Incidental Mutation 'R5080:Or2y1b'
ID 387088
Institutional Source Beutler Lab
Gene Symbol Or2y1b
Ensembl Gene ENSMUSG00000100923
Gene Name olfactory receptor family 2 subfamily Y member 1B
Synonyms L45, MOR256-55, Olfr10, GA_x6K02T2QP88-6117098-6116163
MMRRC Submission 042669-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R5080 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 49208375-49209310 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 49208914 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 180 (M180I)
Ref Sequence ENSEMBL: ENSMUSP00000149724 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000187570] [ENSMUST00000215671] [ENSMUST00000217290]
AlphaFold Q60883
Predicted Effect probably benign
Transcript: ENSMUST00000187570
AA Change: M180I

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000139744
Gene: ENSMUSG00000100923
AA Change: M180I

DomainStartEndE-ValueType
low complexity region 23 34 N/A INTRINSIC
Pfam:7TM_GPCR_Srsx 35 222 4.7e-7 PFAM
Pfam:7tm_1 41 289 1.3e-33 PFAM
Pfam:7tm_4 139 282 4.6e-43 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215671
Predicted Effect probably benign
Transcript: ENSMUST00000217290
AA Change: M180I

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
Meta Mutation Damage Score 0.2003 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 92.5%
Validation Efficiency 96% (54/56)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acod1 G A 14: 103,286,744 (GRCm39) G16S possibly damaging Het
Adcy4 A T 14: 56,009,832 (GRCm39) M740K probably damaging Het
Atp1a2 T C 1: 172,112,012 (GRCm39) probably benign Het
Atrn T A 2: 130,812,044 (GRCm39) I663N possibly damaging Het
Cacna2d1 T C 5: 16,567,394 (GRCm39) probably null Het
Carf C A 1: 60,189,772 (GRCm39) Q631K probably damaging Het
Ces1d T C 8: 93,908,175 (GRCm39) D306G probably benign Het
Corin T A 5: 72,511,194 (GRCm39) probably benign Het
Csf1r T C 18: 61,257,373 (GRCm39) F575L probably damaging Het
Dcaf6 T C 1: 165,247,690 (GRCm39) D181G probably damaging Het
Dnah11 C T 12: 118,162,565 (GRCm39) M1I probably null Het
Dnah7b C T 1: 46,221,540 (GRCm39) R1215* probably null Het
Dpp3 T A 19: 4,965,108 (GRCm39) D464V probably benign Het
Drosha C A 15: 12,842,229 (GRCm39) A344D probably benign Het
Fat3 G T 9: 15,910,634 (GRCm39) S1789R probably benign Het
Fhip2a A T 19: 57,361,713 (GRCm39) K134I probably damaging Het
Frg2f1 T C 4: 119,388,230 (GRCm39) T90A possibly damaging Het
Frrs1 T C 3: 116,696,585 (GRCm39) I544T probably benign Het
Gm20939 T C 17: 95,184,419 (GRCm39) C356R probably damaging Het
Ifi206 T A 1: 173,301,414 (GRCm39) I755F possibly damaging Het
Kntc1 T A 5: 123,900,649 (GRCm39) V249E possibly damaging Het
Lama5 A T 2: 179,848,993 (GRCm39) L230* probably null Het
Lce1e C T 3: 92,615,137 (GRCm39) C70Y unknown Het
Ltbp2 T C 12: 84,850,638 (GRCm39) N892S probably damaging Het
Mfsd4b5 T A 10: 39,846,570 (GRCm39) M337L probably damaging Het
Noxo1 T A 17: 24,918,331 (GRCm39) C164S probably damaging Het
Or5j3 G A 2: 86,128,258 (GRCm39) V33M probably benign Het
Osbpl6 T C 2: 76,354,429 (GRCm39) S15P probably benign Het
Pcdh17 A G 14: 84,770,750 (GRCm39) Y1076C probably benign Het
Pik3c2a T A 7: 115,947,509 (GRCm39) H1391L probably damaging Het
Plcg2 A G 8: 118,316,742 (GRCm39) Y573C probably benign Het
Prpf3 T A 3: 95,741,109 (GRCm39) H600L probably benign Het
Rilpl2 T C 5: 124,607,876 (GRCm39) T115A probably benign Het
Rpl15-ps6 A G 15: 52,341,446 (GRCm39) noncoding transcript Het
Serpini1 T C 3: 75,523,967 (GRCm39) S192P probably damaging Het
Sp110 G T 1: 85,523,776 (GRCm39) Y18* probably null Het
Stard6 A T 18: 70,629,293 (GRCm39) I126F probably damaging Het
Strip2 T A 6: 29,945,592 (GRCm39) L660H probably damaging Het
Tmed3 G A 9: 89,581,825 (GRCm39) R213* probably null Het
Tns1 G T 1: 73,992,099 (GRCm39) P860T probably damaging Het
Togaram1 T C 12: 65,030,177 (GRCm39) S994P probably benign Het
Tomm34 G A 2: 163,912,816 (GRCm39) probably benign Het
Trank1 G A 9: 111,218,289 (GRCm39) E1890K probably damaging Het
Wasf3 C T 5: 146,397,907 (GRCm39) H225Y probably benign Het
Wdr37 A T 13: 8,897,710 (GRCm39) probably null Het
Zbtb7c A C 18: 76,270,413 (GRCm39) D167A probably benign Het
Zkscan4 A G 13: 21,665,498 (GRCm39) T158A probably benign Het
Other mutations in Or2y1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01349:Or2y1b APN 11 49,209,127 (GRCm39) nonsense probably null 0.00
IGL02283:Or2y1b APN 11 49,209,162 (GRCm39) missense probably benign
IGL03010:Or2y1b APN 11 49,208,973 (GRCm39) missense probably damaging 0.99
R0575:Or2y1b UTSW 11 49,208,880 (GRCm39) missense probably damaging 1.00
R1430:Or2y1b UTSW 11 49,208,928 (GRCm39) splice site probably null
R1891:Or2y1b UTSW 11 49,208,684 (GRCm39) missense probably benign 0.00
R2509:Or2y1b UTSW 11 49,209,048 (GRCm39) missense probably damaging 0.97
R2511:Or2y1b UTSW 11 49,209,048 (GRCm39) missense probably damaging 0.97
R4942:Or2y1b UTSW 11 49,208,375 (GRCm39) start codon destroyed probably null 0.99
R5413:Or2y1b UTSW 11 49,209,240 (GRCm39) missense probably damaging 1.00
R5843:Or2y1b UTSW 11 49,209,076 (GRCm39) missense probably benign 0.34
R6354:Or2y1b UTSW 11 49,208,465 (GRCm39) missense probably damaging 0.98
R6605:Or2y1b UTSW 11 49,208,541 (GRCm39) missense probably damaging 0.97
R8005:Or2y1b UTSW 11 49,208,968 (GRCm39) missense probably benign 0.12
R8284:Or2y1b UTSW 11 49,209,002 (GRCm39) missense probably benign
R8902:Or2y1b UTSW 11 49,209,206 (GRCm39) missense probably benign 0.03
R9003:Or2y1b UTSW 11 49,209,155 (GRCm39) missense possibly damaging 0.66
R9431:Or2y1b UTSW 11 49,208,459 (GRCm39) missense probably benign
R9696:Or2y1b UTSW 11 49,208,390 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TATTTCTTGCTCTGGGATCCACAG -3'
(R):5'- GCCTTTCTGCGTGCAGTTAC -3'

Sequencing Primer
(F):5'- ACAGAGAGTGTGCTCCTGG -3'
(R):5'- GCGTGCAGTTACTGACTTGACC -3'
Posted On 2016-06-06