Incidental Mutation 'R5089:Or2y10'
ID 387647
Institutional Source Beutler Lab
Gene Symbol Or2y10
Ensembl Gene ENSMUSG00000107645
Gene Name olfactory receptor family 2 subfamily Y member 10
Synonyms GA_x6K02T2QP88-5871967-5871032, MOR256-66_i, Olfr1380
MMRRC Submission 042678-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.161) question?
Stock # R5089 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 49454750-49455685 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 49455240 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 164 (M164K)
Ref Sequence ENSEMBL: ENSMUSP00000151039 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000204300] [ENSMUST00000215360]
AlphaFold Q7TQT5
Predicted Effect possibly damaging
Transcript: ENSMUST00000188518
AA Change: M164K

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000140977
Gene: ENSMUSG00000100997
AA Change: M164K

DomainStartEndE-ValueType
Pfam:7tm_1 41 289 1.5e-31 PFAM
Pfam:7tm_4 139 282 1.4e-39 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000204300
AA Change: M164K

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000145428
Gene: ENSMUSG00000107645
AA Change: M164K

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 5.4e-47 PFAM
Pfam:7tm_1 41 289 9.6e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215360
AA Change: M164K

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
Meta Mutation Damage Score 0.4348 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.0%
  • 20x: 91.3%
Validation Efficiency 98% (65/66)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030J22Rik T C 8: 117,698,672 (GRCm39) N145S possibly damaging Het
Acp2 T C 2: 91,042,267 (GRCm39) probably benign Het
Adgrf2 G A 17: 43,020,988 (GRCm39) A612V probably benign Het
Bltp1 T A 3: 37,041,651 (GRCm39) D2676E probably benign Het
Cct3 T G 3: 88,208,150 (GRCm39) M46R probably damaging Het
Cdc123 T C 2: 5,809,811 (GRCm39) D200G probably benign Het
Cdh9 T A 15: 16,778,362 (GRCm39) F59Y probably damaging Het
Cluh A G 11: 74,551,198 (GRCm39) E349G probably damaging Het
Col16a1 C T 4: 129,972,988 (GRCm39) T643M probably benign Het
Col5a1 G A 2: 27,908,614 (GRCm39) W67* probably null Het
Crbn T C 6: 106,758,679 (GRCm39) H381R possibly damaging Het
Crim1 A G 17: 78,681,519 (GRCm39) D991G probably damaging Het
Dhx16 A T 17: 36,194,981 (GRCm39) M503L probably damaging Het
Dthd1 A G 5: 63,007,248 (GRCm39) T650A probably benign Het
Etfa T A 9: 55,396,150 (GRCm39) K139* probably null Het
Flnc T C 6: 29,447,812 (GRCm39) I1205T probably damaging Het
Fzd6 T A 15: 38,870,875 (GRCm39) C32S probably damaging Het
Gm1110 T A 9: 26,793,683 (GRCm39) D515V probably damaging Het
Gm7676 T C 8: 13,946,401 (GRCm39) noncoding transcript Het
Gpr157 T C 4: 150,186,750 (GRCm39) S293P possibly damaging Het
Hc T C 2: 34,914,902 (GRCm39) D810G probably benign Het
Helz2 T C 2: 180,876,942 (GRCm39) H1184R probably benign Het
Hoxc5 A T 15: 102,922,487 (GRCm39) probably benign Het
Iah1 C T 12: 21,373,309 (GRCm39) S196L possibly damaging Het
Il5 C T 11: 53,612,655 (GRCm39) T55I possibly damaging Het
Kras T C 6: 145,170,869 (GRCm39) K169E probably benign Het
Larp1 C A 11: 57,938,693 (GRCm39) T492K possibly damaging Het
Lgr5 T C 10: 115,314,328 (GRCm39) D203G probably damaging Het
Lpcat2 G A 8: 93,606,071 (GRCm39) V241M probably damaging Het
Mpeg1 G A 19: 12,440,361 (GRCm39) M606I probably benign Het
Ms4a1 G A 19: 11,236,176 (GRCm39) P4S probably benign Het
Nat10 A T 2: 103,587,488 (GRCm39) probably benign Het
Ncaph2 T A 15: 89,240,148 (GRCm39) probably null Het
Nfat5 T A 8: 108,078,070 (GRCm39) V403D probably damaging Het
Or4c109 A G 2: 88,818,516 (GRCm39) F10S probably damaging Het
Pax7 T C 4: 139,557,576 (GRCm39) H65R probably damaging Het
Phf20 C A 2: 156,144,782 (GRCm39) H797N probably benign Het
Pkhd1l1 T A 15: 44,455,283 (GRCm39) S4015T probably benign Het
Prdm5 C T 6: 65,833,074 (GRCm39) H148Y probably benign Het
Prpf8 A G 11: 75,400,054 (GRCm39) probably null Het
Rangap1 A C 15: 81,594,664 (GRCm39) D388E probably benign Het
Sardh A G 2: 27,129,625 (GRCm39) probably null Het
Serpinb6b G A 13: 33,162,133 (GRCm39) E192K probably benign Het
Shfl A T 9: 20,780,212 (GRCm39) M1L probably benign Het
Skor1 A G 9: 63,053,205 (GRCm39) S216P probably damaging Het
Slc51a A G 16: 32,296,364 (GRCm39) probably null Het
Smarcb1 T C 10: 75,751,013 (GRCm39) T74A probably benign Het
Spg11 A T 2: 121,945,198 (GRCm39) Y107* probably null Het
Spmip5 A T 19: 58,774,678 (GRCm39) L176H probably damaging Het
Stk25 T A 1: 93,552,330 (GRCm39) K350M probably benign Het
Syne1 C T 10: 5,355,444 (GRCm39) W379* probably null Het
Taco1 A T 11: 105,960,437 (GRCm39) E126V probably benign Het
Tbc1d12 T A 19: 38,905,232 (GRCm39) L649* probably null Het
Trpm3 G A 19: 22,744,120 (GRCm39) G238R probably damaging Het
Yy1 C A 12: 108,759,663 (GRCm39) Q109K probably damaging Het
Other mutations in Or2y10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00163:Or2y10 APN 11 49,454,747 (GRCm39) utr 5 prime probably benign
IGL01354:Or2y10 APN 11 49,455,024 (GRCm39) missense probably damaging 0.99
R0183:Or2y10 UTSW 11 49,455,675 (GRCm39) missense probably benign 0.14
R0849:Or2y10 UTSW 11 49,455,129 (GRCm39) missense probably damaging 0.99
R3855:Or2y10 UTSW 11 49,454,918 (GRCm39) missense probably damaging 0.98
R3904:Or2y10 UTSW 11 49,455,585 (GRCm39) missense possibly damaging 0.50
R4598:Or2y10 UTSW 11 49,455,545 (GRCm39) missense probably damaging 1.00
R4599:Or2y10 UTSW 11 49,455,545 (GRCm39) missense probably damaging 1.00
R6029:Or2y10 UTSW 11 49,455,428 (GRCm39) missense possibly damaging 0.94
R6551:Or2y10 UTSW 11 49,454,816 (GRCm39) missense probably benign
R6953:Or2y10 UTSW 11 49,455,117 (GRCm39) missense probably damaging 1.00
R7223:Or2y10 UTSW 11 49,454,925 (GRCm39) missense probably damaging 0.99
R7343:Or2y10 UTSW 11 49,455,329 (GRCm39) missense possibly damaging 0.91
R7725:Or2y10 UTSW 11 49,455,359 (GRCm39) missense probably benign 0.01
R7762:Or2y10 UTSW 11 49,455,588 (GRCm39) missense possibly damaging 0.76
R8881:Or2y10 UTSW 11 49,455,209 (GRCm39) missense probably benign 0.01
R9361:Or2y10 UTSW 11 49,455,303 (GRCm39) missense probably damaging 0.99
R9380:Or2y10 UTSW 11 49,454,904 (GRCm39) missense possibly damaging 0.91
R9421:Or2y10 UTSW 11 49,455,201 (GRCm39) missense probably benign 0.03
R9733:Or2y10 UTSW 11 49,454,961 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGACCATCAGCTTTGGAAG -3'
(R):5'- CCCTGGCAATGTGAGCATAG -3'

Sequencing Primer
(F):5'- GTGCTCTCACTGGGAGGAACTG -3'
(R):5'- TGTGAGCATAGGAGCCTAGAATTAGC -3'
Posted On 2016-06-06