Incidental Mutation 'R0426:Arhgef12'
| ID |
38659 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgef12
|
| Ensembl Gene |
ENSMUSG00000059495 |
| Gene Name |
Rho guanine nucleotide exchange factor 12 |
| Synonyms |
2310014B11Rik, LARG |
| MMRRC Submission |
038628-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.936)
|
| Stock # |
R0426 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
42875138-43017069 bp(-) (GRCm39) |
| Type of Mutation |
splice site (3 bp from exon) |
| DNA Base Change (assembly) |
T to C
at 42882286 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126598
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000072767]
[ENSMUST00000165665]
|
| AlphaFold |
Q8R4H2 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000072767
|
| SMART Domains |
Protein: ENSMUSP00000072547
Gene: ENSMUSG00000059495
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
49 |
64 |
N/A |
INTRINSIC |
|
PDZ
|
80 |
148 |
1.64e-19 |
SMART |
|
coiled coil region
|
196 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
293 |
313 |
N/A |
INTRINSIC |
|
Pfam:RGS-like
|
368 |
558 |
8.6e-87 |
PFAM |
|
low complexity region
|
583 |
596 |
N/A |
INTRINSIC |
|
low complexity region
|
663 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
721 |
733 |
N/A |
INTRINSIC |
|
RhoGEF
|
791 |
976 |
6.35e-66 |
SMART |
|
PH
|
1020 |
1134 |
6.26e-6 |
SMART |
|
low complexity region
|
1256 |
1269 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000165665
|
| SMART Domains |
Protein: ENSMUSP00000126598
Gene: ENSMUSG00000059495
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
49 |
64 |
N/A |
INTRINSIC |
|
PDZ
|
80 |
148 |
1.64e-19 |
SMART |
|
coiled coil region
|
196 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
293 |
313 |
N/A |
INTRINSIC |
|
Pfam:RGS-like
|
369 |
559 |
1.6e-88 |
PFAM |
|
low complexity region
|
584 |
597 |
N/A |
INTRINSIC |
|
low complexity region
|
664 |
677 |
N/A |
INTRINSIC |
|
low complexity region
|
722 |
734 |
N/A |
INTRINSIC |
|
RhoGEF
|
792 |
977 |
6.35e-66 |
SMART |
|
PH
|
1021 |
1135 |
6.26e-6 |
SMART |
|
low complexity region
|
1257 |
1270 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000216016
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.9%
|
| Validation Efficiency |
96% (86/90) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased sensitivity to certain vasoconstrictors and resistance to salt-induced hypertension. Mice homozygous for a different knock-out allele exhibit partial prenatal lethality. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 87 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8b |
G |
T |
11: 109,845,853 (GRCm39) |
|
probably benign |
Het |
| Acadl |
A |
T |
1: 66,880,805 (GRCm39) |
F320L |
probably damaging |
Het |
| Acsbg1 |
T |
C |
9: 54,530,030 (GRCm39) |
D222G |
probably benign |
Het |
| Anapc15 |
A |
G |
7: 101,547,240 (GRCm39) |
T39A |
probably benign |
Het |
| Ano3 |
A |
T |
2: 110,491,519 (GRCm39) |
V919E |
probably damaging |
Het |
| Atad5 |
T |
A |
11: 80,003,658 (GRCm39) |
I1091N |
probably benign |
Het |
| Atf1 |
A |
T |
15: 100,130,708 (GRCm39) |
H26L |
possibly damaging |
Het |
| Atp10a |
T |
C |
7: 58,434,482 (GRCm39) |
M252T |
probably benign |
Het |
| Btbd8 |
C |
T |
5: 107,658,239 (GRCm39) |
T1603I |
probably damaging |
Het |
| Cd55 |
C |
T |
1: 130,376,109 (GRCm39) |
R347H |
probably benign |
Het |
| Cdc27 |
A |
C |
11: 104,403,853 (GRCm39) |
|
probably null |
Het |
| Cdh9 |
G |
A |
15: 16,823,540 (GRCm39) |
|
probably null |
Het |
| Cdk11b |
T |
C |
4: 155,726,969 (GRCm39) |
|
probably benign |
Het |
| Cep70 |
A |
G |
9: 99,179,737 (GRCm39) |
D567G |
probably benign |
Het |
| Cep78 |
A |
T |
19: 15,948,334 (GRCm39) |
Y382* |
probably null |
Het |
| Cgas |
G |
A |
9: 78,343,020 (GRCm39) |
|
probably benign |
Het |
| Col9a2 |
T |
C |
4: 120,901,857 (GRCm39) |
|
probably benign |
Het |
| Cyp2d12 |
G |
A |
15: 82,443,164 (GRCm39) |
D409N |
probably benign |
Het |
| Ddx39a |
A |
G |
8: 84,448,398 (GRCm39) |
T217A |
probably benign |
Het |
| Dennd1b |
T |
A |
1: 139,097,934 (GRCm39) |
D733E |
probably benign |
Het |
| Dicer1 |
A |
G |
12: 104,668,801 (GRCm39) |
S1294P |
probably damaging |
Het |
| Dnah3 |
T |
C |
7: 119,542,795 (GRCm39) |
E3539G |
probably benign |
Het |
| Dnmbp |
A |
G |
19: 43,840,875 (GRCm39) |
|
probably benign |
Het |
| Dysf |
T |
C |
6: 84,126,739 (GRCm39) |
L1332P |
probably damaging |
Het |
| F5 |
A |
G |
1: 164,010,409 (GRCm39) |
D380G |
probably damaging |
Het |
| Fam171a1 |
T |
C |
2: 3,226,433 (GRCm39) |
V522A |
probably benign |
Het |
| Fhip1b |
A |
C |
7: 105,038,680 (GRCm39) |
C186W |
probably damaging |
Het |
| Galr2 |
C |
A |
11: 116,172,517 (GRCm39) |
A69D |
probably damaging |
Het |
| Grk2 |
T |
C |
19: 4,340,628 (GRCm39) |
|
probably null |
Het |
| Gtf3c1 |
A |
T |
7: 125,262,188 (GRCm39) |
Y1119* |
probably null |
Het |
| Hgd |
A |
T |
16: 37,409,047 (GRCm39) |
|
probably benign |
Het |
| Ildr2 |
G |
T |
1: 166,136,468 (GRCm39) |
V436L |
probably benign |
Het |
| Intu |
G |
A |
3: 40,629,735 (GRCm39) |
C355Y |
probably damaging |
Het |
| Irf2bpl |
G |
T |
12: 86,929,870 (GRCm39) |
P268T |
probably benign |
Het |
| Jarid2 |
T |
C |
13: 44,994,358 (GRCm39) |
|
probably null |
Het |
| Jup |
A |
T |
11: 100,263,227 (GRCm39) |
M716K |
probably benign |
Het |
| Kank1 |
G |
A |
19: 25,388,837 (GRCm39) |
V809I |
probably damaging |
Het |
| Kdm1b |
T |
A |
13: 47,217,720 (GRCm39) |
|
probably benign |
Het |
| Kdm3a |
C |
T |
6: 71,577,739 (GRCm39) |
C687Y |
probably damaging |
Het |
| Kdm5d |
T |
A |
Y: 942,437 (GRCm39) |
|
probably benign |
Het |
| Kifap3 |
T |
A |
1: 163,693,121 (GRCm39) |
|
probably benign |
Het |
| Macf1 |
T |
A |
4: 123,377,453 (GRCm39) |
K1400* |
probably null |
Het |
| Majin |
A |
G |
19: 6,262,147 (GRCm39) |
|
probably benign |
Het |
| Mctp1 |
A |
G |
13: 77,168,940 (GRCm39) |
I846V |
probably benign |
Het |
| Mrgpra2b |
T |
A |
7: 47,113,875 (GRCm39) |
I286F |
possibly damaging |
Het |
| Neil3 |
T |
G |
8: 54,062,431 (GRCm39) |
|
probably benign |
Het |
| Nox3 |
G |
T |
17: 3,745,838 (GRCm39) |
N23K |
probably damaging |
Het |
| Nt5c3 |
T |
C |
6: 56,860,797 (GRCm39) |
K219E |
probably benign |
Het |
| Or1e29 |
T |
A |
11: 73,667,263 (GRCm39) |
M297L |
probably benign |
Het |
| Or52b4i |
T |
A |
7: 102,191,893 (GRCm39) |
I250N |
probably damaging |
Het |
| Or5b105 |
G |
A |
19: 13,080,642 (GRCm39) |
R3C |
possibly damaging |
Het |
| Or6b13 |
A |
C |
7: 139,782,029 (GRCm39) |
F218C |
possibly damaging |
Het |
| Or6d13 |
A |
T |
6: 116,517,446 (GRCm39) |
N11Y |
probably damaging |
Het |
| Or8g34 |
T |
C |
9: 39,372,889 (GRCm39) |
L54P |
probably damaging |
Het |
| Pacsin2 |
A |
G |
15: 83,263,996 (GRCm39) |
V347A |
possibly damaging |
Het |
| Pcdhb7 |
A |
T |
18: 37,475,857 (GRCm39) |
E331V |
probably damaging |
Het |
| Pcid2 |
A |
C |
8: 13,131,262 (GRCm39) |
|
probably null |
Het |
| Pcsk9 |
T |
C |
4: 106,307,274 (GRCm39) |
D323G |
possibly damaging |
Het |
| Pdhb |
T |
C |
14: 8,169,801 (GRCm38) |
E203G |
probably damaging |
Het |
| Phlpp2 |
A |
G |
8: 110,655,095 (GRCm39) |
Y630C |
probably benign |
Het |
| Pidd1 |
C |
T |
7: 141,019,046 (GRCm39) |
A812T |
probably damaging |
Het |
| Plau |
G |
A |
14: 20,892,382 (GRCm39) |
R389H |
probably benign |
Het |
| Plekhg6 |
G |
A |
6: 125,341,592 (GRCm39) |
|
probably null |
Het |
| Ppox |
T |
C |
1: 171,105,322 (GRCm39) |
Y321C |
probably damaging |
Het |
| Pxdn |
A |
G |
12: 30,037,065 (GRCm39) |
N281S |
possibly damaging |
Het |
| Pycr3 |
A |
T |
15: 75,790,237 (GRCm39) |
M138K |
probably benign |
Het |
| Radil |
T |
C |
5: 142,483,628 (GRCm39) |
Y526C |
probably damaging |
Het |
| Ranbp3 |
C |
A |
17: 57,014,169 (GRCm39) |
D233E |
probably benign |
Het |
| Rhpn1 |
A |
G |
15: 75,583,721 (GRCm39) |
Q402R |
possibly damaging |
Het |
| Sec23b |
T |
A |
2: 144,410,532 (GRCm39) |
|
probably benign |
Het |
| Sel1l2 |
A |
T |
2: 140,082,832 (GRCm39) |
L602* |
probably null |
Het |
| Sema5b |
G |
A |
16: 35,466,725 (GRCm39) |
G209D |
probably damaging |
Het |
| Svep1 |
T |
C |
4: 58,073,333 (GRCm39) |
Y1992C |
possibly damaging |
Het |
| Syncrip |
T |
A |
9: 88,338,312 (GRCm39) |
|
probably benign |
Het |
| Synj1 |
G |
T |
16: 90,764,242 (GRCm39) |
A65E |
probably damaging |
Het |
| Taar2 |
G |
A |
10: 23,817,393 (GRCm39) |
R311H |
probably benign |
Het |
| Tecrl |
T |
C |
5: 83,502,610 (GRCm39) |
|
probably benign |
Het |
| Tenm4 |
G |
T |
7: 96,427,058 (GRCm39) |
G698C |
probably damaging |
Het |
| Tmem209 |
G |
A |
6: 30,491,181 (GRCm39) |
L259F |
probably damaging |
Het |
| Tmem247 |
G |
A |
17: 87,225,931 (GRCm39) |
E124K |
possibly damaging |
Het |
| Tnks2 |
C |
A |
19: 36,830,221 (GRCm39) |
A218E |
probably damaging |
Het |
| Tppp |
T |
A |
13: 74,169,430 (GRCm39) |
F57I |
probably damaging |
Het |
| Trim36 |
A |
G |
18: 46,305,592 (GRCm39) |
W452R |
probably damaging |
Het |
| Vars2 |
A |
T |
17: 35,975,476 (GRCm39) |
V262E |
probably damaging |
Het |
| Vmn2r92 |
C |
T |
17: 18,388,219 (GRCm39) |
A408V |
probably damaging |
Het |
| Zfp516 |
G |
T |
18: 82,973,897 (GRCm39) |
A32S |
probably benign |
Het |
| Zfy2 |
G |
T |
Y: 2,107,348 (GRCm39) |
L429I |
possibly damaging |
Het |
|
| Other mutations in Arhgef12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00923:Arhgef12
|
APN |
9 |
42,931,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00942:Arhgef12
|
APN |
9 |
42,893,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01529:Arhgef12
|
APN |
9 |
42,901,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01845:Arhgef12
|
APN |
9 |
42,934,137 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL02039:Arhgef12
|
APN |
9 |
42,883,563 (GRCm39) |
missense |
probably benign |
|
|
IGL02135:Arhgef12
|
APN |
9 |
42,883,461 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02272:Arhgef12
|
APN |
9 |
42,912,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02498:Arhgef12
|
APN |
9 |
42,893,339 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02507:Arhgef12
|
APN |
9 |
42,903,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02574:Arhgef12
|
APN |
9 |
42,916,919 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02586:Arhgef12
|
APN |
9 |
42,917,200 (GRCm39) |
nonsense |
probably null |
|
|
IGL02803:Arhgef12
|
APN |
9 |
42,883,324 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02892:Arhgef12
|
APN |
9 |
42,912,268 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02937:Arhgef12
|
APN |
9 |
42,927,216 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02992:Arhgef12
|
APN |
9 |
42,910,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03028:Arhgef12
|
APN |
9 |
42,937,524 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL03146:Arhgef12
|
APN |
9 |
42,885,866 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03193:Arhgef12
|
APN |
9 |
42,903,829 (GRCm39) |
splice site |
probably benign |
|
|
IGL03398:Arhgef12
|
APN |
9 |
42,889,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0019:Arhgef12
|
UTSW |
9 |
42,889,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0143:Arhgef12
|
UTSW |
9 |
42,916,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0211:Arhgef12
|
UTSW |
9 |
42,883,300 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0330:Arhgef12
|
UTSW |
9 |
42,931,982 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0364:Arhgef12
|
UTSW |
9 |
42,929,697 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0658:Arhgef12
|
UTSW |
9 |
42,893,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0686:Arhgef12
|
UTSW |
9 |
42,904,324 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0693:Arhgef12
|
UTSW |
9 |
42,929,697 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0990:Arhgef12
|
UTSW |
9 |
42,883,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1147:Arhgef12
|
UTSW |
9 |
42,955,552 (GRCm39) |
unclassified |
probably benign |
|
|
R1395:Arhgef12
|
UTSW |
9 |
42,917,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1419:Arhgef12
|
UTSW |
9 |
42,938,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1451:Arhgef12
|
UTSW |
9 |
42,903,874 (GRCm39) |
splice site |
probably benign |
|
|
R1458:Arhgef12
|
UTSW |
9 |
42,900,294 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1654:Arhgef12
|
UTSW |
9 |
42,908,956 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1722:Arhgef12
|
UTSW |
9 |
42,932,013 (GRCm39) |
makesense |
probably null |
|
|
R1773:Arhgef12
|
UTSW |
9 |
42,916,838 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1895:Arhgef12
|
UTSW |
9 |
42,917,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2109:Arhgef12
|
UTSW |
9 |
42,890,768 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R2215:Arhgef12
|
UTSW |
9 |
42,917,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2421:Arhgef12
|
UTSW |
9 |
42,912,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3967:Arhgef12
|
UTSW |
9 |
42,916,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3968:Arhgef12
|
UTSW |
9 |
42,916,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3969:Arhgef12
|
UTSW |
9 |
42,916,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4077:Arhgef12
|
UTSW |
9 |
42,886,588 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4079:Arhgef12
|
UTSW |
9 |
42,886,588 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4111:Arhgef12
|
UTSW |
9 |
42,883,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Arhgef12
|
UTSW |
9 |
42,929,645 (GRCm39) |
nonsense |
probably null |
|
|
R4327:Arhgef12
|
UTSW |
9 |
42,886,525 (GRCm39) |
nonsense |
probably null |
|
|
R4462:Arhgef12
|
UTSW |
9 |
42,893,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4583:Arhgef12
|
UTSW |
9 |
42,888,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4603:Arhgef12
|
UTSW |
9 |
42,921,489 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4650:Arhgef12
|
UTSW |
9 |
42,893,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4741:Arhgef12
|
UTSW |
9 |
42,883,449 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R4823:Arhgef12
|
UTSW |
9 |
42,931,992 (GRCm39) |
missense |
probably benign |
|
|
R4840:Arhgef12
|
UTSW |
9 |
42,886,364 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4912:Arhgef12
|
UTSW |
9 |
42,904,361 (GRCm39) |
nonsense |
probably null |
|
|
R5176:Arhgef12
|
UTSW |
9 |
42,931,982 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5426:Arhgef12
|
UTSW |
9 |
42,897,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5579:Arhgef12
|
UTSW |
9 |
42,921,489 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5838:Arhgef12
|
UTSW |
9 |
42,916,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6230:Arhgef12
|
UTSW |
9 |
42,900,261 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6741:Arhgef12
|
UTSW |
9 |
42,883,503 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6959:Arhgef12
|
UTSW |
9 |
42,927,249 (GRCm39) |
missense |
probably benign |
|
|
R7252:Arhgef12
|
UTSW |
9 |
42,927,205 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7470:Arhgef12
|
UTSW |
9 |
42,951,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7658:Arhgef12
|
UTSW |
9 |
42,903,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7724:Arhgef12
|
UTSW |
9 |
42,938,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7980:Arhgef12
|
UTSW |
9 |
42,882,595 (GRCm39) |
nonsense |
probably null |
|
|
R8074:Arhgef12
|
UTSW |
9 |
42,882,399 (GRCm39) |
nonsense |
probably null |
|
|
R8155:Arhgef12
|
UTSW |
9 |
42,953,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8270:Arhgef12
|
UTSW |
9 |
42,882,354 (GRCm39) |
missense |
probably benign |
|
|
R8407:Arhgef12
|
UTSW |
9 |
42,937,475 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8527:Arhgef12
|
UTSW |
9 |
42,908,944 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9116:Arhgef12
|
UTSW |
9 |
42,893,241 (GRCm39) |
splice site |
probably benign |
|
|
R9127:Arhgef12
|
UTSW |
9 |
42,885,870 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9602:Arhgef12
|
UTSW |
9 |
42,895,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9665:Arhgef12
|
UTSW |
9 |
42,929,650 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9733:Arhgef12
|
UTSW |
9 |
42,901,294 (GRCm39) |
nonsense |
probably null |
|
|
R9735:Arhgef12
|
UTSW |
9 |
42,882,399 (GRCm39) |
nonsense |
probably null |
|
|
R9760:Arhgef12
|
UTSW |
9 |
42,903,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF020:Arhgef12
|
UTSW |
9 |
42,901,285 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
Z1176:Arhgef12
|
UTSW |
9 |
42,882,368 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1186:Arhgef12
|
UTSW |
9 |
42,911,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGATTGACAGCCACGAAAGCCC -3'
(R):5'- AGCAACATTCCCCTCAGAATGTGC -3'
Sequencing Primer
(F):5'- TGGAAACCAACTGACCCAGTATTTAG -3'
(R):5'- GTTTCACCATTCACCCCAGA -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation