Incidental Mutation 'R5074:Myh8'
| ID |
386862 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myh8
|
| Ensembl Gene |
ENSMUSG00000055775 |
| Gene Name |
myosin, heavy polypeptide 8, skeletal muscle, perinatal |
| Synonyms |
Myhsp, MyHC-pn, Myhs-p, 4832426G23Rik |
| MMRRC Submission |
042663-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.826)
|
| Stock # |
R5074 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
67167950-67199460 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 67196742 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 1792
(T1792S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000019625
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000019625]
|
| AlphaFold |
P13542 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000019625
AA Change: T1792S
PolyPhen 2
Score 0.791 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000019625
Gene: ENSMUSG00000055775
AA Change: T1792S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
37 |
76 |
2.1e-13 |
PFAM |
|
MYSc
|
82 |
782 |
N/A |
SMART |
|
IQ
|
783 |
805 |
5.44e-3 |
SMART |
|
Pfam:Myosin_tail_1
|
846 |
1927 |
2.4e-164 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.0%
- 20x: 94.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a myosin heavy chain. The encoded protein forms a hexamer with two heavy chains, two alkali light chains, and two regulatory light chain components. This complex functions in muscle contraction. This gene is located in a cluster of related genes on chromosome 11. [provided by RefSeq, Jun 2013]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 115 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700006A11Rik |
A |
T |
3: 124,210,482 (GRCm39) |
H143Q |
probably benign |
Het |
| Abca3 |
C |
T |
17: 24,593,274 (GRCm39) |
R224C |
probably damaging |
Het |
| Adcy8 |
A |
T |
15: 64,659,207 (GRCm39) |
W528R |
probably damaging |
Het |
| Agbl1 |
A |
G |
7: 76,071,665 (GRCm39) |
E329G |
probably damaging |
Het |
| Agbl5 |
G |
A |
5: 31,060,403 (GRCm39) |
R141Q |
probably damaging |
Het |
| Ampd2 |
A |
T |
3: 107,986,549 (GRCm39) |
M245K |
probably damaging |
Het |
| Apob |
G |
A |
12: 8,055,219 (GRCm39) |
|
probably null |
Het |
| Apool |
C |
T |
X: 111,259,540 (GRCm39) |
Q60* |
probably null |
Het |
| Aqp1 |
A |
T |
6: 55,322,520 (GRCm39) |
I172F |
probably damaging |
Het |
| Atp7a |
A |
G |
X: 105,153,374 (GRCm39) |
D1092G |
probably benign |
Het |
| Ccdc83 |
A |
T |
7: 89,899,737 (GRCm39) |
F45Y |
probably damaging |
Het |
| Cct8l1 |
G |
A |
5: 25,721,881 (GRCm39) |
V199I |
probably benign |
Het |
| Cdc23 |
C |
A |
18: 34,784,742 (GRCm39) |
V7L |
unknown |
Het |
| Cdc25a |
T |
A |
9: 109,713,208 (GRCm39) |
C227S |
possibly damaging |
Het |
| Ces1a |
A |
G |
8: 93,759,303 (GRCm39) |
S278P |
possibly damaging |
Het |
| Cfap65 |
A |
T |
1: 74,962,137 (GRCm39) |
S695T |
probably benign |
Het |
| Col13a1 |
A |
G |
10: 61,709,797 (GRCm39) |
|
silent |
Het |
| Ctps1 |
A |
T |
4: 120,411,170 (GRCm39) |
L282Q |
probably damaging |
Het |
| Cyp2a22 |
A |
T |
7: 26,631,906 (GRCm39) |
F450Y |
probably benign |
Het |
| Cyp2d10 |
C |
T |
15: 82,287,954 (GRCm39) |
R383H |
probably benign |
Het |
| Dennd3 |
G |
A |
15: 73,419,144 (GRCm39) |
R645H |
probably damaging |
Het |
| Dnaaf5 |
G |
T |
5: 139,159,962 (GRCm39) |
R620L |
probably damaging |
Het |
| Dnah11 |
A |
T |
12: 118,046,188 (GRCm39) |
L1750* |
probably null |
Het |
| Dnah9 |
A |
G |
11: 65,740,866 (GRCm39) |
F4107L |
probably damaging |
Het |
| Dnaja3 |
A |
T |
16: 4,514,289 (GRCm39) |
T274S |
probably damaging |
Het |
| Dot1l |
A |
G |
10: 80,620,480 (GRCm39) |
D514G |
possibly damaging |
Het |
| Dst |
A |
C |
1: 34,334,344 (GRCm39) |
K4857N |
probably damaging |
Het |
| Dysf |
A |
T |
6: 84,114,254 (GRCm39) |
K1226M |
probably damaging |
Het |
| Enpep |
T |
A |
3: 129,097,404 (GRCm39) |
Q409L |
probably damaging |
Het |
| Fign |
A |
T |
2: 63,810,037 (GRCm39) |
L411* |
probably null |
Het |
| Flt1 |
C |
A |
5: 147,620,749 (GRCm39) |
A132S |
probably benign |
Het |
| Fryl |
G |
A |
5: 73,232,110 (GRCm39) |
P1550L |
probably damaging |
Het |
| Gas2l3 |
CACTCGTCATACT |
CACT |
10: 89,266,820 (GRCm39) |
|
probably benign |
Het |
| H2ab3 |
T |
C |
X: 119,222,543 (GRCm39) |
T84A |
probably damaging |
Het |
| Hal |
A |
T |
10: 93,349,904 (GRCm39) |
I555F |
probably damaging |
Het |
| Hibadh |
C |
T |
6: 52,597,079 (GRCm39) |
V122M |
possibly damaging |
Het |
| Hsd3b3 |
T |
C |
3: 98,649,340 (GRCm39) |
T328A |
possibly damaging |
Het |
| Ifi44 |
T |
C |
3: 151,455,269 (GRCm39) |
|
probably benign |
Het |
| Ifi47 |
A |
G |
11: 48,986,361 (GRCm39) |
T43A |
probably benign |
Het |
| Inf2 |
A |
T |
12: 112,578,473 (GRCm39) |
|
probably null |
Het |
| Itga10 |
C |
T |
3: 96,559,527 (GRCm39) |
Q475* |
probably null |
Het |
| Itga6 |
T |
A |
2: 71,656,779 (GRCm39) |
D344E |
probably benign |
Het |
| Kcnmb4 |
T |
C |
10: 116,309,102 (GRCm39) |
T109A |
probably benign |
Het |
| Kif19a |
G |
A |
11: 114,658,053 (GRCm39) |
M37I |
probably benign |
Het |
| Kiss1r |
C |
A |
10: 79,754,596 (GRCm39) |
S30* |
probably null |
Het |
| Lrrc66 |
G |
A |
5: 73,765,354 (GRCm39) |
P563L |
probably damaging |
Het |
| Mamdc2 |
T |
C |
19: 23,356,160 (GRCm39) |
D96G |
probably benign |
Het |
| Map3k12 |
A |
T |
15: 102,410,267 (GRCm39) |
|
probably null |
Het |
| Mc3r |
A |
T |
2: 172,091,533 (GRCm39) |
I252F |
possibly damaging |
Het |
| Metrn |
C |
T |
17: 26,015,613 (GRCm39) |
G34D |
probably damaging |
Het |
| Mipep |
A |
G |
14: 61,046,462 (GRCm39) |
E328G |
probably benign |
Het |
| Mrtfa |
A |
G |
15: 80,906,627 (GRCm39) |
V91A |
probably damaging |
Het |
| Muc5b |
A |
T |
7: 141,412,999 (GRCm39) |
T1982S |
unknown |
Het |
| Myo1a |
T |
C |
10: 127,543,288 (GRCm39) |
|
probably null |
Het |
| Myo5a |
T |
A |
9: 75,081,438 (GRCm39) |
S1008T |
probably benign |
Het |
| Ncald |
A |
T |
15: 37,397,478 (GRCm39) |
H67Q |
probably damaging |
Het |
| Nudt5 |
T |
A |
2: 5,869,198 (GRCm39) |
H141Q |
probably benign |
Het |
| Numbl |
G |
A |
7: 26,980,415 (GRCm39) |
D466N |
probably damaging |
Het |
| Nup210 |
T |
A |
6: 91,032,309 (GRCm39) |
I20F |
probably benign |
Het |
| Odad1 |
T |
A |
7: 45,578,514 (GRCm39) |
M29K |
probably benign |
Het |
| Or10ak12 |
A |
C |
4: 118,666,057 (GRCm39) |
W319G |
possibly damaging |
Het |
| Or10p21 |
T |
C |
10: 128,847,213 (GRCm39) |
Y20H |
possibly damaging |
Het |
| Or14c46 |
A |
G |
7: 85,918,799 (GRCm39) |
I66T |
probably damaging |
Het |
| Or51l14 |
A |
T |
7: 103,100,617 (GRCm39) |
E24D |
probably benign |
Het |
| Or52e8b |
A |
T |
7: 104,673,260 (GRCm39) |
M309K |
probably benign |
Het |
| Or52n2c |
A |
C |
7: 104,574,700 (GRCm39) |
N90K |
probably benign |
Het |
| Or7h8 |
A |
T |
9: 20,123,878 (GRCm39) |
I78F |
possibly damaging |
Het |
| Or8h10 |
A |
T |
2: 86,808,666 (GRCm39) |
V158D |
possibly damaging |
Het |
| Papolg |
G |
A |
11: 23,817,331 (GRCm39) |
T153I |
possibly damaging |
Het |
| Pappa |
A |
G |
4: 65,123,365 (GRCm39) |
H900R |
probably benign |
Het |
| Pcdh17 |
T |
C |
14: 84,770,782 (GRCm39) |
S1087P |
probably benign |
Het |
| Phf11a |
T |
G |
14: 59,521,849 (GRCm39) |
L107F |
possibly damaging |
Het |
| Phlpp2 |
A |
T |
8: 110,652,461 (GRCm39) |
I602F |
probably damaging |
Het |
| Pik3c2g |
T |
A |
6: 139,665,873 (GRCm39) |
C65S |
probably null |
Het |
| Pilra |
A |
G |
5: 137,833,674 (GRCm39) |
F131L |
probably damaging |
Het |
| Pomt2 |
A |
C |
12: 87,180,234 (GRCm39) |
C256G |
probably damaging |
Het |
| Ppl |
A |
T |
16: 4,906,742 (GRCm39) |
S1184R |
probably benign |
Het |
| Prkaa1 |
G |
T |
15: 5,206,392 (GRCm39) |
R416L |
possibly damaging |
Het |
| Prkdc |
C |
A |
16: 15,589,912 (GRCm39) |
R2592S |
probably damaging |
Het |
| Prmt2 |
C |
T |
10: 76,058,390 (GRCm39) |
V140I |
probably damaging |
Het |
| Prodh |
A |
T |
16: 17,895,653 (GRCm39) |
|
probably null |
Het |
| Psg29 |
T |
A |
7: 16,945,763 (GRCm39) |
D444E |
probably damaging |
Het |
| Ptgs1 |
A |
T |
2: 36,141,272 (GRCm39) |
N573I |
probably damaging |
Het |
| Rbm38 |
C |
T |
2: 172,863,875 (GRCm39) |
P15S |
probably benign |
Het |
| Riox2 |
T |
C |
16: 59,312,236 (GRCm39) |
S458P |
possibly damaging |
Het |
| Rnase4 |
T |
C |
14: 51,342,702 (GRCm39) |
V142A |
possibly damaging |
Het |
| Rnf138 |
A |
G |
18: 21,159,204 (GRCm39) |
N244S |
probably benign |
Het |
| Rnf40 |
T |
C |
7: 127,196,458 (GRCm39) |
L802P |
probably damaging |
Het |
| Sfxn4 |
C |
T |
19: 60,839,450 (GRCm39) |
V203M |
probably damaging |
Het |
| Skor2 |
G |
T |
18: 76,946,649 (GRCm39) |
E124* |
probably null |
Het |
| Slc4a2 |
G |
A |
5: 24,643,760 (GRCm39) |
S855N |
probably benign |
Het |
| Slc8a2 |
T |
C |
7: 15,884,508 (GRCm39) |
L626P |
possibly damaging |
Het |
| Slco4c1 |
G |
A |
1: 96,768,953 (GRCm39) |
P303L |
probably damaging |
Het |
| Slirp |
A |
G |
12: 87,490,784 (GRCm39) |
T29A |
probably damaging |
Het |
| Snrpd3 |
G |
T |
10: 75,355,227 (GRCm39) |
C20F |
possibly damaging |
Het |
| Spag17 |
T |
A |
3: 99,987,434 (GRCm39) |
Y1575N |
possibly damaging |
Het |
| St8sia4 |
G |
A |
1: 95,594,910 (GRCm39) |
A26V |
probably benign |
Het |
| Stab2 |
A |
T |
10: 86,699,422 (GRCm39) |
I481N |
probably benign |
Het |
| Tenm2 |
T |
A |
11: 35,959,208 (GRCm39) |
T1114S |
probably damaging |
Het |
| Tgm1 |
A |
G |
14: 55,947,392 (GRCm39) |
V323A |
probably damaging |
Het |
| Tmco4 |
A |
G |
4: 138,785,433 (GRCm39) |
H501R |
probably damaging |
Het |
| Tob1 |
A |
T |
11: 94,104,567 (GRCm39) |
R34S |
possibly damaging |
Het |
| Trhr2 |
C |
T |
8: 123,084,110 (GRCm39) |
V297I |
probably benign |
Het |
| Trim30d |
A |
C |
7: 104,137,165 (GRCm39) |
V13G |
probably damaging |
Het |
| Trpm3 |
T |
C |
19: 22,862,713 (GRCm39) |
V485A |
possibly damaging |
Het |
| Trrap |
T |
C |
5: 144,787,989 (GRCm39) |
I3518T |
probably damaging |
Het |
| Ttc27 |
T |
C |
17: 75,054,750 (GRCm39) |
L352P |
probably damaging |
Het |
| Ush1g |
A |
G |
11: 115,209,123 (GRCm39) |
L357P |
possibly damaging |
Het |
| Usp24 |
A |
G |
4: 106,277,644 (GRCm39) |
H2258R |
probably benign |
Het |
| Vcam1 |
A |
G |
3: 115,918,037 (GRCm39) |
V308A |
probably damaging |
Het |
| Vdr |
A |
G |
15: 97,755,459 (GRCm39) |
S355P |
probably benign |
Het |
| Vldlr |
T |
C |
19: 27,215,677 (GRCm39) |
S184P |
probably damaging |
Het |
| Xpo4 |
C |
A |
14: 57,822,098 (GRCm39) |
A1073S |
probably benign |
Het |
| Zfand2b |
A |
G |
1: 75,147,634 (GRCm39) |
D224G |
probably benign |
Het |
| Zfp263 |
A |
G |
16: 3,564,704 (GRCm39) |
R240G |
possibly damaging |
Het |
|
| Other mutations in Myh8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00236:Myh8
|
APN |
11 |
67,174,644 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01020:Myh8
|
APN |
11 |
67,174,229 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01348:Myh8
|
APN |
11 |
67,188,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01382:Myh8
|
APN |
11 |
67,192,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01454:Myh8
|
APN |
11 |
67,174,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01457:Myh8
|
APN |
11 |
67,183,505 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01472:Myh8
|
APN |
11 |
67,179,205 (GRCm39) |
splice site |
probably benign |
|
|
IGL01473:Myh8
|
APN |
11 |
67,192,651 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01613:Myh8
|
APN |
11 |
67,192,536 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL01763:Myh8
|
APN |
11 |
67,177,245 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01828:Myh8
|
APN |
11 |
67,194,652 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL01862:Myh8
|
APN |
11 |
67,180,520 (GRCm39) |
nonsense |
probably null |
|
|
IGL01905:Myh8
|
APN |
11 |
67,175,477 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL02280:Myh8
|
APN |
11 |
67,174,198 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02386:Myh8
|
APN |
11 |
67,185,266 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02449:Myh8
|
APN |
11 |
67,185,440 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02500:Myh8
|
APN |
11 |
67,196,536 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02745:Myh8
|
APN |
11 |
67,188,327 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02799:Myh8
|
APN |
11 |
67,192,418 (GRCm39) |
splice site |
probably benign |
|
|
IGL03063:Myh8
|
APN |
11 |
67,179,031 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03223:Myh8
|
APN |
11 |
67,174,644 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03336:Myh8
|
APN |
11 |
67,175,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03338:Myh8
|
APN |
11 |
67,189,172 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03351:Myh8
|
APN |
11 |
67,194,739 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03392:Myh8
|
APN |
11 |
67,185,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB003:Myh8
|
UTSW |
11 |
67,169,732 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
BB009:Myh8
|
UTSW |
11 |
67,185,430 (GRCm39) |
missense |
probably benign |
0.00 |
|
BB013:Myh8
|
UTSW |
11 |
67,169,732 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
BB019:Myh8
|
UTSW |
11 |
67,185,430 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4354001:Myh8
|
UTSW |
11 |
67,180,456 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0012:Myh8
|
UTSW |
11 |
67,190,847 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0016:Myh8
|
UTSW |
11 |
67,189,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0016:Myh8
|
UTSW |
11 |
67,189,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0115:Myh8
|
UTSW |
11 |
67,197,090 (GRCm39) |
splice site |
probably benign |
|
|
R0131:Myh8
|
UTSW |
11 |
67,183,014 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0131:Myh8
|
UTSW |
11 |
67,183,014 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0132:Myh8
|
UTSW |
11 |
67,183,014 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0238:Myh8
|
UTSW |
11 |
67,192,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0238:Myh8
|
UTSW |
11 |
67,192,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0239:Myh8
|
UTSW |
11 |
67,192,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0239:Myh8
|
UTSW |
11 |
67,192,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0393:Myh8
|
UTSW |
11 |
67,196,843 (GRCm39) |
splice site |
probably benign |
|
|
R0453:Myh8
|
UTSW |
11 |
67,183,731 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0454:Myh8
|
UTSW |
11 |
67,194,591 (GRCm39) |
nonsense |
probably null |
|
|
R0466:Myh8
|
UTSW |
11 |
67,189,405 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0487:Myh8
|
UTSW |
11 |
67,192,837 (GRCm39) |
missense |
probably benign |
|
|
R0511:Myh8
|
UTSW |
11 |
67,175,333 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0557:Myh8
|
UTSW |
11 |
67,192,624 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0589:Myh8
|
UTSW |
11 |
67,189,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0658:Myh8
|
UTSW |
11 |
67,175,358 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0782:Myh8
|
UTSW |
11 |
67,180,580 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0829:Myh8
|
UTSW |
11 |
67,174,326 (GRCm39) |
unclassified |
probably benign |
|
|
R0845:Myh8
|
UTSW |
11 |
67,177,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0930:Myh8
|
UTSW |
11 |
67,196,824 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0972:Myh8
|
UTSW |
11 |
67,188,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1132:Myh8
|
UTSW |
11 |
67,187,957 (GRCm39) |
nonsense |
probably null |
|
|
R1417:Myh8
|
UTSW |
11 |
67,197,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1478:Myh8
|
UTSW |
11 |
67,183,551 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1497:Myh8
|
UTSW |
11 |
67,180,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1605:Myh8
|
UTSW |
11 |
67,192,497 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1701:Myh8
|
UTSW |
11 |
67,170,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1950:Myh8
|
UTSW |
11 |
67,169,830 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1989:Myh8
|
UTSW |
11 |
67,183,550 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2010:Myh8
|
UTSW |
11 |
67,187,990 (GRCm39) |
nonsense |
probably null |
|
|
R2095:Myh8
|
UTSW |
11 |
67,177,050 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2132:Myh8
|
UTSW |
11 |
67,183,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2152:Myh8
|
UTSW |
11 |
67,185,295 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2229:Myh8
|
UTSW |
11 |
67,199,174 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2302:Myh8
|
UTSW |
11 |
67,177,065 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2364:Myh8
|
UTSW |
11 |
67,185,344 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2429:Myh8
|
UTSW |
11 |
67,194,723 (GRCm39) |
missense |
probably benign |
0.21 |
|
R2880:Myh8
|
UTSW |
11 |
67,188,090 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3692:Myh8
|
UTSW |
11 |
67,192,744 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3756:Myh8
|
UTSW |
11 |
67,175,443 (GRCm39) |
unclassified |
probably benign |
|
|
R3924:Myh8
|
UTSW |
11 |
67,187,963 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4172:Myh8
|
UTSW |
11 |
67,183,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4255:Myh8
|
UTSW |
11 |
67,190,560 (GRCm39) |
missense |
probably benign |
|
|
R4621:Myh8
|
UTSW |
11 |
67,177,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4623:Myh8
|
UTSW |
11 |
67,177,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4790:Myh8
|
UTSW |
11 |
67,170,789 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4914:Myh8
|
UTSW |
11 |
67,183,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5119:Myh8
|
UTSW |
11 |
67,189,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5159:Myh8
|
UTSW |
11 |
67,179,179 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5229:Myh8
|
UTSW |
11 |
67,175,310 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5320:Myh8
|
UTSW |
11 |
67,177,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5455:Myh8
|
UTSW |
11 |
67,192,244 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R5523:Myh8
|
UTSW |
11 |
67,196,788 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5540:Myh8
|
UTSW |
11 |
67,177,266 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5726:Myh8
|
UTSW |
11 |
67,185,392 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5770:Myh8
|
UTSW |
11 |
67,188,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6135:Myh8
|
UTSW |
11 |
67,188,326 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6253:Myh8
|
UTSW |
11 |
67,192,793 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6318:Myh8
|
UTSW |
11 |
67,190,167 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6432:Myh8
|
UTSW |
11 |
67,189,405 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6452:Myh8
|
UTSW |
11 |
67,196,565 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6452:Myh8
|
UTSW |
11 |
67,183,275 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6512:Myh8
|
UTSW |
11 |
67,180,488 (GRCm39) |
nonsense |
probably null |
|
|
R6714:Myh8
|
UTSW |
11 |
67,197,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6842:Myh8
|
UTSW |
11 |
67,175,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7007:Myh8
|
UTSW |
11 |
67,179,142 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7025:Myh8
|
UTSW |
11 |
67,188,365 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7086:Myh8
|
UTSW |
11 |
67,183,453 (GRCm39) |
splice site |
probably null |
|
|
R7098:Myh8
|
UTSW |
11 |
67,169,879 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7498:Myh8
|
UTSW |
11 |
67,174,263 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7716:Myh8
|
UTSW |
11 |
67,189,478 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R7765:Myh8
|
UTSW |
11 |
67,194,481 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7825:Myh8
|
UTSW |
11 |
67,194,538 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7921:Myh8
|
UTSW |
11 |
67,174,644 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7926:Myh8
|
UTSW |
11 |
67,169,732 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7932:Myh8
|
UTSW |
11 |
67,185,430 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8003:Myh8
|
UTSW |
11 |
67,190,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8028:Myh8
|
UTSW |
11 |
67,194,502 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8121:Myh8
|
UTSW |
11 |
67,180,647 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8125:Myh8
|
UTSW |
11 |
67,190,598 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8170:Myh8
|
UTSW |
11 |
67,179,092 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8277:Myh8
|
UTSW |
11 |
67,183,735 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8304:Myh8
|
UTSW |
11 |
67,195,162 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8431:Myh8
|
UTSW |
11 |
67,174,440 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8535:Myh8
|
UTSW |
11 |
67,169,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8795:Myh8
|
UTSW |
11 |
67,174,203 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R8858:Myh8
|
UTSW |
11 |
67,192,820 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8927:Myh8
|
UTSW |
11 |
67,174,081 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8928:Myh8
|
UTSW |
11 |
67,174,081 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9031:Myh8
|
UTSW |
11 |
67,190,141 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R9172:Myh8
|
UTSW |
11 |
67,183,260 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9252:Myh8
|
UTSW |
11 |
67,177,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9365:Myh8
|
UTSW |
11 |
67,174,632 (GRCm39) |
missense |
probably benign |
0.42 |
|
R9468:Myh8
|
UTSW |
11 |
67,197,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9564:Myh8
|
UTSW |
11 |
67,177,215 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9565:Myh8
|
UTSW |
11 |
67,177,215 (GRCm39) |
missense |
probably benign |
0.40 |
|
T0722:Myh8
|
UTSW |
11 |
67,195,262 (GRCm39) |
missense |
probably benign |
0.41 |
|
Z1088:Myh8
|
UTSW |
11 |
67,189,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Myh8
|
UTSW |
11 |
67,194,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Myh8
|
UTSW |
11 |
67,199,181 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
Z1177:Myh8
|
UTSW |
11 |
67,192,250 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1187:Myh8
|
UTSW |
11 |
67,188,312 (GRCm39) |
missense |
probably benign |
|
|
Z1188:Myh8
|
UTSW |
11 |
67,188,312 (GRCm39) |
missense |
probably benign |
|
|
Z1190:Myh8
|
UTSW |
11 |
67,188,312 (GRCm39) |
missense |
probably benign |
|
|
Z1191:Myh8
|
UTSW |
11 |
67,188,312 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CACAGCTGCAGAGTGAAGTG -3'
(R):5'- GAGCAGGGTATACTTGACCC -3'
Sequencing Primer
(F):5'- AGCCATTACTGATGTGAGCAC -3'
(R):5'- TTGACCCCACAACAATAAGAGTGTG -3'
|
| Posted On |
2016-06-06 |
Incidental Mutation