Mutagenetix > Incidental Mutation

Incidental Mutation 'R0427:Or13c7'

38729

Institutional Source

Beutler Lab

Gene Symbol

Or13c7

Ensembl Gene

ENSMUSG00000071000

Gene Name

olfactory receptor family 13 subfamily C member 7

Synonyms

MOR262-14, mOR37a, OR37A, GA_x6K02T2N78B-16092200-16091241, Olfr37a, Olfr155

MMRRC Submission

038629-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R0427 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

43854292-43855463 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 43854417 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 36 (Y36C)

Ref Sequence

ENSEMBL: ENSMUSP00000103492 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095108] [ENSMUST00000107860]

AlphaFold

Q9QZ22

Predicted Effect

probably damaging
Transcript: ENSMUST00000095108
AA Change: Y36C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000092726
Gene: ENSMUSG00000071000
AA Change: Y36C

Domain	Start	End	E-Value	Type
Pfam:7tm_1	42	297	2.8e-35	PFAM
Pfam:7tm_4	140	290	1.4e-45	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000107860
AA Change: Y36C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000103492
Gene: ENSMUSG00000071000
AA Change: Y36C

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	315	9.7e-59	PFAM
Pfam:7tm_1	42	297	3.5e-25	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.2%
20x: 92.9%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 79 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam34	T	G	8: 44,105,493 (GRCm39)	T51P	probably benign	Het
Alpk1	A	T	3: 127,464,720 (GRCm39)	V1186E	probably damaging	Het
Ankfn1	T	C	11: 89,296,423 (GRCm39)	D102G	probably damaging	Het
Armc2	A	G	10: 41,876,406 (GRCm39)	I127T	possibly damaging	Het
Atp6v1b2	T	C	8: 69,554,084 (GRCm39)	L87P	probably damaging	Het
Atp9a	T	A	2: 168,482,617 (GRCm39)		probably null	Het
BC048679	C	G	7: 81,144,993 (GRCm39)	V123L	probably benign	Het
Birc7	G	A	2: 180,571,307 (GRCm39)		probably null	Het
Btbd9	C	T	17: 30,493,916 (GRCm39)	D492N	possibly damaging	Het
Cacna1d	T	A	14: 30,068,774 (GRCm39)	N155I	probably damaging	Het
Cd300lg	T	C	11: 101,933,852 (GRCm39)	V33A	probably damaging	Het
Cep290	A	G	10: 100,352,041 (GRCm39)	D742G	probably benign	Het
Cep95	A	G	11: 106,681,578 (GRCm39)	N14S	probably benign	Het
Cfap74	A	T	4: 155,525,734 (GRCm39)	M728L	probably benign	Het
Ctsll3	T	A	13: 60,949,205 (GRCm39)	T9S	probably benign	Het
Cyp3a44	A	G	5: 145,716,412 (GRCm39)	S393P	possibly damaging	Het
Dmbt1	T	A	7: 130,642,632 (GRCm39)	L150*	probably null	Het
Dnah2	A	G	11: 69,343,705 (GRCm39)	I2868T	probably damaging	Het
Dop1a	A	G	9: 86,389,585 (GRCm39)	H505R	probably damaging	Het
Exo1	A	G	1: 175,733,519 (GRCm39)	K781R	probably damaging	Het
Fam184a	A	G	10: 53,566,211 (GRCm39)	Y459H	probably damaging	Het
Foxp1	C	T	6: 98,907,164 (GRCm39)	D540N	probably damaging	Het
Fstl5	T	A	3: 76,615,034 (GRCm39)	Y698*	probably null	Het
Gm5141	T	C	13: 62,922,525 (GRCm39)	K215E	probably damaging	Het
Grik5	C	A	7: 24,757,923 (GRCm39)	R386L	probably benign	Het
Ikbke	A	T	1: 131,185,647 (GRCm39)	S620R	possibly damaging	Het
Kcnh3	A	T	15: 99,131,180 (GRCm39)	M518L	probably benign	Het
Lrrcc1	G	T	3: 14,623,416 (GRCm39)	A748S	probably damaging	Het
Mbd5	T	G	2: 49,169,091 (GRCm39)	S1191A	probably benign	Het
Med27	T	C	2: 29,390,283 (GRCm39)	I70T	probably damaging	Het
Mplkipl1	A	G	19: 61,163,908 (GRCm39)	Y176H	probably damaging	Het
Myh4	A	G	11: 67,149,479 (GRCm39)	D1737G	probably damaging	Het
Myo5a	A	G	9: 75,081,478 (GRCm39)	D1021G	probably benign	Het
Ncor1	T	C	11: 62,301,746 (GRCm39)	E212G	probably damaging	Het
Neb	A	T	2: 52,133,896 (GRCm39)	N3362K	possibly damaging	Het
Neb	A	G	2: 52,134,081 (GRCm39)	S3301P	probably damaging	Het
Neurod1	T	G	2: 79,284,526 (GRCm39)	K286Q	probably damaging	Het
Noc3l	T	C	19: 38,778,095 (GRCm39)	Q773R	probably benign	Het
Nup205	T	A	6: 35,171,398 (GRCm39)	N420K	probably benign	Het
Olfml3	A	T	3: 103,644,330 (GRCm39)	V113E	probably benign	Het
Opa1	T	C	16: 29,430,279 (GRCm39)	V439A	probably damaging	Het
Or14j7	A	T	17: 38,234,520 (GRCm39)	H21L	probably benign	Het
Or1j14	C	T	2: 36,417,994 (GRCm39)	S190L	probably damaging	Het
Or1o11	T	A	17: 37,756,593 (GRCm39)	D60E	probably damaging	Het
Pcdhb11	T	C	18: 37,555,818 (GRCm39)	S383P	probably damaging	Het
Pkd1	T	C	17: 24,812,476 (GRCm39)	V3803A	probably damaging	Het
Plekhg1	A	G	10: 3,914,235 (GRCm39)	D1319G	probably benign	Het
Polq	T	A	16: 36,882,355 (GRCm39)	C1227*	probably null	Het
Pramel22	A	T	4: 143,380,993 (GRCm39)	N343K	probably benign	Het
Psmc1	T	C	12: 100,085,487 (GRCm39)	F283L	probably damaging	Het
Psmd8	T	C	7: 28,875,552 (GRCm39)	N189S	probably damaging	Het
Ptger4	G	A	15: 5,272,382 (GRCm39)	T104I	probably benign	Het
Ptpro	T	G	6: 137,345,294 (GRCm39)	V100G	possibly damaging	Het
Rab11fip1	T	A	8: 27,644,520 (GRCm39)	T422S	probably damaging	Het
Rad54l2	A	G	9: 106,570,891 (GRCm39)	L1143P	possibly damaging	Het
Rnf148	A	G	6: 23,654,072 (GRCm39)	M308T	probably damaging	Het
Sbsn	T	A	7: 30,451,523 (GRCm39)		probably benign	Het
Scube2	T	A	7: 109,424,044 (GRCm39)	T487S	probably benign	Het
Sema4c	C	A	1: 36,592,892 (GRCm39)	E109*	probably null	Het
Sipa1l2	A	T	8: 126,207,071 (GRCm39)	L544Q	probably damaging	Het
Slc28a2	A	G	2: 122,288,702 (GRCm39)	T603A	probably benign	Het
Tbc1d7	T	A	13: 43,306,563 (GRCm39)	T138S	probably benign	Het
Timd4	A	T	11: 46,710,084 (GRCm39)	T239S	probably benign	Het
Trp53bp1	A	G	2: 121,066,498 (GRCm39)	S743P	probably damaging	Het
Tspan10	T	A	11: 120,335,120 (GRCm39)	Y77N	probably damaging	Het
Ttc14	T	C	3: 33,857,633 (GRCm39)	S245P	probably damaging	Het
Ttf1	T	A	2: 28,955,054 (GRCm39)	S139R	probably benign	Het
Tubd1	C	A	11: 86,448,616 (GRCm39)	Q279K	possibly damaging	Het
Twnk	A	G	19: 44,996,026 (GRCm39)	E153G	probably benign	Het
Ush2a	A	G	1: 188,132,478 (GRCm39)	D900G	probably damaging	Het
Usp54	A	G	14: 20,620,432 (GRCm39)	V691A	probably benign	Het
Usp8	T	C	2: 126,559,952 (GRCm39)		probably benign	Het
Vmn1r231	C	T	17: 21,110,490 (GRCm39)	V142I	probably benign	Het
Vmn2r15	C	T	5: 109,434,953 (GRCm39)	A584T	probably damaging	Het
Vmn2r6	A	G	3: 64,467,008 (GRCm39)	S164P	probably damaging	Het
Vps16	A	G	2: 130,280,770 (GRCm39)	Y233C	probably benign	Het
Vwf	C	G	6: 125,650,902 (GRCm39)	H2511D	probably benign	Het
Wipf3	T	G	6: 54,460,882 (GRCm39)	L110R	possibly damaging	Het
Zfp945	T	A	17: 23,084,226 (GRCm39)	N11I	probably benign	Het

Other mutations in Or13c7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02729:Or13c7	APN	4	43,854,439 (GRCm39)	missense	probably damaging	1.00
R0240:Or13c7	UTSW	4	43,854,512 (GRCm39)	missense	probably damaging	1.00
R0240:Or13c7	UTSW	4	43,854,512 (GRCm39)	missense	probably damaging	1.00
R0285:Or13c7	UTSW	4	43,854,398 (GRCm39)	missense	possibly damaging	0.46
R4468:Or13c7	UTSW	4	43,854,737 (GRCm39)	missense	probably benign	0.08
R4548:Or13c7	UTSW	4	43,854,834 (GRCm39)	missense	probably damaging	1.00
R4583:Or13c7	UTSW	4	43,855,262 (GRCm39)	missense	probably benign
R4793:Or13c7	UTSW	4	43,854,323 (GRCm39)	missense	probably benign	0.37
R4884:Or13c7	UTSW	4	43,854,890 (GRCm39)	missense	probably damaging	1.00
R5016:Or13c7	UTSW	4	43,854,596 (GRCm39)	missense	probably benign	0.02
R5220:Or13c7	UTSW	4	43,854,624 (GRCm39)	missense	possibly damaging	0.89
R5613:Or13c7	UTSW	4	43,854,528 (GRCm39)	missense	probably damaging	0.99
R5805:Or13c7	UTSW	4	43,855,152 (GRCm39)	missense	probably benign	0.15
R5955:Or13c7	UTSW	4	43,854,898 (GRCm39)	missense	probably damaging	1.00
R6250:Or13c7	UTSW	4	43,854,363 (GRCm39)	missense	possibly damaging	0.58
R6768:Or13c7	UTSW	4	43,854,351 (GRCm39)	missense	probably benign	0.01
R6801:Or13c7	UTSW	4	43,855,206 (GRCm39)	nonsense	probably null
R6835:Or13c7	UTSW	4	43,854,912 (GRCm39)	missense	probably benign	0.00
R7510:Or13c7	UTSW	4	43,854,482 (GRCm39)	missense	probably benign	0.20
R8013:Or13c7	UTSW	4	43,854,958 (GRCm39)	missense	probably benign	0.00
R8014:Or13c7	UTSW	4	43,854,958 (GRCm39)	missense	probably benign	0.00
R8312:Or13c7	UTSW	4	43,854,461 (GRCm39)	missense	probably benign	0.04
R9116:Or13c7	UTSW	4	43,854,602 (GRCm39)	missense	probably damaging	1.00
R9636:Or13c7	UTSW	4	43,854,898 (GRCm39)	missense	probably damaging	1.00
R9643:Or13c7	UTSW	4	43,855,183 (GRCm39)	missense	probably benign	0.31
W0251:Or13c7	UTSW	4	43,855,058 (GRCm39)	missense	probably benign	0.42

Predicted Primers

PCR Primer
(F):5'- ACACTGGTCCTTGTGCATCAAGTC -3'
(R):5'- ATACTCAGGAGCACACACTCCGTG -3'

Sequencing Primer
(F):5'- tgttttatacactttgccgttttttc -3'
(R):5'- CGAGAAGGAGATGGTCTTCCTG -3'

Posted On

2013-05-23