Mutagenetix > Incidental Mutation

Incidental Mutation 'R4991:Vmn2r72'

386194

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r72

Ensembl Gene

ENSMUSG00000051877

Gene Name

vomeronasal 2, receptor 72

Synonyms

EG244114, Vmn2r72-ps

MMRRC Submission

042585-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.089) question?

Stock #

R4991 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

85386992-85404189 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 85400338 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Serine at position 237 (L237S)

Ref Sequence

ENSEMBL: ENSMUSP00000133014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063425]

AlphaFold

D3Z4N8

Predicted Effect

probably damaging
Transcript: ENSMUST00000063425
AA Change: L237S

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: L237S

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	2.3e-28	PFAM
Pfam:NCD3G	512	564	1.2e-18	PFAM
Pfam:7tm_3	594	832	4e-53	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.0%
3x: 98.2%
10x: 95.7%
20x: 90.0%

Validation Efficiency

95% (73/77)

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adcy4	G	T	14: 56,010,922 (GRCm39)	T665K	probably benign	Het
Adgrf3	C	T	5: 30,404,146 (GRCm39)	V369M	probably benign	Het
Als2	T	C	1: 59,246,927 (GRCm39)	K571E	probably benign	Het
Amer3	A	C	1: 34,627,822 (GRCm39)	D687A	probably benign	Het
Asb14	T	C	14: 26,637,015 (GRCm39)	S586P	probably damaging	Het
Catspere2	A	C	1: 177,925,987 (GRCm39)	I218L	probably benign	Het
Chmp4b	A	G	2: 154,534,545 (GRCm39)	E187G	probably benign	Het
Cox6b2	T	C	7: 4,755,160 (GRCm39)	D38G	probably damaging	Het
Cpm	G	A	10: 117,504,008 (GRCm39)	C138Y	probably damaging	Het
Csmd3	G	T	15: 47,864,874 (GRCm39)	P785Q	probably damaging	Het
Cstf1	A	G	2: 172,219,720 (GRCm39)	Y277C	probably damaging	Het
Cstf2t	T	A	19: 31,061,983 (GRCm39)	N506K	probably damaging	Het
Dmpk	C	G	7: 18,821,944 (GRCm39)	L301V	probably benign	Het
Ebf2	A	T	14: 67,627,106 (GRCm39)	T265S	possibly damaging	Het
Elmo1	T	C	13: 20,526,689 (GRCm39)	F413S	probably damaging	Het
Fbp1	C	T	13: 63,012,888 (GRCm39)	V102I	probably benign	Het
Gm19684	A	G	17: 36,438,364 (GRCm39)		probably benign	Het
Gm29106	T	C	1: 118,106,121 (GRCm39)	M37T	probably benign	Het
Grem2	A	G	1: 174,664,379 (GRCm39)	C157R	probably damaging	Het
Hdac5	T	A	11: 102,096,450 (GRCm39)	E252D	probably damaging	Het
Ifitm3	A	T	7: 140,590,372 (GRCm39)	F63I	probably damaging	Het
Igkv4-80	A	C	6: 68,993,649 (GRCm39)	S81A	probably benign	Het
Irx4	G	T	13: 73,413,626 (GRCm39)	R32L	probably benign	Het
Itgb1bp1	C	T	12: 21,324,849 (GRCm39)	G69D	probably damaging	Het
Kcnh3	A	G	15: 99,130,637 (GRCm39)	D418G	probably benign	Het
Kif1a	T	C	1: 93,006,530 (GRCm39)	T46A	probably benign	Het
Klk1b26	T	A	7: 43,665,673 (GRCm39)		probably null	Het
Lca5l	T	C	16: 95,960,932 (GRCm39)	E510G	possibly damaging	Het
Lrriq1	A	G	10: 103,036,420 (GRCm39)	I911T	probably damaging	Het
Mios	T	G	6: 8,215,847 (GRCm39)	S348A	probably benign	Het
Mog	T	C	17: 37,328,381 (GRCm39)		probably null	Het
Mtmr7	A	G	8: 41,007,386 (GRCm39)	S516P	probably damaging	Het
Nat8f4	T	C	6: 85,878,122 (GRCm39)	K134E	probably benign	Het
Nbeal2	C	T	9: 110,467,835 (GRCm39)	C451Y	probably damaging	Het
Nkx2-1	T	C	12: 56,581,724 (GRCm39)	Y41C	possibly damaging	Het
Nmnat1	G	A	4: 149,553,584 (GRCm39)	T176M	possibly damaging	Het
Nrxn3	T	A	12: 89,227,244 (GRCm39)	I293N	probably damaging	Het
Or5af2	T	C	11: 58,708,544 (GRCm39)	S237P	probably damaging	Het
Or5b97	T	G	19: 12,878,815 (GRCm39)	T110P	probably damaging	Het
Or5m8	A	G	2: 85,822,631 (GRCm39)	M157V	probably damaging	Het
Osgin1	A	G	8: 120,172,028 (GRCm39)	E274G	probably damaging	Het
Otof	G	A	5: 30,551,525 (GRCm39)	R343W	probably damaging	Het
Pcdha9	A	T	18: 37,131,398 (GRCm39)	I156F	probably damaging	Het
Pcsk4	A	G	10: 80,161,215 (GRCm39)	I233T	possibly damaging	Het
Pira12	T	G	7: 3,898,571 (GRCm39)	Q292H	probably benign	Het
Samd4	A	T	14: 47,311,467 (GRCm39)	S262C	probably damaging	Het
Snap91	T	C	9: 86,672,207 (GRCm39)		probably null	Het
Spata31d1a	T	C	13: 59,850,965 (GRCm39)	N388D	probably benign	Het
St3gal4	A	G	9: 34,964,432 (GRCm39)	V190A	possibly damaging	Het
Sv2b	T	C	7: 74,767,470 (GRCm39)	N642S	possibly damaging	Het
Svil	T	A	18: 5,056,810 (GRCm39)	I561K	probably benign	Het
Tmem201	A	T	4: 149,812,612 (GRCm39)	Y235N	possibly damaging	Het
Tpx2	T	C	2: 152,711,644 (GRCm39)	S60P	probably benign	Het
Trpa1	T	C	1: 14,980,970 (GRCm39)	Y144C	probably benign	Het
U90926	G	A	5: 92,357,879 (GRCm39)	P91S	probably benign	Het
Utp20	G	T	10: 88,582,796 (GRCm39)	H2780Q	probably benign	Het
Vmn1r215	T	G	13: 23,260,697 (GRCm39)	F246V	probably damaging	Het
Washc5	A	G	15: 59,215,929 (GRCm39)	S817P	probably damaging	Het
Zbtb24	A	G	10: 41,332,614 (GRCm39)		probably null	Het
Zfp212	G	A	6: 47,903,796 (GRCm39)	R127H	probably damaging	Het
Zfp268	C	A	4: 145,348,904 (GRCm39)	Q114K	probably benign	Het
Zfp740	G	T	15: 102,116,714 (GRCm39)		probably null	Het

Other mutations in Vmn2r72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00931:Vmn2r72	APN	7	85,398,854 (GRCm39)	missense	probably benign	0.01
IGL01019:Vmn2r72	APN	7	85,387,542 (GRCm39)	missense	probably benign	0.26
IGL01445:Vmn2r72	APN	7	85,398,854 (GRCm39)	missense	probably benign	0.06
IGL02076:Vmn2r72	APN	7	85,387,575 (GRCm39)	missense	probably damaging	1.00
IGL02082:Vmn2r72	APN	7	85,387,374 (GRCm39)	missense	probably benign	0.00
IGL02086:Vmn2r72	APN	7	85,387,374 (GRCm39)	missense	probably benign	0.00
IGL02089:Vmn2r72	APN	7	85,387,374 (GRCm39)	missense	probably benign	0.00
IGL02125:Vmn2r72	APN	7	85,399,919 (GRCm39)	missense	probably benign	0.00
IGL02146:Vmn2r72	APN	7	85,387,170 (GRCm39)	missense	probably damaging	1.00
IGL02272:Vmn2r72	APN	7	85,399,901 (GRCm39)	missense	probably benign
IGL02514:Vmn2r72	APN	7	85,387,907 (GRCm39)	missense	possibly damaging	0.90
IGL02662:Vmn2r72	APN	7	85,387,391 (GRCm39)	missense	probably benign	0.26
IGL02697:Vmn2r72	APN	7	85,387,879 (GRCm39)	missense	probably benign	0.36
IGL02733:Vmn2r72	APN	7	85,401,021 (GRCm39)	missense	probably benign	0.05
IGL03070:Vmn2r72	APN	7	85,401,249 (GRCm39)	splice site	probably benign
IGL03150:Vmn2r72	APN	7	85,400,384 (GRCm39)	missense	probably damaging	1.00
IGL03159:Vmn2r72	APN	7	85,404,162 (GRCm39)	missense	probably benign	0.05
IGL03333:Vmn2r72	APN	7	85,400,075 (GRCm39)	missense	probably benign	0.10
R0081:Vmn2r72	UTSW	7	85,401,044 (GRCm39)	missense	probably benign	0.01
R0090:Vmn2r72	UTSW	7	85,404,084 (GRCm39)	missense	probably benign
R0655:Vmn2r72	UTSW	7	85,387,319 (GRCm39)	nonsense	probably null
R0778:Vmn2r72	UTSW	7	85,398,947 (GRCm39)	missense	probably benign	0.00
R1169:Vmn2r72	UTSW	7	85,400,517 (GRCm39)	missense	probably benign	0.01
R1172:Vmn2r72	UTSW	7	85,401,152 (GRCm39)	missense	probably damaging	1.00
R1173:Vmn2r72	UTSW	7	85,401,152 (GRCm39)	missense	probably damaging	1.00
R1175:Vmn2r72	UTSW	7	85,401,152 (GRCm39)	missense	probably damaging	1.00
R1248:Vmn2r72	UTSW	7	85,398,396 (GRCm39)	missense	probably benign	0.02
R1302:Vmn2r72	UTSW	7	85,387,465 (GRCm39)	missense	probably damaging	1.00
R1506:Vmn2r72	UTSW	7	85,398,419 (GRCm39)	missense	probably benign
R1632:Vmn2r72	UTSW	7	85,401,000 (GRCm39)	missense	probably benign	0.13
R1775:Vmn2r72	UTSW	7	85,387,378 (GRCm39)	missense	probably benign	0.01
R1962:Vmn2r72	UTSW	7	85,398,369 (GRCm39)	missense	probably benign	0.00
R2201:Vmn2r72	UTSW	7	85,387,444 (GRCm39)	missense	probably benign	0.12
R2290:Vmn2r72	UTSW	7	85,387,549 (GRCm39)	missense	probably damaging	1.00
R2327:Vmn2r72	UTSW	7	85,387,464 (GRCm39)	missense	probably damaging	1.00
R2424:Vmn2r72	UTSW	7	85,400,161 (GRCm39)	missense	probably damaging	1.00
R2655:Vmn2r72	UTSW	7	85,400,477 (GRCm39)	missense	possibly damaging	0.95
R2860:Vmn2r72	UTSW	7	85,400,044 (GRCm39)	missense	probably damaging	0.99
R2861:Vmn2r72	UTSW	7	85,400,044 (GRCm39)	missense	probably damaging	0.99
R2862:Vmn2r72	UTSW	7	85,400,044 (GRCm39)	missense	probably damaging	0.99
R3009:Vmn2r72	UTSW	7	85,398,850 (GRCm39)	missense	probably benign	0.00
R3797:Vmn2r72	UTSW	7	85,387,285 (GRCm39)	missense	probably benign	0.44
R3798:Vmn2r72	UTSW	7	85,387,285 (GRCm39)	missense	probably benign	0.44
R3902:Vmn2r72	UTSW	7	85,398,943 (GRCm39)	missense	possibly damaging	0.52
R3959:Vmn2r72	UTSW	7	85,400,339 (GRCm39)	missense	probably benign	0.36
R3974:Vmn2r72	UTSW	7	85,399,017 (GRCm39)	missense	probably damaging	1.00
R4399:Vmn2r72	UTSW	7	85,387,708 (GRCm39)	missense	probably damaging	1.00
R4421:Vmn2r72	UTSW	7	85,387,708 (GRCm39)	missense	probably damaging	1.00
R4426:Vmn2r72	UTSW	7	85,387,036 (GRCm39)	nonsense	probably null
R4522:Vmn2r72	UTSW	7	85,401,134 (GRCm39)	missense	probably benign	0.44
R4523:Vmn2r72	UTSW	7	85,401,134 (GRCm39)	missense	probably benign	0.44
R4533:Vmn2r72	UTSW	7	85,401,134 (GRCm39)	missense	probably benign	0.44
R4691:Vmn2r72	UTSW	7	85,387,119 (GRCm39)	nonsense	probably null
R4781:Vmn2r72	UTSW	7	85,387,069 (GRCm39)	missense	probably benign	0.14
R4863:Vmn2r72	UTSW	7	85,399,806 (GRCm39)	missense	possibly damaging	0.91
R4952:Vmn2r72	UTSW	7	85,400,317 (GRCm39)	missense	probably benign
R4995:Vmn2r72	UTSW	7	85,387,693 (GRCm39)	missense	probably damaging	1.00
R5095:Vmn2r72	UTSW	7	85,387,061 (GRCm39)	missense	probably damaging	0.98
R5174:Vmn2r72	UTSW	7	85,387,048 (GRCm39)	missense	probably benign	0.00
R5276:Vmn2r72	UTSW	7	85,387,462 (GRCm39)	missense	possibly damaging	0.90
R5395:Vmn2r72	UTSW	7	85,400,105 (GRCm39)	missense	possibly damaging	0.71
R5560:Vmn2r72	UTSW	7	85,401,150 (GRCm39)	missense	probably damaging	0.96
R5933:Vmn2r72	UTSW	7	85,387,058 (GRCm39)	missense	probably benign	0.05
R6033:Vmn2r72	UTSW	7	85,387,137 (GRCm39)	missense	probably damaging	1.00
R6033:Vmn2r72	UTSW	7	85,387,137 (GRCm39)	missense	probably damaging	1.00
R6354:Vmn2r72	UTSW	7	85,399,747 (GRCm39)	critical splice donor site	probably null
R6362:Vmn2r72	UTSW	7	85,400,382 (GRCm39)	missense	probably damaging	1.00
R6594:Vmn2r72	UTSW	7	85,398,892 (GRCm39)	missense	probably benign	0.32
R6794:Vmn2r72	UTSW	7	85,387,204 (GRCm39)	missense	probably damaging	1.00
R7113:Vmn2r72	UTSW	7	85,399,011 (GRCm39)	splice site	probably null
R7189:Vmn2r72	UTSW	7	85,404,125 (GRCm39)	missense	probably benign	0.36
R7266:Vmn2r72	UTSW	7	85,387,482 (GRCm39)	nonsense	probably null
R7323:Vmn2r72	UTSW	7	85,399,771 (GRCm39)	missense	probably benign
R7426:Vmn2r72	UTSW	7	85,400,348 (GRCm39)	missense	probably benign
R7606:Vmn2r72	UTSW	7	85,400,362 (GRCm39)	missense	possibly damaging	0.91
R7651:Vmn2r72	UTSW	7	85,401,146 (GRCm39)	missense	probably damaging	1.00
R7688:Vmn2r72	UTSW	7	85,404,098 (GRCm39)	missense	probably benign	0.32
R7753:Vmn2r72	UTSW	7	85,399,834 (GRCm39)	missense	probably damaging	1.00
R7843:Vmn2r72	UTSW	7	85,398,838 (GRCm39)	missense	probably benign	0.01
R8157:Vmn2r72	UTSW	7	85,400,441 (GRCm39)	missense	probably benign	0.09
R8254:Vmn2r72	UTSW	7	85,400,227 (GRCm39)	missense	probably damaging	1.00
R8389:Vmn2r72	UTSW	7	85,401,168 (GRCm39)	missense	probably damaging	0.99
R8444:Vmn2r72	UTSW	7	85,387,383 (GRCm39)	missense	probably benign
R8989:Vmn2r72	UTSW	7	85,404,134 (GRCm39)	missense	probably benign	0.10
R9015:Vmn2r72	UTSW	7	85,398,388 (GRCm39)	missense	probably benign	0.01
R9080:Vmn2r72	UTSW	7	85,387,464 (GRCm39)	missense	probably damaging	1.00
R9269:Vmn2r72	UTSW	7	85,400,411 (GRCm39)	missense	probably benign	0.03
R9317:Vmn2r72	UTSW	7	85,404,022 (GRCm39)	missense	probably benign	0.04
R9509:Vmn2r72	UTSW	7	85,404,075 (GRCm39)	missense	probably benign
Z1176:Vmn2r72	UTSW	7	85,398,399 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- TGTCCCAGAGGAGGAATATAGC -3'
(R):5'- ATGAGCAATTTCCTCACCTTTACCAG -3'

Sequencing Primer
(F):5'- TTGTGACACACTAACCCAGATTC -3'
(R):5'- TCACCTTTACCAGATATCTCCAAAGG -3'

Posted On

2016-05-10