Incidental Mutation 'R5084:Or7g17'
ID 387313
Institutional Source Beutler Lab
Gene Symbol Or7g17
Ensembl Gene ENSMUSG00000051414
Gene Name olfactory receptor family 7 subfamily G member 17
Synonyms Olfr829, GA_x6K02T2PVTD-12599710-12600648, MOR147-1
MMRRC Submission 042673-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.231) question?
Stock # R5084 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 18767923-18768888 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 18768632 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 237 (M237K)
Ref Sequence ENSEMBL: ENSMUSP00000058101 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058411] [ENSMUST00000212229]
AlphaFold Q8VGX1
Predicted Effect probably benign
Transcript: ENSMUST00000058411
AA Change: M237K

PolyPhen 2 Score 0.431 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000058101
Gene: ENSMUSG00000051414
AA Change: M237K

DomainStartEndE-ValueType
Pfam:7tm_4 40 317 2e-52 PFAM
Pfam:7TM_GPCR_Srsx 44 174 1e-10 PFAM
Pfam:7tm_1 50 299 1.6e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212229
AA Change: M228K

PolyPhen 2 Score 0.175 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.3%
  • 20x: 92.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp3 T A 9: 104,204,116 (GRCm39) E59D probably damaging Het
Akap7 T A 10: 25,155,640 (GRCm39) probably benign Het
Anpep C A 7: 79,476,618 (GRCm39) probably null Het
Aste1 T A 9: 105,274,886 (GRCm39) Y314* probably null Het
Ccdc183 G A 2: 25,498,802 (GRCm39) T497I probably damaging Het
Cd4 A T 6: 124,847,402 (GRCm39) I254N probably damaging Het
Crot G T 5: 9,019,994 (GRCm39) H449Q probably damaging Het
Dact2 A T 17: 14,418,214 (GRCm39) W164R possibly damaging Het
Dapk3 C A 10: 81,026,152 (GRCm39) probably null Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Fbrsl1 G A 5: 110,527,272 (GRCm39) probably benign Het
Flg T C 3: 93,184,922 (GRCm39) F15L probably damaging Het
Fscn2 A G 11: 120,252,686 (GRCm39) D51G probably damaging Het
H2-Ob G T 17: 34,460,102 (GRCm39) G71V probably damaging Het
Hmgcs1 T C 13: 120,161,520 (GRCm39) V104A possibly damaging Het
Hs3st4 G T 7: 123,996,518 (GRCm39) D395Y probably damaging Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Ldlrad3 G A 2: 101,900,329 (GRCm39) R58C probably damaging Het
Lpin1 A G 12: 16,626,983 (GRCm39) S188P probably damaging Het
Mamdc2 G T 19: 23,336,516 (GRCm39) T331K possibly damaging Het
Matr3 G A 18: 35,715,135 (GRCm39) S195N probably damaging Het
Nktr T C 9: 121,577,176 (GRCm39) Y390H possibly damaging Het
Notch3 C T 17: 32,376,864 (GRCm39) probably null Het
Olfm3 T C 3: 114,698,202 (GRCm39) probably null Het
Or10ak11 A G 4: 118,686,767 (GRCm39) V290A probably damaging Het
Or2a20 T C 6: 43,194,594 (GRCm39) L249P probably damaging Het
Or5h25 C T 16: 58,930,436 (GRCm39) C179Y possibly damaging Het
Or7e173 T A 9: 19,938,551 (GRCm39) I228F probably damaging Het
Pask A G 1: 93,249,819 (GRCm39) V527A probably benign Het
Pcdha6 A T 18: 37,102,016 (GRCm39) N403I probably damaging Het
Peg3 T C 7: 6,710,848 (GRCm39) E1458G probably damaging Het
Pip4k2b G A 11: 97,610,569 (GRCm39) T386M probably damaging Het
Pkd1l1 T C 11: 8,892,004 (GRCm39) M272V probably benign Het
Plcb4 A G 2: 135,844,571 (GRCm39) E163G probably damaging Het
Plk5 C A 10: 80,194,723 (GRCm39) R149S possibly damaging Het
Pou4f3 A T 18: 42,528,933 (GRCm39) Y292F probably damaging Het
Rasgef1c A G 11: 49,860,332 (GRCm39) K272E probably damaging Het
Rbl2 C T 8: 91,841,759 (GRCm39) T942M probably benign Het
Sipa1l3 G A 7: 29,048,000 (GRCm39) S247F probably damaging Het
Smarca4 T C 9: 21,572,059 (GRCm39) L777P probably damaging Het
Smpd1 T C 7: 105,206,185 (GRCm39) Y438H probably damaging Het
Sorl1 T C 9: 41,887,673 (GRCm39) K2052R probably benign Het
Spata31d1c C A 13: 65,182,944 (GRCm39) P162Q probably damaging Het
Spmip9 A G 6: 70,892,688 (GRCm39) S20P possibly damaging Het
Ston1 A T 17: 88,944,002 (GRCm39) E469D probably benign Het
Syde2 AGTTC AGTTCGTTC 3: 145,707,164 (GRCm39) probably null Het
Syde2 CAGTT CAGTTAGTT 3: 145,707,163 (GRCm39) probably null Het
Taar5 T A 10: 23,846,836 (GRCm39) L78Q probably damaging Het
Tas2r114 A T 6: 131,666,251 (GRCm39) L259* probably null Het
Topaz1 T A 9: 122,577,883 (GRCm39) H264Q probably benign Het
Vcl G T 14: 21,059,027 (GRCm39) V548L possibly damaging Het
Vmn2r57 C A 7: 41,075,974 (GRCm39) probably null Het
Vmn2r92 A G 17: 18,405,439 (GRCm39) *861W probably null Het
Ylpm1 T G 12: 85,076,095 (GRCm39) V940G probably damaging Het
Zfp236 A G 18: 82,627,556 (GRCm39) S1500P probably damaging Het
Zfp384 G T 6: 125,000,642 (GRCm39) probably benign Het
Zfp786 T C 6: 47,796,953 (GRCm39) M662V probably benign Het
Other mutations in Or7g17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01142:Or7g17 APN 9 18,768,830 (GRCm39) missense probably damaging 0.97
IGL01696:Or7g17 APN 9 18,768,352 (GRCm39) missense probably benign 0.19
IGL02285:Or7g17 APN 9 18,768,286 (GRCm39) missense possibly damaging 0.87
R0133:Or7g17 UTSW 9 18,767,925 (GRCm39) start codon destroyed probably null
R0173:Or7g17 UTSW 9 18,768,325 (GRCm39) missense probably damaging 0.98
R0270:Or7g17 UTSW 9 18,768,127 (GRCm39) missense probably damaging 1.00
R0449:Or7g17 UTSW 9 18,767,945 (GRCm39) missense probably benign 0.00
R1111:Or7g17 UTSW 9 18,768,888 (GRCm39) makesense probably null
R1462:Or7g17 UTSW 9 18,768,407 (GRCm39) missense probably benign 0.30
R1462:Or7g17 UTSW 9 18,768,407 (GRCm39) missense probably benign 0.30
R1845:Or7g17 UTSW 9 18,768,782 (GRCm39) missense possibly damaging 0.95
R4090:Or7g17 UTSW 9 18,768,398 (GRCm39) missense probably benign 0.00
R4096:Or7g17 UTSW 9 18,767,933 (GRCm39) missense probably benign
R4097:Or7g17 UTSW 9 18,767,933 (GRCm39) missense probably benign
R4755:Or7g17 UTSW 9 18,768,476 (GRCm39) missense probably benign 0.03
R4867:Or7g17 UTSW 9 18,768,862 (GRCm39) missense probably benign 0.00
R7216:Or7g17 UTSW 9 18,768,632 (GRCm39) missense probably benign 0.43
R7252:Or7g17 UTSW 9 18,768,548 (GRCm39) missense probably damaging 1.00
R7300:Or7g17 UTSW 9 18,768,530 (GRCm39) missense not run
R7412:Or7g17 UTSW 9 18,768,085 (GRCm39) missense possibly damaging 0.51
R8079:Or7g17 UTSW 9 18,768,725 (GRCm39) missense possibly damaging 0.54
R9083:Or7g17 UTSW 9 18,768,550 (GRCm39) missense probably benign 0.00
R9648:Or7g17 UTSW 9 18,768,748 (GRCm39) missense possibly damaging 0.84
X0024:Or7g17 UTSW 9 18,768,320 (GRCm39) missense probably damaging 1.00
X0057:Or7g17 UTSW 9 18,767,933 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AAATGCCCTGGTCAATGGTC -3'
(R):5'- AGGGATTTATCATTTGAGGGACTACTG -3'

Sequencing Primer
(F):5'- AATGCCCTGGTCAATGGTCTAATG -3'
(R):5'- CATTTGAGGGACTACTGAATACAGC -3'
Posted On 2016-06-06