Incidental Mutation 'R5078:Gpx5'
ID 386976
Institutional Source Beutler Lab
Gene Symbol Gpx5
Ensembl Gene ENSMUSG00000004344
Gene Name glutathione peroxidase 5
Synonyms Arep
MMRRC Submission 042667-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5078 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 21470599-21476897 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 21472881 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 151 (F151S)
Ref Sequence ENSEMBL: ENSMUSP00000106117 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110491]
AlphaFold P21765
Predicted Effect probably damaging
Transcript: ENSMUST00000004456
AA Change: F151S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000004456
Gene: ENSMUSG00000004344
AA Change: F151S

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:GSHPx 40 153 8e-45 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000110491
AA Change: F151S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000106117
Gene: ENSMUSG00000004344
AA Change: F151S

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
Pfam:GSHPx 56 169 3.4e-45 PFAM
Meta Mutation Damage Score 0.4997 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]
PHENOTYPE: Male mice homozygous for a knock-out allele exhibit age-dependent reduced fertility due to increased sensitivity of sperm DNA to oxidative attack. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy9 T C 16: 4,141,771 (GRCm39) S345G probably benign Het
Adgrf2 A T 17: 43,021,877 (GRCm39) F316I probably damaging Het
Ank2 A G 3: 126,736,002 (GRCm39) probably benign Het
Auts2 T C 5: 132,287,786 (GRCm39) K66E possibly damaging Het
Bicra T C 7: 15,709,382 (GRCm39) D1144G probably damaging Het
Cabin1 A G 10: 75,557,312 (GRCm39) S1109P probably damaging Het
Camkv T C 9: 107,822,572 (GRCm39) V29A probably damaging Het
Ccdc178 A T 18: 22,200,685 (GRCm39) probably null Het
Ccser1 G A 6: 61,288,350 (GRCm39) R171H probably damaging Het
Cdk19 A G 10: 40,312,150 (GRCm39) Y133C probably damaging Het
Cerkl T A 2: 79,223,352 (GRCm39) D123V probably benign Het
Chd1 T C 17: 15,946,616 (GRCm39) S121P possibly damaging Het
Col4a2 T C 8: 11,493,936 (GRCm39) V1459A probably benign Het
Dlg1 T A 16: 31,675,287 (GRCm39) Y704* probably null Het
Dsg2 T C 18: 20,729,140 (GRCm39) probably null Het
Egln3 T C 12: 54,228,453 (GRCm39) R218G probably damaging Het
Gm11568 T C 11: 99,749,181 (GRCm39) C129R unknown Het
Gm13991 T C 2: 116,358,355 (GRCm39) noncoding transcript Het
Gmnc C A 16: 26,784,332 (GRCm39) V58L probably benign Het
Helz G A 11: 107,546,922 (GRCm39) G1079R probably damaging Het
Ice1 T C 13: 70,752,969 (GRCm39) E1039G probably benign Het
Kif18a T C 2: 109,125,487 (GRCm39) probably benign Het
Klhl29 T C 12: 5,143,530 (GRCm39) T500A possibly damaging Het
Lrfn5 A C 12: 61,890,660 (GRCm39) K650Q possibly damaging Het
Lrp2 T C 2: 69,331,874 (GRCm39) D1627G possibly damaging Het
Nxn T C 11: 76,152,433 (GRCm39) K354E probably damaging Het
Or5d20-ps1 T A 2: 87,931,879 (GRCm39) I151L probably benign Het
Pcnx2 T C 8: 126,478,895 (GRCm39) T2118A probably benign Het
Phldb2 A G 16: 45,598,105 (GRCm39) F861L possibly damaging Het
Piezo2 A G 18: 63,157,607 (GRCm39) Y2368H probably damaging Het
Pnp T A 14: 51,188,963 (GRCm39) L252* probably null Het
Prom2 T C 2: 127,373,757 (GRCm39) Q641R probably benign Het
Prpf31 T C 7: 3,637,702 (GRCm39) S180P possibly damaging Het
Prss27 C A 17: 24,263,414 (GRCm39) Y142* probably null Het
Ripk1 T G 13: 34,201,082 (GRCm39) M265R probably damaging Het
Rnd2 C T 11: 101,359,825 (GRCm39) L57F probably damaging Het
Ropn1 T A 16: 34,487,161 (GRCm39) D32E probably damaging Het
Rps23 T C 13: 91,071,822 (GRCm39) F41L probably benign Het
Sec24d A G 3: 123,084,201 (GRCm39) I127V probably benign Het
Selenot C T 3: 58,492,692 (GRCm39) R60W probably damaging Het
Tll1 T C 8: 64,546,921 (GRCm39) K342E probably damaging Het
Tlx1 A T 19: 45,144,460 (GRCm39) N61Y probably damaging Het
Vmn2r117 T A 17: 23,679,122 (GRCm39) I701F probably damaging Het
Zmynd12 A G 4: 119,302,047 (GRCm39) K229E probably damaging Het
Other mutations in Gpx5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01351:Gpx5 APN 13 21,471,669 (GRCm39) missense probably damaging 1.00
R0233:Gpx5 UTSW 13 21,471,573 (GRCm39) missense probably damaging 1.00
R0233:Gpx5 UTSW 13 21,471,573 (GRCm39) missense probably damaging 1.00
R1836:Gpx5 UTSW 13 21,471,624 (GRCm39) missense probably benign
R2356:Gpx5 UTSW 13 21,475,538 (GRCm39) missense possibly damaging 0.92
R2495:Gpx5 UTSW 13 21,475,610 (GRCm39) missense probably benign 0.24
R5023:Gpx5 UTSW 13 21,472,915 (GRCm39) missense probably damaging 0.97
R5479:Gpx5 UTSW 13 21,476,805 (GRCm39) missense probably benign
R6166:Gpx5 UTSW 13 21,473,435 (GRCm39) missense probably damaging 1.00
R6370:Gpx5 UTSW 13 21,472,872 (GRCm39) critical splice donor site probably null
R6989:Gpx5 UTSW 13 21,471,669 (GRCm39) missense probably damaging 1.00
R7017:Gpx5 UTSW 13 21,475,561 (GRCm39) missense probably damaging 1.00
R7891:Gpx5 UTSW 13 21,472,918 (GRCm39) missense probably damaging 1.00
R8155:Gpx5 UTSW 13 21,472,917 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTCCCGTGGATGCTAACAGAC -3'
(R):5'- ATGTCACCAACCCCTGCTG -3'

Sequencing Primer
(F):5'- CGTGGATGCTAACAGACTCATATCTC -3'
(R):5'- AACCCCTGCTGCATCTCTAC -3'
Posted On 2016-06-06