163 (GRCm39) K251N probably benign Het
Zfp263 T C 16: 3,566,992 (GRCm39) C148R probably damaging Het
Zfp687 A C 3: 94,917,697 (GRCm39) F692V probably damaging Het
Other mutations in Or5k3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01937:Or5k3 APN 16 58,969,827 (GRCm39) missense probably benign 0.01
IGL01945:Or5k3 APN 16 58,969,827 (GRCm39) missense probably benign 0.01
R0071:Or5k3 UTSW 16 58,969,578 (GRCm39) missense probably benign 0.23
R0390:Or5k3 UTSW 16 58,969,662 (GRCm39) missense probably benign 0.01
R0601:Or5k3 UTSW 16 58,970,117 (GRCm39) missense probably benign 0.00
R1499:Or5k3 UTSW 16 58,969,287 (GRCm39) missense probably benign
R1612:Or5k3 UTSW 16 58,969,987 (GRCm39) missense probably benign 0.00
R1785:Or5k3 UTSW 16 58,969,660 (GRCm39) missense probably damaging 1.00
R2082:Or5k3 UTSW 16 58,969,248 (GRCm39) missense probably damaging 0.99
R3605:Or5k3 UTSW 16 58,969,846 (GRCm39) missense probably damaging 1.00
R4168:Or5k3 UTSW 16 58,969,363 (GRCm39) missense probably benign 0.00
R4839:Or5k3 UTSW 16 58,969,393 (GRCm39) missense probably damaging 1.00
R5285:Or5k3 UTSW 16 58,969,633 (GRCm39) missense probably damaging 1.00
R7107:Or5k3 UTSW 16 58,969,279 (GRCm39) missense probably benign 0.10
R7136:Or5k3 UTSW 16 58,969,327 (GRCm39) missense probably damaging 1.00
R7317:Or5k3 UTSW 16 58,969,684 (GRCm39) missense possibly damaging 0.80
R7601:Or5k3 UTSW 16 58,969,597 (GRCm39) missense probably benign 0.01
R7729:Or5k3 UTSW 16 58,969,570 (GRCm39) missense probably damaging 1.00
R8004:Or5k3 UTSW 16 58,969,351 (GRCm39) missense probably damaging 1.00
R8208:Or5k3 UTSW 16 58,969,382 (GRCm39) missense probably benign 0.41
R8282:Or5k3 UTSW 16 58,969,529 (GRCm39) nonsense probably null
R8954:Or5k3 UTSW 16 58,969,319 (GRCm39) nonsense probably null
R9137:Or5k3 UTSW 16 58,969,635 (GRCm39) missense probably benign 0.30
R9197:Or5k3 UTSW 16 58,969,489 (GRCm39) missense probably damaging 0.99
R9396:Or5k3 UTSW 16 58,969,302 (GRCm39) missense probably damaging 0.97
R9547:Or5k3 UTSW 16 58,970,107 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- TTACTTGTCTTGGCAGGTTCAATTC -3'
(R):5'- CGGTGACTAGATACATTCCATTACTTC -3'

Sequencing Primer
(F):5'- CTTGGCAGGTTCAATTCAAGTC -3'
(R):5'- CAGTTGTCCAAATCAGATAATCCTTG -3'
Posted On 2016-05-10