Incidental Mutation 'R5086:Vmn2r1'
ID 387420
Institutional Source Beutler Lab
Gene Symbol Vmn2r1
Ensembl Gene ENSMUSG00000027824
Gene Name vomeronasal 2, receptor 1
Synonyms V2r83, EG56544
MMRRC Submission 042675-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.133) question?
Stock # R5086 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 63988968-64016905 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 63997418 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 358 (V358D)
Ref Sequence ENSEMBL: ENSMUSP00000029406 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029406]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000029406
AA Change: V358D

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000029406
Gene: ENSMUSG00000027824
AA Change: V358D

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 86 504 6e-92 PFAM
Pfam:NCD3G 546 599 2.4e-17 PFAM
Pfam:7tm_3 632 866 4.1e-48 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.3%
  • 20x: 92.3%
Validation Efficiency 99% (80/81)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adsl T A 15: 80,847,901 (GRCm39) M278K probably damaging Het
Ago1 T C 4: 126,347,397 (GRCm39) I147V probably benign Het
Ank1 T C 8: 23,578,634 (GRCm39) L261P probably damaging Het
Ank2 T C 3: 126,740,997 (GRCm39) probably benign Het
Ap1b1 T C 11: 4,968,020 (GRCm39) V177A possibly damaging Het
Arhgap21 A G 2: 20,853,645 (GRCm39) S1906P probably benign Het
Asb1 A G 1: 91,482,533 (GRCm39) Y214C probably benign Het
BC049715 C T 6: 136,817,429 (GRCm39) T223M probably damaging Het
C1ra T A 6: 124,496,688 (GRCm39) C375S probably damaging Het
Cdh26 C T 2: 178,083,210 (GRCm39) R26* probably null Het
Chordc1 A G 9: 18,224,131 (GRCm39) M304V probably benign Het
Cpne8 T C 15: 90,532,771 (GRCm39) probably benign Het
Cracd A G 5: 77,004,971 (GRCm39) E444G unknown Het
Csf1 T C 3: 107,656,026 (GRCm39) E335G possibly damaging Het
Ctnnd2 C T 15: 30,683,493 (GRCm39) P498L possibly damaging Het
Cyp4f18 C T 8: 72,756,276 (GRCm39) R100H probably benign Het
Dnaaf2 G A 12: 69,244,060 (GRCm39) R334C probably damaging Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Dock10 A G 1: 80,529,189 (GRCm39) S1071P possibly damaging Het
Dtnb T C 12: 3,682,942 (GRCm39) V7A probably benign Het
Eif1 T C 11: 100,211,552 (GRCm39) I62T probably damaging Het
Fbxo44 T A 4: 148,240,669 (GRCm39) T145S probably benign Het
G530012D18Rik G C 1: 85,504,941 (GRCm39) probably benign Het
Gabbr2 A T 4: 46,724,342 (GRCm39) M17K probably damaging Het
Gm5860 T A 4: 81,984,173 (GRCm39) noncoding transcript Het
Gm7964 T A 7: 83,406,560 (GRCm39) F439Y possibly damaging Het
Gpbp1l1 C A 4: 116,445,789 (GRCm39) T297N probably benign Het
Greb1 C T 12: 16,758,023 (GRCm39) probably benign Het
Gvin3 A T 7: 106,197,234 (GRCm39) noncoding transcript Het
Hkdc1 T C 10: 62,231,053 (GRCm39) probably benign Het
Ighv16-1 T A 12: 114,032,510 (GRCm39) L97F probably benign Het
Il21r A G 7: 125,232,027 (GRCm39) D485G probably damaging Het
Inpp5d A G 1: 87,633,686 (GRCm39) H441R probably damaging Het
Iqgap2 G T 13: 95,772,088 (GRCm39) R1364S probably benign Het
Krtap20-2 G T 16: 89,002,806 (GRCm39) C2F unknown Het
Man2c1 T A 9: 57,038,924 (GRCm39) D111E probably damaging Het
Map1a G A 2: 121,134,985 (GRCm39) E1696K probably damaging Het
Mdc1 T A 17: 36,159,522 (GRCm39) V634E probably benign Het
Mgam2-ps A G 6: 40,800,547 (GRCm39) noncoding transcript Het
Mllt3 T A 4: 87,707,535 (GRCm39) N68Y probably damaging Het
Mrps18a T A 17: 46,436,621 (GRCm39) D143E probably benign Het
Myl12a T C 17: 71,301,611 (GRCm39) D172G possibly damaging Het
Notch3 T C 17: 32,362,308 (GRCm39) N1439S probably benign Het
Npepps T C 11: 97,108,625 (GRCm39) M764V probably benign Het
Or8d2b T C 9: 38,789,087 (GRCm39) L205P probably damaging Het
Paxbp1 A T 16: 90,812,104 (GRCm39) probably benign Het
Pcdhb7 A T 18: 37,476,162 (GRCm39) T433S possibly damaging Het
Pcdhb8 A T 18: 37,489,159 (GRCm39) Y279F probably damaging Het
Pim3 T C 15: 88,748,606 (GRCm39) L235P probably damaging Het
Plekha4 C T 7: 45,203,082 (GRCm39) S685F possibly damaging Het
Plekhg1 C A 10: 3,853,649 (GRCm39) H167Q probably damaging Het
Plekhn1 G C 4: 156,306,881 (GRCm39) P503A probably benign Het
Sar1a T C 10: 61,527,125 (GRCm39) L181P probably damaging Het
Sec22a G T 16: 35,168,112 (GRCm39) S133* probably null Het
Sipa1l3 G A 7: 29,048,000 (GRCm39) S247F probably damaging Het
Slc31a1 T C 4: 62,306,190 (GRCm39) S103P probably damaging Het
Spag6 A C 2: 18,747,688 (GRCm39) probably benign Het
Stab1 T A 14: 30,865,581 (GRCm39) D1769V probably damaging Het
Stab1 G A 14: 30,881,261 (GRCm39) L590F probably damaging Het
Syde2 CAGTT CAGTTAGTT 3: 145,707,163 (GRCm39) probably null Het
Tbc1d2b A G 9: 90,109,510 (GRCm39) L322P probably benign Het
Tdrp T C 8: 14,024,590 (GRCm39) E18G possibly damaging Het
Tlr3 T A 8: 45,855,862 (GRCm39) N106I probably damaging Het
Tmem104 T A 11: 115,092,227 (GRCm39) I112N probably damaging Het
Tmem14c C T 13: 41,174,598 (GRCm39) T69I probably benign Het
Tmprss11g G A 5: 86,644,377 (GRCm39) P156S possibly damaging Het
Ttn A T 2: 76,700,947 (GRCm39) probably benign Het
Vmn1r45 A T 6: 89,910,082 (GRCm39) I296N probably benign Het
Zc3h7b T C 15: 81,677,375 (GRCm39) L892P probably damaging Het
Zfp366 A G 13: 99,365,451 (GRCm39) Q204R probably benign Het
Zfp598 C A 17: 24,899,872 (GRCm39) probably benign Het
Other mutations in Vmn2r1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00233:Vmn2r1 APN 3 64,012,389 (GRCm39) nonsense probably null
IGL00335:Vmn2r1 APN 3 64,012,809 (GRCm39) missense probably damaging 0.96
IGL01509:Vmn2r1 APN 3 64,010,466 (GRCm39) missense probably benign 0.03
IGL01641:Vmn2r1 APN 3 64,011,924 (GRCm39) missense probably benign 0.19
IGL01656:Vmn2r1 APN 3 63,989,274 (GRCm39) missense probably damaging 0.96
IGL01927:Vmn2r1 APN 3 63,989,105 (GRCm39) missense probably benign 0.01
IGL02093:Vmn2r1 APN 3 64,012,130 (GRCm39) missense probably benign
IGL02146:Vmn2r1 APN 3 64,012,104 (GRCm39) missense probably benign 0.39
IGL02186:Vmn2r1 APN 3 63,989,138 (GRCm39) missense probably benign 0.01
IGL02320:Vmn2r1 APN 3 63,989,180 (GRCm39) missense possibly damaging 0.61
IGL02423:Vmn2r1 APN 3 63,997,665 (GRCm39) missense probably benign 0.00
IGL02709:Vmn2r1 APN 3 64,012,355 (GRCm39) missense probably benign 0.24
R0034:Vmn2r1 UTSW 3 63,997,435 (GRCm39) missense probably damaging 1.00
R0064:Vmn2r1 UTSW 3 64,012,209 (GRCm39) missense possibly damaging 0.76
R0152:Vmn2r1 UTSW 3 63,989,240 (GRCm39) missense possibly damaging 0.92
R0305:Vmn2r1 UTSW 3 63,997,087 (GRCm39) missense probably damaging 1.00
R0314:Vmn2r1 UTSW 3 63,993,980 (GRCm39) missense probably damaging 1.00
R0317:Vmn2r1 UTSW 3 63,989,240 (GRCm39) missense possibly damaging 0.92
R0465:Vmn2r1 UTSW 3 63,989,180 (GRCm39) missense possibly damaging 0.61
R1144:Vmn2r1 UTSW 3 63,997,541 (GRCm39) missense probably damaging 1.00
R1163:Vmn2r1 UTSW 3 63,994,046 (GRCm39) missense probably benign 0.03
R1448:Vmn2r1 UTSW 3 64,008,734 (GRCm39) missense probably damaging 1.00
R1491:Vmn2r1 UTSW 3 63,997,034 (GRCm39) missense probably damaging 1.00
R1543:Vmn2r1 UTSW 3 63,996,994 (GRCm39) missense probably damaging 1.00
R1611:Vmn2r1 UTSW 3 64,011,958 (GRCm39) nonsense probably null
R1676:Vmn2r1 UTSW 3 63,997,603 (GRCm39) nonsense probably null
R1727:Vmn2r1 UTSW 3 63,989,163 (GRCm39) missense probably benign
R1851:Vmn2r1 UTSW 3 64,008,926 (GRCm39) missense probably benign 0.32
R3080:Vmn2r1 UTSW 3 63,997,205 (GRCm39) missense probably damaging 1.00
R3790:Vmn2r1 UTSW 3 63,994,185 (GRCm39) critical splice donor site probably null
R4111:Vmn2r1 UTSW 3 63,997,176 (GRCm39) missense probably benign 0.23
R4689:Vmn2r1 UTSW 3 64,012,074 (GRCm39) missense possibly damaging 0.94
R4747:Vmn2r1 UTSW 3 63,989,267 (GRCm39) missense probably benign 0.00
R4970:Vmn2r1 UTSW 3 63,997,544 (GRCm39) missense possibly damaging 0.81
R5033:Vmn2r1 UTSW 3 64,012,501 (GRCm39) missense probably damaging 1.00
R5112:Vmn2r1 UTSW 3 63,997,544 (GRCm39) missense possibly damaging 0.81
R5385:Vmn2r1 UTSW 3 64,008,819 (GRCm39) missense possibly damaging 0.89
R5629:Vmn2r1 UTSW 3 64,012,538 (GRCm39) missense possibly damaging 0.87
R5762:Vmn2r1 UTSW 3 63,997,474 (GRCm39) missense probably benign 0.24
R5867:Vmn2r1 UTSW 3 64,011,990 (GRCm39) missense probably benign
R5893:Vmn2r1 UTSW 3 63,993,974 (GRCm39) missense probably damaging 1.00
R6037:Vmn2r1 UTSW 3 63,989,150 (GRCm39) missense probably benign 0.00
R6037:Vmn2r1 UTSW 3 63,989,150 (GRCm39) missense probably benign 0.00
R6290:Vmn2r1 UTSW 3 64,012,873 (GRCm39) missense probably benign 0.02
R6443:Vmn2r1 UTSW 3 64,012,374 (GRCm39) missense possibly damaging 0.78
R6464:Vmn2r1 UTSW 3 64,008,766 (GRCm39) missense probably benign
R6826:Vmn2r1 UTSW 3 64,012,567 (GRCm39) nonsense probably null
R6874:Vmn2r1 UTSW 3 64,012,376 (GRCm39) missense probably damaging 1.00
R6882:Vmn2r1 UTSW 3 63,997,529 (GRCm39) missense possibly damaging 0.64
R6983:Vmn2r1 UTSW 3 63,989,118 (GRCm39) missense probably benign
R7010:Vmn2r1 UTSW 3 64,012,146 (GRCm39) missense probably benign 0.19
R7144:Vmn2r1 UTSW 3 63,997,362 (GRCm39) missense probably damaging 1.00
R7341:Vmn2r1 UTSW 3 64,012,877 (GRCm39) makesense probably null
R7510:Vmn2r1 UTSW 3 63,993,922 (GRCm39) missense probably damaging 1.00
R7557:Vmn2r1 UTSW 3 63,997,475 (GRCm39) missense probably damaging 0.99
R7895:Vmn2r1 UTSW 3 63,997,130 (GRCm39) missense possibly damaging 0.90
R8108:Vmn2r1 UTSW 3 64,010,471 (GRCm39) missense probably damaging 0.98
R8209:Vmn2r1 UTSW 3 63,997,199 (GRCm39) missense possibly damaging 0.64
R8365:Vmn2r1 UTSW 3 63,994,034 (GRCm39) missense possibly damaging 0.80
R8514:Vmn2r1 UTSW 3 63,993,942 (GRCm39) missense probably benign 0.11
R8554:Vmn2r1 UTSW 3 63,997,334 (GRCm39) missense probably damaging 0.98
R8980:Vmn2r1 UTSW 3 64,010,501 (GRCm39) missense
R9140:Vmn2r1 UTSW 3 63,997,465 (GRCm39) missense probably benign 0.05
R9239:Vmn2r1 UTSW 3 64,011,959 (GRCm39) missense probably damaging 0.99
R9441:Vmn2r1 UTSW 3 64,012,674 (GRCm39) missense probably damaging 1.00
R9549:Vmn2r1 UTSW 3 63,997,493 (GRCm39) missense probably benign 0.17
R9771:Vmn2r1 UTSW 3 63,997,559 (GRCm39) missense possibly damaging 0.79
X0065:Vmn2r1 UTSW 3 63,997,678 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TGACCTCAGCCTGTTTGTG -3'
(R):5'- AGCTGTGATGTATCCAGATAGGTG -3'

Sequencing Primer
(F):5'- TCATAACATAACTGACAGGACATGG -3'
(R):5'- ATAGGTGTTTTTCAGATCTTCCAGC -3'
Posted On 2016-06-06