Mutagenetix > Incidental Mutation

Incidental Mutation 'R5078:Vmn2r117'

386988

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r117

Ensembl Gene

ENSMUSG00000091407

Gene Name

vomeronasal 2, receptor 117

Synonyms

EG619788, V2Rp6

MMRRC Submission

042667-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

R5078 (G1)

Quality Score

189

Status

Validated

Chromosome

Chromosomal Location

23678649-23698571 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 23679122 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 701 (I701F)

Ref Sequence

ENSEMBL: ENSMUSP00000126885 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171996]

AlphaFold

K7N6V1

Predicted Effect

probably damaging
Transcript: ENSMUST00000171996
AA Change: I701F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000126885
Gene: ENSMUSG00000091407
AA Change: I701F

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	2.6e-28	PFAM
Pfam:NCD3G	512	565	5e-20	PFAM
Pfam:7tm_3	595	833	8.2e-54	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.1%
20x: 94.8%

Validation Efficiency

100% (53/53)

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adcy9	T	C	16: 4,141,771 (GRCm39)	S345G	probably benign	Het
Adgrf2	A	T	17: 43,021,877 (GRCm39)	F316I	probably damaging	Het
Ank2	A	G	3: 126,736,002 (GRCm39)		probably benign	Het
Auts2	T	C	5: 132,287,786 (GRCm39)	K66E	possibly damaging	Het
Bicra	T	C	7: 15,709,382 (GRCm39)	D1144G	probably damaging	Het
Cabin1	A	G	10: 75,557,312 (GRCm39)	S1109P	probably damaging	Het
Camkv	T	C	9: 107,822,572 (GRCm39)	V29A	probably damaging	Het
Ccdc178	A	T	18: 22,200,685 (GRCm39)		probably null	Het
Ccser1	G	A	6: 61,288,350 (GRCm39)	R171H	probably damaging	Het
Cdk19	A	G	10: 40,312,150 (GRCm39)	Y133C	probably damaging	Het
Cerkl	T	A	2: 79,223,352 (GRCm39)	D123V	probably benign	Het
Chd1	T	C	17: 15,946,616 (GRCm39)	S121P	possibly damaging	Het
Col4a2	T	C	8: 11,493,936 (GRCm39)	V1459A	probably benign	Het
Dlg1	T	A	16: 31,675,287 (GRCm39)	Y704*	probably null	Het
Dsg2	T	C	18: 20,729,140 (GRCm39)		probably null	Het
Egln3	T	C	12: 54,228,453 (GRCm39)	R218G	probably damaging	Het
Gm11568	T	C	11: 99,749,181 (GRCm39)	C129R	unknown	Het
Gm13991	T	C	2: 116,358,355 (GRCm39)		noncoding transcript	Het
Gmnc	C	A	16: 26,784,332 (GRCm39)	V58L	probably benign	Het
Gpx5	A	G	13: 21,472,881 (GRCm39)	F151S	probably damaging	Het
Helz	G	A	11: 107,546,922 (GRCm39)	G1079R	probably damaging	Het
Ice1	T	C	13: 70,752,969 (GRCm39)	E1039G	probably benign	Het
Kif18a	T	C	2: 109,125,487 (GRCm39)		probably benign	Het
Klhl29	T	C	12: 5,143,530 (GRCm39)	T500A	possibly damaging	Het
Lrfn5	A	C	12: 61,890,660 (GRCm39)	K650Q	possibly damaging	Het
Lrp2	T	C	2: 69,331,874 (GRCm39)	D1627G	possibly damaging	Het
Nxn	T	C	11: 76,152,433 (GRCm39)	K354E	probably damaging	Het
Or5d20-ps1	T	A	2: 87,931,879 (GRCm39)	I151L	probably benign	Het
Pcnx2	T	C	8: 126,478,895 (GRCm39)	T2118A	probably benign	Het
Phldb2	A	G	16: 45,598,105 (GRCm39)	F861L	possibly damaging	Het
Piezo2	A	G	18: 63,157,607 (GRCm39)	Y2368H	probably damaging	Het
Pnp	T	A	14: 51,188,963 (GRCm39)	L252*	probably null	Het
Prom2	T	C	2: 127,373,757 (GRCm39)	Q641R	probably benign	Het
Prpf31	T	C	7: 3,637,702 (GRCm39)	S180P	possibly damaging	Het
Prss27	C	A	17: 24,263,414 (GRCm39)	Y142*	probably null	Het
Ripk1	T	G	13: 34,201,082 (GRCm39)	M265R	probably damaging	Het
Rnd2	C	T	11: 101,359,825 (GRCm39)	L57F	probably damaging	Het
Ropn1	T	A	16: 34,487,161 (GRCm39)	D32E	probably damaging	Het
Rps23	T	C	13: 91,071,822 (GRCm39)	F41L	probably benign	Het
Sec24d	A	G	3: 123,084,201 (GRCm39)	I127V	probably benign	Het
Selenot	C	T	3: 58,492,692 (GRCm39)	R60W	probably damaging	Het
Tll1	T	C	8: 64,546,921 (GRCm39)	K342E	probably damaging	Het
Tlx1	A	T	19: 45,144,460 (GRCm39)	N61Y	probably damaging	Het
Zmynd12	A	G	4: 119,302,047 (GRCm39)	K229E	probably damaging	Het

Other mutations in Vmn2r117

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r117	APN	17	23,698,520 (GRCm39)	missense	probably benign
IGL00990:Vmn2r117	APN	17	23,696,814 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r117	APN	17	23,694,403 (GRCm39)	missense	probably damaging	1.00
IGL01078:Vmn2r117	APN	17	23,696,778 (GRCm39)	missense	probably damaging	1.00
IGL01139:Vmn2r117	APN	17	23,696,778 (GRCm39)	missense	probably damaging	1.00
IGL01374:Vmn2r117	APN	17	23,697,356 (GRCm39)	missense	possibly damaging	0.46
IGL01779:Vmn2r117	APN	17	23,696,215 (GRCm39)	missense	probably benign	0.00
IGL02283:Vmn2r117	APN	17	23,694,356 (GRCm39)	missense	probably damaging	0.99
IGL02527:Vmn2r117	APN	17	23,696,199 (GRCm39)	missense	possibly damaging	0.65
IGL02612:Vmn2r117	APN	17	23,678,758 (GRCm39)	missense	possibly damaging	0.91
IGL02887:Vmn2r117	APN	17	23,694,552 (GRCm39)	splice site	probably benign
IGL03167:Vmn2r117	APN	17	23,696,681 (GRCm39)	missense	probably damaging	1.00
R0315:Vmn2r117	UTSW	17	23,679,139 (GRCm39)	missense	probably benign	0.11
R0610:Vmn2r117	UTSW	17	23,694,488 (GRCm39)	missense	probably benign	0.00
R0747:Vmn2r117	UTSW	17	23,694,477 (GRCm39)	nonsense	probably null
R1411:Vmn2r117	UTSW	17	23,679,527 (GRCm39)	missense	probably damaging	1.00
R1471:Vmn2r117	UTSW	17	23,697,447 (GRCm39)	missense	probably benign	0.00
R1853:Vmn2r117	UTSW	17	23,696,429 (GRCm39)	missense	probably damaging	0.99
R1925:Vmn2r117	UTSW	17	23,697,363 (GRCm39)	missense	probably benign	0.00
R1940:Vmn2r117	UTSW	17	23,696,454 (GRCm39)	missense	probably damaging	1.00
R2005:Vmn2r117	UTSW	17	23,696,618 (GRCm39)	missense	probably damaging	1.00
R2082:Vmn2r117	UTSW	17	23,679,230 (GRCm39)	missense	possibly damaging	0.55
R2698:Vmn2r117	UTSW	17	23,678,885 (GRCm39)	missense	probably damaging	0.98
R2972:Vmn2r117	UTSW	17	23,678,830 (GRCm39)	missense	probably damaging	1.00
R2973:Vmn2r117	UTSW	17	23,678,830 (GRCm39)	missense	probably damaging	1.00
R2974:Vmn2r117	UTSW	17	23,678,830 (GRCm39)	missense	probably damaging	1.00
R3160:Vmn2r117	UTSW	17	23,679,352 (GRCm39)	missense	probably damaging	1.00
R3161:Vmn2r117	UTSW	17	23,679,352 (GRCm39)	missense	probably damaging	1.00
R3162:Vmn2r117	UTSW	17	23,679,352 (GRCm39)	missense	probably damaging	1.00
R3847:Vmn2r117	UTSW	17	23,679,389 (GRCm39)	missense	probably damaging	0.97
R3848:Vmn2r117	UTSW	17	23,679,389 (GRCm39)	missense	probably damaging	0.97
R4082:Vmn2r117	UTSW	17	23,679,080 (GRCm39)	missense	probably benign	0.00
R4320:Vmn2r117	UTSW	17	23,698,487 (GRCm39)	frame shift	probably null
R4560:Vmn2r117	UTSW	17	23,678,851 (GRCm39)	missense	probably damaging	1.00
R4658:Vmn2r117	UTSW	17	23,697,390 (GRCm39)	missense	probably benign	0.01
R4881:Vmn2r117	UTSW	17	23,696,859 (GRCm39)	missense	probably damaging	1.00
R4908:Vmn2r117	UTSW	17	23,678,812 (GRCm39)	missense	probably damaging	1.00
R4910:Vmn2r117	UTSW	17	23,698,487 (GRCm39)	frame shift	probably null
R5327:Vmn2r117	UTSW	17	23,696,848 (GRCm39)	nonsense	probably null
R5774:Vmn2r117	UTSW	17	23,696,176 (GRCm39)	missense	probably damaging	0.98
R6014:Vmn2r117	UTSW	17	23,698,535 (GRCm39)	missense	probably damaging	0.97
R6390:Vmn2r117	UTSW	17	23,679,088 (GRCm39)	missense	possibly damaging	0.95
R6520:Vmn2r117	UTSW	17	23,679,193 (GRCm39)	missense	probably damaging	0.99
R6674:Vmn2r117	UTSW	17	23,679,023 (GRCm39)	nonsense	probably null
R6736:Vmn2r117	UTSW	17	23,697,282 (GRCm39)	missense	probably damaging	0.99
R6909:Vmn2r117	UTSW	17	23,698,479 (GRCm39)	missense	possibly damaging	0.67
R6913:Vmn2r117	UTSW	17	23,698,537 (GRCm39)	missense	probably damaging	0.99
R7220:Vmn2r117	UTSW	17	23,696,177 (GRCm39)	missense	probably damaging	1.00
R7260:Vmn2r117	UTSW	17	23,694,359 (GRCm39)	missense	probably benign	0.06
R7440:Vmn2r117	UTSW	17	23,694,539 (GRCm39)	missense	probably benign	0.26
R7443:Vmn2r117	UTSW	17	23,679,319 (GRCm39)	missense	probably damaging	1.00
R7443:Vmn2r117	UTSW	17	23,679,107 (GRCm39)	missense	probably benign	0.25
R7449:Vmn2r117	UTSW	17	23,678,869 (GRCm39)	missense	probably damaging	1.00
R7644:Vmn2r117	UTSW	17	23,696,265 (GRCm39)	missense	probably damaging	0.98
R7914:Vmn2r117	UTSW	17	23,679,100 (GRCm39)	missense	possibly damaging	0.95
R8001:Vmn2r117	UTSW	17	23,698,381 (GRCm39)	missense	possibly damaging	0.89
R8029:Vmn2r117	UTSW	17	23,696,744 (GRCm39)	missense	probably benign	0.00
R8340:Vmn2r117	UTSW	17	23,679,511 (GRCm39)	missense	probably benign	0.01
R8519:Vmn2r117	UTSW	17	23,698,442 (GRCm39)	missense	probably benign
R8723:Vmn2r117	UTSW	17	23,696,343 (GRCm39)	missense	probably damaging	1.00
R8914:Vmn2r117	UTSW	17	23,679,143 (GRCm39)	missense	probably benign	0.02
R9010:Vmn2r117	UTSW	17	23,679,445 (GRCm39)	missense	probably benign	0.10
R9129:Vmn2r117	UTSW	17	23,678,918 (GRCm39)	nonsense	probably null
R9244:Vmn2r117	UTSW	17	23,696,589 (GRCm39)	missense	probably damaging	0.98
R9464:Vmn2r117	UTSW	17	23,696,578 (GRCm39)	missense	probably benign	0.23
R9620:Vmn2r117	UTSW	17	23,697,450 (GRCm39)	missense	probably damaging	0.97
V5622:Vmn2r117	UTSW	17	23,698,479 (GRCm39)	missense	possibly damaging	0.67
V5622:Vmn2r117	UTSW	17	23,696,814 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r117	UTSW	17	23,678,740 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GGGTAGCCAAGTATCCCAGAAC -3'
(R):5'- GTGAAGCACCACAGTACTCC -3'

Sequencing Primer
(F):5'- CAGAACACAGTAAAATGCATTGACTG -3'
(R):5'- CAGTACTCCAATTGTTAAGGCC -3'

Posted On

2016-06-06