Incidental Mutation 'R0426:Or5b105'
ID 38699
Institutional Source Beutler Lab
Gene Symbol Or5b105
Ensembl Gene ENSMUSG00000062844
Gene Name olfactory receptor family 5 subfamily B member 105
Synonyms GA_x6K02T2RE5P-3430689-3429787, Olfr1458, MOR202-24, EG667271
MMRRC Submission 038628-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # R0426 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 13079743-13080669 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 13080642 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 3 (R3C)
Ref Sequence ENSEMBL: ENSMUSP00000076019 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076729] [ENSMUST00000207340] [ENSMUST00000215160]
AlphaFold A0A1L1SSD5
Predicted Effect possibly damaging
Transcript: ENSMUST00000076729
AA Change: R3C

PolyPhen 2 Score 0.759 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000076019
Gene: ENSMUSG00000062844
AA Change: R3C

DomainStartEndE-ValueType
Pfam:7tm_4 23 300 7.9e-51 PFAM
Pfam:7TM_GPCR_Srsx 27 297 1.2e-6 PFAM
Pfam:7tm_1 33 282 5.8e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207340
AA Change: R9C
Predicted Effect probably benign
Transcript: ENSMUST00000215160
AA Change: R9C

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 93.9%
Validation Efficiency 96% (86/90)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Feb 2010]
Allele List at MGI
Other mutations in this stock
Total: 87 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b G T 11: 109,845,853 (GRCm39) probably benign Het
Acadl A T 1: 66,880,805 (GRCm39) F320L probably damaging Het
Acsbg1 T C 9: 54,530,030 (GRCm39) D222G probably benign Het
Anapc15 A G 7: 101,547,240 (GRCm39) T39A probably benign Het
Ano3 A T 2: 110,491,519 (GRCm39) V919E probably damaging Het
Arhgef12 T C 9: 42,882,286 (GRCm39) probably null Het
Atad5 T A 11: 80,003,658 (GRCm39) I1091N probably benign Het
Atf1 A T 15: 100,130,708 (GRCm39) H26L possibly damaging Het
Atp10a T C 7: 58,434,482 (GRCm39) M252T probably benign Het
Btbd8 C T 5: 107,658,239 (GRCm39) T1603I probably damaging Het
Cd55 C T 1: 130,376,109 (GRCm39) R347H probably benign Het
Cdc27 A C 11: 104,403,853 (GRCm39) probably null Het
Cdh9 G A 15: 16,823,540 (GRCm39) probably null Het
Cdk11b T C 4: 155,726,969 (GRCm39) probably benign Het
Cep70 A G 9: 99,179,737 (GRCm39) D567G probably benign Het
Cep78 A T 19: 15,948,334 (GRCm39) Y382* probably null Het
Cgas G A 9: 78,343,020 (GRCm39) probably benign Het
Col9a2 T C 4: 120,901,857 (GRCm39) probably benign Het
Cyp2d12 G A 15: 82,443,164 (GRCm39) D409N probably benign Het
Ddx39a A G 8: 84,448,398 (GRCm39) T217A probably benign Het
Dennd1b T A 1: 139,097,934 (GRCm39) D733E probably benign Het
Dicer1 A G 12: 104,668,801 (GRCm39) S1294P probably damaging Het
Dnah3 T C 7: 119,542,795 (GRCm39) E3539G probably benign Het
Dnmbp A G 19: 43,840,875 (GRCm39) probably benign Het
Dysf T C 6: 84,126,739 (GRCm39) L1332P probably damaging Het
F5 A G 1: 164,010,409 (GRCm39) D380G probably damaging Het
Fam171a1 T C 2: 3,226,433 (GRCm39) V522A probably benign Het
Fhip1b A C 7: 105,038,680 (GRCm39) C186W probably damaging Het
Galr2 C A 11: 116,172,517 (GRCm39) A69D probably damaging Het
Grk2 T C 19: 4,340,628 (GRCm39) probably null Het
Gtf3c1 A T 7: 125,262,188 (GRCm39) Y1119* probably null Het
Hgd A T 16: 37,409,047 (GRCm39) probably benign Het
Ildr2 G T 1: 166,136,468 (GRCm39) V436L probably benign Het
Intu G A 3: 40,629,735 (GRCm39) C355Y probably damaging Het
Irf2bpl G T 12: 86,929,870 (GRCm39) P268T probably benign Het
Jarid2 T C 13: 44,994,358 (GRCm39) probably null Het
Jup A T 11: 100,263,227 (GRCm39) M716K probably benign Het
Kank1 G A 19: 25,388,837 (GRCm39) V809I probably damaging Het
Kdm1b T A 13: 47,217,720 (GRCm39) probably benign Het
Kdm3a C T 6: 71,577,739 (GRCm39) C687Y probably damaging Het
Kdm5d T A Y: 942,437 (GRCm39) probably benign Het
Kifap3 T A 1: 163,693,121 (GRCm39) probably benign Het
Macf1 T A 4: 123,377,453 (GRCm39) K1400* probably null Het
Majin A G 19: 6,262,147 (GRCm39) probably benign Het
Mctp1 A G 13: 77,168,940 (GRCm39) I846V probably benign Het
Mrgpra2b T A 7: 47,113,875 (GRCm39) I286F possibly damaging Het
Neil3 T G 8: 54,062,431 (GRCm39) probably benign Het
Nox3 G T 17: 3,745,838 (GRCm39) N23K probably damaging Het
Nt5c3 T C 6: 56,860,797 (GRCm39) K219E probably benign Het
Or1e29 T A 11: 73,667,263 (GRCm39) M297L probably benign Het
Or52b4i T A 7: 102,191,893 (GRCm39) I250N probably damaging Het
Or6b13 A C 7: 139,782,029 (GRCm39) F218C possibly damaging Het
Or6d13 A T 6: 116,517,446 (GRCm39) N11Y probably damaging Het
Or8g34 T C 9: 39,372,889 (GRCm39) L54P probably damaging Het
Pacsin2 A G 15: 83,263,996 (GRCm39) V347A possibly damaging Het
Pcdhb7 A T 18: 37,475,857 (GRCm39) E331V probably damaging Het
Pcid2 A C 8: 13,131,262 (GRCm39) probably null Het
Pcsk9 T C 4: 106,307,274 (GRCm39) D323G possibly damaging Het
Pdhb T C 14: 8,169,801 (GRCm38) E203G probably damaging Het
Phlpp2 A G 8: 110,655,095 (GRCm39) Y630C probably benign Het
Pidd1 C T 7: 141,019,046 (GRCm39) A812T probably damaging Het
Plau G A 14: 20,892,382 (GRCm39) R389H probably benign Het
Plekhg6 G A 6: 125,341,592 (GRCm39) probably null Het
Ppox T C 1: 171,105,322 (GRCm39) Y321C probably damaging Het
Pxdn A G 12: 30,037,065 (GRCm39) N281S possibly damaging Het
Pycr3 A T 15: 75,790,237 (GRCm39) M138K probably benign Het
Radil T C 5: 142,483,628 (GRCm39) Y526C probably damaging Het
Ranbp3 C A 17: 57,014,169 (GRCm39) D233E probably benign Het
Rhpn1 A G 15: 75,583,721 (GRCm39) Q402R possibly damaging Het
Sec23b T A 2: 144,410,532 (GRCm39) probably benign Het
Sel1l2 A T 2: 140,082,832 (GRCm39) L602* probably null Het
Sema5b G A 16: 35,466,725 (GRCm39) G209D probably damaging Het
Svep1 T C 4: 58,073,333 (GRCm39) Y1992C possibly damaging Het
Syncrip T A 9: 88,338,312 (GRCm39) probably benign Het
Synj1 G T 16: 90,764,242 (GRCm39) A65E probably damaging Het
Taar2 G A 10: 23,817,393 (GRCm39) R311H probably benign Het
Tecrl T C 5: 83,502,610 (GRCm39) probably benign Het
Tenm4 G T 7: 96,427,058 (GRCm39) G698C probably damaging Het
Tmem209 G A 6: 30,491,181 (GRCm39) L259F probably damaging Het
Tmem247 G A 17: 87,225,931 (GRCm39) E124K possibly damaging Het
Tnks2 C A 19: 36,830,221 (GRCm39) A218E probably damaging Het
Tppp T A 13: 74,169,430 (GRCm39) F57I probably damaging Het
Trim36 A G 18: 46,305,592 (GRCm39) W452R probably damaging Het
Vars2 A T 17: 35,975,476 (GRCm39) V262E probably damaging Het
Vmn2r92 C T 17: 18,388,219 (GRCm39) A408V probably damaging Het
Zfp516 G T 18: 82,973,897 (GRCm39) A32S probably benign Het
Zfy2 G T Y: 2,107,348 (GRCm39) L429I possibly damaging Het
Other mutations in Or5b105
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01684:Or5b105 APN 19 13,080,353 (GRCm39) missense possibly damaging 0.93
IGL02319:Or5b105 APN 19 13,080,026 (GRCm39) missense probably benign 0.14
IGL02926:Or5b105 APN 19 13,080,187 (GRCm39) missense possibly damaging 0.74
IGL03107:Or5b105 APN 19 13,080,401 (GRCm39) missense probably benign
IGL03304:Or5b105 APN 19 13,080,105 (GRCm39) missense probably damaging 1.00
R0046:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0049:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0099:Or5b105 UTSW 19 13,080,504 (GRCm39) missense probably benign 0.07
R0103:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0144:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0189:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0206:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0207:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0208:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0212:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0344:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0506:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0507:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0607:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0661:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R0734:Or5b105 UTSW 19 13,080,642 (GRCm39) missense possibly damaging 0.76
R1347:Or5b105 UTSW 19 13,080,054 (GRCm39) missense probably benign 0.03
R1347:Or5b105 UTSW 19 13,080,054 (GRCm39) missense probably benign 0.03
R1443:Or5b105 UTSW 19 13,080,568 (GRCm39) nonsense probably null
R1446:Or5b105 UTSW 19 13,080,380 (GRCm39) missense possibly damaging 0.59
R1567:Or5b105 UTSW 19 13,080,006 (GRCm39) missense probably benign 0.00
R2190:Or5b105 UTSW 19 13,079,857 (GRCm39) missense probably damaging 1.00
R2438:Or5b105 UTSW 19 13,079,785 (GRCm39) missense probably benign 0.00
R4020:Or5b105 UTSW 19 13,079,790 (GRCm39) missense probably damaging 0.99
R4406:Or5b105 UTSW 19 13,079,958 (GRCm39) missense possibly damaging 0.70
R4631:Or5b105 UTSW 19 13,080,636 (GRCm39) missense probably benign 0.07
R4847:Or5b105 UTSW 19 13,079,898 (GRCm39) missense probably damaging 1.00
R4979:Or5b105 UTSW 19 13,080,053 (GRCm39) missense probably damaging 0.97
R6086:Or5b105 UTSW 19 13,079,745 (GRCm39) makesense probably null
R6480:Or5b105 UTSW 19 13,079,838 (GRCm39) missense probably benign 0.34
R6484:Or5b105 UTSW 19 13,080,431 (GRCm39) missense probably benign 0.34
R6786:Or5b105 UTSW 19 13,080,567 (GRCm39) missense probably benign 0.09
R7121:Or5b105 UTSW 19 13,080,537 (GRCm39) missense probably benign 0.03
R7547:Or5b105 UTSW 19 13,080,407 (GRCm39) missense not run
R7822:Or5b105 UTSW 19 13,080,417 (GRCm39) missense probably benign 0.00
R7949:Or5b105 UTSW 19 13,080,610 (GRCm39) splice site probably null
R8219:Or5b105 UTSW 19 13,080,284 (GRCm39) missense probably damaging 1.00
R8441:Or5b105 UTSW 19 13,080,020 (GRCm39) missense probably damaging 0.98
R8458:Or5b105 UTSW 19 13,079,840 (GRCm39) missense probably damaging 1.00
R9283:Or5b105 UTSW 19 13,079,821 (GRCm39) missense probably damaging 0.99
R9330:Or5b105 UTSW 19 13,080,588 (GRCm39) missense probably benign 0.10
R9592:Or5b105 UTSW 19 13,079,906 (GRCm39) missense probably benign 0.13
R9677:Or5b105 UTSW 19 13,080,518 (GRCm39) missense probably damaging 0.99
R9725:Or5b105 UTSW 19 13,080,272 (GRCm39) missense possibly damaging 0.74
X0024:Or5b105 UTSW 19 13,080,573 (GRCm39) missense probably benign 0.22
X0027:Or5b105 UTSW 19 13,080,588 (GRCm39) missense probably benign 0.10
Predicted Primers
Posted On 2013-05-23