Incidental Mutation 'R5092:Ptprk'
| ID |
387841 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ptprk
|
| Ensembl Gene |
ENSMUSG00000019889 |
| Gene Name |
protein tyrosine phosphatase receptor type K |
| Synonyms |
RPTPkappa, PTPk |
| MMRRC Submission |
042681-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5092 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
27950816-28473393 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 28468769 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 1396
(N1396K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126279
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166468]
[ENSMUST00000218276]
[ENSMUST00000218359]
[ENSMUST00000220357]
|
| AlphaFold |
P35822 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000166468
AA Change: N1396K
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000126279
Gene: ENSMUSG00000019889
AA Change: N1396K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
MAM
|
30 |
193 |
1.61e-73 |
SMART |
|
IG
|
200 |
288 |
2.16e-8 |
SMART |
|
FN3
|
290 |
373 |
1.48e-4 |
SMART |
|
FN3
|
389 |
475 |
4.24e1 |
SMART |
|
FN3
|
491 |
579 |
3.32e-7 |
SMART |
|
transmembrane domain
|
753 |
774 |
N/A |
INTRINSIC |
|
PTPc
|
898 |
1161 |
3.56e-132 |
SMART |
|
PTPc
|
1190 |
1455 |
2.68e-86 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000218276
AA Change: N1410K
PolyPhen 2
Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000218359
AA Change: N1384K
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000220357
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000220404
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 93.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930433I11Rik |
C |
T |
7: 40,637,091 (GRCm39) |
|
probably benign |
Het |
| Abca13 |
T |
A |
11: 9,208,535 (GRCm39) |
L236Q |
probably damaging |
Het |
| Acp2 |
A |
T |
2: 91,038,391 (GRCm39) |
T255S |
probably benign |
Het |
| Acsf3 |
A |
C |
8: 123,544,131 (GRCm39) |
R536S |
probably benign |
Het |
| Adgrb1 |
T |
G |
15: 74,401,664 (GRCm39) |
V220G |
probably benign |
Het |
| Anks6 |
C |
T |
4: 47,030,795 (GRCm39) |
G601S |
probably damaging |
Het |
| Atp5f1b |
A |
G |
10: 127,919,854 (GRCm39) |
Q74R |
probably benign |
Het |
| Bltp1 |
A |
T |
3: 37,054,234 (GRCm39) |
M3118L |
probably benign |
Het |
| Brf1 |
G |
A |
12: 112,943,352 (GRCm39) |
T166M |
probably damaging |
Het |
| Capn9 |
A |
G |
8: 125,324,264 (GRCm39) |
K188R |
probably damaging |
Het |
| Casp8 |
A |
T |
1: 58,883,835 (GRCm39) |
N381Y |
possibly damaging |
Het |
| Ccdc88b |
A |
G |
19: 6,825,600 (GRCm39) |
S1218P |
probably damaging |
Het |
| Cdc42bpg |
C |
T |
19: 6,363,250 (GRCm39) |
P403S |
probably benign |
Het |
| Cdkal1 |
T |
A |
13: 30,030,222 (GRCm39) |
Y91F |
probably damaging |
Het |
| Cdyl2 |
T |
C |
8: 117,350,679 (GRCm39) |
N151D |
possibly damaging |
Het |
| Cnot1 |
T |
A |
8: 96,479,396 (GRCm39) |
R875S |
possibly damaging |
Het |
| Cpd |
A |
G |
11: 76,702,530 (GRCm39) |
S613P |
possibly damaging |
Het |
| Cyp2e1 |
G |
T |
7: 140,354,648 (GRCm39) |
R492L |
probably damaging |
Het |
| D5Ertd579e |
G |
A |
5: 36,760,047 (GRCm39) |
T1371M |
probably benign |
Het |
| Dcaf8 |
A |
G |
1: 172,014,476 (GRCm39) |
T394A |
probably benign |
Het |
| Dgka |
T |
C |
10: 128,571,702 (GRCm39) |
E117G |
probably damaging |
Het |
| Dock4 |
G |
A |
12: 40,894,440 (GRCm39) |
V1867I |
probably benign |
Het |
| E2f2 |
G |
T |
4: 135,914,248 (GRCm39) |
A333S |
probably benign |
Het |
| Eif3l |
T |
C |
15: 78,968,354 (GRCm39) |
S208P |
probably benign |
Het |
| Elovl3 |
A |
T |
19: 46,122,961 (GRCm39) |
H179L |
probably damaging |
Het |
| Eml5 |
T |
C |
12: 98,758,875 (GRCm39) |
D1766G |
probably damaging |
Het |
| Eno4 |
A |
G |
19: 58,934,023 (GRCm39) |
T75A |
probably benign |
Het |
| Fam135a |
C |
T |
1: 24,067,888 (GRCm39) |
D94N |
probably benign |
Het |
| Fasn |
G |
T |
11: 120,705,862 (GRCm39) |
Q1136K |
probably benign |
Het |
| Fcer1a |
T |
G |
1: 173,053,022 (GRCm39) |
N58T |
probably damaging |
Het |
| Frmd4b |
T |
A |
6: 97,272,941 (GRCm39) |
D763V |
probably damaging |
Het |
| Gm43518 |
A |
G |
5: 124,076,297 (GRCm39) |
T115A |
probably damaging |
Het |
| Gria4 |
C |
T |
9: 4,472,176 (GRCm39) |
E438K |
probably benign |
Het |
| Grin2d |
T |
C |
7: 45,503,692 (GRCm39) |
E681G |
probably damaging |
Het |
| Gtf3c5 |
G |
T |
2: 28,472,885 (GRCm39) |
N35K |
possibly damaging |
Het |
| Hydin |
A |
G |
8: 111,309,300 (GRCm39) |
T4031A |
probably benign |
Het |
| Igfn1 |
G |
T |
1: 135,892,564 (GRCm39) |
N2185K |
probably benign |
Het |
| Il17rb |
T |
C |
14: 29,724,333 (GRCm39) |
T174A |
probably benign |
Het |
| Kdm3b |
T |
A |
18: 34,946,515 (GRCm39) |
C835S |
probably benign |
Het |
| Lgi2 |
A |
T |
5: 52,695,429 (GRCm39) |
I510N |
probably damaging |
Het |
| Map3k6 |
A |
G |
4: 132,979,054 (GRCm39) |
E1164G |
probably benign |
Het |
| Mpv17l |
T |
A |
16: 13,758,537 (GRCm39) |
M1K |
probably null |
Het |
| Myoc |
T |
A |
1: 162,467,203 (GRCm39) |
L124Q |
probably damaging |
Het |
| Nbeal2 |
C |
A |
9: 110,455,796 (GRCm39) |
|
probably null |
Het |
| Nek10 |
A |
G |
14: 14,820,851 (GRCm38) |
K13E |
possibly damaging |
Het |
| Nt5dc2 |
A |
G |
14: 30,860,989 (GRCm39) |
H491R |
possibly damaging |
Het |
| Or4f61 |
A |
C |
2: 111,922,452 (GRCm39) |
M198R |
possibly damaging |
Het |
| Or51b6 |
T |
A |
7: 103,556,406 (GRCm39) |
Y250* |
probably null |
Het |
| Or8k21 |
T |
C |
2: 86,144,706 (GRCm39) |
Q308R |
probably benign |
Het |
| Pclo |
T |
A |
5: 14,727,322 (GRCm39) |
|
probably benign |
Het |
| Pgm2 |
A |
T |
5: 64,265,092 (GRCm39) |
N371I |
possibly damaging |
Het |
| Phf20l1 |
T |
A |
15: 66,508,762 (GRCm39) |
S873T |
possibly damaging |
Het |
| Plch1 |
T |
C |
3: 63,606,131 (GRCm39) |
T1249A |
probably benign |
Het |
| Plekhn1 |
A |
T |
4: 156,309,222 (GRCm39) |
I228N |
possibly damaging |
Het |
| Ppp1r12a |
A |
T |
10: 108,103,263 (GRCm39) |
|
probably null |
Het |
| Ptchd3 |
T |
C |
11: 121,721,972 (GRCm39) |
Y282H |
probably damaging |
Het |
| Rap1gap2 |
T |
C |
11: 74,329,121 (GRCm39) |
E81G |
probably damaging |
Het |
| Rpf2 |
T |
C |
10: 40,122,971 (GRCm39) |
M1V |
probably null |
Het |
| Rpgrip1l |
G |
A |
8: 91,948,012 (GRCm39) |
Q1224* |
probably null |
Het |
| Rreb1 |
A |
G |
13: 38,112,254 (GRCm39) |
D286G |
probably benign |
Het |
| Rufy4 |
T |
C |
1: 74,186,822 (GRCm39) |
C537R |
probably damaging |
Het |
| Senp5 |
A |
T |
16: 31,807,960 (GRCm39) |
N431K |
probably benign |
Het |
| Serpina1f |
A |
C |
12: 103,659,809 (GRCm39) |
S158A |
probably damaging |
Het |
| Sertad3 |
T |
A |
7: 27,176,145 (GRCm39) |
I193N |
probably damaging |
Het |
| Slc22a8 |
T |
A |
19: 8,571,528 (GRCm39) |
N86K |
probably damaging |
Het |
| Slc6a2 |
T |
C |
8: 93,721,347 (GRCm39) |
V492A |
possibly damaging |
Het |
| Slf2 |
T |
A |
19: 44,940,523 (GRCm39) |
D773E |
probably benign |
Het |
| Slmap |
A |
C |
14: 26,184,744 (GRCm39) |
L272R |
probably damaging |
Het |
| Smyd5 |
T |
C |
6: 85,422,185 (GRCm39) |
|
probably benign |
Het |
| Snx21 |
G |
T |
2: 164,628,666 (GRCm39) |
R103L |
probably damaging |
Het |
| Sphk2 |
T |
A |
7: 45,361,777 (GRCm39) |
|
probably null |
Het |
| Stab1 |
T |
C |
14: 30,867,812 (GRCm39) |
K1653E |
probably benign |
Het |
| Syde1 |
A |
G |
10: 78,425,252 (GRCm39) |
V253A |
probably benign |
Het |
| Sympk |
G |
T |
7: 18,776,584 (GRCm39) |
R492L |
probably benign |
Het |
| Taar7f |
T |
C |
10: 23,925,451 (GRCm39) |
I15T |
probably benign |
Het |
| Tas2r140 |
A |
G |
6: 40,468,200 (GRCm39) |
D10G |
probably benign |
Het |
| Tbcc |
A |
G |
17: 47,202,600 (GRCm39) |
S329G |
probably benign |
Het |
| Teddm3 |
G |
A |
16: 20,971,900 (GRCm39) |
T223M |
probably benign |
Het |
| Tex14 |
G |
T |
11: 87,405,668 (GRCm39) |
C860F |
probably benign |
Het |
| Thada |
A |
T |
17: 84,751,896 (GRCm39) |
L360Q |
probably damaging |
Het |
| Thop1 |
C |
A |
10: 80,916,412 (GRCm39) |
H473Q |
probably damaging |
Het |
| Tln2 |
T |
C |
9: 67,163,310 (GRCm39) |
D1075G |
probably benign |
Het |
| Tmem130 |
G |
A |
5: 144,680,528 (GRCm39) |
T292I |
probably benign |
Het |
| Tmem198b |
T |
C |
10: 128,637,305 (GRCm39) |
N278S |
probably benign |
Het |
| Ttc21a |
A |
T |
9: 119,771,731 (GRCm39) |
T177S |
probably benign |
Het |
| Ubr2 |
A |
T |
17: 47,280,173 (GRCm39) |
C659S |
probably damaging |
Het |
| Vmn2r4 |
T |
C |
3: 64,298,373 (GRCm39) |
K585R |
probably benign |
Het |
| Vmn2r86 |
A |
G |
10: 130,282,456 (GRCm39) |
I720T |
probably damaging |
Het |
| Wdr35 |
G |
T |
12: 9,037,327 (GRCm39) |
W311L |
probably damaging |
Het |
| Zfp39 |
A |
T |
11: 58,782,028 (GRCm39) |
F245I |
possibly damaging |
Het |
| Zftraf1 |
A |
T |
15: 76,530,512 (GRCm39) |
F269L |
probably benign |
Het |
| Zmym5 |
G |
A |
14: 57,034,236 (GRCm39) |
T325I |
probably benign |
Het |
| Zng1 |
A |
T |
19: 24,898,383 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Ptprk |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00310:Ptprk
|
APN |
10 |
28,212,506 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL00533:Ptprk
|
APN |
10 |
28,461,971 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01062:Ptprk
|
APN |
10 |
28,456,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01295:Ptprk
|
APN |
10 |
28,351,174 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL01372:Ptprk
|
APN |
10 |
28,445,923 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01452:Ptprk
|
APN |
10 |
28,450,913 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01829:Ptprk
|
APN |
10 |
28,449,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01861:Ptprk
|
APN |
10 |
28,259,441 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL01955:Ptprk
|
APN |
10 |
28,471,861 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02263:Ptprk
|
APN |
10 |
27,951,110 (GRCm39) |
missense |
unknown |
|
|
IGL02489:Ptprk
|
APN |
10 |
28,259,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02697:Ptprk
|
APN |
10 |
28,451,614 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02713:Ptprk
|
APN |
10 |
28,468,807 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02943:Ptprk
|
APN |
10 |
28,351,172 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL03240:Ptprk
|
APN |
10 |
28,368,957 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03373:Ptprk
|
APN |
10 |
28,442,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
LCD18:Ptprk
|
UTSW |
10 |
28,450,983 (GRCm39) |
intron |
probably benign |
|
|
PIT4366001:Ptprk
|
UTSW |
10 |
28,462,015 (GRCm39) |
missense |
probably benign |
|
|
R0010:Ptprk
|
UTSW |
10 |
28,461,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0021:Ptprk
|
UTSW |
10 |
28,468,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0021:Ptprk
|
UTSW |
10 |
28,468,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0035:Ptprk
|
UTSW |
10 |
28,139,504 (GRCm39) |
nonsense |
probably null |
|
|
R0035:Ptprk
|
UTSW |
10 |
28,139,504 (GRCm39) |
nonsense |
probably null |
|
|
R0053:Ptprk
|
UTSW |
10 |
28,351,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0063:Ptprk
|
UTSW |
10 |
28,139,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0063:Ptprk
|
UTSW |
10 |
28,139,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0244:Ptprk
|
UTSW |
10 |
28,082,221 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0281:Ptprk
|
UTSW |
10 |
28,449,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0387:Ptprk
|
UTSW |
10 |
28,230,625 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0480:Ptprk
|
UTSW |
10 |
28,461,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0480:Ptprk
|
UTSW |
10 |
28,461,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0585:Ptprk
|
UTSW |
10 |
28,451,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Ptprk
|
UTSW |
10 |
27,951,132 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0684:Ptprk
|
UTSW |
10 |
28,359,294 (GRCm39) |
splice site |
probably benign |
|
|
R1073:Ptprk
|
UTSW |
10 |
28,372,943 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1377:Ptprk
|
UTSW |
10 |
28,462,022 (GRCm39) |
missense |
probably benign |
0.42 |
|
R1422:Ptprk
|
UTSW |
10 |
28,351,276 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R1482:Ptprk
|
UTSW |
10 |
28,139,512 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1532:Ptprk
|
UTSW |
10 |
28,461,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1576:Ptprk
|
UTSW |
10 |
28,427,647 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1618:Ptprk
|
UTSW |
10 |
28,369,166 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1654:Ptprk
|
UTSW |
10 |
28,259,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1701:Ptprk
|
UTSW |
10 |
28,342,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1747:Ptprk
|
UTSW |
10 |
28,230,688 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2033:Ptprk
|
UTSW |
10 |
28,468,763 (GRCm39) |
unclassified |
probably benign |
|
|
R2059:Ptprk
|
UTSW |
10 |
28,442,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2076:Ptprk
|
UTSW |
10 |
28,465,364 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2164:Ptprk
|
UTSW |
10 |
28,436,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2260:Ptprk
|
UTSW |
10 |
28,082,145 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2394:Ptprk
|
UTSW |
10 |
28,427,713 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2432:Ptprk
|
UTSW |
10 |
28,468,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2437:Ptprk
|
UTSW |
10 |
28,230,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2495:Ptprk
|
UTSW |
10 |
28,351,074 (GRCm39) |
splice site |
probably benign |
|
|
R3037:Ptprk
|
UTSW |
10 |
28,456,474 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3162:Ptprk
|
UTSW |
10 |
28,468,822 (GRCm39) |
missense |
probably benign |
|
|
R3162:Ptprk
|
UTSW |
10 |
28,468,822 (GRCm39) |
missense |
probably benign |
|
|
R3687:Ptprk
|
UTSW |
10 |
28,349,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3722:Ptprk
|
UTSW |
10 |
28,259,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3892:Ptprk
|
UTSW |
10 |
28,139,617 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3963:Ptprk
|
UTSW |
10 |
28,427,661 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4077:Ptprk
|
UTSW |
10 |
28,139,508 (GRCm39) |
missense |
probably benign |
|
|
R4079:Ptprk
|
UTSW |
10 |
28,139,508 (GRCm39) |
missense |
probably benign |
|
|
R4112:Ptprk
|
UTSW |
10 |
28,351,284 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4255:Ptprk
|
UTSW |
10 |
28,082,241 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4523:Ptprk
|
UTSW |
10 |
28,342,048 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4651:Ptprk
|
UTSW |
10 |
28,139,686 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4652:Ptprk
|
UTSW |
10 |
28,139,686 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4828:Ptprk
|
UTSW |
10 |
28,436,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4829:Ptprk
|
UTSW |
10 |
28,456,480 (GRCm39) |
nonsense |
probably null |
|
|
R4883:Ptprk
|
UTSW |
10 |
28,464,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5004:Ptprk
|
UTSW |
10 |
28,462,059 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5013:Ptprk
|
UTSW |
10 |
28,427,713 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5126:Ptprk
|
UTSW |
10 |
28,451,640 (GRCm39) |
splice site |
probably null |
|
|
R5183:Ptprk
|
UTSW |
10 |
28,351,232 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5264:Ptprk
|
UTSW |
10 |
28,461,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5304:Ptprk
|
UTSW |
10 |
28,468,050 (GRCm39) |
splice site |
probably null |
|
|
R5330:Ptprk
|
UTSW |
10 |
28,463,076 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5474:Ptprk
|
UTSW |
10 |
28,372,926 (GRCm39) |
nonsense |
probably null |
|
|
R5516:Ptprk
|
UTSW |
10 |
28,372,926 (GRCm39) |
nonsense |
probably null |
|
|
R5796:Ptprk
|
UTSW |
10 |
28,259,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5843:Ptprk
|
UTSW |
10 |
28,369,060 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5952:Ptprk
|
UTSW |
10 |
28,461,671 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6065:Ptprk
|
UTSW |
10 |
28,351,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6226:Ptprk
|
UTSW |
10 |
28,440,099 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6264:Ptprk
|
UTSW |
10 |
28,442,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6638:Ptprk
|
UTSW |
10 |
28,471,807 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6843:Ptprk
|
UTSW |
10 |
28,467,978 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6860:Ptprk
|
UTSW |
10 |
28,210,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6869:Ptprk
|
UTSW |
10 |
28,349,055 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7214:Ptprk
|
UTSW |
10 |
28,450,905 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7307:Ptprk
|
UTSW |
10 |
28,465,004 (GRCm39) |
nonsense |
probably null |
|
|
R7349:Ptprk
|
UTSW |
10 |
28,468,834 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7442:Ptprk
|
UTSW |
10 |
28,450,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7585:Ptprk
|
UTSW |
10 |
28,436,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7661:Ptprk
|
UTSW |
10 |
28,342,036 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7694:Ptprk
|
UTSW |
10 |
28,465,366 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R7740:Ptprk
|
UTSW |
10 |
28,372,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7810:Ptprk
|
UTSW |
10 |
28,468,853 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7831:Ptprk
|
UTSW |
10 |
28,444,404 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7836:Ptprk
|
UTSW |
10 |
28,449,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8049:Ptprk
|
UTSW |
10 |
28,259,565 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8235:Ptprk
|
UTSW |
10 |
28,465,037 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8274:Ptprk
|
UTSW |
10 |
28,456,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8286:Ptprk
|
UTSW |
10 |
28,444,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8372:Ptprk
|
UTSW |
10 |
28,230,688 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R8727:Ptprk
|
UTSW |
10 |
28,442,541 (GRCm39) |
unclassified |
probably benign |
|
|
R8794:Ptprk
|
UTSW |
10 |
28,139,504 (GRCm39) |
nonsense |
probably null |
|
|
R8842:Ptprk
|
UTSW |
10 |
28,442,497 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8861:Ptprk
|
UTSW |
10 |
28,446,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8897:Ptprk
|
UTSW |
10 |
28,467,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8910:Ptprk
|
UTSW |
10 |
28,368,993 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8919:Ptprk
|
UTSW |
10 |
28,359,203 (GRCm39) |
nonsense |
probably null |
|
|
R8976:Ptprk
|
UTSW |
10 |
28,461,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8982:Ptprk
|
UTSW |
10 |
28,436,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9036:Ptprk
|
UTSW |
10 |
28,461,928 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9135:Ptprk
|
UTSW |
10 |
28,456,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9308:Ptprk
|
UTSW |
10 |
28,450,850 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9317:Ptprk
|
UTSW |
10 |
28,230,731 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9475:Ptprk
|
UTSW |
10 |
28,210,476 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9585:Ptprk
|
UTSW |
10 |
28,369,147 (GRCm39) |
nonsense |
probably null |
|
|
R9625:Ptprk
|
UTSW |
10 |
28,462,006 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9700:Ptprk
|
UTSW |
10 |
28,456,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9745:Ptprk
|
UTSW |
10 |
28,139,608 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
Z1177:Ptprk
|
UTSW |
10 |
28,369,116 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTCATAAGCTCCTGAGAGAACTTC -3'
(R):5'- TCCTCTATGTGCGTGAAGACC -3'
Sequencing Primer
(F):5'- GAGAGAACTTCATCCTCTAGTATCC -3'
(R):5'- CCCACAAGTCAGTAGGTATATGACTG -3'
|
| Posted On |
2016-06-06 |
Incidental Mutation