Mutagenetix > Incidental Mutations

Incidental Mutation 'R5060:Vmn1r73'

386561

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r73

Ensembl Gene

ENSMUSG00000051687

Gene Name

vomeronasal 1 receptor 73

Synonyms

V1rg2

MMRRC Submission

042650-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

R5060 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

11730266-11762081 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 11756756 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 167 (Y167C)

Ref Sequence

ENSEMBL: ENSMUSP00000153827 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055070] [ENSMUST00000226516]

Predicted Effect

probably damaging
Transcript: ENSMUST00000055070
AA Change: Y167C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000055353
Gene: ENSMUSG00000051687
AA Change: Y167C

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	301	7.5e-7	PFAM
Pfam:V1R	32	297	1.9e-27	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000226516
AA Change: Y167C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.5%
20x: 92.9%

Validation Efficiency

98% (52/53)

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A530064D06Rik	A	T	17: 48,166,939	L17Q	probably damaging	Het
Abca6	A	G	11: 110,219,604	V573A	possibly damaging	Het
Abcc9	A	G	6: 142,626,110		probably benign	Het
Actg1	A	G	11: 120,347,013	S234P	probably benign	Het
Acvr2a	A	G	2: 48,890,299	D177G	probably damaging	Het
Adamts12	T	C	15: 11,299,968	C914R	probably damaging	Het
Adprhl1	A	G	8: 13,248,621	I103T	possibly damaging	Het
Als2cl	C	T	9: 110,884,137	L32F	probably damaging	Het
Ank2	T	C	3: 126,945,921		probably benign	Het
Ankrd52	T	A	10: 128,389,841	S959R	possibly damaging	Het
Bnc2	C	A	4: 84,531,635	A122S	probably benign	Het
Cfap54	C	T	10: 93,039,151	V443M	probably damaging	Het
Clca4b	T	A	3: 144,911,506	R794S	probably damaging	Het
Col4a3bp	A	T	13: 96,603,155	K226N	probably benign	Het
Cyp2c65	T	C	19: 39,061,070	L14P	unknown	Het
Ggt5	T	C	10: 75,604,774	M243T	probably benign	Het
Gmds	A	G	13: 31,940,499	I292T	probably benign	Het
Gpcpd1	A	T	2: 132,544,435	V341E	probably damaging	Het
Grm3	A	G	5: 9,570,167	F359S	probably damaging	Het
Hcn1	A	T	13: 117,873,905	K340*	probably null	Het
Heatr9	T	C	11: 83,512,432	E427G	probably benign	Het
Ick	C	T	9: 78,153,696	T208I	probably benign	Het
Kif26b	G	A	1: 178,530,630	G102D	unknown	Het
Mark3	T	C	12: 111,618,326	F119L	probably damaging	Het
Melk	T	C	4: 44,350,959	V500A	probably benign	Het
Mrpl41	A	G	2: 24,974,283	F126L	probably damaging	Het
Olfr803	C	T	10: 129,691,830	M70I	probably benign	Het
Olfr95	C	A	17: 37,211,416	A146S	probably benign	Het
Pax7	A	T	4: 139,779,617	S372T	probably benign	Het
Pax7	A	T	4: 139,829,595	I118N	probably damaging	Het
Plcl1	G	T	1: 55,696,512	M337I	possibly damaging	Het
Poc1a	G	T	9: 106,349,813		probably benign	Het
Rabgef1	A	G	5: 130,212,003	Y321C	probably damaging	Het
Rhobtb3	A	C	13: 75,913,270	L252R	probably benign	Het
Rlf	A	G	4: 121,146,866	V1639A	probably benign	Het
Tff1	A	G	17: 31,162,708	V65A	probably damaging	Het
Trpm4	G	T	7: 45,321,834	D222E	probably damaging	Het
Ttn	A	T	2: 76,813,397	D13162E	probably damaging	Het
Unc5d	A	T	8: 28,719,695	S466T	probably benign	Het
Vwde	C	T	6: 13,208,324		probably null	Het
Xpr1	T	C	1: 155,328,684		probably null	Het
Zbtb40	A	G	4: 137,001,293	V413A	possibly damaging	Het

Other mutations in Vmn1r73

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01782:Vmn1r73	APN	7	11756738	missense	probably benign	0.02
IGL02337:Vmn1r73	APN	7	11756713	missense	possibly damaging	0.69
IGL02666:Vmn1r73	APN	7	11756938	missense	probably damaging	1.00
IGL02741:Vmn1r73	APN	7	11756783	missense	probably benign	0.05
IGL02756:Vmn1r73	APN	7	11756647	missense	possibly damaging	0.95
IGL03113:Vmn1r73	APN	7	11756600	missense	probably benign
IGL03195:Vmn1r73	APN	7	11757080	missense	probably damaging	1.00
R0023:Vmn1r73	UTSW	7	11757070	missense	probably benign	0.43
R0379:Vmn1r73	UTSW	7	11756846	missense	probably benign	0.16
R3941:Vmn1r73	UTSW	7	11756755	missense	probably damaging	1.00
R4224:Vmn1r73	UTSW	7	11756579	missense	probably damaging	0.99
R4631:Vmn1r73	UTSW	7	11756831	missense	probably benign	0.22
R4912:Vmn1r73	UTSW	7	11756669	missense	probably damaging	0.99
R5450:Vmn1r73	UTSW	7	11756449	missense	possibly damaging	0.63
R5609:Vmn1r73	UTSW	7	11756664	nonsense	probably null
R6059:Vmn1r73	UTSW	7	11756611	missense	probably benign	0.40
R6508:Vmn1r73	UTSW	7	11756704	missense	possibly damaging	0.73
R6967:Vmn1r73	UTSW	7	11756617	nonsense	probably null
R7099:Vmn1r73	UTSW	7	11756393	missense	probably damaging	1.00
R7304:Vmn1r73	UTSW	7	11756897	missense	probably damaging	1.00
R7579:Vmn1r73	UTSW	7	11757155	missense	probably benign	0.08
R7891:Vmn1r73	UTSW	7	11757109	missense	possibly damaging	0.87
R7974:Vmn1r73	UTSW	7	11757109	missense	possibly damaging	0.87
Z1176:Vmn1r73	UTSW	7	11756956	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- TGTGCATACTGAGTTGCTTCC -3'
(R):5'- GCTCTGTTTTCAGGTGAAGC -3'

Sequencing Primer
(F):5'- TTCCAAGCAATCACAATTAGCC -3'
(R):5'- TTCAGGTGAAGCATTTAGAAAGTGC -3'

Posted On

2016-06-06