Mutagenetix > Incidental Mutation

Incidental Mutation 'R0427:Dnah2'

38768

Institutional Source

Beutler Lab

Gene Symbol

Dnah2

Ensembl Gene

ENSMUSG00000005237

Gene Name

dynein, axonemal, heavy chain 2

Synonyms

Dnahc2, Dnhd3, D330014H01Rik, 2900022L05Rik

MMRRC Submission

038629-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0427 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

69420809-69549110 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 69452879 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 2868 (I2868T)

Ref Sequence

ENSEMBL: ENSMUSP00000104299 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035539] [ENSMUST00000108659]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000035539
AA Change: I2862T

PolyPhen 2 Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000047329
Gene: ENSMUSG00000005237
AA Change: I2862T

Domain	Start	End	E-Value	Type
low complexity region	4	25	N/A	INTRINSIC
Pfam:DHC_N1	273	429	6.6e-37	PFAM
Pfam:DHC_N1	432	761	1.3e-54	PFAM
Pfam:DHC_N2	1253	1668	3.4e-144	PFAM
AAA	1826	1962	2.95e-1	SMART
Pfam:AAA_5	2108	2251	1.3e-5	PFAM
AAA	2437	2584	3.63e-5	SMART
Pfam:AAA_8	2752	3022	1.1e-75	PFAM
Pfam:MT	3034	3370	8.7e-55	PFAM
Pfam:AAA_9	3386	3616	7.4e-68	PFAM
Pfam:Dynein_heavy	3748	4453	1.2e-220	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000108659
AA Change: I2868T

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000104299
Gene: ENSMUSG00000005237
AA Change: I2868T

Domain	Start	End	E-Value	Type
low complexity region	4	25	N/A	INTRINSIC
Pfam:DHC_N1	274	429	1.1e-47	PFAM
Pfam:DHC_N1	438	760	1.5e-75	PFAM
Pfam:DHC_N2	1255	1666	4.4e-144	PFAM
low complexity region	1711	1720	N/A	INTRINSIC
AAA	1832	1968	2.95e-1	SMART
Blast:AAA	2111	2251	2e-86	BLAST
AAA	2443	2590	3.63e-5	SMART
Pfam:AAA_8	2758	3028	5.5e-77	PFAM
Pfam:MT	3040	3376	7.6e-55	PFAM
Pfam:AAA_9	3396	3621	7.5e-94	PFAM
Pfam:Dynein_heavy	3759	4458	4.9e-264	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124108

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.2%
20x: 92.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH2 is an axonemal inner arm dynein heavy chain (Chapelin et al., 1997 [PubMed 9256245]).[supplied by OMIM, Mar 2008]

Allele List at MGI

Other mutations in this stock

Total: 79 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam34	T	G	8: 43,652,456	T51P	probably benign	Het
Alpk1	A	T	3: 127,671,071	V1186E	probably damaging	Het
Ankfn1	T	C	11: 89,405,597	D102G	probably damaging	Het
Armc2	A	G	10: 42,000,410	I127T	possibly damaging	Het
Atp6v1b2	T	C	8: 69,101,432	L87P	probably damaging	Het
Atp9a	T	A	2: 168,640,697		probably null	Het
BC048679	C	G	7: 81,495,245	V123L	probably benign	Het
Birc7	G	A	2: 180,929,514		probably null	Het
Btbd9	C	T	17: 30,274,942	D492N	possibly damaging	Het
Cacna1d	T	A	14: 30,346,817	N155I	probably damaging	Het
Cd300lg	T	C	11: 102,043,026	V33A	probably damaging	Het
Cep290	A	G	10: 100,516,179	D742G	probably benign	Het
Cep95	A	G	11: 106,790,752	N14S	probably benign	Het
Cfap74	A	T	4: 155,441,277	M728L	probably benign	Het
Ctsll3	T	A	13: 60,801,391	T9S	probably benign	Het
Cyp3a44	A	G	5: 145,779,602	S393P	possibly damaging	Het
Dmbt1	T	A	7: 131,040,902	L150*	probably null	Het
Dopey1	A	G	9: 86,507,532	H505R	probably damaging	Het
Exo1	A	G	1: 175,905,953	K781R	probably damaging	Het
Fam184a	A	G	10: 53,690,115	Y459H	probably damaging	Het
Foxp1	C	T	6: 98,930,203	D540N	probably damaging	Het
Fstl5	T	A	3: 76,707,727	Y698*	probably null	Het
Gm13088	A	T	4: 143,654,423	N343K	probably benign	Het
Gm5141	T	C	13: 62,774,711	K215E	probably damaging	Het
Gm7102	A	G	19: 61,175,470	Y176H	probably damaging	Het
Grik5	C	A	7: 25,058,498	R386L	probably benign	Het
Ikbke	A	T	1: 131,257,910	S620R	possibly damaging	Het
Kcnh3	A	T	15: 99,233,299	M518L	probably benign	Het
Lrrcc1	G	T	3: 14,558,356	A748S	probably damaging	Het
Mbd5	T	G	2: 49,279,079	S1191A	probably benign	Het
Med27	T	C	2: 29,500,271	I70T	probably damaging	Het
Myh4	A	G	11: 67,258,653	D1737G	probably damaging	Het
Myo5a	A	G	9: 75,174,196	D1021G	probably benign	Het
Ncor1	T	C	11: 62,410,920	E212G	probably damaging	Het
Neb	A	G	2: 52,244,069	S3301P	probably damaging	Het
Neb	A	T	2: 52,243,884	N3362K	possibly damaging	Het
Neurod1	T	G	2: 79,454,182	K286Q	probably damaging	Het
Noc3l	T	C	19: 38,789,651	Q773R	probably benign	Het
Nup205	T	A	6: 35,194,463	N420K	probably benign	Het
Olfml3	A	T	3: 103,737,014	V113E	probably benign	Het
Olfr108	T	A	17: 37,445,702	D60E	probably damaging	Het
Olfr128	A	T	17: 37,923,629	H21L	probably benign	Het
Olfr155	A	G	4: 43,854,417	Y36C	probably damaging	Het
Olfr342	C	T	2: 36,527,982	S190L	probably damaging	Het
Opa1	T	C	16: 29,611,461	V439A	probably damaging	Het
Pcdhb11	T	C	18: 37,422,765	S383P	probably damaging	Het
Pkd1	T	C	17: 24,593,502	V3803A	probably damaging	Het
Plekhg1	A	G	10: 3,964,235	D1319G	probably benign	Het
Polq	T	A	16: 37,061,993	C1227*	probably null	Het
Psmc1	T	C	12: 100,119,228	F283L	probably damaging	Het
Psmd8	T	C	7: 29,176,127	N189S	probably damaging	Het
Ptger4	G	A	15: 5,242,901	T104I	probably benign	Het
Ptpro	T	G	6: 137,368,296	V100G	possibly damaging	Het
Rab11fip1	T	A	8: 27,154,492	T422S	probably damaging	Het
Rad54l2	A	G	9: 106,693,692	L1143P	possibly damaging	Het
Rnf148	A	G	6: 23,654,073	M308T	probably damaging	Het
Sbsn	T	A	7: 30,752,098		probably benign	Het
Scube2	T	A	7: 109,824,837	T487S	probably benign	Het
Sema4c	C	A	1: 36,553,811	E109*	probably null	Het
Sipa1l2	A	T	8: 125,480,332	L544Q	probably damaging	Het
Slc28a2	A	G	2: 122,458,221	T603A	probably benign	Het
Tbc1d7	T	A	13: 43,153,087	T138S	probably benign	Het
Timd4	A	T	11: 46,819,257	T239S	probably benign	Het
Trp53bp1	A	G	2: 121,236,017	S743P	probably damaging	Het
Tspan10	T	A	11: 120,444,294	Y77N	probably damaging	Het
Ttc14	T	C	3: 33,803,484	S245P	probably damaging	Het
Ttf1	T	A	2: 29,065,042	S139R	probably benign	Het
Tubd1	C	A	11: 86,557,790	Q279K	possibly damaging	Het
Twnk	A	G	19: 45,007,587	E153G	probably benign	Het
Ush2a	A	G	1: 188,400,281	D900G	probably damaging	Het
Usp54	A	G	14: 20,570,364	V691A	probably benign	Het
Usp8	T	C	2: 126,718,032		probably benign	Het
Vmn1r231	C	T	17: 20,890,228	V142I	probably benign	Het
Vmn2r15	C	T	5: 109,287,087	A584T	probably damaging	Het
Vmn2r6	A	G	3: 64,559,587	S164P	probably damaging	Het
Vps16	A	G	2: 130,438,850	Y233C	probably benign	Het
Vwf	C	G	6: 125,673,939	H2511D	probably benign	Het
Wipf3	T	G	6: 54,483,897	L110R	possibly damaging	Het
Zfp945	T	A	17: 22,865,252	N11I	probably benign	Het

Other mutations in Dnah2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00087:Dnah2	APN	11	69,492,672 (GRCm38)	missense	possibly damaging	0.93
IGL00418:Dnah2	APN	11	69,495,066 (GRCm38)	splice site	probably benign
IGL00772:Dnah2	APN	11	69,451,257 (GRCm38)	missense	probably damaging	0.97
IGL00819:Dnah2	APN	11	69,473,350 (GRCm38)	critical splice donor site	probably null
IGL00827:Dnah2	APN	11	69,448,457 (GRCm38)	missense	probably damaging	1.00
IGL01060:Dnah2	APN	11	69,478,092 (GRCm38)	missense	possibly damaging	0.86
IGL01340:Dnah2	APN	11	69,493,184 (GRCm38)	missense	probably damaging	0.99
IGL01349:Dnah2	APN	11	69,475,606 (GRCm38)	missense	probably damaging	0.99
IGL01413:Dnah2	APN	11	69,432,964 (GRCm38)	missense	probably damaging	0.99
IGL01451:Dnah2	APN	11	69,474,191 (GRCm38)	splice site	probably benign
IGL01480:Dnah2	APN	11	69,458,371 (GRCm38)	missense	possibly damaging	0.91
IGL01537:Dnah2	APN	11	69,516,080 (GRCm38)	missense	probably benign	0.17
IGL01592:Dnah2	APN	11	69,431,087 (GRCm38)	missense	probably benign	0.14
IGL01612:Dnah2	APN	11	69,465,063 (GRCm38)	splice site	probably benign
IGL01667:Dnah2	APN	11	69,544,395 (GRCm38)	missense	probably benign
IGL01667:Dnah2	APN	11	69,520,941 (GRCm38)	missense	probably damaging	0.98
IGL01691:Dnah2	APN	11	69,539,443 (GRCm38)	missense	probably benign
IGL02019:Dnah2	APN	11	69,474,285 (GRCm38)	missense	probably damaging	1.00
IGL02039:Dnah2	APN	11	69,499,212 (GRCm38)	missense	probably damaging	1.00
IGL02076:Dnah2	APN	11	69,422,559 (GRCm38)	missense	probably damaging	0.99
IGL02085:Dnah2	APN	11	69,458,185 (GRCm38)	missense	probably benign	0.07
IGL02158:Dnah2	APN	11	69,458,123 (GRCm38)	missense	probably benign
IGL02381:Dnah2	APN	11	69,446,292 (GRCm38)	missense	probably benign	0.25
IGL02681:Dnah2	APN	11	69,452,933 (GRCm38)	missense	probably benign	0.40
IGL02957:Dnah2	APN	11	69,448,507 (GRCm38)	missense	possibly damaging	0.96
IGL02961:Dnah2	APN	11	69,518,414 (GRCm38)	missense	probably damaging	1.00
IGL02969:Dnah2	APN	11	69,521,187 (GRCm38)	missense	possibly damaging	0.80
IGL03117:Dnah2	APN	11	69,436,291 (GRCm38)	splice site	probably benign
IGL03120:Dnah2	APN	11	69,421,848 (GRCm38)	missense	probably damaging	1.00
IGL03183:Dnah2	APN	11	69,458,488 (GRCm38)	missense	possibly damaging	0.94
IGL03197:Dnah2	APN	11	69,459,263 (GRCm38)	missense	probably damaging	1.00
IGL03263:Dnah2	APN	11	69,529,381 (GRCm38)	critical splice donor site	probably null
IGL03333:Dnah2	APN	11	69,495,123 (GRCm38)	missense	probably damaging	1.00
IGL03338:Dnah2	APN	11	69,496,577 (GRCm38)	missense	probably benign	0.13
argyrios	UTSW	11	69,516,590 (GRCm38)	missense	possibly damaging	0.47
Aureus	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
platinum	UTSW	11	69,458,042 (GRCm38)	missense	probably damaging	0.96
R0334_dnah2_144	UTSW	11	69,436,836 (GRCm38)	missense	probably damaging	1.00
R2150_dnah2_212	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
BB005:Dnah2	UTSW	11	69,430,835 (GRCm38)	missense	probably damaging	0.98
BB015:Dnah2	UTSW	11	69,430,835 (GRCm38)	missense	probably damaging	0.98
E0370:Dnah2	UTSW	11	69,515,615 (GRCm38)	splice site	probably null
P0026:Dnah2	UTSW	11	69,464,947 (GRCm38)	missense	probably damaging	1.00
R0133:Dnah2	UTSW	11	69,421,009 (GRCm38)	missense	probably damaging	1.00
R0190:Dnah2	UTSW	11	69,435,249 (GRCm38)	missense	probably damaging	1.00
R0334:Dnah2	UTSW	11	69,436,836 (GRCm38)	missense	probably damaging	1.00
R0359:Dnah2	UTSW	11	69,529,531 (GRCm38)	missense	probably benign	0.00
R0386:Dnah2	UTSW	11	69,447,861 (GRCm38)	missense	probably damaging	1.00
R0414:Dnah2	UTSW	11	69,499,238 (GRCm38)	missense	probably benign	0.26
R0433:Dnah2	UTSW	11	69,459,288 (GRCm38)	missense	probably damaging	1.00
R0442:Dnah2	UTSW	11	69,448,542 (GRCm38)	missense	probably damaging	1.00
R0462:Dnah2	UTSW	11	69,459,201 (GRCm38)	missense	probably damaging	1.00
R0463:Dnah2	UTSW	11	69,423,126 (GRCm38)	missense	probably damaging	1.00
R0611:Dnah2	UTSW	11	69,499,194 (GRCm38)	missense	probably damaging	1.00
R0626:Dnah2	UTSW	11	69,477,683 (GRCm38)	missense	probably benign	0.07
R0924:Dnah2	UTSW	11	69,421,308 (GRCm38)	missense	probably damaging	1.00
R0968:Dnah2	UTSW	11	69,448,519 (GRCm38)	missense	possibly damaging	0.67
R1066:Dnah2	UTSW	11	69,447,819 (GRCm38)	missense	probably damaging	1.00
R1183:Dnah2	UTSW	11	69,446,648 (GRCm38)	missense	possibly damaging	0.95
R1184:Dnah2	UTSW	11	69,499,190 (GRCm38)	missense	probably damaging	1.00
R1186:Dnah2	UTSW	11	69,515,700 (GRCm38)	missense	probably damaging	0.99
R1453:Dnah2	UTSW	11	69,451,050 (GRCm38)	missense	probably damaging	0.99
R1498:Dnah2	UTSW	11	69,520,667 (GRCm38)	splice site	probably null
R1538:Dnah2	UTSW	11	69,477,202 (GRCm38)	missense	probably benign	0.17
R1574:Dnah2	UTSW	11	69,514,688 (GRCm38)	missense	probably benign	0.26
R1574:Dnah2	UTSW	11	69,514,688 (GRCm38)	missense	probably benign	0.26
R1590:Dnah2	UTSW	11	69,521,198 (GRCm38)	missense	probably benign	0.00
R1590:Dnah2	UTSW	11	69,422,754 (GRCm38)	critical splice donor site	probably null
R1655:Dnah2	UTSW	11	69,473,854 (GRCm38)	missense	probably damaging	1.00
R1695:Dnah2	UTSW	11	69,514,691 (GRCm38)	missense	possibly damaging	0.74
R1726:Dnah2	UTSW	11	69,497,889 (GRCm38)	missense	probably damaging	1.00
R1764:Dnah2	UTSW	11	69,423,543 (GRCm38)	missense	probably damaging	1.00
R1815:Dnah2	UTSW	11	69,475,574 (GRCm38)	missense	probably damaging	1.00
R1822:Dnah2	UTSW	11	69,514,804 (GRCm38)	missense	probably damaging	1.00
R1859:Dnah2	UTSW	11	69,437,886 (GRCm38)	missense	probably damaging	0.99
R1911:Dnah2	UTSW	11	69,515,752 (GRCm38)	missense	possibly damaging	0.64
R1913:Dnah2	UTSW	11	69,464,930 (GRCm38)	missense	probably damaging	1.00
R1981:Dnah2	UTSW	11	69,474,325 (GRCm38)	missense	probably damaging	1.00
R2010:Dnah2	UTSW	11	69,458,358 (GRCm38)	critical splice donor site	probably null
R2016:Dnah2	UTSW	11	69,437,070 (GRCm38)	missense	probably damaging	0.97
R2017:Dnah2	UTSW	11	69,437,070 (GRCm38)	missense	probably damaging	0.97
R2044:Dnah2	UTSW	11	69,524,240 (GRCm38)	missense	probably benign	0.14
R2077:Dnah2	UTSW	11	69,496,606 (GRCm38)	missense	possibly damaging	0.73
R2096:Dnah2	UTSW	11	69,455,916 (GRCm38)	missense	probably damaging	0.98
R2099:Dnah2	UTSW	11	69,493,237 (GRCm38)	missense	probably damaging	1.00
R2127:Dnah2	UTSW	11	69,458,185 (GRCm38)	missense	probably benign	0.02
R2128:Dnah2	UTSW	11	69,458,185 (GRCm38)	missense	probably benign	0.02
R2146:Dnah2	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
R2147:Dnah2	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
R2150:Dnah2	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
R2404:Dnah2	UTSW	11	69,437,221 (GRCm38)	missense	probably damaging	0.99
R2510:Dnah2	UTSW	11	69,524,206 (GRCm38)	nonsense	probably null
R2517:Dnah2	UTSW	11	69,516,644 (GRCm38)	missense	probably damaging	1.00
R3014:Dnah2	UTSW	11	69,430,478 (GRCm38)	missense	probably benign
R3741:Dnah2	UTSW	11	69,448,469 (GRCm38)	missense	probably damaging	1.00
R3814:Dnah2	UTSW	11	69,492,650 (GRCm38)	splice site	probably null
R3872:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3873:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3874:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3875:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3881:Dnah2	UTSW	11	69,451,347 (GRCm38)	missense	possibly damaging	0.94
R3953:Dnah2	UTSW	11	69,454,103 (GRCm38)	missense	probably damaging	1.00
R3956:Dnah2	UTSW	11	69,484,021 (GRCm38)	missense	probably benign	0.00
R4501:Dnah2	UTSW	11	69,477,659 (GRCm38)	missense	probably benign
R4515:Dnah2	UTSW	11	69,465,631 (GRCm38)	missense	possibly damaging	0.61
R4612:Dnah2	UTSW	11	69,483,367 (GRCm38)	missense	possibly damaging	0.93
R4625:Dnah2	UTSW	11	69,463,661 (GRCm38)	missense	probably damaging	1.00
R4627:Dnah2	UTSW	11	69,465,376 (GRCm38)	missense	probably damaging	1.00
R4642:Dnah2	UTSW	11	69,496,559 (GRCm38)	missense	probably benign	0.00
R4683:Dnah2	UTSW	11	69,458,942 (GRCm38)	missense	probably damaging	1.00
R4698:Dnah2	UTSW	11	69,498,532 (GRCm38)	missense	probably damaging	1.00
R4710:Dnah2	UTSW	11	69,478,077 (GRCm38)	missense	probably damaging	1.00
R4712:Dnah2	UTSW	11	69,516,590 (GRCm38)	missense	possibly damaging	0.47
R4713:Dnah2	UTSW	11	69,476,688 (GRCm38)	missense	probably damaging	1.00
R4717:Dnah2	UTSW	11	69,429,357 (GRCm38)	missense	probably benign	0.00
R4740:Dnah2	UTSW	11	69,458,042 (GRCm38)	missense	probably damaging	0.96
R4780:Dnah2	UTSW	11	69,473,871 (GRCm38)	missense	probably damaging	0.97
R4825:Dnah2	UTSW	11	69,423,205 (GRCm38)	missense	probably damaging	1.00
R4864:Dnah2	UTSW	11	69,422,590 (GRCm38)	missense	probably damaging	0.98
R4868:Dnah2	UTSW	11	69,463,648 (GRCm38)	missense	probably damaging	1.00
R4879:Dnah2	UTSW	11	69,476,691 (GRCm38)	missense	probably damaging	1.00
R4908:Dnah2	UTSW	11	69,521,147 (GRCm38)	missense	probably benign	0.00
R4911:Dnah2	UTSW	11	69,499,104 (GRCm38)	critical splice donor site	probably null
R4954:Dnah2	UTSW	11	69,539,496 (GRCm38)	missense	possibly damaging	0.61
R4962:Dnah2	UTSW	11	69,455,973 (GRCm38)	nonsense	probably null
R5015:Dnah2	UTSW	11	69,497,882 (GRCm38)	missense	possibly damaging	0.89
R5049:Dnah2	UTSW	11	69,448,166 (GRCm38)	missense	probably damaging	1.00
R5055:Dnah2	UTSW	11	69,520,773 (GRCm38)	missense	possibly damaging	0.67
R5153:Dnah2	UTSW	11	69,520,933 (GRCm38)	missense	possibly damaging	0.84
R5155:Dnah2	UTSW	11	69,422,536 (GRCm38)	missense	probably damaging	1.00
R5186:Dnah2	UTSW	11	69,435,884 (GRCm38)	missense	probably damaging	1.00
R5187:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5208:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5252:Dnah2	UTSW	11	69,529,469 (GRCm38)	missense	probably damaging	0.98
R5296:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5298:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5299:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5301:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5324:Dnah2	UTSW	11	69,457,993 (GRCm38)	missense	probably benign	0.07
R5350:Dnah2	UTSW	11	69,516,036 (GRCm38)	missense	possibly damaging	0.48
R5377:Dnah2	UTSW	11	69,421,848 (GRCm38)	missense	probably damaging	1.00
R5393:Dnah2	UTSW	11	69,500,857 (GRCm38)	missense	probably benign
R5421:Dnah2	UTSW	11	69,435,636 (GRCm38)	missense	probably damaging	1.00
R5452:Dnah2	UTSW	11	69,524,383 (GRCm38)	missense	probably damaging	1.00
R5461:Dnah2	UTSW	11	69,473,351 (GRCm38)	critical splice donor site	probably null
R5474:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5476:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5477:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5510:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5527:Dnah2	UTSW	11	69,437,188 (GRCm38)	nonsense	probably null
R5566:Dnah2	UTSW	11	69,516,569 (GRCm38)	nonsense	probably null
R5587:Dnah2	UTSW	11	69,437,242 (GRCm38)	missense	probably damaging	1.00
R5628:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5688:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5690:Dnah2	UTSW	11	69,491,544 (GRCm38)	missense	probably benign	0.15
R5711:Dnah2	UTSW	11	69,435,390 (GRCm38)	missense	probably damaging	1.00
R5735:Dnah2	UTSW	11	69,430,817 (GRCm38)	missense	possibly damaging	0.93
R5826:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5913:Dnah2	UTSW	11	69,448,430 (GRCm38)	missense	probably damaging	1.00
R5914:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5960:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5961:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5961:Dnah2	UTSW	11	69,431,148 (GRCm38)	missense	probably damaging	1.00
R5977:Dnah2	UTSW	11	69,520,881 (GRCm38)	missense	possibly damaging	0.79
R6020:Dnah2	UTSW	11	69,500,839 (GRCm38)	missense	probably benign
R6036:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6036:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6050:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6086:Dnah2	UTSW	11	69,516,008 (GRCm38)	missense	probably benign	0.30
R6115:Dnah2	UTSW	11	69,446,649 (GRCm38)	missense	probably damaging	1.00
R6123:Dnah2	UTSW	11	69,518,359 (GRCm38)	missense	probably benign	0.29
R6159:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6159:Dnah2	UTSW	11	69,458,542 (GRCm38)	missense	probably damaging	1.00
R6163:Dnah2	UTSW	11	69,520,903 (GRCm38)	nonsense	probably null
R6171:Dnah2	UTSW	11	69,423,042 (GRCm38)	missense	probably damaging	1.00
R6263:Dnah2	UTSW	11	69,457,412 (GRCm38)	missense	probably damaging	1.00
R6298:Dnah2	UTSW	11	69,491,641 (GRCm38)	missense	probably benign	0.25
R6352:Dnah2	UTSW	11	69,448,227 (GRCm38)	missense	probably damaging	1.00
R6399:Dnah2	UTSW	11	69,458,518 (GRCm38)	missense	probably damaging	0.98
R6466:Dnah2	UTSW	11	69,539,415 (GRCm38)	missense	probably benign
R6478:Dnah2	UTSW	11	69,516,010 (GRCm38)	missense	probably benign	0.01
R6516:Dnah2	UTSW	11	69,465,386 (GRCm38)	missense	probably benign	0.34
R6538:Dnah2	UTSW	11	69,437,197 (GRCm38)	missense	possibly damaging	0.87
R6802:Dnah2	UTSW	11	69,423,690 (GRCm38)	missense	probably damaging	1.00
R6861:Dnah2	UTSW	11	69,455,963 (GRCm38)	missense	possibly damaging	0.64
R6869:Dnah2	UTSW	11	69,429,471 (GRCm38)	missense	probably damaging	1.00
R6894:Dnah2	UTSW	11	69,484,260 (GRCm38)	missense	probably benign	0.12
R6935:Dnah2	UTSW	11	69,421,741 (GRCm38)	missense	probably damaging	1.00
R7017:Dnah2	UTSW	11	69,491,547 (GRCm38)	nonsense	probably null
R7073:Dnah2	UTSW	11	69,430,492 (GRCm38)	nonsense	probably null
R7111:Dnah2	UTSW	11	69,446,753 (GRCm38)	splice site	probably null
R7125:Dnah2	UTSW	11	69,436,182 (GRCm38)	missense	probably damaging	0.99
R7137:Dnah2	UTSW	11	69,491,555 (GRCm38)	missense	probably damaging	1.00
R7190:Dnah2	UTSW	11	69,549,097 (GRCm38)	splice site	probably null
R7214:Dnah2	UTSW	11	69,431,109 (GRCm38)	missense	probably damaging	1.00
R7227:Dnah2	UTSW	11	69,421,396 (GRCm38)	missense	probably damaging	0.99
R7238:Dnah2	UTSW	11	69,459,146 (GRCm38)	critical splice donor site	probably null
R7256:Dnah2	UTSW	11	69,431,094 (GRCm38)	missense	probably damaging	1.00
R7267:Dnah2	UTSW	11	69,500,817 (GRCm38)	missense	probably damaging	1.00
R7420:Dnah2	UTSW	11	69,478,797 (GRCm38)	missense	possibly damaging	0.94
R7421:Dnah2	UTSW	11	69,492,805 (GRCm38)	missense	probably benign	0.25
R7437:Dnah2	UTSW	11	69,498,627 (GRCm38)	missense	probably damaging	1.00
R7461:Dnah2	UTSW	11	69,548,990 (GRCm38)	critical splice donor site	probably null
R7473:Dnah2	UTSW	11	69,491,658 (GRCm38)	missense	probably damaging	0.99
R7528:Dnah2	UTSW	11	69,500,796 (GRCm38)	missense	probably damaging	0.99
R7613:Dnah2	UTSW	11	69,548,990 (GRCm38)	critical splice donor site	probably null
R7615:Dnah2	UTSW	11	69,435,304 (GRCm38)	missense	probably damaging	0.99
R7626:Dnah2	UTSW	11	69,498,685 (GRCm38)	missense	probably damaging	0.99
R7745:Dnah2	UTSW	11	69,451,318 (GRCm38)	nonsense	probably null
R7764:Dnah2	UTSW	11	69,458,158 (GRCm38)	missense	probably benign	0.29
R7793:Dnah2	UTSW	11	69,495,214 (GRCm38)	missense	probably benign	0.00
R7819:Dnah2	UTSW	11	69,516,593 (GRCm38)	missense	probably benign	0.01
R7881:Dnah2	UTSW	11	69,431,238 (GRCm38)	missense	probably damaging	1.00
R7900:Dnah2	UTSW	11	69,518,428 (GRCm38)	missense	probably damaging	1.00
R7916:Dnah2	UTSW	11	69,421,148 (GRCm38)	critical splice acceptor site	probably null
R7921:Dnah2	UTSW	11	69,520,834 (GRCm38)	missense	probably benign
R7928:Dnah2	UTSW	11	69,430,835 (GRCm38)	missense	probably damaging	0.98
R7937:Dnah2	UTSW	11	69,517,685 (GRCm38)	nonsense	probably null
R7995:Dnah2	UTSW	11	69,520,737 (GRCm38)	missense	possibly damaging	0.77
R8202:Dnah2	UTSW	11	69,478,823 (GRCm38)	missense	probably benign	0.00
R8208:Dnah2	UTSW	11	69,520,852 (GRCm38)	missense	probably benign	0.05
R8215:Dnah2	UTSW	11	69,435,367 (GRCm38)	missense	probably damaging	1.00
R8279:Dnah2	UTSW	11	69,475,573 (GRCm38)	missense	probably damaging	1.00
R8338:Dnah2	UTSW	11	69,487,296 (GRCm38)	missense	probably damaging	1.00
R8348:Dnah2	UTSW	11	69,429,447 (GRCm38)	missense	possibly damaging	0.95
R8405:Dnah2	UTSW	11	69,458,463 (GRCm38)	missense	probably damaging	1.00
R8407:Dnah2	UTSW	11	69,459,278 (GRCm38)	missense	probably benign	0.00
R8493:Dnah2	UTSW	11	69,452,978 (GRCm38)	missense	probably damaging	1.00
R8673:Dnah2	UTSW	11	69,514,697 (GRCm38)	missense	probably benign	0.23
R8725:Dnah2	UTSW	11	69,524,179 (GRCm38)	missense	probably damaging	1.00
R8727:Dnah2	UTSW	11	69,524,179 (GRCm38)	missense	probably damaging	1.00
R8730:Dnah2	UTSW	11	69,493,261 (GRCm38)	missense	possibly damaging	0.73
R8804:Dnah2	UTSW	11	69,465,685 (GRCm38)	missense	probably benign	0.01
R8876:Dnah2	UTSW	11	69,491,522 (GRCm38)	missense	probably damaging	1.00
R8894:Dnah2	UTSW	11	69,492,222 (GRCm38)	missense	probably benign	0.01
R8938:Dnah2	UTSW	11	69,437,928 (GRCm38)	missense	probably damaging	0.99
R9044:Dnah2	UTSW	11	69,529,421 (GRCm38)	missense	probably benign
R9085:Dnah2	UTSW	11	69,429,398 (GRCm38)	missense	possibly damaging	0.69
R9110:Dnah2	UTSW	11	69,544,382 (GRCm38)	missense	probably benign
R9156:Dnah2	UTSW	11	69,422,861 (GRCm38)	missense
R9251:Dnah2	UTSW	11	69,515,793 (GRCm38)	missense	probably damaging	1.00
R9258:Dnah2	UTSW	11	69,477,253 (GRCm38)	missense	probably damaging	1.00
R9279:Dnah2	UTSW	11	69,518,278 (GRCm38)	missense	probably benign	0.01
R9318:Dnah2	UTSW	11	69,484,329 (GRCm38)	missense	probably benign	0.07
R9321:Dnah2	UTSW	11	69,448,113 (GRCm38)	critical splice donor site	probably null
R9350:Dnah2	UTSW	11	69,493,247 (GRCm38)	missense	probably benign	0.10
R9358:Dnah2	UTSW	11	69,515,766 (GRCm38)	missense	probably damaging	0.99
R9417:Dnah2	UTSW	11	69,436,164 (GRCm38)	missense	probably damaging	1.00
R9420:Dnah2	UTSW	11	69,478,116 (GRCm38)	missense	probably benign	0.09
R9438:Dnah2	UTSW	11	69,473,394 (GRCm38)	missense	probably damaging	1.00
R9469:Dnah2	UTSW	11	69,431,070 (GRCm38)	missense	probably damaging	1.00
R9487:Dnah2	UTSW	11	69,515,791 (GRCm38)	missense	possibly damaging	0.47
R9495:Dnah2	UTSW	11	69,454,382 (GRCm38)	missense	possibly damaging	0.89
R9579:Dnah2	UTSW	11	69,477,215 (GRCm38)	missense	probably damaging	1.00
R9608:Dnah2	UTSW	11	69,454,062 (GRCm38)	missense	probably null	1.00
R9651:Dnah2	UTSW	11	69,450,998 (GRCm38)	critical splice donor site	probably null
R9662:Dnah2	UTSW	11	69,452,937 (GRCm38)	missense	probably benign
RF004:Dnah2	UTSW	11	69,437,187 (GRCm38)	missense	probably benign	0.24
U24488:Dnah2	UTSW	11	69,483,822 (GRCm38)	missense	probably damaging	0.99
X0021:Dnah2	UTSW	11	69,448,562 (GRCm38)	missense	possibly damaging	0.81
Z1088:Dnah2	UTSW	11	69,430,793 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,421,821 (GRCm38)	missense	possibly damaging	0.46
Z1176:Dnah2	UTSW	11	69,516,523 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,516,481 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,498,667 (GRCm38)	missense	probably benign	0.12
Z1176:Dnah2	UTSW	11	69,487,054 (GRCm38)	missense	possibly damaging	0.46
Z1176:Dnah2	UTSW	11	69,451,120 (GRCm38)	missense	probably benign
Z1177:Dnah2	UTSW	11	69,544,557 (GRCm38)	critical splice acceptor site	probably null
Z1177:Dnah2	UTSW	11	69,463,453 (GRCm38)	missense	possibly damaging	0.63

Predicted Primers

PCR Primer
(F):5'- TGAGAAACAGGCTTCAGCCCAC -3'
(R):5'- TTCCAGATCGAGGTCACCAAGCAC -3'

Sequencing Primer
(F):5'- TTCAGCCCACAGGGACTG -3'
(R):5'- TTCCGAGACGGTAAGGCTG -3'

Posted On

2013-05-23