Incidental Mutation 'R5079:Or5w13'
ID 387001
Institutional Source Beutler Lab
Gene Symbol Or5w13
Ensembl Gene ENSMUSG00000075151
Gene Name olfactory receptor family 5 subfamily W member 13
Synonyms Olfr1136, MOR177-3, GA_x6K02T2Q125-49193051-49192119
MMRRC Submission 042668-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.189) question?
Stock # R5079 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87523225-87524291 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 87523552 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Phenylalanine at position 225 (V225F)
Ref Sequence ENSEMBL: ENSMUSP00000076681 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077471] [ENSMUST00000099852]
AlphaFold Q0VBI4
Predicted Effect probably damaging
Transcript: ENSMUST00000077471
AA Change: V225F

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000076681
Gene: ENSMUSG00000075151
AA Change: V225F

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 6e-48 PFAM
Pfam:7tm_1 40 289 2e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000099852
AA Change: V225F

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000097438
Gene: ENSMUSG00000068815
AA Change: V225F

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2e-41 PFAM
Pfam:7tm_1 41 290 4.3e-14 PFAM
Meta Mutation Damage Score 0.2777 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 91.6%
Validation Efficiency 90% (63/70)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522L14Rik T C 5: 109,885,196 (GRCm39) S221G probably benign Het
Abca9 A T 11: 110,036,395 (GRCm39) F571L possibly damaging Het
Agbl4 T A 4: 111,423,826 (GRCm39) M284K possibly damaging Het
Ankrd16 A G 2: 11,783,710 (GRCm39) D104G probably damaging Het
Bpifc T C 10: 85,817,168 (GRCm39) D230G probably damaging Het
Casc3 C T 11: 98,701,252 (GRCm39) probably benign Het
Catsperd T C 17: 56,965,153 (GRCm39) probably null Het
Cpxm2 C T 7: 131,756,014 (GRCm39) probably null Het
Crisp1 A T 17: 40,619,867 (GRCm39) probably null Het
Crybg2 T C 4: 133,801,564 (GRCm39) I908T possibly damaging Het
Csn3 T C 5: 88,077,626 (GRCm39) V44A possibly damaging Het
Dipk1c A T 18: 84,748,702 (GRCm39) H100L probably benign Het
Dop1a T A 9: 86,369,474 (GRCm39) D102E probably damaging Het
Etfdh T C 3: 79,525,705 (GRCm39) Y111C probably damaging Het
Fat3 T C 9: 15,910,423 (GRCm39) S1860G probably benign Het
Gba2 G T 4: 43,568,640 (GRCm39) probably benign Het
Ggta1 A G 2: 35,312,249 (GRCm39) I43T possibly damaging Het
Glb1l2 T C 9: 26,682,405 (GRCm39) I149V probably benign Het
Gm5084 T A 13: 60,360,639 (GRCm39) noncoding transcript Het
Gm5591 G T 7: 38,221,560 (GRCm39) P170T probably benign Het
Gucy2d A T 7: 98,107,475 (GRCm39) probably null Het
Itpr3 T C 17: 27,317,397 (GRCm39) F851L probably damaging Het
Kat2b T A 17: 53,970,666 (GRCm39) I684N probably damaging Het
Klra17 C A 6: 129,849,159 (GRCm39) K138N possibly damaging Het
Lrrc4 T A 6: 28,830,769 (GRCm39) H282L possibly damaging Het
Lyst T C 13: 13,931,938 (GRCm39) I3522T probably benign Het
Man2c1 A G 9: 57,044,000 (GRCm39) T312A probably damaging Het
Mapkbp1 A G 2: 119,844,214 (GRCm39) R313G probably damaging Het
N4bp2 G A 5: 65,969,320 (GRCm39) G1361R probably damaging Het
Nbas A T 12: 13,424,712 (GRCm39) I984F probably damaging Het
Ncor1 T A 11: 62,236,063 (GRCm39) Q579L possibly damaging Het
Nme9 A G 9: 99,341,755 (GRCm39) Y35C probably damaging Het
Ormdl1 T C 1: 53,348,093 (GRCm39) V145A probably damaging Het
Paxbp1 C A 16: 90,822,034 (GRCm39) probably null Het
Pcnx1 C A 12: 82,025,863 (GRCm39) S1530* probably null Het
Pogk A G 1: 166,226,733 (GRCm39) W473R probably damaging Het
Pot1b A T 17: 55,976,801 (GRCm39) S374T probably benign Het
Rcn1 A G 2: 105,229,402 (GRCm39) F50S probably damaging Het
Rcvrn T A 11: 67,593,767 (GRCm39) I186N probably damaging Het
Rnd2 C T 11: 101,359,825 (GRCm39) L57F probably damaging Het
Ror1 T A 4: 100,298,619 (GRCm39) I664N probably damaging Het
Sall2 G T 14: 52,552,211 (GRCm39) A326E probably damaging Het
Sh2d6 G A 6: 72,496,833 (GRCm39) P66S probably benign Het
Slc6a20b T A 9: 123,427,563 (GRCm39) S449C probably damaging Het
Slc9a3 A T 13: 74,312,406 (GRCm39) N668Y probably damaging Het
Slco1a8 A C 6: 141,918,073 (GRCm39) I601R probably benign Het
Sorcs2 T G 5: 36,200,796 (GRCm39) K584T probably damaging Het
Stam T C 2: 14,079,350 (GRCm39) M8T probably benign Het
Styk1 G A 6: 131,278,676 (GRCm39) P333S probably damaging Het
Sycp1 A G 3: 102,786,116 (GRCm39) C589R possibly damaging Het
Tas2r123 A G 6: 132,824,681 (GRCm39) I193V probably benign Het
Tnks1bp1 C A 2: 84,892,970 (GRCm39) Q304K probably damaging Het
Traf3ip2 T C 10: 39,502,473 (GRCm39) L207P probably damaging Het
Usp49 A G 17: 47,984,146 (GRCm39) S384G possibly damaging Het
Vezt T C 10: 93,856,486 (GRCm39) probably null Het
Vmn1r87 C A 7: 12,866,253 (GRCm39) M11I probably benign Het
Vmn2r39 A G 7: 9,026,489 (GRCm39) V504A probably benign Het
Wapl G A 14: 34,446,714 (GRCm39) A607T probably damaging Het
Zfp638 A G 6: 83,906,438 (GRCm39) N201S probably benign Het
Other mutations in Or5w13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01809:Or5w13 APN 2 87,524,089 (GRCm39) missense possibly damaging 0.73
IGL02190:Or5w13 APN 2 87,523,407 (GRCm39) missense probably benign 0.21
IGL02902:Or5w13 APN 2 87,523,344 (GRCm39) missense probably damaging 1.00
PIT4508001:Or5w13 UTSW 2 87,524,059 (GRCm39) missense probably damaging 1.00
R0153:Or5w13 UTSW 2 87,523,948 (GRCm39) missense probably benign 0.05
R0665:Or5w13 UTSW 2 87,524,152 (GRCm39) missense probably benign 0.00
R1462:Or5w13 UTSW 2 87,523,720 (GRCm39) missense probably damaging 1.00
R1462:Or5w13 UTSW 2 87,523,720 (GRCm39) missense probably damaging 1.00
R1518:Or5w13 UTSW 2 87,523,872 (GRCm39) missense probably damaging 1.00
R1812:Or5w13 UTSW 2 87,523,447 (GRCm39) missense probably benign 0.01
R1993:Or5w13 UTSW 2 87,523,777 (GRCm39) missense probably benign 0.07
R2098:Or5w13 UTSW 2 87,524,073 (GRCm39) missense probably benign 0.25
R3106:Or5w13 UTSW 2 87,523,849 (GRCm39) missense probably damaging 0.98
R4622:Or5w13 UTSW 2 87,523,987 (GRCm39) nonsense probably null
R4694:Or5w13 UTSW 2 87,524,104 (GRCm39) missense probably benign 0.03
R5474:Or5w13 UTSW 2 87,523,401 (GRCm39) missense probably damaging 1.00
R6432:Or5w13 UTSW 2 87,523,872 (GRCm39) missense probably damaging 1.00
R6667:Or5w13 UTSW 2 87,523,914 (GRCm39) missense probably benign 0.00
R7519:Or5w13 UTSW 2 87,523,753 (GRCm39) missense probably benign 0.01
R7652:Or5w13 UTSW 2 87,523,704 (GRCm39) missense probably damaging 1.00
R7657:Or5w13 UTSW 2 87,523,336 (GRCm39) missense probably damaging 0.99
R8230:Or5w13 UTSW 2 87,523,705 (GRCm39) missense probably damaging 1.00
R8439:Or5w13 UTSW 2 87,524,088 (GRCm39) missense probably damaging 1.00
R8799:Or5w13 UTSW 2 87,524,057 (GRCm39) missense possibly damaging 0.73
R9448:Or5w13 UTSW 2 87,523,824 (GRCm39) missense probably damaging 0.98
R9657:Or5w13 UTSW 2 87,524,121 (GRCm39) missense probably damaging 1.00
Z1176:Or5w13 UTSW 2 87,523,495 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGAGCCTGACCAATGCTTC -3'
(R):5'- GGCATTCAGCTTATGTTTCTGC -3'

Sequencing Primer
(F):5'- TCAGAGGGTTTATCATAGGGATAAC -3'
(R):5'- TGCCACTCTACTCAGATCAATC -3'
Posted On 2016-06-06