Incidental Mutation 'R5060:Kif26b'
ID 386542
Institutional Source Beutler Lab
Gene Symbol Kif26b
Ensembl Gene ENSMUSG00000026494
Gene Name kinesin family member 26B
Synonyms D230039L06Rik, N-11 kinesin
MMRRC Submission 042650-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5060 (G1)
Quality Score 174
Status Validated
Chromosome 1
Chromosomal Location 178356690-178766765 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 178358195 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Aspartic acid at position 102 (G102D)
Ref Sequence ENSEMBL: ENSMUSP00000124462 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000161017]
AlphaFold Q7TNC6
Predicted Effect unknown
Transcript: ENSMUST00000161017
AA Change: G102D
SMART Domains Protein: ENSMUSP00000124462
Gene: ENSMUSG00000026494
AA Change: G102D

DomainStartEndE-ValueType
low complexity region 58 123 N/A INTRINSIC
low complexity region 144 155 N/A INTRINSIC
low complexity region 220 228 N/A INTRINSIC
Blast:KISc 365 446 4e-8 BLAST
KISc 448 809 2.48e-42 SMART
low complexity region 810 822 N/A INTRINSIC
low complexity region 849 863 N/A INTRINSIC
low complexity region 907 913 N/A INTRINSIC
low complexity region 1007 1047 N/A INTRINSIC
low complexity region 1099 1109 N/A INTRINSIC
low complexity region 1269 1288 N/A INTRINSIC
low complexity region 1485 1495 N/A INTRINSIC
low complexity region 1741 1769 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193931
Meta Mutation Damage Score 0.1215 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 92.9%
Validation Efficiency 98% (52/53)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit neonatal lethality with impaired kidney development due to loss of cortical nephrogenic zone mesenchyme and failure of ureteric buds to invade and branch into the mesenchyme. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530064D06Rik A T 17: 48,474,107 (GRCm39) L17Q probably damaging Het
Abca6 A G 11: 110,110,430 (GRCm39) V573A possibly damaging Het
Abcc9 A G 6: 142,571,836 (GRCm39) probably benign Het
Actg1 A G 11: 120,237,839 (GRCm39) S234P probably benign Het
Acvr2a A G 2: 48,780,311 (GRCm39) D177G probably damaging Het
Adamts12 T C 15: 11,300,054 (GRCm39) C914R probably damaging Het
Adprhl1 A G 8: 13,298,621 (GRCm39) I103T possibly damaging Het
Als2cl C T 9: 110,713,205 (GRCm39) L32F probably damaging Het
Ank2 T C 3: 126,739,570 (GRCm39) probably benign Het
Ankrd52 T A 10: 128,225,710 (GRCm39) S959R possibly damaging Het
Bnc2 C A 4: 84,449,872 (GRCm39) A122S probably benign Het
Cert1 A T 13: 96,739,663 (GRCm39) K226N probably benign Het
Cfap54 C T 10: 92,875,013 (GRCm39) V443M probably damaging Het
Cilk1 C T 9: 78,060,978 (GRCm39) T208I probably benign Het
Clca4b T A 3: 144,617,267 (GRCm39) R794S probably damaging Het
Cyp2c65 T C 19: 39,049,514 (GRCm39) L14P unknown Het
Ggt5 T C 10: 75,440,608 (GRCm39) M243T probably benign Het
Gmds A G 13: 32,124,482 (GRCm39) I292T probably benign Het
Gpcpd1 A T 2: 132,386,355 (GRCm39) V341E probably damaging Het
Grm3 A G 5: 9,620,167 (GRCm39) F359S probably damaging Het
Hcn1 A T 13: 118,010,441 (GRCm39) K340* probably null Het
Heatr9 T C 11: 83,403,258 (GRCm39) E427G probably benign Het
Mark3 T C 12: 111,584,760 (GRCm39) F119L probably damaging Het
Melk T C 4: 44,350,959 (GRCm39) V500A probably benign Het
Mrpl41 A G 2: 24,864,295 (GRCm39) F126L probably damaging Het
Or10c1 C A 17: 37,522,307 (GRCm39) A146S probably benign Het
Or6c3b C T 10: 129,527,699 (GRCm39) M70I probably benign Het
Pax7 A T 4: 139,506,928 (GRCm39) S372T probably benign Het
Pax7 A T 4: 139,556,906 (GRCm39) I118N probably damaging Het
Plcl1 G T 1: 55,735,671 (GRCm39) M337I possibly damaging Het
Poc1a G T 9: 106,227,012 (GRCm39) probably benign Het
Rabgef1 A G 5: 130,240,844 (GRCm39) Y321C probably damaging Het
Rhobtb3 A C 13: 76,061,389 (GRCm39) L252R probably benign Het
Rlf A G 4: 121,004,063 (GRCm39) V1639A probably benign Het
Tff1 A G 17: 31,381,682 (GRCm39) V65A probably damaging Het
Trpm4 G T 7: 44,971,258 (GRCm39) D222E probably damaging Het
Ttn A T 2: 76,643,741 (GRCm39) D13162E probably damaging Het
Unc5d A T 8: 29,209,723 (GRCm39) S466T probably benign Het
Vmn1r73 A G 7: 11,490,683 (GRCm39) Y167C probably damaging Het
Vwde C T 6: 13,208,323 (GRCm39) probably null Het
Xpr1 T C 1: 155,204,430 (GRCm39) probably null Het
Zbtb40 A G 4: 136,728,604 (GRCm39) V413A possibly damaging Het
Other mutations in Kif26b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00337:Kif26b APN 1 178,743,213 (GRCm39) missense probably damaging 1.00
IGL00425:Kif26b APN 1 178,743,866 (GRCm39) missense probably damaging 0.96
IGL00952:Kif26b APN 1 178,759,770 (GRCm39) missense probably damaging 1.00
IGL01100:Kif26b APN 1 178,744,809 (GRCm39) missense probably benign
IGL01347:Kif26b APN 1 178,698,240 (GRCm39) missense probably damaging 1.00
IGL01543:Kif26b APN 1 178,506,526 (GRCm39) missense probably benign 0.41
IGL01938:Kif26b APN 1 178,743,603 (GRCm39) missense probably damaging 0.99
IGL02100:Kif26b APN 1 178,743,512 (GRCm39) missense probably damaging 0.99
IGL02262:Kif26b APN 1 178,743,633 (GRCm39) missense probably benign 0.05
IGL02576:Kif26b APN 1 178,743,912 (GRCm39) missense probably benign
IGL02673:Kif26b APN 1 178,649,170 (GRCm39) missense probably damaging 1.00
IGL03078:Kif26b APN 1 178,698,291 (GRCm39) missense probably damaging 1.00
IGL03155:Kif26b APN 1 178,701,693 (GRCm39) missense probably damaging 1.00
IGL03157:Kif26b APN 1 178,743,930 (GRCm39) missense probably damaging 1.00
IGL03162:Kif26b APN 1 178,744,497 (GRCm39) missense probably benign
IGL03220:Kif26b APN 1 178,692,434 (GRCm39) missense probably damaging 1.00
IGL03299:Kif26b APN 1 178,649,125 (GRCm39) missense probably benign 0.09
IGL03368:Kif26b APN 1 178,743,773 (GRCm39) missense probably damaging 1.00
IGL03370:Kif26b APN 1 178,742,946 (GRCm39) missense probably benign 0.39
PIT4449001:Kif26b UTSW 1 178,745,651 (GRCm39) missense probably damaging 1.00
R0142:Kif26b UTSW 1 178,742,954 (GRCm39) missense probably damaging 1.00
R0621:Kif26b UTSW 1 178,743,218 (GRCm39) missense probably benign 0.02
R0987:Kif26b UTSW 1 178,649,185 (GRCm39) missense probably damaging 1.00
R1107:Kif26b UTSW 1 178,745,238 (GRCm39) missense probably benign 0.03
R1367:Kif26b UTSW 1 178,744,028 (GRCm39) missense probably damaging 1.00
R1386:Kif26b UTSW 1 178,743,209 (GRCm39) missense probably benign
R1619:Kif26b UTSW 1 178,744,043 (GRCm39) missense probably benign 0.00
R1664:Kif26b UTSW 1 178,759,704 (GRCm39) missense probably damaging 1.00
R2240:Kif26b UTSW 1 178,543,488 (GRCm39) missense probably benign 0.00
R2264:Kif26b UTSW 1 178,756,407 (GRCm39) critical splice acceptor site probably null
R2443:Kif26b UTSW 1 178,742,579 (GRCm39) missense probably damaging 0.99
R3023:Kif26b UTSW 1 178,692,433 (GRCm39) missense probably damaging 0.99
R3744:Kif26b UTSW 1 178,506,595 (GRCm39) missense probably benign 0.00
R3831:Kif26b UTSW 1 178,744,181 (GRCm39) frame shift probably null
R3832:Kif26b UTSW 1 178,744,181 (GRCm39) frame shift probably null
R3833:Kif26b UTSW 1 178,744,181 (GRCm39) frame shift probably null
R3843:Kif26b UTSW 1 178,755,742 (GRCm39) missense probably damaging 1.00
R4108:Kif26b UTSW 1 178,744,530 (GRCm39) missense possibly damaging 0.88
R4181:Kif26b UTSW 1 178,742,991 (GRCm39) missense probably damaging 0.98
R4551:Kif26b UTSW 1 178,711,600 (GRCm39) missense probably damaging 1.00
R4552:Kif26b UTSW 1 178,711,600 (GRCm39) missense probably damaging 1.00
R4597:Kif26b UTSW 1 178,744,358 (GRCm39) missense probably damaging 1.00
R4599:Kif26b UTSW 1 178,358,024 (GRCm39) missense unknown
R4610:Kif26b UTSW 1 178,506,920 (GRCm39) missense probably damaging 1.00
R4746:Kif26b UTSW 1 178,701,546 (GRCm39) nonsense probably null
R4873:Kif26b UTSW 1 178,742,892 (GRCm39) missense probably benign 0.38
R4875:Kif26b UTSW 1 178,742,892 (GRCm39) missense probably benign 0.38
R5015:Kif26b UTSW 1 178,755,895 (GRCm39) missense probably damaging 0.99
R5301:Kif26b UTSW 1 178,358,233 (GRCm39) missense unknown
R5368:Kif26b UTSW 1 178,743,449 (GRCm39) missense probably damaging 1.00
R5387:Kif26b UTSW 1 178,742,441 (GRCm39) missense probably benign 0.01
R5589:Kif26b UTSW 1 178,743,864 (GRCm39) missense probably benign 0.05
R6150:Kif26b UTSW 1 178,743,111 (GRCm39) missense probably damaging 1.00
R6259:Kif26b UTSW 1 178,744,970 (GRCm39) missense probably damaging 0.97
R6355:Kif26b UTSW 1 178,743,743 (GRCm39) missense probably damaging 1.00
R6408:Kif26b UTSW 1 178,745,133 (GRCm39) missense probably damaging 1.00
R6488:Kif26b UTSW 1 178,357,138 (GRCm39) missense unknown
R6546:Kif26b UTSW 1 178,755,871 (GRCm39) missense probably damaging 1.00
R6702:Kif26b UTSW 1 178,744,852 (GRCm39) missense possibly damaging 0.90
R6886:Kif26b UTSW 1 178,701,703 (GRCm39) missense probably damaging 1.00
R6953:Kif26b UTSW 1 178,701,637 (GRCm39) missense possibly damaging 0.89
R7262:Kif26b UTSW 1 178,745,219 (GRCm39) missense possibly damaging 0.84
R7291:Kif26b UTSW 1 178,506,611 (GRCm39) missense possibly damaging 0.86
R7346:Kif26b UTSW 1 178,358,306 (GRCm39) missense probably damaging 1.00
R7383:Kif26b UTSW 1 178,358,275 (GRCm39) missense probably damaging 1.00
R7448:Kif26b UTSW 1 178,742,339 (GRCm39) missense probably damaging 1.00
R7506:Kif26b UTSW 1 178,357,064 (GRCm39) start gained probably benign
R7562:Kif26b UTSW 1 178,742,541 (GRCm39) missense probably damaging 1.00
R7583:Kif26b UTSW 1 178,358,010 (GRCm39) nonsense probably null
R7585:Kif26b UTSW 1 178,744,061 (GRCm39) missense probably benign 0.01
R7644:Kif26b UTSW 1 178,506,839 (GRCm39) missense probably benign 0.04
R7759:Kif26b UTSW 1 178,506,509 (GRCm39) missense probably damaging 1.00
R7775:Kif26b UTSW 1 178,692,441 (GRCm39) missense probably benign 0.15
R7954:Kif26b UTSW 1 178,696,944 (GRCm39) missense probably damaging 0.99
R7960:Kif26b UTSW 1 178,506,484 (GRCm39) missense probably damaging 1.00
R8012:Kif26b UTSW 1 178,743,815 (GRCm39) missense probably benign 0.20
R8152:Kif26b UTSW 1 178,506,794 (GRCm39) missense possibly damaging 0.46
R8320:Kif26b UTSW 1 178,711,641 (GRCm39) critical splice donor site probably null
R8360:Kif26b UTSW 1 178,743,938 (GRCm39) missense probably benign 0.18
R8428:Kif26b UTSW 1 178,744,923 (GRCm39) missense probably benign 0.09
R8670:Kif26b UTSW 1 178,741,349 (GRCm39) missense probably damaging 1.00
R8737:Kif26b UTSW 1 178,692,430 (GRCm39) missense probably damaging 0.99
R8788:Kif26b UTSW 1 178,357,090 (GRCm39) start gained probably benign
R8854:Kif26b UTSW 1 178,743,948 (GRCm39) missense possibly damaging 0.93
R8870:Kif26b UTSW 1 178,692,594 (GRCm39) missense probably damaging 1.00
R8963:Kif26b UTSW 1 178,743,714 (GRCm39) missense probably benign 0.00
R9232:Kif26b UTSW 1 178,742,511 (GRCm39) missense probably damaging 1.00
R9297:Kif26b UTSW 1 178,543,374 (GRCm39) nonsense probably null
R9338:Kif26b UTSW 1 178,744,058 (GRCm39) missense probably damaging 1.00
R9572:Kif26b UTSW 1 178,745,042 (GRCm39) missense probably benign
R9580:Kif26b UTSW 1 178,506,643 (GRCm39) nonsense probably null
R9694:Kif26b UTSW 1 178,743,815 (GRCm39) missense probably benign 0.20
X0021:Kif26b UTSW 1 178,755,724 (GRCm39) missense probably damaging 1.00
X0024:Kif26b UTSW 1 178,506,647 (GRCm39) missense probably benign 0.14
X0025:Kif26b UTSW 1 178,742,948 (GRCm39) missense possibly damaging 0.70
X0025:Kif26b UTSW 1 178,742,831 (GRCm39) nonsense probably null
Z1177:Kif26b UTSW 1 178,742,970 (GRCm39) nonsense probably null
Z1177:Kif26b UTSW 1 178,649,115 (GRCm39) nonsense probably null
Z1177:Kif26b UTSW 1 178,649,113 (GRCm39) missense probably benign 0.11
Predicted Primers PCR Primer
(F):5'- AAATGTGCTCGCCCACCAAG -3'
(R):5'- GGAGAACCTGTATGGCTAACCC -3'

Sequencing Primer
(F):5'- TCTCCTGAGAGCTGGTACC -3'
(R):5'- TCGAGGCAGCATCCTAAGGTG -3'
Posted On 2016-06-06