|Institutional Source||Beutler Lab|
|Gene Name||cadherin 9|
|Is this an essential gene?||Probably non essential (E-score: 0.152)|
|Stock #||R0426 (G1)|
|Chromosomal Location||16728756-16857094 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (1 bp from exon)|
|DNA Base Change (assembly)||G to A at 16823454 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000154022 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000026432] [ENSMUST00000228307]|
|AlphaFold||no structure available at present|
|Meta Mutation Damage Score||0.9479|
|Coding Region Coverage||
|Validation Efficiency||96% (86/90)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous knockout results in the formation of abnormal axonal arbors in some retinal type 5 bipolar cells. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cdh9||
(F):5'- TTCACGCTGCAAAGAGACTAGACAG -3'
(R):5'- GGTGTTGCTGCCATTGGAATCAAAC -3'
(F):5'- CTGCAAAGAGACTAGACAGAGAAG -3'
(R):5'- TGCCATTGGAATCAAACAACTTCTC -3'